BAG6 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description BCL2-associated athanogene 6|This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 7917)
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Genes

227 genes differentially expressed following the BAG6 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SPHK1 sphingosine kinase 1 2.45307
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.45307
CELF6 CUGBP, Elav-like family member 6 2.45307
UCN urocortin 2.45307
SLC6A7 solute carrier family 6 (neurotransmitter transporter), member 7 2.45307
MAPRE1 microtubule-associated protein, RP/EB family, member 1 2.45307
COL20A1 collagen, type XX, alpha 1 2.45307
SIX2 SIX homeobox 2 2.45307
LOX lysyl oxidase 2.45307
OR5H2 olfactory receptor, family 5, subfamily H, member 2 2.45307
RAB44 RAB44, member RAS oncogene family 2.45307
DAO D-amino-acid oxidase 2.45307
IL31RA interleukin 31 receptor A 2.45307
GZMM granzyme M (lymphocyte met-ase 1) 2.45307
GZMK granzyme K (granzyme 3; tryptase II) 2.45307
MYH13 myosin, heavy chain 13, skeletal muscle 2.45307
MAGEA8 melanoma antigen family A8 2.45307
KRT23 keratin 23, type I 2.45307
DDN dendrin 2.45307
TMC2 transmembrane channel-like 2 2.45307
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 2.45307
CRYGC crystallin, gamma C 2.45307
HBM hemoglobin, mu 2.45307
MUC22 mucin 22 2.45307
CD68 CD68 molecule 2.45307
KCNIP3 Kv channel interacting protein 3, calsenilin 2.45307
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.45307
TRPV5 transient receptor potential cation channel, subfamily V, member 5 2.45307
SLC39A8 solute carrier family 39 (zinc transporter), member 8 2.45307
HSPH1 heat shock 105kDa/110kDa protein 1 2.45307
LILRB4 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4 2.45307
CCL5 chemokine (C-C motif) ligand 5 2.45307
GJA10 gap junction protein, alpha 10, 62kDa 2.45307
TMEM191B transmembrane protein 191B 2.45307
SLC45A2 solute carrier family 45, member 2 2.45307
MC1R melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) 2.45307
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 2.45307
IRAG2 inositol 1,4,5-triphosphate receptor associated 2 2.45307
ANGPTL8 angiopoietin like 8 2.45307
DERPC DERPC proline and glycine rich nuclear protein 2.45307
PPP1R2B PPP1R2 family member B 2.45307
CCDC198 coiled-coil domain containing 198 2.45307
TBXT T-box transcription factor T 2.45307
CALHM5 calcium homeostasis modulator family member 5 2.45307
PCNX2 pecanex 2 2.45307
FREY1 Frey regulator of sperm-oocyte fusion 1 2.45307
STPG3 sperm-tail PG-rich repeat containing 3 2.45307
CPHXL cytoplasmic polyadenylated homeobox like 2.45307
NOTCH2NLB notch 2 N-terminal like B 2.45307
SPATA31H1 SPATA31 subfamily H member 1 2.45307
ACKR5 atypical chemokine receptor 5 2.45307
TMEM276-ZFTRAF1 TMEM276-ZFTRAF1 readthrough 2.45307
CES4A carboxylesterase 4A 2.45307
OTOS otospiralin 2.45307
GPR33 G protein-coupled receptor 33 (gene/pseudogene) 2.45307
KCNT1 potassium channel, sodium activated subfamily T, member 1 2.45307
UTS2 urotensin 2 2.45307
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 2.45307
TAS1R1 taste receptor, type 1, member 1 2.45307
TMEM119 transmembrane protein 119 2.45307
ASIC3 acid sensing (proton gated) ion channel 3 2.45307
DYNAP dynactin associated protein 2.45307
CSAG2 CSAG family, member 2 2.45307
SPATA25 spermatogenesis associated 25 2.45307
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 2.45307
DOK7 docking protein 7 2.45307
MYEOV myeloma overexpressed 2.45307
OR6F1 olfactory receptor, family 6, subfamily F, member 1 2.45307
OTOR otoraplin 2.45307
PNLIPRP1 pancreatic lipase-related protein 1 2.45307
LOC124901872 uncharacterized LOC124901872 2.45307
NLRP14 NLR family, pyrin domain containing 14 2.45307
C22ORF42 chromosome 22 open reading frame 42 2.45307
