BAG2 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description BCL2-associated athanogene 2|BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 9532)
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Genes

312 genes differentially expressed following the BAG2 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COX4I2 cytochrome c oxidase subunit IV isoform 2 (lung) 3.77792
DNASE1L2 deoxyribonuclease I-like 2 3.77792
EPPIN epididymal peptidase inhibitor 3.77792
NCF1 neutrophil cytosolic factor 1 3.77792
MYBPC1 myosin binding protein C, slow type 3.77792
SH2D7 SH2 domain containing 7 3.77792
CCL1 chemokine (C-C motif) ligand 1 3.77792
LRRC52 leucine rich repeat containing 52 3.77792
MUC5B mucin 5B, oligomeric mucus/gel-forming 3.77792
DNASE1L3 deoxyribonuclease I-like 3 3.77792
AKR1C2 aldo-keto reductase family 1, member C2 3.77792
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 3.77792
HLF hepatic leukemia factor 3.77792
FAM90A26 family with sequence similarity 90, member A26, pseudogene 3.77792
CLEC12A C-type lectin domain family 12, member A 3.77792
DNAJC5G DnaJ (Hsp40) homolog, subfamily C, member 5 gamma 3.77792
SCGN secretagogin, EF-hand calcium binding protein 3.77792
FBXL8 F-box and leucine-rich repeat protein 8 3.77792
SCN2B sodium channel, voltage gated, type II beta subunit 3.77792
SERPINA12 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 3.77792
APOA2 apolipoprotein A-II 3.77792
DMRTC1B DMRT-like family C1B 3.77792
FAM9B family with sequence similarity 9, member B 3.77792
SMCO3 single-pass membrane protein with coiled-coil domains 3 3.77792
PITX1 paired-like homeodomain 1 3.77792
OR6B1 olfactory receptor, family 6, subfamily B, member 1 3.77792
APOA5 apolipoprotein A-V 3.77792
IRX3 iroquois homeobox 3 3.77792
ASCL1 achaete-scute family bHLH transcription factor 1 3.77792
IL17B interleukin 17B 3.77792
RNF39 ring finger protein 39 3.77792
MYL4 myosin, light chain 4, alkali; atrial, embryonic 3.77792
GYS2 glycogen synthase 2 (liver) 3.77792
LRG1 leucine-rich alpha-2-glycoprotein 1 3.77792
TAL1 T-cell acute lymphocytic leukemia 1 3.77792
TRIM77 tripartite motif containing 77 3.77792
C1ORF146 chromosome 1 open reading frame 146 3.77792
SLC28A2 solute carrier family 28 (concentrative nucleoside transporter), member 2 3.77792
OR7A17 olfactory receptor, family 7, subfamily A, member 17 3.77792
TREML1 triggering receptor expressed on myeloid cells-like 1 3.77792
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 3.77792
ANGPTL3 angiopoietin-like 3 3.77792
FAM240A family with sequence similarity 240 member A 3.77792
CCN6 cellular communication network factor 6 3.77792
C3AR1 complement component 3a receptor 1 3.77792
MCHR1 melanin-concentrating hormone receptor 1 3.77792
SMLR1 small leucine-rich protein 1 3.77792
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 3.77792
MYZAP myocardial zonula adherens protein 3.77792
TMPRSS6 transmembrane protease, serine 6 3.77792
PROX2 prospero homeobox 2 3.77792
CBLIF cobalamin binding intrinsic factor 3.77792
CCDC187 coiled-coil domain containing 187 3.77792
RTL5 retrotransposon Gag like 5 3.77792
LINC02268 long intergenic non-protein coding RNA 2268 3.77792
CIMIP3 ciliary microtubule inner protein 3 3.77792
CFAP97D2 CFAP97 domain containing 2 3.77792
SMIM35 small integral membrane protein 35 3.77792
LY6L lymphocyte antigen 6 family member L 3.77792
MUCL3 mucin like 3 3.77792
UBE2L5 ubiquitin conjugating enzyme E2 L5 3.77792
CBY2 chibby family member 2 3.77792
OR52E5 olfactory receptor, family 52, subfamily E, member 5 3.77792
ZNF705A zinc finger protein 705A 3.77792
SPMIP11 sperm microtubule inner protein 11 3.77792
GOLGA7B golgin A7 family, member B 3.77792
NR1I3 nuclear receptor subfamily 1, group I, member 3 3.77792
PTPRC protein tyrosine phosphatase, receptor type, C 3.77792
ACTL10 actin-like 10 3.77792
DNMT3L DNA (cytosine-5-)-methyltransferase 3-like 3.77792
TAS2R30 taste receptor, type 2, member 30 3.77792
