Azithromycin (hydrate)_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in SW48 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Azithromycin (hydrate)_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AREG amphiregulin 0.103687
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.087617
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0683602
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0610244
RPS12 ribosomal protein S12 0.0521957
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0503624
RPS6 ribosomal protein S6 0.0485164
HILPDA hypoxia inducible lipid droplet-associated 0.0428591
TSC22D2 TSC22 domain family, member 2 0.0403861
CPOX coproporphyrinogen oxidase 0.0403068
ATXN1 ataxin 1 0.039971
GOLGA4 golgin A4 0.0396969
GCLC glutamate-cysteine ligase, catalytic subunit 0.0392145
TXNIP thioredoxin interacting protein 0.039107
EZR ezrin 0.036583
RPS2 ribosomal protein S2 0.0358445
KTN1 kinectin 1 (kinesin receptor) 0.0357282
YAP1 Yes-associated protein 1 0.0346737
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0338942
FN1 fibronectin 1 0.0331819
KIF5B kinesin family member 5B 0.033123
AKAP9 A kinase (PRKA) anchor protein 9 0.0323456
H1-2 H1.2 linker histone, cluster member 0.0319566
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0313044
DPY19L1 dpy-19-like 1 (C. elegans) 0.0307896
IGFBP3 insulin-like growth factor binding protein 3 0.0303887
VMP1 vacuole membrane protein 1 0.0298861
PRRC2C proline-rich coiled-coil 2C 0.0298316
SNX9 sorting nexin 9 0.0297141
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.029607
CSNK1A1 casein kinase 1, alpha 1 0.0275674
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0273949
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0273382
PDE4D phosphodiesterase 4D, cAMP-specific 0.0273219
KMT2E lysine (K)-specific methyltransferase 2E 0.0271262
EFNB2 ephrin-B2 0.0266813
PDE4B phosphodiesterase 4B, cAMP-specific 0.0256114
PNN pinin, desmosome associated protein 0.0255081
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0252269
CLIP2 CAP-GLY domain containing linker protein 2 0.0245005
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.0234854
PDIA3 protein disulfide isomerase family A, member 3 0.0232721
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0232498
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0231173
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0225851
ARHGAP42 Rho GTPase activating protein 42 0.0224873
LUC7L LUC7-like (S. cerevisiae) 0.0222824
SYAP1 synapse associated protein 1 0.0220956
ASPH aspartate beta-hydroxylase 0.0219621
LOC102724023 ES1 protein homolog, mitochondrial 0.0218678
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa 0.0217892
ANKRD12 ankyrin repeat domain 12 0.0216838
SEPTIN7 septin 7 0.0216453
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0212494
CENPF centromere protein F, 350/400kDa 0.0211734
AXIN2 axin 2 0.0208996
DSCAM Down syndrome cell adhesion molecule 0.0208842
RPL21 ribosomal protein L21 0.0208724
SEPTIN9 septin 9 0.0208263
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0207367
DST dystonin 0.0206942
MXI1 MAX interactor 1, dimerization protein 0.0206828
ZFP36 ZFP36 ring finger protein 0.0205701
DSPP dentin sialophosphoprotein 0.0204661
H1-4 H1.4 linker histone, cluster member 0.0204188
FBXL17 F-box and leucine-rich repeat protein 17 0.0203735
FNDC3B fibronectin type III domain containing 3B 0.0203567
FBXO11 F-box protein 11 0.0202854
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0201013
ARRDC3 arrestin domain containing 3 0.0198311
TPR translocated promoter region, nuclear basket protein 0.019714
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0194998
CEP350 centrosomal protein 350kDa 0.0194761
APLP2 amyloid beta (A4) precursor-like protein 2 0.0193502
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0191676
TMEM41B transmembrane protein 41B 0.0191492
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0191454
ENO1 enolase 1, (alpha) 0.0189534
ZNF292 zinc finger protein 292 0.0188757
FXR1 fragile X mental retardation, autosomal homolog 1 0.0188468
KDM2A lysine (K)-specific demethylase 2A 0.0186805
CHD4 chromodomain helicase DNA binding protein 4 0.0185754
KMT2C lysine (K)-specific methyltransferase 2C 0.0185588
NUP58 nucleoporin 58 0.0185269
SNX6 sorting nexin 6 0.0184998
DENR density-regulated protein 0.0184299
XPO1 exportin 1 0.0182823
USP6NL USP6 N-terminal like 0.0182552
AKAP12 A kinase (PRKA) anchor protein 12 0.0182168
RNF43 ring finger protein 43 0.0181905
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0180845
USP9X ubiquitin specific peptidase 9, X-linked 0.0180072
MAN1A2 mannosidase, alpha, class 1A, member 2 0.0179715
SRSF4 serine/arginine-rich splicing factor 4 0.0177819
CLDND1 claudin domain containing 1 0.0177584
SPRED2 sprouty-related, EVH1 domain containing 2 0.0177317
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0176929
