BARD1 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description BRCA1 associated RING domain 1|This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] (NCBI Entrez Gene Database, 580)
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Genes

306 genes differentially expressed following the BARD1 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
C5AR1 complement component 5a receptor 1 2.8257
DNAAF1 dynein, axonemal, assembly factor 1 2.8257
FMO1 flavin containing monooxygenase 1 2.8257
PROC protein C (inactivator of coagulation factors Va and VIIIa) 2.8257
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 2.8257
TMEM139 transmembrane protein 139 2.8257
ANKFN1 ankyrin-repeat and fibronectin type III domain containing 1 2.8257
CAGE1 cancer antigen 1 2.8257
SERTM1 serine-rich and transmembrane domain containing 1 2.8257
CYP2C18 cytochrome P450, family 2, subfamily C, polypeptide 18 2.8257
CD1D CD1d molecule 2.8257
SCIMP SLP adaptor and CSK interacting membrane protein 2.8257
CLDN34 claudin 34 2.8257
CELF6 CUGBP, Elav-like family member 6 2.8257
LRTM3 leucine rich repeat transmembrane protein 3 2.8257
KCNJ10 potassium channel, inwardly rectifying subfamily J, member 10 2.8257
ACTL8 actin-like 8 2.8257
DUSP9 dual specificity phosphatase 9 2.8257
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 2.8257
MESP1 mesoderm posterior basic helix-loop-helix transcription factor 1 2.8257
ZNF750 zinc finger protein 750 2.8257
MYO1G myosin IG 2.8257
FAM187B family with sequence similarity 187, member B 2.8257
RPH3A rabphilin 3A 2.8257
CTXND1 cortexin domain containing 1 2.8257
OR52A1 olfactory receptor, family 52, subfamily A, member 1 2.8257
HEATR9 HEAT repeat containing 9 2.72461
TMC3 transmembrane channel-like 3 2.72461
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 2.72461
SLC46A1 solute carrier family 46 (folate transporter), member 1 2.72461
RPEL1 ribulose-5-phosphate-3-epimerase-like 1 2.72461
NXPH3 neurexophilin 3 2.72461
TMEM225 transmembrane protein 225 2.72461
CD93 CD93 molecule 2.72461
SOX1 SRY (sex determining region Y)-box 1 2.72461
MYO1A myosin IA 2.72461
MOCS2 molybdenum cofactor synthesis 2 2.72461
BMP3 bone morphogenetic protein 3 2.72461
GADL1 glutamate decarboxylase-like 1 2.72461
GPR20 G protein-coupled receptor 20 2.72461
LCN12 lipocalin 12 2.72461
KCNE3 potassium channel, voltage gated subfamily E regulatory beta subunit 3 2.72461
COPZ2 coatomer protein complex, subunit zeta 2 2.72461
C8ORF48 chromosome 8 open reading frame 48 2.72461
ATOH8 atonal homolog 8 (Drosophila) 2.72461
PPP1R1C protein phosphatase 1, regulatory (inhibitor) subunit 1C 2.72461
OR2B6 olfactory receptor, family 2, subfamily B, member 6 2.72461
PCDHB4 protocadherin beta 4 2.72461
BMP2 bone morphogenetic protein 2 2.72461
PLIN4 perilipin 4 2.72461
CYTIP cytohesin 1 interacting protein 2.72461
PI15 peptidase inhibitor 15 2.72461
TMPRSS11A transmembrane protease, serine 11A 2.72461
C20ORF202 chromosome 20 open reading frame 202 2.72461
RHCG Rh family, C glycoprotein 2.72461
VN1R1 vomeronasal 1 receptor 1 2.72461
SAPCD1 suppressor APC domain containing 1 2.72461
RAG2 recombination activating gene 2 2.72461
ELFN2 extracellular leucine-rich repeat and fibronectin type III domain containing 2 2.72461
PHF24 PHD finger protein 24 2.72461
LOC122539214 Zinc finger protein LOC122539214 2.72461
MATCAP2 microtubule associated tyrosine carboxypeptidase 2 2.72461
RNF227 ring finger protein 227 2.72461
SPACDR sperm acrosome developmental regulator 2.72461
ODAPH odontogenesis associated phosphoprotein 2.72461
SEPTIN12 septin 12 2.72461
UBE2L5 ubiquitin conjugating enzyme E2 L5 2.72461
GLYATL1B glycine-N-acyltransferase like 1B 2.72461
H4C12 H4 clustered histone 12 2.72461
ASB5 ankyrin repeat and SOCS box containing 5 2.72461
XKR3 XK, Kell blood group complex subunit-related family, member 3 2.72461
GPR37L1 G protein-coupled receptor 37 like 1 2.72461
