Aztreonam Gene Set

Dataset DeepCoverMOA Drug Mechanisms of Action
Category proteomics
Type drug perturbation
External Link https://pubchem.ncbi.nlm.nih.gov/compound/5742832
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Genes

198 proteins with high or low expression in Aztreonam relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.

high expression

Symbol Name Standardized Value
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 0.64
ZNF410 zinc finger protein 410 0.57
ZFP90 ZFP90 zinc finger protein 0.52
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.43
H3C1 H3 clustered histone 1 0.43
RNF145 ring finger protein 145 0.42
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 0.4
ZFAND2A zinc finger, AN1-type domain 2A 0.4
FMNL3 formin-like 3 0.38
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 0.38
COL1A1 collagen, type I, alpha 1 0.37
RHOD ras homolog family member D 0.36
RGN regucalcin 0.36
ARHGEF39 Rho guanine nucleotide exchange factor (GEF) 39 0.34
RPS26 ribosomal protein S26 0.34
LRRC58 leucine rich repeat containing 58 0.34
COL2A1 collagen, type II, alpha 1 0.34
MYNN myoneurin 0.34
SYTL3 synaptotagmin-like 3 0.34
CBLL1 Cbl proto-oncogene-like 1, E3 ubiquitin protein ligase 0.34
IPMK inositol polyphosphate multikinase 0.34
FGB fibrinogen beta chain 0.33
PCLO piccolo presynaptic cytomatrix protein 0.32
CTNND2 catenin (cadherin-associated protein), delta 2 0.31
NOLC1 nucleolar and coiled-body phosphoprotein 1 0.31
BAIAP2 BAI1-associated protein 2 0.31
ESPN espin 0.31
DOCK11 dedicator of cytokinesis 11 0.31
RHBDF1 rhomboid 5 homolog 1 (Drosophila) 0.3
ACTL8 actin-like 8 0.29
FAM133B family with sequence similarity 133, member B 0.29
KLHL18 kelch-like family member 18 0.29
PABPC1 poly(A) binding protein, cytoplasmic 1 0.29
NDUFA3 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa 0.28
AXIN2 axin 2 0.28
JPT1 Jupiter microtubule associated homolog 1 0.28
ZNF275 zinc finger protein 275 0.28
GABPB2 GA binding protein transcription factor, beta subunit 2 0.28
STC2 stanniocalcin 2 0.27
ZNF766 zinc finger protein 766 0.27
METTL25 methyltransferase like 25 0.27
LYST lysosomal trafficking regulator 0.27
LSM11 LSM11, U7 small nuclear RNA associated 0.27
CDC6 cell division cycle 6 0.26
SELENOI selenoprotein I 0.26
CFAP97 cilia and flagella associated protein 97 0.26
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 0.26
TCEA2 transcription elongation factor A (SII), 2 0.26
AZIN1 antizyme inhibitor 1 0.26
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.26
TCEANC2 transcription elongation factor A (SII) N-terminal and central domain containing 2 0.25
ZSCAN25 zinc finger and SCAN domain containing 25 0.25
SAMD4A sterile alpha motif domain containing 4A 0.25
WRB tryptophan rich basic protein 0.25
SLC35F2 solute carrier family 35, member F2 0.25
ZC3H10 zinc finger CCCH-type containing 10 0.25
RPL26 ribosomal protein L26 0.25
SAPCD2 suppressor APC domain containing 2 0.25
ZNF142 zinc finger protein 142 0.25
WNT10B wingless-type MMTV integration site family, member 10B 0.25
SPATA7 spermatogenesis associated 7 0.24
ZIC5 Zic family member 5 0.24
AHI1 Abelson helper integration site 1 0.24
BDNF brain-derived neurotrophic factor 0.24
NAV2 neuron navigator 2 0.24
PUS10 pseudouridylate synthase 10 0.24
DUSP7 dual specificity phosphatase 7 0.24
SKA2 spindle and kinetochore associated complex subunit 2 0.23
ZNF513 zinc finger protein 513 0.23
MTF1 metal-regulatory transcription factor 1 0.23
YBX3 Y box binding protein 3 0.23
PRR3 proline rich 3 0.23
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.23
YAE1 YAE1 maturation factor of ABCE1 0.23
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) 0.23
SP100 SP100 nuclear antigen 0.23
AMD1 adenosylmethionine decarboxylase 1 0.23
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.23
CHRNA5 cholinergic receptor, nicotinic, alpha 5 (neuronal) 0.23
ANKRD13C ankyrin repeat domain 13C 0.22
CCDC28A coiled-coil domain containing 28A 0.22
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 0.22
BAG4 BCL2-associated athanogene 4 0.22
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 0.22
TRIB3 tribbles pseudokinase 3 0.22
CMIP c-Maf inducing protein 0.22
KDM4C lysine (K)-specific demethylase 4C 0.22
CCDC73 coiled-coil domain containing 73 0.22
MBTD1 mbt domain containing 1 0.22
COQ7 coenzyme Q7 homolog, ubiquinone (yeast) 0.22
LAMTOR4 late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 0.21
PTPN18 protein tyrosine phosphatase, non-receptor type 18 (brain-derived) 0.21
GNB5 guanine nucleotide binding protein (G protein), beta 5 0.21
DPH6 diphthamine biosynthesis 6 0.21
PIM1 Pim-1 proto-oncogene, serine/threonine kinase 0.21
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.21
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.21
DNA2 DNA replication helicase/nuclease 2 0.21
CDC25A cell division cycle 25A 0.21

