Azithromycin (hydrate)_SW1417 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in SW1417 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_SW1417 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MACC1 metastasis associated in colon cancer 1 0.113057
RPS6 ribosomal protein S6 0.10713
GOLGA4 golgin A4 0.103056
RPS12 ribosomal protein S12 0.100075
RPS2 ribosomal protein S2 0.0765457
DSPP dentin sialophosphoprotein 0.0749383
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0720813
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0691872
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0681223
FTL ferritin, light polypeptide 0.0675105
OSBPL10 oxysterol binding protein-like 10 0.0646067
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.064174
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0641133
VMP1 vacuole membrane protein 1 0.0626483
ESYT2 extended synaptotagmin-like protein 2 0.0564657
TXNIP thioredoxin interacting protein 0.056438
TMF1 TATA element modulatory factor 1 0.0557001
ZBTB20 zinc finger and BTB domain containing 20 0.0552275
NEBL nebulette 0.0549416
CEMIP cell migration inducing protein, hyaluronan binding 0.0541834
KTN1 kinectin 1 (kinesin receptor) 0.0540393
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0532996
RPS3 ribosomal protein S3 0.0518738
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0508379
PCLO piccolo presynaptic cytomatrix protein 0.0483933
KDM2A lysine (K)-specific demethylase 2A 0.0473281
SYNE2 spectrin repeat containing, nuclear envelope 2 0.046235
RPL37A ribosomal protein L37a 0.0423614
B2M beta-2-microglobulin 0.0423566
BBX bobby sox homolog (Drosophila) 0.0423051
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.041617
KMT2C lysine (K)-specific methyltransferase 2C 0.0408446
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.038687
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0383434
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.038206
SET SET nuclear proto-oncogene 0.0378804
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0376092
RAD51B RAD51 paralog B 0.0376003
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0370749
BCL2L1 BCL2-like 1 0.0370712
TPT1 tumor protein, translationally-controlled 1 0.0367667
AKAP9 A kinase (PRKA) anchor protein 9 0.0366966
TBC1D5 TBC1 domain family, member 5 0.0366477
MAN1A1 mannosidase, alpha, class 1A, member 1 0.035003
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0346087
MYO1E myosin IE 0.0344755
PTBP3 polypyrimidine tract binding protein 3 0.0343881
ANKRD12 ankyrin repeat domain 12 0.0339001
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0338017
PNN pinin, desmosome associated protein 0.0334149
RPLP2 ribosomal protein, large, P2 0.0333786
EIF5B eukaryotic translation initiation factor 5B 0.0327002
ZMYND8 zinc finger, MYND-type containing 8 0.0325827
NKTR natural killer cell triggering receptor 0.0324879
RPS8 ribosomal protein S8 0.0319439
TMEM41B transmembrane protein 41B 0.0319051
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0315689
ADAM19 ADAM metallopeptidase domain 19 0.0310228
RPL21 ribosomal protein L21 0.0302934
YAP1 Yes-associated protein 1 0.0301356
ZNF638 zinc finger protein 638 0.0300824
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0299937
CTNND1 catenin (cadherin-associated protein), delta 1 0.0296716
SETD5 SET domain containing 5 0.0295508
DOCK5 dedicator of cytokinesis 5 0.0294927
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0291949
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0291892
NDRG1 N-myc downstream regulated 1 0.0291301
RPL36 ribosomal protein L36 0.0290737
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 0.0290231
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0280657
LMO7 LIM domain 7 0.0279939
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0279831
ITCH itchy E3 ubiquitin protein ligase 0.0276523
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0276288
PRRC2C proline-rich coiled-coil 2C 0.027508
RPL26 ribosomal protein L26 0.0271803
FBXL20 F-box and leucine-rich repeat protein 20 0.0269223
NPEPPS aminopeptidase puromycin sensitive 0.0267004
NCOA2 nuclear receptor coactivator 2 0.026692
DPY19L1 dpy-19-like 1 (C. elegans) 0.0266471
MBNL1 muscleblind-like splicing regulator 1 0.0265575
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0265477
PDIA3 protein disulfide isomerase family A, member 3 0.0262438
RPL11 ribosomal protein L11 0.0262243
GTF2IRD1 GTF2I repeat domain containing 1 0.0262194
RRBP1 ribosome binding protein 1 0.0260941
VEGFA vascular endothelial growth factor A 0.025907
ETV6 ets variant 6 0.0258908
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0258824
BTG1 B-cell translocation gene 1, anti-proliferative 0.0257934
KIF5B kinesin family member 5B 0.0257626
CSNK1A1 casein kinase 1, alpha 1 0.0256959
LIMA1 LIM domain and actin binding 1 0.0256264
LPP LIM domain containing preferred translocation partner in lipoma 0.0253637
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0251189
ATP9A ATPase, class II, type 9A 0.0249963
