BAD Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description BCL2-associated agonist of cell death|The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 572)
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Genes

334 genes differentially expressed following the BAD gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
AMER2 APC membrane recruitment protein 2 2.97072
SPX spexin hormone 2.97072
BCO1 beta-carotene oxygenase 1 2.97072
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 2.97072
OR2J3 olfactory receptor, family 2, subfamily J, member 3 2.97072
PCDHGB3 protocadherin gamma subfamily B, 3 2.97072
SYCP2 synaptonemal complex protein 2 2.97072
ZFP57 ZFP57 zinc finger protein 2.97072
DNAH10 dynein, axonemal, heavy chain 10 2.97072
A3GALT2 alpha 1,3-galactosyltransferase 2 2.97072
KCNH3 potassium channel, voltage gated eag related subfamily H, member 3 2.97072
GDF10 growth differentiation factor 10 2.97072
NGFR nerve growth factor receptor 2.97072
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.97072
CATSPER3 cation channel, sperm associated 3 2.97072
VTCN1 V-set domain containing T cell activation inhibitor 1 2.97072
GOLGA6L7 golgin A6 family like 7 2.97072
ZPBP zona pellucida binding protein 2.97072
IDI2 isopentenyl-diphosphate delta isomerase 2 2.97072
FAM177B family with sequence similarity 177, member B 2.97072
PVALEF parvalbumin like EF-hand containing 2.97072
NIPSNAP3B nipsnap homolog 3B (C. elegans) 2.95795
SNPH syntaphilin 2.95795
C1QL2 complement component 1, q subcomponent-like 2 2.95795
FBXL8 F-box and leucine-rich repeat protein 8 2.95795
CELF3 CUGBP, Elav-like family member 3 2.95795
UBE2U ubiquitin-conjugating enzyme E2U (putative) 2.95795
OR52H1 olfactory receptor, family 52, subfamily H, member 1 2.95795
NKAPL NFKB activating protein-like 2.95795
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.95795
P2RY8 purinergic receptor P2Y, G-protein coupled, 8 2.95795
ZNF556 zinc finger protein 556 2.95795
CFHR3 complement factor H-related 3 2.95795
TPBGL trophoblast glycoprotein-like 2.95795
GJA9 gap junction protein, alpha 9, 59kDa 2.95795
DDN dendrin 2.95795
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 2.95795
AGTR1 angiotensin II receptor, type 1 2.95795
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.95795
BIRC3 baculoviral IAP repeat containing 3 2.95795
TCAF2 TRPM8 channel-associated factor 2 2.95795
AADACL4 arylacetamide deacetylase-like 4 2.95795
MFAP4 microfibrillar-associated protein 4 2.95795
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 2.95795
NEU4 sialidase 4 2.95795
APOA2 apolipoprotein A-II 2.95795
KCNJ9 potassium channel, inwardly rectifying subfamily J, member 9 2.95795
PAX2 paired box 2 2.95795
KCNJ1 potassium channel, inwardly rectifying subfamily J, member 1 2.95795
IL5RA interleukin 5 receptor, alpha 2.95795
SPDYE4 speedy/RINGO cell cycle regulator family member E4 2.95795
NANOS2 nanos homolog 2 (Drosophila) 2.95795
TXNDC8 thioredoxin domain containing 8 (spermatozoa) 2.95795
PRELP proline/arginine-rich end leucine-rich repeat protein 2.95795
UNC45B unc-45 homolog B (C. elegans) 2.95795
ZNF662 zinc finger protein 662 2.95795
WNT3A wingless-type MMTV integration site family, member 3A 2.95795
TMPRSS6 transmembrane protease, serine 6 2.95795
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 2.95795
PDE7B phosphodiesterase 7B 2.95795
FAM240A family with sequence similarity 240 member A 2.95795
