Azithromycin (hydrate)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.101194
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0909166
AKAP12 A kinase (PRKA) anchor protein 12 0.0902361
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0671607
EXT1 exostosin glycosyltransferase 1 0.0589538
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0540434
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0501109
PDLIM5 PDZ and LIM domain 5 0.042433
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0393053
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0386548
TXNIP thioredoxin interacting protein 0.0374133
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0365864
DOCK5 dedicator of cytokinesis 5 0.0362524
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0353845
RPS12 ribosomal protein S12 0.0332183
WWTR1 WW domain containing transcription regulator 1 0.0326739
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0279088
INTS6 integrator complex subunit 6 0.027271
SON SON DNA binding protein 0.0272533
NPAS2 neuronal PAS domain protein 2 0.0272247
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0263484
FNDC3A fibronectin type III domain containing 3A 0.0261688
STC1 stanniocalcin 1 0.0260834
JMJD1C jumonji domain containing 1C 0.0254164
FHL2 four and a half LIM domains 2 0.0251677
PLIN2 perilipin 2 0.0249871
ANGPTL4 angiopoietin-like 4 0.0247994
SVIL supervillin 0.0245019
CLIP2 CAP-GLY domain containing linker protein 2 0.024102
VMP1 vacuole membrane protein 1 0.0238105
AREG amphiregulin 0.0236648
FLNB filamin B, beta 0.0231687
RPS2 ribosomal protein S2 0.0226165
EGFR epidermal growth factor receptor 0.0225518
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0211272
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0210078
ITPRID2 ITPR interacting domain containing 2 0.0209934
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0208623
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.020855
OXR1 oxidation resistance 1 0.0207954
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0204769
GOLGA4 golgin A4 0.0204213
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0203976
ZC3H12C zinc finger CCCH-type containing 12C 0.0200412
ERBIN erbb2 interacting protein 0.0198928
ZEB2 zinc finger E-box binding homeobox 2 0.0198798
CSNK1A1 casein kinase 1, alpha 1 0.0196839
NFE2L1 nuclear factor, erythroid 2-like 1 0.0192243
HSPA1A heat shock 70kDa protein 1A 0.0190122
RAB10 RAB10, member RAS oncogene family 0.0189663
RBPMS RNA binding protein with multiple splicing 0.018945
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0189344
RND3 Rho family GTPase 3 0.0188717
HDAC9 histone deacetylase 9 0.0188332
NKD1 naked cuticle homolog 1 (Drosophila) 0.0186748
TPT1 tumor protein, translationally-controlled 1 0.0186297
GOLM2 golgi membrane protein 2 0.0185803
PTPRF protein tyrosine phosphatase, receptor type, F 0.0185734
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0185572
NRIP1 nuclear receptor interacting protein 1 0.0185005
PHF3 PHD finger protein 3 0.0184695
MT2A metallothionein 2A 0.0183247
ARHGAP5 Rho GTPase activating protein 5 0.0181855
ATXN1 ataxin 1 0.0180869
KTN1 kinectin 1 (kinesin receptor) 0.0180857
DDX24 DEAD (Asp-Glu-Ala-Asp) box helicase 24 0.0180809
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.018016
CTBP2 C-terminal binding protein 2 0.0178642
PRKCE protein kinase C, epsilon 0.0178143
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0178002
SHB Src homology 2 domain containing adaptor protein B 0.0177823
VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 0.0174931
PDE10A phosphodiesterase 10A 0.0174518
MAML3 mastermind-like 3 (Drosophila) 0.0174077
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0173936
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.017332
XRRA1 X-ray radiation resistance associated 1 0.0172664
UTRN utrophin 0.0171898
NALF1 NALCN channel auxiliary factor 1 0.0171629
DSTN destrin (actin depolymerizing factor) 0.0170719
LIMCH1 LIM and calponin homology domains 1 0.0169288
NEBL nebulette 0.0167832
PDE4D phosphodiesterase 4D, cAMP-specific 0.0167678
BPTF bromodomain PHD finger transcription factor 0.0167312
DPY19L1 dpy-19-like 1 (C. elegans) 0.0166859
LOXL2 lysyl oxidase-like 2 0.0164141
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.016145
RPL21 ribosomal protein L21 0.0159333
SOX9 SRY (sex determining region Y)-box 9 0.0159192
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.0157694
PTPRM protein tyrosine phosphatase, receptor type, M 0.0157582
AKAP9 A kinase (PRKA) anchor protein 9 0.0157353
LYST lysosomal trafficking regulator 0.0157105
MSN moesin 0.015494
FTL ferritin, light polypeptide 0.0154811
AFDN afadin, adherens junction formation factor 0.015416
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.015414
MACF1 microtubule-actin crosslinking factor 1 0.0153492
ANKRD17 ankyrin repeat domain 17 0.0152324