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.77792
SLC45A2 solute carrier family 45, member 2 3.77792
ZAN zonadhesin (gene/pseudogene) 3.77792
ZNF257 zinc finger protein 257 3.77792
FAM228A family with sequence similarity 228, member A 3.77792
HTR3C 5-hydroxytryptamine (serotonin) receptor 3C, ionotropic 3.77792
CCDC42 coiled-coil domain containing 42 3.77792
FRK fyn-related Src family tyrosine kinase 3.77792
FAM131C family with sequence similarity 131, member C 3.77792
PTH parathyroid hormone 3.77792
PLB1 phospholipase B1 3.77792
CDK5R2 cyclin-dependent kinase 5, regulatory subunit 2 (p39) 3.77792
TAS2R3 taste receptor, type 2, member 3 3.77792
IFITM10 interferon induced transmembrane protein 10 3.77792
LRRC46 leucine rich repeat containing 46 3.77792
TEKT2 tektin 2 (testicular) 3.77792
LYL1 lymphoblastic leukemia associated hematopoiesis regulator 1 3.77792
RSPH10B radial spoke head 10 homolog B (Chlamydomonas) 3.77792
TRIM55 tripartite motif containing 55 3.77792
CD53 CD53 molecule 3.77792
TBC1D10C TBC1 domain family, member 10C 3.77792
CAMK2A calcium/calmodulin-dependent protein kinase II alpha 3.77792
HRCT1 histidine rich carboxyl terminus 1 3.77792
ANKRD65 ankyrin repeat domain 65 3.77792
IFI44 interferon-induced protein 44 3.77792
TNR tenascin R 3.77792
NOG noggin 3.77792
FNDC9 fibronectin type III domain containing 9 3.77792
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains) 3.77792
DUSP26 dual specificity phosphatase 26 (putative) 3.77792
CABP5 calcium binding protein 5 3.77792
PHOSPHO1 phosphatase, orphan 1 3.77792
P2RX2 purinergic receptor P2X, ligand gated ion channel, 2 3.77792
PATE4 prostate and testis expressed 4 3.77792
LRRC24 leucine rich repeat containing 24 3.77792
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 3.77792
MB myoglobin 3.77792
CXORF58 chromosome X open reading frame 58 3.77792
LRRN4 leucine rich repeat neuronal 4 3.77792
IL24 interleukin 24 3.77792
PCDHAC1 protocadherin alpha subfamily C, 1 3.77792
RIPK3 receptor-interacting serine-threonine kinase 3 3.77792
TYR tyrosinase 3.77792
MYLK2 myosin light chain kinase 2 3.77792
HMGB4 high mobility group box 4 3.77792
QRFP pyroglutamylated RFamide peptide 3.77792
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 3.77792
C7ORF33 chromosome 7 open reading frame 33 3.77792
AMN amnion associated transmembrane protein 3.77792
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 3.77792
IGF2 insulin-like growth factor 2 3.77792
SMIM22 small integral membrane protein 22 3.77792
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 3.77792
MAGEA10 melanoma antigen family A10 3.77792
ZBED6 zinc finger, BED-type containing 6 3.77792
DNAJC22 DnaJ (Hsp40) homolog, subfamily C, member 22 3.77792
LRRC74A leucine rich repeat containing 74A 3.77792
TECRL trans-2,3-enoyl-CoA reductase-like 3.77792
GLT6D1 glycosyltransferase 6 domain containing 1 3.77792
NUTM2A NUT family member 2A 3.77792
CARNS1 carnosine synthase 1 3.77792
PRSS57 protease, serine, 57 3.77792
RORC RAR-related orphan receptor C 3.77792
IL10RA interleukin 10 receptor, alpha 3.77792
CMTM5 CKLF-like MARVEL transmembrane domain containing 5 3.77792
PADI6 peptidyl arginine deiminase, type VI 3.77792
HEPN1 hepatocellular carcinoma, down-regulated 1 3.77792
PF4V1 platelet factor 4 variant 1 3.77792
ALLC allantoicase 3.77792
ESAM endothelial cell adhesion molecule 3.77792
A4GALT alpha 1,4-galactosyltransferase 3.69212
GPX2 glutathione peroxidase 2 3.69212
TRDMT1 tRNA aspartic acid methyltransferase 1 3.65896
NOD1 nucleotide-binding oligomerization domain containing 1 3.4153
TENM1 teneurin transmembrane protein 1 3.36689
EPHB4 EPH receptor B4 3.21319
CYB5D2 cytochrome b5 domain containing 2 3.08388
GET4 golgi to ER traffic protein 4 homolog (S. cerevisiae) 2.98431
EMILIN3 elastin microfibril interfacer 3 2.94839
THRAP3 thyroid hormone receptor associated protein 3 2.78736
UBE2R2 ubiquitin-conjugating enzyme E2R 2 2.73379