PARD3B par-3 family cell polarity regulator beta 0.024955
RPL7A ribosomal protein L7a 0.0249531
RPS7 ribosomal protein S7 0.024546

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.169333
KRT8 keratin 8, type II -0.166156
TMSB10 thymosin beta 10 -0.128954
ACTN4 actinin, alpha 4 -0.11832
FTH1 ferritin, heavy polypeptide 1 -0.109809
KRT18 keratin 18, type I -0.0972076
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0866112
CCND1 cyclin D1 -0.0812482
TMEM123 transmembrane protein 123 -0.0804195
H1-0 H1.0 linker histone -0.0747936
ANXA2 annexin A2 -0.0736294
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0715282
RAD21 RAD21 homolog (S. pombe) -0.0679867
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0677492
LOC112694756 uncharaterized LOC112694756 -0.0676703
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0634299
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0568827
GARS1 glycyl-tRNA synthetase 1 -0.0552451
FLNA filamin A, alpha -0.054275
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0523339
GNAS GNAS complex locus -0.0520203
AHNAK AHNAK nucleoprotein -0.0490365
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0466694
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0461233
UBC ubiquitin C -0.0458442
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.045532
STT3B STT3B, subunit of the oligosaccharyltransferase complex (catalytic) -0.0451988
HDLBP high density lipoprotein binding protein -0.04467
OSBPL3 oxysterol binding protein-like 3 -0.0443573
RHEB Ras homolog enriched in brain -0.0441359
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0438719
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0430625
NAMPT nicotinamide phosphoribosyltransferase -0.0427876
TXNRD1 thioredoxin reductase 1 -0.0416116
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0402706
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0401738
SDC4 syndecan 4 -0.0396255
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.038622
ACTG1 actin gamma 1 -0.037836
RYBP RING1 and YY1 binding protein -0.0377977
IER3 immediate early response 3 -0.0372176
PERP PERP, TP53 apoptosis effector -0.0371084
GLS2 glutaminase 2 (liver, mitochondrial) -0.0370251
PLEC plectin -0.036924
ZNF217 zinc finger protein 217 -0.0364096
SLC38A2 solute carrier family 38, member 2 -0.0359509
IARS1 isoleucyl-tRNA synthetase 1 -0.0352674
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0351623
AZIN1 antizyme inhibitor 1 -0.0337464
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 -0.0334099
RPL4 ribosomal protein L4 -0.0327031
OLA1 Obg-like ATPase 1 -0.032487
RBM39 RNA binding motif protein 39 -0.0323219
ARF1 ADP-ribosylation factor 1 -0.0321115
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0318982
TMSB4X thymosin beta 4, X-linked -0.0315289
CANX calnexin -0.0311415
RPL35A ribosomal protein L35a -0.0309967
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0308618
ECT2 epithelial cell transforming 2 -0.030771
CCNL1 cyclin L1 -0.0304205
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 -0.0301415
SAR1A secretion associated, Ras related GTPase 1A -0.0298032
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0294486
MAPRE1 microtubule-associated protein, RP/EB family, member 1 -0.0292078
ANKRD28 ankyrin repeat domain 28 -0.0292017
RPL32 ribosomal protein L32 -0.0291976
TUFT1 tuftelin 1 -0.028936
CTSD cathepsin D -0.0286992
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0284017
HMGA1 high mobility group AT-hook 1 -0.0280706
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0279006
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0275785
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme -0.0275578
EGR1 early growth response 1 -0.0274299
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.027423
VCL vinculin -0.0271806
HBP1 HMG-box transcription factor 1 -0.0271615
POTEF POTE ankyrin domain family, member F -0.0267743
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.026395
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.025889
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0256741
S100A10 S100 calcium binding protein A10 -0.0256688
TCERG1 transcription elongation regulator 1 -0.0256105
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0251927
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0249811
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0249435
DLG1 discs, large homolog 1 (Drosophila) -0.0246705
OGT O-linked N-acetylglucosamine (GlcNAc) transferase -0.0242755
ATF6 activating transcription factor 6 -0.0239783
THBS1 thrombospondin 1 -0.0239238
RLIM ring finger protein, LIM domain interacting -0.0239141
SERINC3 serine incorporator 3 -0.0237073
RAB22A RAB22A, member RAS oncogene family -0.0235509
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0234909
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0234407
PPARG peroxisome proliferator-activated receptor gamma -0.0232742
HM13 histocompatibility (minor) 13 -0.0229316
ZFAND5 zinc finger, AN1-type domain 5 -0.0228458
UBE2D1 ubiquitin-conjugating enzyme E2D 1 -0.02278