TPBGL trophoblast glycoprotein-like 2.72461
ELAVL4 ELAV like neuron-specific RNA binding protein 4 2.72461
ATP13A4 ATPase type 13A4 2.72461
TMEM229A transmembrane protein 229A 2.72461
ACOT1 acyl-CoA thioesterase 1 2.72461
SLC35D3 solute carrier family 35, member D3 2.72461
OLAH oleoyl-ACP hydrolase 2.72461
ULBP1 UL16 binding protein 1 2.72461
TMEM235 transmembrane protein 235 2.72461
RBM44 RNA binding motif protein 44 2.72461
VCX3B variable charge, X-linked 3B 2.72461
GDF6 growth differentiation factor 6 2.72461
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 2.72461
C15ORF62 chromosome 15 open reading frame 62 2.72461
SPATC1 spermatogenesis and centriole associated 1 2.72461
BHLHE41 basic helix-loop-helix family, member e41 2.72461
H3C13 H3 clustered histone 13 2.72461
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 2.72461
MT1M metallothionein 1M 2.72461
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) 2.72461
TMEM132D transmembrane protein 132D 2.72461
TMEM132E transmembrane protein 132E 2.72461
SHOX2 short stature homeobox 2 2.72461
OR56A3 olfactory receptor, family 56, subfamily A, member 3 2.72461
EFCAB3 EF-hand calcium binding domain 3 2.72461
C11ORF91 chromosome 11 open reading frame 91 2.72461
CLRN1 clarin 1 2.72461
MORC1 MORC family CW-type zinc finger 1 2.72461
STAB1 stabilin 1 2.72461
POTEJ POTE ankyrin domain family, member J 2.72461
FITM1 fat storage-inducing transmembrane protein 1 2.72461
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.72461
ACKR2 atypical chemokine receptor 2 2.72461
SHOX short stature homeobox 2.72461
PRSS51 protease, serine, 51 2.72461
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 2.72461
DIABLO diablo, IAP-binding mitochondrial protein 2.72461
OLFML1 olfactomedin-like 1 2.72461
ADAM2 ADAM metallopeptidase domain 2 2.72461
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.72461
TSPAN16 tetraspanin 16 2.72461
RIPK3 receptor-interacting serine-threonine kinase 3 2.72461
GPR142 G protein-coupled receptor 142 2.72461
PLA2G2C phospholipase A2, group IIC 2.72461
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) 2.72461
GJC2 gap junction protein, gamma 2, 47kDa 2.72461
BHLHA15 basic helix-loop-helix family, member a15 2.72461
GOLGA8T golgin A8 family, member T 2.72461
INSL3 insulin-like 3 (Leydig cell) 2.72461
CAPSL calcyphosine-like 2.72461
SIGIRR single immunoglobulin and toll-interleukin 1 receptor (TIR) domain 2.72461
HKDC1 hexokinase domain containing 1 2.72461
NRIP2 nuclear receptor interacting protein 2 2.72461
KLK14 kallikrein-related peptidase 14 2.72461
EGR1 early growth response 1 2.72461
FAM135B family with sequence similarity 135, member B 2.72461
SAMD9 sterile alpha motif domain containing 9 2.72461
FCRLB Fc receptor-like B 2.72461
LRRC24 leucine rich repeat containing 24 2.72461
TDO2 tryptophan 2,3-dioxygenase 2.72461
LHX1 LIM homeobox 1 2.72461
SLC10A4 solute carrier family 10, member 4 2.72461
DCST2 DC-STAMP domain containing 2 2.72461
TAS2R46 taste receptor, type 2, member 46 2.72461
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 2.72461
CEACAM21 carcinoembryonic antigen-related cell adhesion molecule 21 2.72461
ZNF804A zinc finger protein 804A 2.72461
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.72461
DNAH1 dynein, axonemal, heavy chain 1 2.72461
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 2.72461
HIGD1C HIG1 hypoxia inducible domain family, member 1C 2.72461
HSD17B13 hydroxysteroid (17-beta) dehydrogenase 13 2.72461
NPR3 natriuretic peptide receptor 3 2.72461
GPAT2 glycerol-3-phosphate acyltransferase 2, mitochondrial 2.72461
CD8A CD8a molecule 2.72461
CHAD chondroadherin 2.72461
TMEM184A transmembrane protein 184A 2.72461
FAT4 FAT atypical cadherin 4 2.6925
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 2.6925
RNF103 ring finger protein 103 2.6925
GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2.6925
R3HDM1 R3H domain containing 1 2.6925
