BARD1 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description BRCA1 associated RING domain 1|This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013] (NCBI Entrez Gene Database, 580)
External Link http://www.ncbi.nlm.nih.gov/gene/580
Similar Terms
Downloads & Tools

Genes

323 interacting proteins for BARD1 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ACP1 acid phosphatase 1, soluble
ACP2 acid phosphatase 2, lysosomal
ADNP activity-dependent neuroprotector homeobox
ADNP2 ADNP homeobox 2
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
AKAP8 A kinase (PRKA) anchor protein 8
AKAP8L A kinase (PRKA) anchor protein 8-like
AKIP1 A kinase (PRKA) interacting protein 1
ALB albumin
AP1B1 adaptor-related protein complex 1, beta 1 subunit
ASH2L ash2 (absent, small, or homeotic)-like (Drosophila)
ATM ATM serine/threonine kinase
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATR ATR serine/threonine kinase
AURKA aurora kinase A
AURKB aurora kinase B
BABAM1 BRISC and BRCA1 A complex member 1
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BAG5 BCL2-associated athanogene 5
BCCIP BRCA2 and CDKN1A interacting protein
BCL3 B-cell CLL/lymphoma 3
BCLAF1 BCL2-associated transcription factor 1
BEND3 BEN domain containing 3
BRCA1 breast cancer 1, early onset
BRCA2 breast cancer 2, early onset
BRCC3 BRCA1/BRCA2-containing complex, subunit 3
BRD7 bromodomain containing 7
BRE brain and reproductive organ-expressed (TNFRSF1A modulator)
BRIP1 BRCA1 interacting protein C-terminal helicase 1
C2ORF69 chromosome 2 open reading frame 69
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast)
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1
CAPZB capping protein (actin filament) muscle Z-line, beta
CASC1 cancer susceptibility candidate 1
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family)
CBX1 chromobox homolog 1
CBX3 chromobox homolog 3
CBX5 chromobox homolog 5
CCAR1 cell division cycle and apoptosis regulator 1
CCDC148 coiled-coil domain containing 148
CCDC88A coiled-coil domain containing 88A
CCNA2 cyclin A2
CCNE1 cyclin E1
CCNK cyclin K
CCNT1 cyclin T1
CDK1 cyclin-dependent kinase 1
CDK12 cyclin-dependent kinase 12
CDK13 cyclin-dependent kinase 13
CDK2 cyclin-dependent kinase 2
CDK4 cyclin-dependent kinase 4
CDK9 cyclin-dependent kinase 9
CDKN2AIP CDKN2A interacting protein
CEP126 centrosomal protein 126kDa
CHAF1A chromatin assembly factor 1, subunit A (p150)
CHAF1B chromatin assembly factor 1, subunit B (p60)
CHAMP1 chromosome alignment maintaining phosphoprotein 1
CHD3 chromodomain helicase DNA binding protein 3
CHD4 chromodomain helicase DNA binding protein 4
CIRBP cold inducible RNA binding protein
CLASRP CLK4-associating serine/arginine rich protein
CNTN4 contactin 4
COL1A1 collagen, type I, alpha 1
COMMD1 copper metabolism (Murr1) domain containing 1
COPS2 COP9 signalosome subunit 2
CPNE1 copine I
CPSF2 cleavage and polyadenylation specific factor 2, 100kDa
CPSF3 cleavage and polyadenylation specific factor 3, 73kDa
CPSF6 cleavage and polyadenylation specific factor 6, 68kDa
CRIPAK cysteine-rich PAK1 inhibitor
CSTF1 cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
CSTF2 cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa
DCAF16 DDB1 and CUL4 associated factor 16
DCAF7 DDB1 and CUL4 associated factor 7
DCC DCC netrin 1 receptor
DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57
DPY30 dpy-30 homolog (C. elegans)
DRG1 developmentally regulated GTP binding protein 1
DTNA dystrobrevin, alpha
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
E2F1 E2F transcription factor 1
EIF5B eukaryotic translation initiation factor 5B
ELAVL1 ELAV like RNA binding protein 1
ERCC6L excision repair cross-complementation group 6-like
ERP44 endoplasmic reticulum protein 44
ESR1 estrogen receptor 1
EWSR1 EWS RNA-binding protein 1
EXOSC2 exosome component 2
F7 coagulation factor VII (serum prothrombin conversion accelerator)
FAM175A family with sequence similarity 175, member A
FAM175B family with sequence similarity 175, member B
FANCA Fanconi anemia, complementation group A
FANCC Fanconi anemia, complementation group C
FANCD2 Fanconi anemia, complementation group D2
FANCE Fanconi anemia, complementation group E
FANCF Fanconi anemia, complementation group F
FANCG Fanconi anemia, complementation group G
FANCL Fanconi anemia, complementation group L