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0151278

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.291519
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.288092
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.259659
PTMA prothymosin, alpha -0.127184
NAMPT nicotinamide phosphoribosyltransferase -0.11366
FTH1 ferritin, heavy polypeptide 1 -0.111436
TMSB4X thymosin beta 4, X-linked -0.108342
NRG1 neuregulin 1 -0.0962992
HLA-B major histocompatibility complex, class I, B -0.0957003
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0862306
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0825634
S100A6 S100 calcium binding protein A6 -0.0807666
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0794898
TMSB10 thymosin beta 10 -0.0700509
IFI27 interferon, alpha-inducible protein 27 -0.0690431
SFTPA2 surfactant protein A2 -0.0680658
TRIO trio Rho guanine nucleotide exchange factor -0.0679763
CANX calnexin -0.0677949
RAD21 RAD21 homolog (S. pombe) -0.0589882
SOD2 superoxide dismutase 2, mitochondrial -0.0585628
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0575403
LMNA lamin A/C -0.0557464
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0540524
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0540472
PGK1 phosphoglycerate kinase 1 -0.0526602
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0523781
MKI67 marker of proliferation Ki-67 -0.0519808
GLIS3 GLIS family zinc finger 3 -0.0519742
SPAG9 sperm associated antigen 9 -0.0509471
CENPF centromere protein F, 350/400kDa -0.0497411
KLHL5 kelch-like family member 5 -0.0493847
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0468843
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0452334
COPA coatomer protein complex, subunit alpha -0.0449716
CADM1 cell adhesion molecule 1 -0.0448404
PKM pyruvate kinase, muscle -0.0442511
LOC112694756 uncharaterized LOC112694756 -0.042964
RAB1A RAB1A, member RAS oncogene family -0.0428627
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0427718
AEBP2 AE binding protein 2 -0.0422547
ITGA1 integrin, alpha 1 -0.042086
LCORL ligand dependent nuclear receptor corepressor-like -0.0415692
CALU calumenin -0.0412569
KDM5B lysine (K)-specific demethylase 5B -0.0404659
MYH9 myosin, heavy chain 9, non-muscle -0.0397309
SYT1 synaptotagmin I -0.0396726
H1-0 H1.0 linker histone -0.0391117
EGR1 early growth response 1 -0.0390549
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.038931
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0382744
MARCHF6 membrane associated ring-CH-type finger 6 -0.0381322
TMEM156 transmembrane protein 156 -0.0380531
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0376881
RPL35A ribosomal protein L35a -0.0374919
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0370703
LOC102724023 ES1 protein homolog, mitochondrial -0.0370595
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0364762
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0359502
TAS2R14 taste receptor, type 2, member 14 -0.0357614
NAP1L1 nucleosome assembly protein 1-like 1 -0.0356659
WDR45B WD repeat domain 45B -0.0354626
ETNK1 ethanolamine kinase 1 -0.0351136
ZFAND3 zinc finger, AN1-type domain 3 -0.035088
KDM3A lysine (K)-specific demethylase 3A -0.0348821
GNAS GNAS complex locus -0.0348361
IER3 immediate early response 3 -0.0347523
SQSTM1 sequestosome 1 -0.0345147
WAC WW domain containing adaptor with coiled-coil -0.034335
RUNX2 runt-related transcription factor 2 -0.0334796
VIM vimentin -0.0333332
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0332985
ARF1 ADP-ribosylation factor 1 -0.0328846
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0328662
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0327054
RPL34 ribosomal protein L34 -0.0327044
ETV6 ets variant 6 -0.0325103
BHLHE40 basic helix-loop-helix family, member e40 -0.0320774
SDCBP syndecan binding protein (syntenin) -0.0319219
EPS8 epidermal growth factor receptor pathway substrate 8 -0.031126
HMGB3 high mobility group box 3 -0.0310044
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0305223
TPR translocated promoter region, nuclear basket protein -0.0305169
HPCAL1 hippocalcin-like 1 -0.0302936
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0301904
MAP1B microtubule-associated protein 1B -0.0301764
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0300424
TAGLN2 transgelin 2 -0.0299564
SSBP2 single-stranded DNA binding protein 2 -0.0296394
SEC31A SEC31 homolog A (S. cerevisiae) -0.0296248
RPS20 ribosomal protein S20 -0.0291353
CDC73 cell division cycle 73 -0.0290881
SEC23A Sec23 homolog A (S. cerevisiae) -0.0290017
CLINT1 clathrin interactor 1 -0.0289893
ETV1 ets variant 1 -0.0288063
TENM4 teneurin transmembrane protein 4 -0.0287687
STC2 stanniocalcin 2 -0.0283317
SEPTIN7 septin 7 -0.0281044
SSH1 slingshot protein phosphatase 1 -0.0280844
RNF145 ring finger protein 145 -0.0277549
DENND5B DENN/MADD domain containing 5B -0.0276455