ANO6 anoctamin 6 2.69452
ZNRF3 zinc and ring finger 3 2.6838
PTBP1 polypyrimidine tract binding protein 1 2.6838
MUC3A mucin 3A, cell surface associated 2.65186
HEY1 hes-related family bHLH transcription factor with YRPW motif 1 2.63317
PCDHA1 protocadherin alpha 1 2.63317
NLRC3 NLR family, CARD domain containing 3 2.63317
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 2.51073
PTPN12 protein tyrosine phosphatase, non-receptor type 12 2.50751
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3 2.3948
AP2A1 adaptor-related protein complex 2, alpha 1 subunit 2.3948
ANKH ANKH inorganic pyrophosphate transport regulator 2.36371
UXT ubiquitously-expressed, prefoldin-like chaperone 2.36233
PIGP phosphatidylinositol glycan anchor biosynthesis, class P 2.34274
BMERB1 bMERB domain containing 1 2.33117
ANKRD42-DT ANKRD42 divergent transcript 2.31098
UNC93A unc-93 homolog A (C. elegans) 2.31098
TP53BP1 tumor protein p53 binding protein 1 2.30538
KLHL18 kelch-like family member 18 2.30031
HEATR1 HEAT repeat containing 1 2.29873
ZNF764 zinc finger protein 764 2.29517
DTX3 deltex 3, E3 ubiquitin ligase 2.27956
SPATA6 spermatogenesis associated 6 2.27932
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.27852
NDUFA6 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 6, 14kDa 2.25927
SPRY3 sprouty homolog 3 (Drosophila) 2.21199
ARGFX arginine-fifty homeobox 2.20053
JAZF1 JAZF zinc finger 1 2.1793
ADORA2A adenosine A2a receptor 2.17918
DEDD death effector domain containing 2.17918
WIZ widely interspaced zinc finger motifs 2.17787
FBXO43 F-box protein 43 2.17449
CHSY1 chondroitin sulfate synthase 1 2.15237
PGS1 phosphatidylglycerophosphate synthase 1 2.14268
SCPEP1 serine carboxypeptidase 1 2.12382
POU2F1 POU class 2 homeobox 1 2.12382
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2.11776
PLEKHD1 pleckstrin homology domain containing, family D (with coiled-coil domains) member 1 2.11776
CLTA clathrin, light chain A 2.11776
TMPRSS9 transmembrane protease, serine 9 2.11776
TIMP3 TIMP metallopeptidase inhibitor 3 2.11386
SLC9A5 solute carrier family 9, subfamily A (NHE5, cation proton antiporter 5), member 5 2.10423
BEX1 brain expressed, X-linked 1 2.10147
ERCC3 excision repair cross-complementation group 3 2.09901
PI4K2A phosphatidylinositol 4-kinase type 2 alpha 2.09843
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha 2.09524
UGP2 UDP-glucose pyrophosphorylase 2 2.09364
RAB12 RAB12, member RAS oncogene family 2.0861
DENND2C DENN/MADD domain containing 2C 2.0806
GAS2L1 growth arrest-specific 2 like 1 2.07225
TPI1 triosephosphate isomerase 1 2.06635
ZNF211 zinc finger protein 211 2.06356
CNFN cornifelin 2.05036
MICU3 mitochondrial calcium uptake family, member 3 2.04086
DGKI diacylglycerol kinase, iota 2.03541
OMD osteomodulin 2.03347
ZBTB45 zinc finger and BTB domain containing 45 2.03249
EFNA4 ephrin-A4 2.024
CD320 CD320 molecule 2.00901
PCNX3 pecanex 3 2.00878

decreased expression

Symbol Name Standardized Value
GOLGA8N golgin A8 family, member N -3.77792
COLEC10 collectin sub-family member 10 (C-type lectin) -3.77792
DRD3 dopamine receptor D3 -3.77792
PCP4L1 Purkinje cell protein 4 like 1 -3.77792
CYSLTR1 cysteinyl leukotriene receptor 1 -3.77792
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -3.77792
MEIG1 meiosis/spermiogenesis associated 1 -3.77792
RBP4 retinol binding protein 4, plasma -3.77792
ARHGAP20 Rho GTPase activating protein 20 -3.77792
WFDC13 WAP four-disulfide core domain 13 -3.77792
SMYD1 SET and MYND domain containing 1 -3.77792
ABHD1 abhydrolase domain containing 1 -3.77792
NRGN neurogranin (protein kinase C substrate, RC3) -3.77792
SLX1A SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae) -3.77792
PATE2 prostate and testis expressed 2 -3.77792
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) -3.77792
CFAP47 cilia and flagella associated protein 47 -3.77792
TMEM225B transmembrane protein 225B -3.77792