FAT1 FAT atypical cadherin 1
FBXO44 F-box protein 44
FBXO5 F-box protein 5
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FKBP1A FK506 binding protein 1A, 12kDa
FKBP2 FK506 binding protein 2, 13kDa
FKBP3 FK506 binding protein 3, 25kDa
FMN1 formin 1
FUCA1 fucosidase, alpha-L- 1, tissue
GEMIN4 gem (nuclear organelle) associated protein 4
GEMIN5 gem (nuclear organelle) associated protein 5
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GNPAT glyceronephosphate O-acyltransferase
GPRASP2 G protein-coupled receptor associated sorting protein 2
GTF3C1 general transcription factor IIIC, polypeptide 1, alpha 220kDa
GTF3C4 general transcription factor IIIC, polypeptide 4, 90kDa
GTSE1 G-2 and S-phase expressed 1
H2AFV H2A histone family, member V
H2AFX H2A histone family, member X
HAP1 huntingtin-associated protein 1
HIC2 hypermethylated in cancer 2
HIST1H2AB histone cluster 1, H2ab
HIST1H2AD histone cluster 1, H2ad
HIST1H2BB histone cluster 1, H2bb
HIST1H2BF histone cluster 1, H2bf
HIST1H4F histone cluster 1, H4f
HIST2H2AB histone cluster 2, H2ab
HIST2H2AC histone cluster 2, H2ac
HIST3H3 histone cluster 3, H3
HMMR hyaluronan-mediated motility receptor (RHAMM)
HNF4A hepatocyte nuclear factor 4, alpha
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPLL heterogeneous nuclear ribonucleoprotein L-like
HNRNPUL1 heterogeneous nuclear ribonucleoprotein U-like 1
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2
HP1BP3 heterochromatin protein 1, binding protein 3
HSPA14 heat shock 70kDa protein 14
IDI1 isopentenyl-diphosphate delta isomerase 1
IKBKAP inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase complex-associated protein
ING5 inhibitor of growth family, member 5
INTS1 integrator complex subunit 1
KAT5 K(lysine) acetyltransferase 5
KAT7 K(lysine) acetyltransferase 7
KBTBD7 kelch repeat and BTB (POZ) domain containing 7
KPNA3 karyopherin alpha 3 (importin alpha 4)
KPNA4 karyopherin alpha 4 (importin alpha 3)
KPNB1 karyopherin (importin) beta 1
KRI1 KRI1 homolog (S. cerevisiae)
LARP1 La ribonucleoprotein domain family, member 1
LARP7 La ribonucleoprotein domain family, member 7
LAS1L LAS1-like (S. cerevisiae)
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS8 lectin, galactoside-binding, soluble, 8
LIN7C lin-7 homolog C (C. elegans)
LRIF1 ligand dependent nuclear receptor interacting factor 1
LRRC41 leucine rich repeat containing 41
LUC7L LUC7-like (S. cerevisiae)
LUC7L2 LUC7-like 2 (S. cerevisiae)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAPK1 mitogen-activated protein kinase 1
MAX MYC associated factor X
MCM6 minichromosome maintenance complex component 6
MDC1 mediator of DNA-damage checkpoint 1
MED17 mediator complex subunit 17
MEPCE methylphosphate capping enzyme
MFAP1 microfibrillar-associated protein 1
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3
MLH1 mutL homolog 1
MOB4 MOB family member 4, phocein
MOV10 Mov10 RISC complex RNA helicase
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
MRPS22 mitochondrial ribosomal protein S22
MSH2 mutS homolog 2
MSH3 mutS homolog 3
MSH6 mutS homolog 6
MT2A metallothionein 2A
MTA2 metastasis associated 1 family, member 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAE1 NEDD8 activating enzyme E1 subunit 1
NBN nibrin
NCBP1 nuclear cap binding protein subunit 1, 80kDa
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NINL ninein-like
NKRF NFKB repressing factor
NLN neurolysin (metallopeptidase M3 family)
NOL9 nucleolar protein 9
NOM1 nucleolar protein with MIF4G domain 1
NPC2 Niemann-Pick disease, type C2
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPM3 nucleophosmin/nucleoplasmin 3
NR1H3 nuclear receptor subfamily 1, group H, member 3
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRD1 nardilysin (N-arginine dibasic convertase)
NSRP1 nuclear speckle splicing regulatory protein 1
OLA1 Obg-like ATPase 1
PARN poly(A)-specific ribonuclease
PCBP2 poly(rC) binding protein 2
PCNA proliferating cell nuclear antigen
PCYT1A phosphate cytidylyltransferase 1, choline, alpha
PDXK pyridoxal (pyridoxine, vitamin B6) kinase
PDZD8 PDZ domain containing 8
PFAS phosphoribosylformylglycinamidine synthase
PGAM5 phosphoglycerate mutase family member 5
PIAS1 protein inhibitor of activated STAT, 1
PIAS4 protein inhibitor of activated STAT, 4
PNN pinin, desmosome associated protein
POGZ pogo transposable element with ZNF domain