SQOR sulfide quinone oxidoreductase 2.95795
ARC activity-regulated cytoskeleton-associated protein 2.95795
CCER2 coiled-coil glutamate-rich protein 2 2.95795
RD3 retinal degeneration 3 2.95795
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.95795
C1QTNF9B C1q and tumor necrosis factor related protein 9B 2.95795
SLC25A2 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 2.95795
TEKTL1 tektin like 1 2.95795
ASB5 ankyrin repeat and SOCS box containing 5 2.95795
SMIM41 small integral membrane protein 41 2.95795
MSANTD5 Myb/SANT DNA binding domain containing 5 2.95795
AGA-DT AGA divergent transcript 2.95795
NHERF4 NHERF family PDZ scaffold protein 4 2.95795
LOC124906010 uncharacterized LOC124906010 2.95795
CD8B2 CD8b2 molecule 2.95795
CALHM4 calcium homeostasis modulator family member 4 2.95795
H2AC1 H2A clustered histone 1 2.95795
CFAP206 cilia and flagella associated protein 206 2.95795
CIROP ciliated left-right organizer metallopeptidase 2.95795
CCDC187 coiled-coil domain containing 187 2.95795
LY6K lymphocyte antigen 6 complex, locus K 2.95795
NKAP NFKB activating protein 2.95795
CXCL16 chemokine (C-X-C motif) ligand 16 2.95795
NR1I3 nuclear receptor subfamily 1, group I, member 3 2.95795
ZSWIM2 zinc finger, SWIM-type containing 2 2.95795
MAGEB2 melanoma antigen family B2 2.95795
DTHD1 death domain containing 1 2.95795
CIMIP2B ciliary microtubule inner protein 2B 2.95795
FPR2 formyl peptide receptor 2 2.95795
FAM153A family with sequence similarity 153, member A 2.95795
RAET1E retinoic acid early transcript 1E 2.95795
ZIC4 Zic family member 4 2.95795
SCRT2 scratch family zinc finger 2 2.95795
FAM228A family with sequence similarity 228, member A 2.95795
MS4A5 membrane-spanning 4-domains, subfamily A, member 5 2.95795
CNGA4 cyclic nucleotide gated channel alpha 4 2.95795
C7ORF57 chromosome 7 open reading frame 57 2.95795
BARX2 BARX homeobox 2 2.95795
SPDYC speedy/RINGO cell cycle regulator family member C 2.95795
OR2L2 olfactory receptor, family 2, subfamily L, member 2 2.95795
TBX3 T-box 3 2.95795
C1ORF162 chromosome 1 open reading frame 162 2.95795
SCARA5 scavenger receptor class A, member 5 2.95795
TDRD6 tudor domain containing 6 2.95795
SCN3A sodium channel, voltage gated, type III alpha subunit 2.95795
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 2.95795
ALOX15B arachidonate 15-lipoxygenase, type B 2.95795
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 2.95795
CPZ carboxypeptidase Z 2.95795
TBPL2 TATA box binding protein like 2 2.95795
DES desmin 2.95795
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.95795
MORC1 MORC family CW-type zinc finger 1 2.95795
IGF2 insulin-like growth factor 2 2.95795
LST1 leukocyte specific transcript 1 2.95795
POTEF POTE ankyrin domain family, member F 2.95795
ADRA1B adrenoceptor alpha 1B 2.95795
TEX36 testis expressed 36 2.95795
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 2.95795
OR10G4 olfactory receptor, family 10, subfamily G, member 4 2.95795
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.95795
CLCA2 chloride channel accessory 2 2.95795
GH2 growth hormone 2 2.95795
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.95795
BRDT bromodomain, testis-specific 2.95795
KCNS2 potassium voltage-gated channel, modifier subfamily S, member 2 2.95795
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 2.95795
PRSS33 protease, serine, 33 2.95795
