Azithromycin (hydrate)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VMP1 vacuole membrane protein 1 0.103762
AKAP12 A kinase (PRKA) anchor protein 12 0.0734616
MACF1 microtubule-actin crosslinking factor 1 0.070324
CD44 CD44 molecule (Indian blood group) 0.0698983
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0697258
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0693192
SMYD3 SET and MYND domain containing 3 0.0675302
BIRC3 baculoviral IAP repeat containing 3 0.0653271
TXNIP thioredoxin interacting protein 0.0637735
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0628449
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0623772
DST dystonin 0.0583387
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0532689
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0530605
CDCP1 CUB domain containing protein 1 0.0524875
ZEB1 zinc finger E-box binding homeobox 1 0.0484507
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0482478
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0468275
NIPBL Nipped-B homolog (Drosophila) 0.0465771
SVIL supervillin 0.0460987
NAV2 neuron navigator 2 0.0458334
NAP1L1 nucleosome assembly protein 1-like 1 0.0439677
FAF2 Fas associated factor family member 2 0.0429382
CAB39 calcium binding protein 39 0.0423153
MBD5 methyl-CpG binding domain protein 5 0.0409383
FBXL7 F-box and leucine-rich repeat protein 7 0.0405517
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0399449
RNF145 ring finger protein 145 0.039713
EIF5 eukaryotic translation initiation factor 5 0.0395034
PBX3 pre-B-cell leukemia homeobox 3 0.0391974
BABAM2 BRISC and BRCA1 A complex member 2 0.0386589
PRKCA protein kinase C, alpha 0.0385627
GLCCI1 glucocorticoid induced 1 0.0380472
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0374505
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0373943
PHF14 PHD finger protein 14 0.0371733
FAM3C family with sequence similarity 3, member C 0.037086
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0364361
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0364357
ANTXR2 anthrax toxin receptor 2 0.0361869
KMT2C lysine (K)-specific methyltransferase 2C 0.0361047
SMAD3 SMAD family member 3 0.0359341
RSRC1 arginine/serine-rich coiled-coil 1 0.0357236
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0356576
IL6ST interleukin 6 signal transducer 0.0353833
PCDH7 protocadherin 7 0.0352791
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0349165
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0346656
ZNF292 zinc finger protein 292 0.034577
SPATS2 spermatogenesis associated, serine-rich 2 0.0345231
MSN moesin 0.0338601
EHBP1 EH domain binding protein 1 0.0337613
STXBP1 syntaxin binding protein 1 0.0335015
ERCC6L2 excision repair cross-complementation group 6-like 2 0.0330796
EXT1 exostosin glycosyltransferase 1 0.032936
ELL2 elongation factor, RNA polymerase II, 2 0.0329315
OSMR oncostatin M receptor 0.0329167
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0325971
PNISR PNN-interacting serine/arginine-rich protein 0.0324613
FAM120B family with sequence similarity 120B 0.0324538
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0324328
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0318936
CEP250 centrosomal protein 250kDa 0.0318698
BCAR3 breast cancer anti-estrogen resistance 3 0.0315972
FAF1 Fas (TNFRSF6) associated factor 1 0.0313771
RPS12 ribosomal protein S12 0.0307458
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0305908
RANBP2 RAN binding protein 2 0.0305244
RTN4 reticulon 4 0.0299812
WWTR1 WW domain containing transcription regulator 1 0.0299678
SON SON DNA binding protein 0.0299645
PDE4D phosphodiesterase 4D, cAMP-specific 0.0297558
SMC4 structural maintenance of chromosomes 4 0.0297088
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0295881
BRIP1 BRCA1 interacting protein C-terminal helicase 1 0.029579
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0291066
GOLM2 golgi membrane protein 2 0.0290447
ZSWIM6 zinc finger, SWIM-type containing 6 0.0289089
REST RE1-silencing transcription factor 0.0289075
TOM1L2 target of myb1-like 2 (chicken) 0.0289015
PDCD6IP programmed cell death 6 interacting protein 0.0284993
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0284451
INHBA inhibin, beta A 0.0283779
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0279554
BICD1 bicaudal D homolog 1 (Drosophila) 0.0279253
ZDBF2 zinc finger, DBF-type containing 2 0.0277511
NALF1 NALCN channel auxiliary factor 1 0.0276904
ANKRD28 ankyrin repeat domain 28 0.0275334
MED13L mediator complex subunit 13-like 0.0274131
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0272675
RPS3 ribosomal protein S3 0.0272175
EXOC6B exocyst complex component 6B 0.0270009
PCLO piccolo presynaptic cytomatrix protein 0.0268875
AFF4 AF4/FMR2 family, member 4 0.026554
NBEA neurobeachin 0.0262849
KIF5B kinesin family member 5B 0.026089
SETD2 SET domain containing 2 0.025985
NFE2L2 nuclear factor, erythroid 2-like 2 0.0257445