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 2.67106
GEMIN7 gem (nuclear organelle) associated protein 7 2.66624
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 2.65939
PVALEF parvalbumin like EF-hand containing 2.65939
LONRF2 LON peptidase N-terminal domain and ring finger 2 2.61516
GDE1 glycerophosphodiester phosphodiesterase 1 2.61516
UTS2B urotensin 2B 2.61516
KCNQ2 potassium channel, voltage gated KQT-like subfamily Q, member 2 2.61516
COL12A1 collagen, type XII, alpha 1 2.53219
GPS2 G protein pathway suppressor 2 2.5284
RPS11 ribosomal protein S11 2.51511
CD151 CD151 molecule (Raph blood group) 2.4133
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 2.36757
CASP7 caspase 7, apoptosis-related cysteine peptidase 2.35188
RAB11FIP5 RAB11 family interacting protein 5 (class I) 2.28161
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 2.27545
RBM3 RNA binding motif (RNP1, RRM) protein 3 2.27414
TSNAX translin-associated factor X 2.26395
IGSF9B immunoglobulin superfamily, member 9B 2.22187
RPL22L1 ribosomal protein L22-like 1 2.21756
DCAF17 DDB1 and CUL4 associated factor 17 2.21756
DNAL4 dynein, axonemal, light chain 4 2.21234
SARDH sarcosine dehydrogenase 2.207
EIF3F eukaryotic translation initiation factor 3, subunit F 2.20523
FBLN1 fibulin 1 2.20523
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 2.20102
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 2.196
CUL5 cullin 5 2.16606
LAP3 leucine aminopeptidase 3 2.15878
SCARB1 scavenger receptor class B, member 1 2.14789
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 2.14534
CNTROB centrobin, centrosomal BRCA2 interacting protein 2.14137
ZC3H3 zinc finger CCCH-type containing 3 2.12233
CNTN4 contactin 4 2.06735
GEMIN6 gem (nuclear organelle) associated protein 6 2.04336
RTN2 reticulon 2 2.0387
TMEM256 transmembrane protein 256 2.03785
RERE arginine-glutamic acid dipeptide (RE) repeats 2.01838
ZC3H4 zinc finger CCCH-type containing 4 2.01838
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 2.01444

decreased expression

Symbol Name Standardized Value
TNFAIP6 tumor necrosis factor, alpha-induced protein 6 -2.8257
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 -2.76778
SMIM24 small integral membrane protein 24 -2.74416
TEPSIN TEPSIN adaptor related protein complex 4 accessory protein -2.74416
HELB helicase (DNA) B -2.72461
CHN1 chimerin 1 -2.72461
GPR108 G protein-coupled receptor 108 -2.72461
SLCO4C1 solute carrier organic anion transporter family, member 4C1 -2.72461
ZSCAN12 zinc finger and SCAN domain containing 12 -2.72461
SLC6A15 solute carrier family 6 (neutral amino acid transporter), member 15 -2.72461
CRB2 crumbs family member 2 -2.72461
HEATR3 HEAT repeat containing 3 -2.72461
ACTG2 actin, gamma 2, smooth muscle, enteric -2.72461
SAXO2 stabilizer of axonemal microtubules 2 -2.72461
STAT5B signal transducer and activator of transcription 5B -2.72461
RPSA2 ribosomal protein SA 2 -2.72461
SPDYE10 speedy/RINGO cell cycle regulator family member E10 -2.72461
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -2.72461
GIPR gastric inhibitory polypeptide receptor -2.72461
MTMR14 myotubularin related protein 14 -2.72461
AMPH amphiphysin -2.72461
ZNF319 zinc finger protein 319 -2.72461
ASAH2 N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2 -2.6925
MANSC4 MANSC domain containing 4 -2.6925
JPH2 junctophilin 2 -2.6925
VCX variable charge, X-linked -2.6925
FXYD2 FXYD domain containing ion transport regulator 2 -2.6925
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.6925
ADAD2 adenosine deaminase domain containing 2 -2.6925
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 -2.6925
TCF24 transcription factor 24 -2.6925
OR2A7 olfactory receptor, family 2, subfamily A, member 7 -2.6925
ZNF582 zinc finger protein 582 -2.6925
CHADL chondroadherin-like -2.6925
SPATA31H1 SPATA31 subfamily H member 1 -2.6925
HORMAD2 HORMA domain containing 2 -2.6925