FIBIN fin bud initiation factor homolog (zebrafish) 2.45307
MAB21L2 mab-21-like 2 (C. elegans) 2.45307
SRA1 steroid receptor RNA activator 1 2.45307
SPINK9 serine peptidase inhibitor, Kazal type 9 2.45307
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial) 2.45307
WFDC8 WAP four-disulfide core domain 8 2.45307
TBC1D10C TBC1 domain family, member 10C 2.45307
KLF4 Kruppel-like factor 4 (gut) 2.45307
CDHR5 cadherin-related family member 5 2.45307
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6 2.45307
CTAGE4 CTAGE family, member 4 2.45307
CRYBB2 crystallin, beta B2 2.45307
EFCAB3 EF-hand calcium binding domain 3 2.45307
DCAF5 DDB1 and CUL4 associated factor 5 2.45307
ERICH4 glutamate-rich 4 2.45307
AGXT2 alanine--glyoxylate aminotransferase 2 2.45307
TEKT2 tektin 2 (testicular) 2.45307
GOLGA8R golgin A8 family, member R 2.45307
BHLHA15 basic helix-loop-helix family, member a15 2.45307
TTC24 tetratricopeptide repeat domain 24 2.45307
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.45307
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) 2.45307
TCAP titin-cap 2.45307
NT5C1A 5'-nucleotidase, cytosolic IA 2.45307
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 2.45307
TF transferrin 2.45307
TG thyroglobulin 2.45307
MOB1A MOB kinase activator 1A 2.45307
SPEF1 sperm flagellar 1 2.45307
SAMD5 sterile alpha motif domain containing 5 2.45307
NOAZFP nucleolar atypical zinc finger 2.45307
PATE4 prostate and testis expressed 4 2.45307
CDC20B cell division cycle 20B 2.45307
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.45307
PCDHGB2 protocadherin gamma subfamily B, 2 2.45307
CHRNB3 cholinergic receptor, nicotinic, beta 3 (neuronal) 2.45307
ACSM4 acyl-CoA synthetase medium-chain family member 4 2.45307
ALOX5AP arachidonate 5-lipoxygenase-activating protein 2.45307
NRBP1 nuclear receptor binding protein 1 2.45307
VTCN1 V-set domain containing T cell activation inhibitor 1 2.45307
PATE3 prostate and testis expressed 3 2.45307
SYTL4 synaptotagmin-like 4 2.45307
ANGPTL6 angiopoietin-like 6 2.45307
CEACAM20 carcinoembryonic antigen-related cell adhesion molecule 20 2.45307
NLRP11 NLR family, pyrin domain containing 11 2.45307
NFE2 nuclear factor, erythroid 2 2.45307
ANXA2R annexin A2 receptor 2.45307
TECTB tectorin beta 2.45307
EPHB3 EPH receptor B3 2.45307
MYL4 myosin, light chain 4, alkali; atrial, embryonic 2.45307
DMTN dematin actin binding protein 2.45307
PHOSPHO1 phosphatase, orphan 1 2.45307
ZMYND10 zinc finger, MYND-type containing 10 2.45307
OR6X1 olfactory receptor, family 6, subfamily X, member 1 2.45307
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 2.45307
ODAM odontogenic, ameloblast asssociated 2.45307
ERMN ermin, ERM-like protein 2.45307
CCT4 chaperonin containing TCP1, subunit 4 (delta) 2.44706
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.41366
TGFBR3 transforming growth factor, beta receptor III 2.39542
H1-1 H1.1 linker histone, cluster member 2.39542
TMEM63A transmembrane protein 63A 2.36321
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa 2.3191
TMEM231 transmembrane protein 231 2.29492
HACD3 3-hydroxyacyl-CoA dehydratase 3 2.25117
SYCP1 synaptonemal complex protein 1 2.24509
SYDE2 synapse defective 1, Rho GTPase, homolog 2 (C. elegans) 2.23826
MAGIX MAGI family member, X-linked 2.23826
SLC35E2B solute carrier family 35, member E2B 2.23826
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 2.23826
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 2.23826
ECH1 enoyl CoA hydratase 1, peroxisomal 2.21793
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 2.17787
NBN nibrin 2.14563
PHACTR2 phosphatase and actin regulator 2 2.14353
TENM3 teneurin transmembrane protein 3 2.13721
MED10 mediator complex subunit 10 2.13231
PFDN5 prefoldin subunit 5 2.12876
OBI1 ORC ubiquitin ligase 1 2.11812
