Azithromycin (hydrate)_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.12659
AKAP12 A kinase (PRKA) anchor protein 12 0.102741
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0852747
CALD1 caldesmon 1 0.0701072
KYNU kynureninase 0.067734
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0675175
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0645861
FAM13A family with sequence similarity 13, member A 0.0591155
TRIO trio Rho guanine nucleotide exchange factor 0.057387
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0514552
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0512501
RPS6 ribosomal protein S6 0.0505768
COL1A1 collagen, type I, alpha 1 0.0492102
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0478389
HILPDA hypoxia inducible lipid droplet-associated 0.0468725
KTN1 kinectin 1 (kinesin receptor) 0.0459629
CSNK1A1 casein kinase 1, alpha 1 0.0456837
HDAC9 histone deacetylase 9 0.0448944
TXNIP thioredoxin interacting protein 0.0448582
FNDC3B fibronectin type III domain containing 3B 0.0442293
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0417264
IGFBP5 insulin-like growth factor binding protein 5 0.0400918
MSN moesin 0.0400721
RIGI RNA sensor RIG-I 0.0399288
ALCAM activated leukocyte cell adhesion molecule 0.0392514
ZBTB38 zinc finger and BTB domain containing 38 0.037734
CXCL8 chemokine (C-X-C motif) ligand 8 0.0367073
GLIS3 GLIS family zinc finger 3 0.0362344
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0357619
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.035374
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0348896
NSRP1 nuclear speckle splicing regulatory protein 1 0.0346078
RPL37A ribosomal protein L37a 0.0341432
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0331557
CDK6 cyclin-dependent kinase 6 0.0327405
SP100 SP100 nuclear antigen 0.0326583
SQSTM1 sequestosome 1 0.0323219
RNF145 ring finger protein 145 0.0322277
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0317267
MBD5 methyl-CpG binding domain protein 5 0.0312571
RPS12 ribosomal protein S12 0.030382
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.029961
PRRC2C proline-rich coiled-coil 2C 0.0299158
SEC22A SEC22 vesicle trafficking protein homolog A (S. cerevisiae) 0.0296788
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 0.029305
RPS14 ribosomal protein S14 0.0291885
DIAPH2 diaphanous-related formin 2 0.0291043
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0290404
DST dystonin 0.0289453
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0287696
VMP1 vacuole membrane protein 1 0.0286385
WDR41 WD repeat domain 41 0.0286203
NAP1L1 nucleosome assembly protein 1-like 1 0.0286019
MYOF myoferlin 0.0285703
UGCG UDP-glucose ceramide glucosyltransferase 0.0283362
EXT1 exostosin glycosyltransferase 1 0.0277219
ABLIM3 actin binding LIM protein family, member 3 0.0276353
ECE1 endothelin converting enzyme 1 0.0270624
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.026687
RND3 Rho family GTPase 3 0.0265526
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0264548
RPS2 ribosomal protein S2 0.0263227
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0261849
CD63 CD63 molecule 0.026181
TRPC1 transient receptor potential cation channel, subfamily C, member 1 0.025901
EIF5B eukaryotic translation initiation factor 5B 0.0256806
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0256152
ZNF148 zinc finger protein 148 0.0255334
RPL28 ribosomal protein L28 0.0254667
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0252407
MAML2 mastermind-like 2 (Drosophila) 0.025237
RUNX1 runt-related transcription factor 1 0.0252053
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0251188
SAMD9 sterile alpha motif domain containing 9 0.0250573
WWOX WW domain containing oxidoreductase 0.0249879
TCEAL9 transcription elongation factor A like 9 0.0248849
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.024876
PGK1 phosphoglycerate kinase 1 0.0246259
CLASP1 cytoplasmic linker associated protein 1 0.0245726
RARS1 arginyl-tRNA synthetase 1 0.0245576
DYNC2I1 dynein 2 intermediate chain 1 0.0245003
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0244287
RRBP1 ribosome binding protein 1 0.0242017
FHIT fragile histidine triad 0.0240992
CEP350 centrosomal protein 350kDa 0.0240235
ANXA2 annexin A2 0.0239716
EHBP1 EH domain binding protein 1 0.0239198
PTN pleiotrophin 0.0238596
LIMCH1 LIM and calponin homology domains 1 0.0234409
IL6 interleukin 6 0.0233927
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0233174
SFXN1 sideroflexin 1 0.0228961
SARNP SAP domain containing ribonucleoprotein 0.0227493
SH3KBP1 SH3-domain kinase binding protein 1 0.022696
FNBP1L formin binding protein 1-like 0.0226335
ENO1 enolase 1, (alpha) 0.0225726
MACF1 microtubule-actin crosslinking factor 1 0.0225618
BAZ1A bromodomain adjacent to zinc finger domain, 1A 0.022553
DSCAM Down syndrome cell adhesion molecule 0.0224961
MT1X metallothionein 1X 0.0224737

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.351421