EFCC1 EF-hand and coiled-coil domain containing 1 2.95795
MSMP microseminoprotein, prostate associated 2.95795
KCNA5 potassium channel, voltage gated shaker related subfamily A, member 5 2.95795
DRC1 dynein regulatory complex subunit 1 2.95795
LRRC24 leucine rich repeat containing 24 2.95795
PHOX2A paired-like homeobox 2a 2.95795
CHRNA1 cholinergic receptor, nicotinic, alpha 1 (muscle) 2.95795
THBD thrombomodulin 2.95795
IL19 interleukin 19 2.95795
RESP18 regulated endocrine-specific protein 18 2.95795
HHLA2 HERV-H LTR-associating 2 2.95795
CTAGE9 CTAGE family, member 9 2.95795
HSPA1L heat shock 70kDa protein 1-like 2.95795
TMEM204 transmembrane protein 204 2.95795
MAB21L1 mab-21-like 1 (C. elegans) 2.95795
P2RY10 purinergic receptor P2Y, G-protein coupled, 10 2.95795
ISLR immunoglobulin superfamily containing leucine-rich repeat 2.95795
SLC36A3 solute carrier family 36, member 3 2.95795
DDX53 DEAD (Asp-Glu-Ala-Asp) box polypeptide 53 2.95795
NLRP8 NLR family, pyrin domain containing 8 2.95795
MS4A10 membrane-spanning 4-domains, subfamily A, member 10 2.95795
TRPC5OS TRPC5 opposite strand 2.95795
OR6B1 olfactory receptor, family 6, subfamily B, member 1 2.95795
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.95795
MYO1A myosin IA 2.95795
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) 2.95795
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.95795
MYOM3 myomesin 3 2.95795
CLEC14A C-type lectin domain family 14, member A 2.95795
NLRP5 NLR family, pyrin domain containing 5 2.95795
ADAM29 ADAM metallopeptidase domain 29 2.95795
LACTBL1 lactamase, beta-like 1 2.95795
UBA7 ubiquitin-like modifier activating enzyme 7 2.95795
GGN gametogenetin 2.95795
WNT8A wingless-type MMTV integration site family, member 8A 2.95795
ZNF397 zinc finger protein 397 2.95795
KIF12 kinesin family member 12 2.95795
ZNF660 zinc finger protein 660 2.95109
PPA1 pyrophosphatase (inorganic) 1 2.93196
MYBPC1 myosin binding protein C, slow type 2.8233
COPG1 coatomer protein complex, subunit gamma 1 2.7718
NOL10 nucleolar protein 10 2.70872
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.67595
C19ORF44 chromosome 19 open reading frame 44 2.64963
NPY neuropeptide Y 2.63171
SMAD6 SMAD family member 6 2.63171
TANGO2 transport and golgi organization 2 homolog (Drosophila) 2.62326
CENPC centromere protein C 2.598
CARMIL1 capping protein regulator and myosin 1 linker 1 2.59705
THEMIS2 thymocyte selection associated family member 2 2.52157
FMO3 flavin containing monooxygenase 3 2.50279
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 2.48084
MTX3 metaxin 3 2.42792
BACE2 beta-site APP-cleaving enzyme 2 2.41874
GOLGA3 golgin A3 2.39618
ADNP activity-dependent neuroprotector homeobox 2.3851
PHRF1 PHD and ring finger domains 1 2.3851
THAP1 THAP domain containing, apoptosis associated protein 1 2.36774
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2.35864
SLC9C1 solute carrier family 9, subfamily C (Na+-transporting carboxylic acid decarboxylase), member 1 2.35653
CLTB clathrin, light chain B 2.35206
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 2.33683
CPSF4L cleavage and polyadenylation specific factor 4-like 2.33683
TTC36 tetratricopeptide repeat domain 36 2.33683
NEU3 sialidase 3 (membrane sialidase) 2.33223
C8ORF76 chromosome 8 open reading frame 76 2.30223
DHRS7B dehydrogenase/reductase (SDR family) member 7B 2.29759
TOP2B topoisomerase (DNA) II beta 180kDa 2.27308