EOMES eomesodermin -3.77792
H2BW2 H2B.W histone 2 -3.77792
SLC26A8 solute carrier family 26 (anion exchanger), member 8 -3.77792
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 -3.77792
ALOX15 arachidonate 15-lipoxygenase -3.77792
GGTA1 glycoprotein alpha-galactosyltransferase 1 (inactive) -3.77792
CD19 CD19 molecule -3.77792
DRD2 dopamine receptor D2 -3.77792
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -3.77792
CRIP1 cysteine-rich protein 1 (intestinal) -3.77792
TLR7 toll-like receptor 7 -3.77792
CHAD chondroadherin -3.77792
C11ORF87 chromosome 11 open reading frame 87 -3.77792
KCNRG potassium channel regulator -3.77792
ADPRHL1 ADP-ribosylhydrolase like 1 -3.72801
BMP1 bone morphogenetic protein 1 -3.24051
IL18 interleukin 18 -2.9537
LZTR1 leucine-zipper-like transcription regulator 1 -2.90455
TELO2 telomere maintenance 2 -2.84164
NTNG1 netrin G1 -2.83647
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 -2.83584
LRRC19 leucine rich repeat containing 19 -2.78836
CLPSL1 colipase-like 1 -2.78836
TTPA tocopherol (alpha) transfer protein -2.78251
SAXO5 stabilizer of axonemal microtubules 5 -2.70069
LYG2 lysozyme G-like 2 -2.70069
CDC26 cell division cycle 26 -2.55022
SCUBE2 signal peptide, CUB domain, EGF-like 2 -2.52861
PARP4 poly (ADP-ribose) polymerase family, member 4 -2.51972
CLDN15 claudin 15 -2.51212
CHST13 carbohydrate (chondroitin 4) sulfotransferase 13 -2.3948
STIM2 stromal interaction molecule 2 -2.37507
CGREF1 cell growth regulator with EF-hand domain 1 -2.37395
RAG1 recombination activating gene 1 -2.35635
BCL2L13 BCL2-like 13 (apoptosis facilitator) -2.3472
LPIN1 lipin 1 -2.32583
LSMEM2 leucine-rich single-pass membrane protein 2 -2.32157
CHTF8 CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) -2.32157
CMKLR2 chemerin chemokine-like receptor 2 -2.32157
EXTL3 exostosin-like glycosyltransferase 3 -2.3165
KYNU kynureninase -2.3165
ZNF654 zinc finger protein 654 -2.30584
ANGPT1 angiopoietin 1 -2.29056
SELENOT selenoprotein T -2.21277
ZNHIT2 zinc finger, HIT-type containing 2 -2.20053
CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 -2.20053
BAIAP3 BAI1-associated protein 3 -2.20053
NRXN3 neurexin 3 -2.18975
ZFAND1 zinc finger, AN1-type domain 1 -2.1807
TAS2R31 taste receptor, type 2, member 31 -2.17918
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa -2.17918
ZNF534 zinc finger protein 534 -2.17918
DENND6B DENN/MADD domain containing 6B -2.17918
NOX3 NADPH oxidase 3 -2.17918
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 -2.17918
MRPS18A mitochondrial ribosomal protein S18A -2.17766
COX15 cytochrome c oxidase assembly homolog 15 (yeast) -2.17073
HENMT1 HEN1 methyltransferase homolog 1 (Arabidopsis) -2.13492
STK40 serine/threonine kinase 40 -2.12382
CLINT1 clathrin interactor 1 -2.11776
LRRC4 leucine rich repeat containing 4 -2.11776
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 -2.11776
ZSCAN30 zinc finger and SCAN domain containing 30 -2.1152
KLHL7 kelch-like family member 7 -2.11386
SPRY2 sprouty homolog 2 (Drosophila) -2.10838
CLCN3 chloride channel, voltage-sensitive 3 -2.10423
ETNK2 ethanolamine kinase 2 -2.09901
MRRF mitochondrial ribosome recycling factor -2.09524
H4C8 H4 clustered histone 8 -2.09047
KLK10 kallikrein-related peptidase 10 -2.09047
PIGM phosphatidylinositol glycan anchor biosynthesis, class M -2.07554
C1QTNF3 C1q and tumor necrosis factor related protein 3 -2.06826
LARS2 leucyl-tRNA synthetase 2, mitochondrial -2.05365
CYB5A cytochrome b5 type A (microsomal) -2.04367
LRP10 low density lipoprotein receptor-related protein 10 -2.03249
CSNK1G1 casein kinase 1, gamma 1 -2.02985
AAMP angio-associated, migratory cell protein -2.00878
CALCOCO1 calcium binding and coiled-coil domain 1 -2.00878
NCOR2 nuclear receptor corepressor 2 -2.00878
SUGCT succinyl-CoA:glutarate-CoA transferase -2.00878
ARMC1 armadillo repeat containing 1 -2.00878
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) -2.00852