TIMP3 TIMP metallopeptidase inhibitor 3 -0.147638
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.146796
TGFBI transforming growth factor, beta-induced, 68kDa -0.126992
COL5A1 collagen, type V, alpha 1 -0.10141
BIRC6 baculoviral IAP repeat containing 6 -0.095222
HLA-B major histocompatibility complex, class I, B -0.0924547
CDH13 cadherin 13 -0.0899074
LOX lysyl oxidase -0.0760736
COL6A1 collagen, type VI, alpha 1 -0.0698769
COL6A2 collagen, type VI, alpha 2 -0.0694366
F3 coagulation factor III (thromboplastin, tissue factor) -0.0693701
HOOK2 hook microtubule-tethering protein 2 -0.0691912
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0683906
COG6 component of oligomeric golgi complex 6 -0.0671976
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0654809
CANX calnexin -0.0653983
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0647131
HLA-A major histocompatibility complex, class I, A -0.0620893
NDRG1 N-myc downstream regulated 1 -0.061761
GARS1 glycyl-tRNA synthetase 1 -0.058626
CALR calreticulin -0.0582801
SEC24D SEC24 family member D -0.0582381
HDLBP high density lipoprotein binding protein -0.0553924
KMT2C lysine (K)-specific methyltransferase 2C -0.0552818
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0525277
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.05113
RAI14 retinoic acid induced 14 -0.0496054
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0463595
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.046206
HLA-C major histocompatibility complex, class I, C -0.0460341
VIM vimentin -0.0458415
TTC3 tetratricopeptide repeat domain 3 -0.0454672
MORF4L2 mortality factor 4 like 2 -0.0437642
AFF4 AF4/FMR2 family, member 4 -0.042883
IARS1 isoleucyl-tRNA synthetase 1 -0.0428607
KAZN kazrin, periplakin interacting protein -0.0412487
TNS3 tensin 3 -0.0406459
AHNAK AHNAK nucleoprotein -0.0403773
PDIA4 protein disulfide isomerase family A, member 4 -0.0403588
SPDYA speedy/RINGO cell cycle regulator family member A -0.0386428
NAV1 neuron navigator 1 -0.038577
FRMD6 FERM domain containing 6 -0.038538
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0383496
NBAS neuroblastoma amplified sequence -0.0381933
SMYD3 SET and MYND domain containing 3 -0.037885
AUTS2 autism susceptibility candidate 2 -0.0377115
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0369864
ANKRD17 ankyrin repeat domain 17 -0.0366472
TMSB4X thymosin beta 4, X-linked -0.0360306
LOC112694756 uncharaterized LOC112694756 -0.0359847
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0359686
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0356507
TENT5A terminal nucleotidyltransferase 5A -0.0351495
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0345354
PDIA3 protein disulfide isomerase family A, member 3 -0.0344585
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0343273
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.034319
RNF216 ring finger protein 216 -0.0340726
ZSWIM6 zinc finger, SWIM-type containing 6 -0.033922
UBC ubiquitin C -0.0336104
ARHGAP24 Rho GTPase activating protein 24 -0.0335326
DKK3 dickkopf WNT signaling pathway inhibitor 3 -0.0334115
PTGES2 prostaglandin E synthase 2 -0.0333751
COL7A1 collagen, type VII, alpha 1 -0.033335
SCFD2 sec1 family domain containing 2 -0.0332186
ITCH itchy E3 ubiquitin protein ligase -0.0321997
GLG1 golgi glycoprotein 1 -0.0309805
FAM3C family with sequence similarity 3, member C -0.0307056
VEGFA vascular endothelial growth factor A -0.0304821
FLNA filamin A, alpha -0.0299407
TMEM123 transmembrane protein 123 -0.0298559
RUNX2 runt-related transcription factor 2 -0.0298318
COL4A2 collagen, type IV, alpha 2 -0.0296555
NUDCD3 NudC domain containing 3 -0.0290444
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0286025
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0283917
BSG basigin (Ok blood group) -0.0283069
CADM1 cell adhesion molecule 1 -0.0279011
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0278973
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0277639
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0275063
EGFR epidermal growth factor receptor -0.0274365
MYSM1 Myb-like, SWIRM and MPN domains 1 -0.0273172
SOD2 superoxide dismutase 2, mitochondrial -0.0272729
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0272687
SCFD1 sec1 family domain containing 1 -0.0269198
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -0.0269132
CTSB cathepsin B -0.0265918
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0265086
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0264825
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0264151
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.0264048
ICE1 interactor of little elongation complex ELL subunit 1 -0.0260689
SEC63 SEC63 homolog (S. cerevisiae) -0.0260031
VCL vinculin -0.0260003
EPB41 erythrocyte membrane protein band 4.1 -0.0259952
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0257165
COPB1 coatomer protein complex, subunit beta 1 -0.0256161
SEC23B Sec23 homolog B (S. cerevisiae) -0.0255612