NELFCD negative elongation factor complex member C/D 2.27308
ACVR2A activin A receptor, type IIA 2.26742
FOXO1 forkhead box O1 2.21517
LEMD3 LEM domain containing 3 2.20606
TUBB4A tubulin, beta 4A class IVa 2.19289
EP400 E1A binding protein p400 2.18937
FMO5 flavin containing monooxygenase 5 2.18418
TOGARAM1 TOG array regulator of axonemal microtubules 1 2.16501
SFT2D1 SFT2 domain containing 1 2.1584
SLC26A5 solute carrier family 26 (anion exchanger), member 5 2.15551
CDK17 cyclin-dependent kinase 17 2.14259
POU5F1B POU class 5 homeobox 1B 2.13915
KIF4A kinesin family member 4A 2.13025
MPI mannose phosphate isomerase 2.1141
SCLY selenocysteine lyase 2.11259
ACVR2B activin A receptor, type IIB 2.10911
MICALL2 MICAL-like 2 2.0988
SPATA7 spermatogenesis associated 7 2.06073
CWC22 CWC22 spliceosome-associated protein 2.05083
STK35 serine/threonine kinase 35 2.04949
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H 2.0475
TMEM182 transmembrane protein 182 2.03842
SRFBP1 serum response factor binding protein 1 2.03723
CPNE4 copine IV 2.0332
UBE2B ubiquitin-conjugating enzyme E2B 2.02954
RNF212 ring finger protein 212 2.02717
NSG1 neuron specific gene family member 1 2.01828
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 2.01828
ELMO3 engulfment and cell motility 3 2.01677

decreased expression

Symbol Name Standardized Value
KPNA7 karyopherin alpha 7 (importin alpha 8) -2.97072
LRRC57 leucine rich repeat containing 57 -2.97072
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled -2.97072
LOC122526780 uncharacterized LOC122526780 -2.95795
C2 complement component 2 -2.95795
SLC22A6 solute carrier family 22 (organic anion transporter), member 6 -2.95795
ABRACL ABRA C-terminal like -2.95795
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -2.95795
TRAF3IP3 TRAF3 interacting protein 3 -2.95795
GREM2 gremlin 2, DAN family BMP antagonist -2.95795
DDX4 DEAD (Asp-Glu-Ala-Asp) box polypeptide 4 -2.95795
MBOAT4 membrane bound O-acyltransferase domain containing 4 -2.95795
PTK6 protein tyrosine kinase 6 -2.95795
MOGAT1 monoacylglycerol O-acyltransferase 1 -2.95795
FMO1 flavin containing monooxygenase 1 -2.95795
IMPG2 interphotoreceptor matrix proteoglycan 2 -2.95795
SSBP3 single stranded DNA binding protein 3 -2.95795
IRF2-DT IRF2 divergent transcript -2.95795
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2 -2.95795
DUXB double homeobox B -2.95795
TRIM36 tripartite motif containing 36 -2.95795
CDNF cerebral dopamine neurotrophic factor -2.95795
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2 -2.95795
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.95795
IGFBP3 insulin-like growth factor binding protein 3 -2.95795
NOP2 NOP2 nucleolar protein -2.95795
ARL13A ADP-ribosylation factor-like 13A -2.95795
FUT2 fucosyltransferase 2 (secretor status included) -2.95795
PPIC peptidylprolyl isomerase C (cyclophilin C) -2.95795
IP6K3 inositol hexakisphosphate kinase 3 -2.95795
TIGD3 tigger transposable element derived 3 -2.95795
CXCR4 chemokine (C-X-C motif) receptor 4 -2.95795
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -2.95795
SNAP91 synaptosomal-associated protein, 91kDa -2.95795
CLIC5 chloride intracellular channel 5 -2.95795
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) -2.90864
SON SON DNA binding protein -2.84389
LUZP1 leucine zipper protein 1 -2.78747
PDE1A phosphodiesterase 1A, calmodulin-dependent -2.7718
ZNF225 zinc finger protein 225 -2.76381