ZFAND3 zinc finger, AN1-type domain 3 0.0256998
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.0256379

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.140372
PTMA prothymosin, alpha -0.136357
TMSB10 thymosin beta 10 -0.124876
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.103471
ANXA2 annexin A2 -0.0952683
IGFBP3 insulin-like growth factor binding protein 3 -0.0904665
POTEF POTE ankyrin domain family, member F -0.0894327
LDHA lactate dehydrogenase A -0.0835229
LOC112694756 uncharaterized LOC112694756 -0.0824037
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0745232
PKM pyruvate kinase, muscle -0.0736198
MT2A metallothionein 2A -0.0716756
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0677716
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0675177
ANXA1 annexin A1 -0.0672274
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0638557
EIF1 eukaryotic translation initiation factor 1 -0.0597758
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.056127
RPLP1 ribosomal protein, large, P1 -0.0559048
DNER delta/notch-like EGF repeat containing -0.055339
IGF2 insulin-like growth factor 2 -0.0552538
FUS FUS RNA binding protein -0.0541447
SPAG9 sperm associated antigen 9 -0.052158
SNX14 sorting nexin 14 -0.0513793
HILPDA hypoxia inducible lipid droplet-associated -0.0511855
FTH1 ferritin, heavy polypeptide 1 -0.049545
IER3 immediate early response 3 -0.0490284
IARS1 isoleucyl-tRNA synthetase 1 -0.0477732
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0468679
PAWR PRKC, apoptosis, WT1, regulator -0.0458153
ERBIN erbb2 interacting protein -0.0457883
NDRG1 N-myc downstream regulated 1 -0.0443713
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0431293
GLS2 glutaminase 2 (liver, mitochondrial) -0.0427365
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.0424858
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0424585
SEPTIN7 septin 7 -0.0410918
GNAS GNAS complex locus -0.0410115
EPAS1 endothelial PAS domain protein 1 -0.0407677
MAP1B microtubule-associated protein 1B -0.0405792
ZNF207 zinc finger protein 207 -0.0396323
LPP LIM domain containing preferred translocation partner in lipoma -0.0395645
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0394572
HDLBP high density lipoprotein binding protein -0.0387694
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.0377659
PFN1 profilin 1 -0.0376389
ESYT2 extended synaptotagmin-like protein 2 -0.037199
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0370678
SP100 SP100 nuclear antigen -0.0367439
ADM adrenomedullin -0.0364219
RPL37A ribosomal protein L37a -0.0363598
FNIP1 folliculin interacting protein 1 -0.0354115
TMEM123 transmembrane protein 123 -0.0349795
STRN3 striatin, calmodulin binding protein 3 -0.0344924
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0342669
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0336782
TAOK1 TAO kinase 1 -0.0335997
PDGFA platelet-derived growth factor alpha polypeptide -0.0330666
APLP2 amyloid beta (A4) precursor-like protein 2 -0.032979
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0327271
RNF213 ring finger protein 213 -0.0326336
GLG1 golgi glycoprotein 1 -0.0326296
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0325719
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0325402
SASH1 SAM and SH3 domain containing 1 -0.0324336
HLA-C major histocompatibility complex, class I, C -0.0322243
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0321941
RNASEH2A ribonuclease H2, subunit A -0.0319302
ZBTB10 zinc finger and BTB domain containing 10 -0.0317884
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0314014
DLG1 discs, large homolog 1 (Drosophila) -0.0309558
FOSL1 FOS-like antigen 1 -0.0308724
DEK DEK proto-oncogene -0.0308453
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0305057
RAB1A RAB1A, member RAS oncogene family -0.0304543
ADAM17 ADAM metallopeptidase domain 17 -0.0304295
WNK1 WNK lysine deficient protein kinase 1 -0.0302567
MORF4L2 mortality factor 4 like 2 -0.0302275
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0301961
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0301534
DENND1A DENN/MADD domain containing 1A -0.029885
WDR45B WD repeat domain 45B -0.029818
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0297943
MYOF myoferlin -0.0295543
RPL35A ribosomal protein L35a -0.0294236
AHCTF1 AT hook containing transcription factor 1 -0.0294111
SEC24A SEC24 family member A -0.0293842
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0293727
CPNE1 copine I -0.0293462
ENO2 enolase 2 (gamma, neuronal) -0.0291435
EMP1 epithelial membrane protein 1 -0.0289997
RPL30 ribosomal protein L30 -0.0289096
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0286615
RPL4 ribosomal protein L4 -0.0286144
SETD5 SET domain containing 5 -0.0285247
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0285124
ZBTB35 zinc finger and BTB domain containing 35 -0.0284674
PCNX1 pecanex 1 -0.0283652
SETX senataxin -0.0282617
SEC31A SEC31 homolog A (S. cerevisiae) -0.0282318