CNTNAP4 contactin associated protein-like 4 -2.6925
SHC2 SHC (Src homology 2 domain containing) transforming protein 2 -2.6925
SLC16A8 solute carrier family 16 (monocarboxylate transporter), member 8 -2.6925
HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 -2.6925
TMOD4 tropomodulin 4 (muscle) -2.6925
FAM209B family with sequence similarity 209, member B -2.6925
ZNF703 zinc finger protein 703 -2.6925
LCNL1 lipocalin-like 1 -2.6925
FBXO32 F-box protein 32 -2.6925
PKLR pyruvate kinase, liver and RBC -2.6925
CDHR4 cadherin-related family member 4 -2.6925
CSRNP1 cysteine-serine-rich nuclear protein 1 -2.6925
SLA2 Src-like-adaptor 2 -2.6925
IER5L immediate early response 5-like -2.6925
NAP1L5 nucleosome assembly protein 1-like 5 -2.6925
PLGLB1 plasminogen-like B1 -2.6925
AOC2 amine oxidase, copper containing 2 (retina-specific) -2.6925
TMEM255B transmembrane protein 255B -2.6925
UPK1B uroplakin 1B -2.6925
SLC24A5 solute carrier family 24 (sodium/potassium/calcium exchanger), member 5 -2.6925
STOX1 storkhead box 1 -2.65914
ATG4B autophagy related 4B, cysteine peptidase -2.62912
DCAF15 DDB1 and CUL4 associated factor 15 -2.62201
ULK3 unc-51 like kinase 3 -2.62201
ISCA2 iron-sulfur cluster assembly 2 -2.58553
CFAP90 cilia and flagella associated protein 90 -2.58214
PROK2 prokineticin 2 -2.58214
FAM89A family with sequence similarity 89, member A -2.58214
OMG oligodendrocyte myelin glycoprotein -2.53219
LMOD1 leiomodin 1 (smooth muscle) -2.51915
RELT RELT tumor necrosis factor receptor -2.51915
SNORC secondary ossification center associated regulator of chondrocyte maturation -2.51915
GCLC glutamate-cysteine ligase, catalytic subunit -2.51877
ZNF563 zinc finger protein 563 -2.49205
USP4 ubiquitin specific peptidase 4 (proto-oncogene) -2.48676
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 -2.4792
MCTP1 multiple C2 domains, transmembrane 1 -2.46793
LIN52 lin-52 DREAM MuvB core complex component -2.43516
KCNIP2 Kv channel interacting protein 2 -2.43226
LPAR4 lysophosphatidic acid receptor 4 -2.43226
THAP10 THAP domain containing 10 -2.43226
SLC25A44 solute carrier family 25, member 44 -2.4047
PYCR3 pyrroline-5-carboxylate reductase 3 -2.38703
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.37414
ITGA7 integrin, alpha 7 -2.35188
SEC14L1 SEC14-like 1 (S. cerevisiae) -2.30632
ZNF501 zinc finger protein 501 -2.30466
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 -2.30005
BAMBI BMP and activin membrane-bound inhibitor -2.28161
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.27756
ANKLE2 ankyrin repeat and LEM domain containing 2 -2.25976
SUPT4H1 suppressor of Ty 4 homolog 1 (S. cerevisiae) -2.2299
GLB1 galactosidase, beta 1 -2.207
FNTB farnesyltransferase, CAAX box, beta -2.20523
LIN37 lin-37 DREAM MuvB core complex component -2.20102
SLC25A26 solute carrier family 25 (S-adenosylmethionine carrier), member 26 -2.1996
SNX21 sorting nexin family member 21 -2.17981
API5 apoptosis inhibitor 5 -2.17698
ETV1 ets variant 1 -2.16606
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 -2.16606
RIF1 replication timing regulatory factor 1 -2.12536
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 -2.12386
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -2.11949
GAPDH glyceraldehyde-3-phosphate dehydrogenase -2.10552
SCN4A sodium channel, voltage gated, type IV alpha subunit -2.10501
PLIN5 perilipin 5 -2.10132
GINM1 glycoprotein integral membrane 1 -2.07734
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) -2.07389
PPP1R36 protein phosphatase 1, regulatory subunit 36 -2.07389
VTA1 vesicle (multivesicular body) trafficking 1 -2.07337
RBM33 RNA binding motif protein 33 -2.06603
ZRANB2 zinc finger, RAN-binding domain containing 2 -2.06114
ANGPT1 angiopoietin 1 -2.04281
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -2.04207
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 -2.04117
CARMIL1 capping protein regulator and myosin 1 linker 1 -2.02992