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 -2.76381
CCDC146 coiled-coil domain containing 146 -2.70872
CPXM2 carboxypeptidase X (M14 family), member 2 -2.68669
ARL14EP ADP-ribosylation factor-like 14 effector protein -2.66252
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -2.64393
FNDC7 fibronectin type III domain containing 7 -2.64393
C11ORF65 chromosome 11 open reading frame 65 -2.64393
ANXA9 annexin A9 -2.64393
AFF4 AF4/FMR2 family, member 4 -2.62326
EEF1AKMT3 EEF1A lysine methyltransferase 3 -2.61507
GRID1 glutamate receptor, ionotropic, delta 1 -2.61507
LRRC42 leucine rich repeat containing 42 -2.59373
ZNF7 zinc finger protein 7 -2.56285
ELAVL3 ELAV like neuron-specific RNA binding protein 3 -2.53373
ZC3H10 zinc finger CCCH-type containing 10 -2.52823
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -2.51509
PDCD5 programmed cell death 5 -2.49221
PER2 period circadian clock 2 -2.45702
C2ORF76 chromosome 2 open reading frame 76 -2.44833
PDE11A phosphodiesterase 11A -2.41552
GLMP glycosylated lysosomal membrane protein -2.36774
ERN2 endoplasmic reticulum to nucleus signaling 2 -2.36527
ITM2A integral membrane protein 2A -2.35653
C2ORF69 chromosome 2 open reading frame 69 -2.35255
CAV2 caveolin 2 -2.35206
PCDHB3 protocadherin beta 3 -2.35202
EMSY EMSY transcriptional repressor, BRCA2 interacting -2.33818
CDK8 cyclin-dependent kinase 8 -2.33683
SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 -2.33683
PRPF4B pre-mRNA processing factor 4B -2.29759
MYT1L myelin transcription factor 1-like -2.28254
IFT54 intraflagellar transport 54 -2.2612
MAP1A microtubule-associated protein 1A -2.24034
CCDC9 coiled-coil domain containing 9 -2.24034
NFE2L1 nuclear factor, erythroid 2-like 1 -2.23862
ABLIM1 actin binding LIM protein 1 -2.2342
EPS8L2 EPS8-like 2 -2.2307
PCTP phosphatidylcholine transfer protein -2.2307
TIMM8B translocase of inner mitochondrial membrane 8 homolog B (yeast) -2.2307
CTDSPL2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2 -2.22349
ECE2 endothelin converting enzyme 2 -2.21348
NBEAL1 neurobeachin-like 1 -2.21348
HMGA1 high mobility group AT-hook 1 -2.2017
PLPPR3 phospholipid phosphatase related 3 -2.18222
TNNC1 troponin C type 1 (slow) -2.16786
HCLS1 hematopoietic cell-specific Lyn substrate 1 -2.16786
ACSM1 acyl-CoA synthetase medium-chain family member 1 -2.16786
ST3GAL3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 -2.15533
SYN2 synapsin II -2.14544
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -2.13915
DUSP4 dual specificity phosphatase 4 -2.13478
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B -2.12113
SMOC2 SPARC related modular calcium binding 2 -2.11815
NDUFB9 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 9, 22kDa -2.11717
TUFM Tu translation elongation factor, mitochondrial -2.11711
GTF3C2 general transcription factor IIIC, polypeptide 2, beta 110kDa -2.11259
RHBDD1 rhomboid domain containing 1 -2.10911
CD58 CD58 molecule -2.10794
RPL22L1 ribosomal protein L22-like 1 -2.10433
ACP1 acid phosphatase 1, soluble -2.09518
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.05331
APCDD1 adenomatosis polyposis coli down-regulated 1 -2.03723
OSBP oxysterol binding protein -2.0332
MRPL48 mitochondrial ribosomal protein L48 -2.02983
RPS6 ribosomal protein S6 -2.02757
MYO15A myosin XVA -2.01828
GTPBP6 GTP binding protein 6 (putative) -2.01427
PMPCB peptidase (mitochondrial processing) beta -2.01148