ZNF233 zinc finger protein 233 2.11102
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) 2.11102
LRP1 low density lipoprotein receptor-related protein 1 2.10205
HADH hydroxyacyl-CoA dehydrogenase 2.05513
GNAL guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type 2.04531
HEATR6 HEAT repeat containing 6 2.01704
GRWD1 glutamate-rich WD repeat containing 1 2.01253
DOK3 docking protein 3 2.01228
TCP11L1 t-complex 11, testis-specific-like 1 2.01061
ERP44 endoplasmic reticulum protein 44 2.0085
SPDYE2 speedy/RINGO cell cycle regulator family member E2 2.00242

decreased expression

Symbol Name Standardized Value
PDE2A phosphodiesterase 2A, cGMP-stimulated -2.45307
TMEM17 transmembrane protein 17 -2.45307
PTP4A3 protein tyrosine phosphatase type IVA, member 3 -2.45307
ERICH6 glutamate-rich 6 -2.45307
MATN1 matrilin 1, cartilage matrix protein -2.45307
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon -2.45307
KAZN kazrin, periplakin interacting protein -2.45307
CHAMP1 chromosome alignment maintaining phosphoprotein 1 -2.45307
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.45307
NKX3-1 NK3 homeobox 1 -2.45307
SFRP5 secreted frizzled-related protein 5 -2.45307
MKRN2OS MKRN2 opposite strand -2.45307
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 -2.45307
LRRC66 leucine rich repeat containing 66 -2.45307
MXRA8 matrix-remodelling associated 8 -2.45307
ACTA2 actin, alpha 2, smooth muscle, aorta -2.45307
WFDC2 WAP four-disulfide core domain 2 -2.43358
SPMAP2L sperm microtubule associated protein 2 like -2.42912
TMEM81 transmembrane protein 81 -2.42912
PKP3 plakophilin 3 -2.42912
PACC1 proton activated chloride channel 1 -2.41217
RB1CC1 RB1-inducible coiled-coil 1 -2.41217
COMMD1 copper metabolism (Murr1) domain containing 1 -2.40077
FAM222A family with sequence similarity 222, member A -2.38967
EXOC2 exocyst complex component 2 -2.35003
DTX3L deltex 3 like, E3 ubiquitin ligase -2.27932
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.26202
TMEM176A transmembrane protein 176A -2.23826
BSND barttin CLCNK-type chloride channel accessory beta subunit -2.23826
LURAP1L leucine rich adaptor protein 1-like -2.23826
PRB3 proline-rich protein BstNI subfamily 3 -2.23826
ZNF436 zinc finger protein 436 -2.23826
SPDYE8 speedy/RINGO cell cycle regulator family member E8 -2.23826
IZUMO1 izumo sperm-egg fusion 1 -2.23826
INSYN1 inhibitory synaptic factor 1 -2.23826
PCDHA1 protocadherin alpha 1 -2.23826
SAMD15 sterile alpha motif domain containing 15 -2.23826
ZNF831 zinc finger protein 831 -2.23826
HCLS1 hematopoietic cell-specific Lyn substrate 1 -2.23826
MS4A12 membrane-spanning 4-domains, subfamily A, member 12 -2.23826
PANO1 proapoptotic nucleolar protein 1 -2.23826
TMEM200C transmembrane protein 200C -2.23826
ART4 ADP-ribosyltransferase 4 (Dombrock blood group) -2.23826
ALOXE3 arachidonate lipoxygenase 3 -2.23826
EPHA10 EPH receptor A10 -2.23826
AMN amnion associated transmembrane protein -2.23826
LMX1B LIM homeobox transcription factor 1, beta -2.23826
FGF13 fibroblast growth factor 13 -2.21433
CCDC141 coiled-coil domain containing 141 -2.20231
PAK1IP1 PAK1 interacting protein 1 -2.14563
USP6NL USP6 N-terminal like -2.13997
GLO1 glyoxalase I -2.13997
SENP5 SUMO1/sentrin specific peptidase 5 -2.11812
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like -2.10799
IL6ST-DT IL6ST divergent transcript -2.10749
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -2.10205
ACTG1 actin gamma 1 -2.06136
JPH4 junctophilin 4 -2.05737
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.05513
CNPY4 canopy FGF signaling regulator 4 -2.05513
AEN apoptosis enhancing nuclease -2.03646
PEX5L peroxisomal biogenesis factor 5-like -2.02657
P3H2 prolyl 3-hydroxylase 2 -2.01704
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -2.01228