Azithromycin (hydrate)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Azithromycin (hydrate) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Azithromycin (hydrate)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.151516
RPS6 ribosomal protein S6 0.135625
RPS12 ribosomal protein S12 0.13506
AKAP12 A kinase (PRKA) anchor protein 12 0.130131
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.128446
TPT1 tumor protein, translationally-controlled 1 0.084382
VMP1 vacuole membrane protein 1 0.0841874
NKD1 naked cuticle homolog 1 (Drosophila) 0.0818343
TXNIP thioredoxin interacting protein 0.0771569
MT2A metallothionein 2A 0.0760983
LOC102724023 ES1 protein homolog, mitochondrial 0.0755256
RPS2 ribosomal protein S2 0.0737833
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0704978
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0699548
DSPP dentin sialophosphoprotein 0.0660077
PDGFA platelet-derived growth factor alpha polypeptide 0.0618815
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0582485
RPS8 ribosomal protein S8 0.0519837
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 0.0514348
ENO1 enolase 1, (alpha) 0.0506142
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0502682
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0474758
DUSP6 dual specificity phosphatase 6 0.0471554
RPL36A ribosomal protein L36a 0.0469106
ITGA6 integrin, alpha 6 0.045504
RPL21 ribosomal protein L21 0.0453935
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0451862
FRMD5 FERM domain containing 5 0.0413732
SET SET nuclear proto-oncogene 0.0409477
RPS7 ribosomal protein S7 0.0403261
MSN moesin 0.0398571
BCL2L1 BCL2-like 1 0.0394658
ADGRL2 adhesion G protein-coupled receptor L2 0.0390051
ZBTB38 zinc finger and BTB domain containing 38 0.0366989
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0363772
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0341118
SNX9 sorting nexin 9 0.0340588
WWOX WW domain containing oxidoreductase 0.0340049
KTN1 kinectin 1 (kinesin receptor) 0.0339548
RSL1D1 ribosomal L1 domain containing 1 0.0331609
ASPH aspartate beta-hydroxylase 0.0329351
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0323299
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.031854
PA2G4 proliferation-associated 2G4, 38kDa 0.0317929
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0315065
BACE2 beta-site APP-cleaving enzyme 2 0.031371
CLIP2 CAP-GLY domain containing linker protein 2 0.0307532
ZEB1 zinc finger E-box binding homeobox 1 0.0303915
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0301472
PCDH9 protocadherin 9 0.0300767
H1-2 H1.2 linker histone, cluster member 0.0300327
ZNF638 zinc finger protein 638 0.029781
SCAF11 SR-related CTD-associated factor 11 0.0294612
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0294365
HIP1 huntingtin interacting protein 1 0.0293068
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0287954
PNN pinin, desmosome associated protein 0.0287041
ZFP36L1 ZFP36 ring finger protein-like 1 0.0283682
KIZ kizuna centrosomal protein 0.0281955
LUC7L LUC7-like (S. cerevisiae) 0.0280058
RPS3 ribosomal protein S3 0.0277977
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase) 0.0276403
DIAPH2 diaphanous-related formin 2 0.0273638
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0272657
CDCP1 CUB domain containing protein 1 0.0271891
NPAS2 neuronal PAS domain protein 2 0.0271167
KIF5B kinesin family member 5B 0.0269532
SKAP1 src kinase associated phosphoprotein 1 0.0266391
PRRC2C proline-rich coiled-coil 2C 0.0265976
RPL26 ribosomal protein L26 0.0265399
SPATA13 spermatogenesis associated 13 0.0264286
DOCK5 dedicator of cytokinesis 5 0.0263513
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 0.0262829
BPTF bromodomain PHD finger transcription factor 0.0260846
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0258817
GOLGA4 golgin A4 0.0256476
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0256405
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0256157
PTBP3 polypyrimidine tract binding protein 3 0.02561
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0255095
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0254615
SRSF4 serine/arginine-rich splicing factor 4 0.0242143
RABGAP1L RAB GTPase activating protein 1-like 0.0240815
CD44 CD44 molecule (Indian blood group) 0.0239311
RAD51B RAD51 paralog B 0.0238319
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.023795
EEA1 early endosome antigen 1 0.0236863
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0236845
RPL37 ribosomal protein L37 0.0236554
IPO7 importin 7 0.0235826
YAP1 Yes-associated protein 1 0.0230049
RPL36 ribosomal protein L36 0.0229844
H1-4 H1.4 linker histone, cluster member 0.0227919
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0227667
YBX3 Y box binding protein 3 0.0227094
TPM4 tropomyosin 4 0.0225021
HUNK hormonally up-regulated Neu-associated kinase 0.0223701
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 0.0222734