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0176124
JMJD1C jumonji domain containing 1C 0.0176071
EIF4B eukaryotic translation initiation factor 4B 0.0172268

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.298199
FRAS1 Fraser extracellular matrix complex subunit 1 -0.129361
FHIT fragile histidine triad -0.0956087
RAD51B RAD51 paralog B -0.0946287
VCL vinculin -0.0924422
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0854677
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0782664
TMSB10 thymosin beta 10 -0.0736859
PTMA prothymosin, alpha -0.0725874
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0725604
RPS24 ribosomal protein S24 -0.0673536
FLOT1 flotillin 1 -0.0649525
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0646859
ANXA2 annexin A2 -0.0602683
HDAC2 histone deacetylase 2 -0.0583834
ACTG1 actin gamma 1 -0.0577117
LAMB3 laminin, beta 3 -0.057179
RPL35A ribosomal protein L35a -0.0561161
MPRIP myosin phosphatase Rho interacting protein -0.052288
LMO7 LIM domain 7 -0.0516276
EGR1 early growth response 1 -0.0510321
OSBPL3 oxysterol binding protein-like 3 -0.0496796
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0489691
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0463571
EEF2 eukaryotic translation elongation factor 2 -0.0444708
RUNX2 runt-related transcription factor 2 -0.0442254
MTAP methylthioadenosine phosphorylase -0.0440227
ACTN4 actinin, alpha 4 -0.0423548
LDHA lactate dehydrogenase A -0.0423481
DENND1A DENN/MADD domain containing 1A -0.0417385
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0413894
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor -0.040124
COG5 component of oligomeric golgi complex 5 -0.0397096
TRAF3 TNF receptor-associated factor 3 -0.0388454
ZBTB7C zinc finger and BTB domain containing 7C -0.0363103
IARS1 isoleucyl-tRNA synthetase 1 -0.036106
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0354788
GPHN gephyrin -0.0352796
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0345203
CUX1 cut-like homeobox 1 -0.0338362
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0332162
FERMT1 fermitin family member 1 -0.0328918
KLF5 Kruppel-like factor 5 (intestinal) -0.0328905
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0325888
RCOR1 REST corepressor 1 -0.032342
GPC5 glypican 5 -0.0304706
GMDS GDP-mannose 4,6-dehydratase -0.0303638
RPL13A ribosomal protein L13a -0.0295743
NFIA nuclear factor I/A -0.0293962
AOPEP aminopeptidase O (putative) -0.0290635
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.0287793
RPL4 ribosomal protein L4 -0.0287229
ATP5F1B ATP synthase F1 subunit beta -0.0286462
MBNL1 muscleblind-like splicing regulator 1 -0.0281814
CMIP c-Maf inducing protein -0.0276652
EXOC4 exocyst complex component 4 -0.0275507
SERINC5 serine incorporator 5 -0.0275275
PDLIM5 PDZ and LIM domain 5 -0.027459
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0269321
TAS2R14 taste receptor, type 2, member 14 -0.0267971
TNS3 tensin 3 -0.0266786
LOC112694756 uncharaterized LOC112694756 -0.0265958
KRT18 keratin 18, type I -0.026493
RREB1 ras responsive element binding protein 1 -0.0264922
ANXA11 annexin A11 -0.0259332
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0257212
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) -0.0254333
PSPC1 paraspeckle component 1 -0.0250947
KLF3 Kruppel-like factor 3 (basic) -0.0250768
CD36 CD36 molecule (thrombospondin receptor) -0.02491
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0247833
CD9 CD9 molecule -0.0247422
ANXA3 annexin A3 -0.0244726
TBC1D22A TBC1 domain family, member 22A -0.0244542
SMYD3 SET and MYND domain containing 3 -0.0244101
RPL34 ribosomal protein L34 -0.0242213
RPL9 ribosomal protein L9 -0.0238806
CCSER1 coiled-coil serine-rich protein 1 -0.0234329
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0234206
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0233382
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0229089
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0227183
THSD4 thrombospondin, type I, domain containing 4 -0.0227172
CCND1 cyclin D1 -0.0224244
ANKRD17 ankyrin repeat domain 17 -0.0224175
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0220563
PRRC2B proline-rich coiled-coil 2B -0.021945
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0218395
ANLN anillin, actin binding protein -0.0214009
SAMD4A sterile alpha motif domain containing 4A -0.0212933
FTH1 ferritin, heavy polypeptide 1 -0.0212865
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0210703
RPL12 ribosomal protein L12 -0.021068
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.0210358
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0209652
ADGRA3 adhesion G protein-coupled receptor A3 -0.0208564
KRT8 keratin 8, type II -0.0208271
GARS1 glycyl-tRNA synthetase 1 -0.020741
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0206641
SCFD1 sec1 family domain containing 1 -0.0206623