low expression

Symbol Name Standardized Value
KLHL23 kelch-like family member 23 -0.99
ZNF564 zinc finger protein 564 -0.78
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.68
TLE5 TLE family member 5, transcriptional modulator -0.66
AZGP1 alpha-2-glycoprotein 1, zinc-binding -0.64
TMC6 transmembrane channel-like 6 -0.63
TICAM1 toll-like receptor adaptor molecule 1 -0.62
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B -0.58
KMT2C lysine (K)-specific methyltransferase 2C -0.57
AKR1C2 aldo-keto reductase family 1, member C2 -0.53
INAVA innate immunity activator -0.51
FHIT fragile histidine triad -0.51
ANO8 anoctamin 8 -0.5
FSTL3 follistatin-like 3 (secreted glycoprotein) -0.49
TOMM5 translocase of outer mitochondrial membrane 5 homolog (yeast) -0.49
DENND5A DENN/MADD domain containing 5A -0.49
GLRX glutaredoxin (thioltransferase) -0.47
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 -0.47
SGSH N-sulfoglucosamine sulfohydrolase -0.46
KMT2B lysine (K)-specific methyltransferase 2B -0.44
CDC26 cell division cycle 26 -0.43
ATP5PF ATP synthase peripheral stalk subunit F6 -0.43
NOTCH3 notch 3 -0.43
PCBD2 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha (TCF1) 2 -0.42
SPAG17 sperm associated antigen 17 -0.42
FBXL15 F-box and leucine-rich repeat protein 15 -0.42
ABTB1 ankyrin repeat and BTB (POZ) domain containing 1 -0.42
PIP prolactin-induced protein -0.42
KPNA5 karyopherin alpha 5 (importin alpha 6) -0.4
MED30 mediator complex subunit 30 -0.4
VGF VGF nerve growth factor inducible -0.4
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 -0.39
DOCK3 dedicator of cytokinesis 3 -0.39
FBXL2 F-box and leucine-rich repeat protein 2 -0.39
YPEL5 yippee-like 5 (Drosophila) -0.38
CFAP54 cilia and flagella associated 54 -0.38
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.38
CLSTN3 calsyntenin 3 -0.38
DPY30 dpy-30 homolog (C. elegans) -0.38
TGFB1I1 transforming growth factor beta 1 induced transcript 1 -0.37
ARHGAP22 Rho GTPase activating protein 22 -0.37
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) -0.37
SLC44A2 solute carrier family 44 (choline transporter), member 2 -0.37
ADIRF adipogenesis regulatory factor -0.36
PCDH1 protocadherin 1 -0.36
RASA4 RAS p21 protein activator 4 -0.36
S100A16 S100 calcium binding protein A16 -0.36
XTBD1 XRN2 binding domain containing 1 -0.36
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F -0.36
AP5S1 adaptor-related protein complex 5, sigma 1 subunit -0.35
ARSD arylsulfatase D -0.35
SPEG SPEG complex locus -0.35
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.35
SHFL shiftless antiviral inhibitor of ribosomal frameshifting -0.35
MIB2 mindbomb E3 ubiquitin protein ligase 2 -0.34
GDF15 growth differentiation factor 15 -0.33
HECW2 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2 -0.33
TRIAP1 TP53 regulated inhibitor of apoptosis 1 -0.33
HSH2D hematopoietic SH2 domain containing -0.33
EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 -0.33
CLIC3 chloride intracellular channel 3 -0.32
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9 -0.32
PTRHD1 peptidyl-tRNA hydrolase domain containing 1 -0.31
SLC16A7 solute carrier family 16 (monocarboxylate transporter), member 7 -0.31
NMRK1 nicotinamide riboside kinase 1 -0.31
INHBA inhibin, beta A -0.31
TANGO2 transport and golgi organization 2 homolog (Drosophila) -0.31
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 -0.3
PPP1R15A protein phosphatase 1, regulatory subunit 15A -0.3
LRP10 low density lipoprotein receptor-related protein 10 -0.3
HEXD hexosaminidase D -0.3
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.3
RELCH RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing -0.3
LYSMD1 LysM, putative peptidoglycan-binding, domain containing 1 -0.3
PGPEP1 pyroglutamyl-peptidase I -0.3
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 -0.3
PSAP prosaposin -0.3
TMSB10 thymosin beta 10 -0.3
FKBP1A FK506 binding protein 1A, 12kDa -0.3
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma -0.3
LARP6 La ribonucleoprotein domain family, member 6 -0.3
S100A6 S100 calcium binding protein A6 -0.3
PSEN1 presenilin 1 -0.3
GCC1 GRIP and coiled-coil domain containing 1 -0.29
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3 -0.29
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 -0.29
GAB1 GRB2-associated binding protein 1 -0.29
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 -0.29
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 -0.28
ATE1 arginyltransferase 1 -0.28
TMPO thymopoietin -0.28
ARHGEF40 Rho guanine nucleotide exchange factor (GEF) 40 -0.28
NPHP1 nephronophthisis 1 (juvenile) -0.28
LMLN leishmanolysin-like (metallopeptidase M8 family) -0.28
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) -0.28
AP1S2 adaptor-related protein complex 1, sigma 2 subunit -0.27
AKTIP AKT interacting protein -0.27
BPTF bromodomain PHD finger transcription factor -0.27
ATP9A ATPase, class II, type 9A -0.27