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0222507
DARS1 aspartyl-tRNA synthetase 1 0.0220668

decreased expression

Symbol Name Standardized Value
KRT8 keratin 8, type II -0.115161
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.101717
RPL35A ribosomal protein L35a -0.0851095
TMSB10 thymosin beta 10 -0.0829732
RUNX1 runt-related transcription factor 1 -0.0824562
EEF2 eukaryotic translation elongation factor 2 -0.0807438
ACTN4 actinin, alpha 4 -0.0802712
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0776996
INTS6 integrator complex subunit 6 -0.0773934
KRT18 keratin 18, type I -0.0758581
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0662907
MORF4L2 mortality factor 4 like 2 -0.066061
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0625079
MAML2 mastermind-like 2 (Drosophila) -0.0624032
LOC112694756 uncharaterized LOC112694756 -0.0608018
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0604606
ACTG1 actin gamma 1 -0.0600984
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0588809
HMGA1 high mobility group AT-hook 1 -0.0560686
CDH13 cadherin 13 -0.0549746
ETNK1 ethanolamine kinase 1 -0.0545198
ATP5F1B ATP synthase F1 subunit beta -0.0537474
DIAPH3 diaphanous-related formin 3 -0.0530598
ANXA2 annexin A2 -0.0520431
SLC38A2 solute carrier family 38, member 2 -0.0514874
TMEM123 transmembrane protein 123 -0.0494685
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.047727
PERP PERP, TP53 apoptosis effector -0.0476808
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0472538
FLNA filamin A, alpha -0.0471286
NAV2 neuron navigator 2 -0.0462243
ANLN anillin, actin binding protein -0.0457388
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0454589
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0448851
PKM pyruvate kinase, muscle -0.0412154
HDAC4 histone deacetylase 4 -0.0410956
SEC31A SEC31 homolog A (S. cerevisiae) -0.0405082
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0397472
P4HB prolyl 4-hydroxylase, beta polypeptide -0.03888
ATXN1 ataxin 1 -0.0379998
ANKRD10 ankyrin repeat domain 10 -0.0379873
MYH9 myosin, heavy chain 9, non-muscle -0.0373867
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0369537
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.036065
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0357831
HDLBP high density lipoprotein binding protein -0.03574
OSBPL3 oxysterol binding protein-like 3 -0.0356683
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0356575
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0355854
CCND1 cyclin D1 -0.0352958
PLEC plectin -0.035214
PFN1 profilin 1 -0.0351885
ARF4 ADP-ribosylation factor 4 -0.0350935
ZFAND3 zinc finger, AN1-type domain 3 -0.0349154
RBM39 RNA binding motif protein 39 -0.0344339
FTH1 ferritin, heavy polypeptide 1 -0.0343426
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0342984
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0342845
WDFY2 WD repeat and FYVE domain containing 2 -0.0342773
UTRN utrophin -0.0342248
ECT2 epithelial cell transforming 2 -0.0341889
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0337894
TBC1D22A TBC1 domain family, member 22A -0.0337051
NONO non-POU domain containing, octamer-binding -0.0336032
IARS1 isoleucyl-tRNA synthetase 1 -0.0334927
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor -0.0334433
CANX calnexin -0.0334211
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0329659
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0323622
RLIM ring finger protein, LIM domain interacting -0.0322172
KRT5 keratin 5, type II -0.0308768
TMSB4X thymosin beta 4, X-linked -0.0306018
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0305555
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0300703
TRA2A transformer 2 alpha homolog (Drosophila) -0.0300651
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0300433
MED21 mediator complex subunit 21 -0.0297889
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0297867
ARCN1 archain 1 -0.0294091
CDK8 cyclin-dependent kinase 8 -0.0291491
CCDC82 coiled-coil domain containing 82 -0.0290351
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0290006
PRPF8 pre-mRNA processing factor 8 -0.0287774
ETV5 ets variant 5 -0.0287168
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0286875
SPDYA speedy/RINGO cell cycle regulator family member A -0.0286762
POU2F1 POU class 2 homeobox 1 -0.028394
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0282801
AHNAK AHNAK nucleoprotein -0.0279675
RPL13A ribosomal protein L13a -0.0277827
GARS1 glycyl-tRNA synthetase 1 -0.0276996
GMDS GDP-mannose 4,6-dehydratase -0.0276981
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0275073
RPL4 ribosomal protein L4 -0.0274306
BIRC6 baculoviral IAP repeat containing 6 -0.0272051
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0270697
ABHD2 abhydrolase domain containing 2 -0.0269996
VCL vinculin -0.0269746
ARF1 ADP-ribosylation factor 1 -0.0269648
BSG basigin (Ok blood group) -0.0267785