POLR1A polymerase (RNA) I polypeptide A, 194kDa
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa
POLR2B polymerase (RNA) II (DNA directed) polypeptide B, 140kDa
POLR2E polymerase (RNA) II (DNA directed) polypeptide E, 25kDa
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
POMZP3 POM121 and ZP3 fusion
POU2F1 POU class 2 homeobox 1
PPM1G protein phosphatase, Mg2+/Mn2+ dependent, 1G
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae)
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7
PTN pleiotrophin
PUF60 poly-U binding splicing factor 60KDa
RAD50 RAD50 homolog (S. cerevisiae)
RAD51 RAD51 recombinase
RBBP8 retinoblastoma binding protein 8
RBM17 RNA binding motif protein 17
RBM22 RNA binding motif protein 22
RBM25 RNA binding motif protein 25
RBM39 RNA binding motif protein 39
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A
RFC2 replication factor C (activator 1) 2, 40kDa
RFC4 replication factor C (activator 1) 4, 37kDa
RNGTT RNA guanylyltransferase and 5'-phosphatase
RPP30 ribonuclease P/MRP 30kDa subunit
RPS20 ribosomal protein S20
RRP1 ribosomal RNA processing 1
SAMHD1 SAM domain and HD domain 1
SCAF11 SR-related CTD-associated factor 11
SCAF4 SR-related CTD-associated factor 4
SELENBP1 selenium binding protein 1
SETDB1 SET domain, bifurcated 1
SIRT7 sirtuin 7
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLFN11 schlafen family member 11
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
SMC1A structural maintenance of chromosomes 1A
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5)
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPC small nuclear ribonucleoprotein polypeptide C
SNX3 sorting nexin 3
SRPK1 SRSF protein kinase 1
SRPK2 SRSF protein kinase 2
SRRM1 serine/arginine repetitive matrix 1
SRRM2 serine/arginine repetitive matrix 2
SRSF1 serine/arginine-rich splicing factor 1
SRSF10 serine/arginine-rich splicing factor 10
SRSF2 serine/arginine-rich splicing factor 2
SRSF4 serine/arginine-rich splicing factor 4
SRSF5 serine/arginine-rich splicing factor 5
SRSF6 serine/arginine-rich splicing factor 6
SRSF7 serine/arginine-rich splicing factor 7
SRSF9 serine/arginine-rich splicing factor 9
SSB Sjogren syndrome antigen B (autoantigen La)
SSH1 slingshot protein phosphatase 1
SSU72 SSU72 RNA polymerase II CTD phosphatase homolog (S. cerevisiae)
STRAP serine/threonine kinase receptor associated protein
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae)
TACC1 transforming, acidic coiled-coil containing protein 1
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TCEB3 transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)
TCERG1 transcription elongation regulator 1
THNSL1 threonine synthase-like 1 (S. cerevisiae)
THRAP3 thyroid hormone receptor associated protein 3
TMEM248 transmembrane protein 248
TOP1 topoisomerase (DNA) I
TOPBP1 topoisomerase (DNA) II binding protein 1
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
TRA2A transformer 2 alpha homolog (Drosophila)
TRA2B transformer 2 beta homolog (Drosophila)
TRAPPC11 trafficking protein particle complex 11
TRAPPC8 trafficking protein particle complex 8
TRIM28 tripartite motif containing 28
TRMT1L tRNA methyltransferase 1 homolog (S. cerevisiae)-like
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)
TULP2 tubby like protein 2
U2AF1 U2 small nuclear RNA auxiliary factor 1
U2AF2 U2 small nuclear RNA auxiliary factor 2
U2SURP U2 snRNP-associated SURP domain containing
UBA3 ubiquitin-like modifier activating enzyme 3
UBC ubiquitin C
UBE2D1 ubiquitin-conjugating enzyme E2D 1
UBE2D2 ubiquitin-conjugating enzyme E2D 2
UBE2D3 ubiquitin-conjugating enzyme E2D 3
UBE2E1 ubiquitin-conjugating enzyme E2E 1
UBE2E2 ubiquitin-conjugating enzyme E2E 2
UBE2E3 ubiquitin-conjugating enzyme E2E 3
UBE2N ubiquitin-conjugating enzyme E2N
UBE2U ubiquitin-conjugating enzyme E2U (putative)
UBE2W ubiquitin-conjugating enzyme E2W (putative)
UBE3A ubiquitin protein ligase E3A
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UBXN1 UBX domain protein 1
UIMC1 ubiquitin interaction motif containing 1
UNC13B unc-13 homolog B (C. elegans)
WDR26 WD repeat domain 26
WDR33 WD repeat domain 33
WDR48 WD repeat domain 48
WDR5 WD repeat domain 5
WDR61 WD repeat domain 61
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZBED4 zinc finger, BED-type containing 4
ZCCHC11 zinc finger, CCHC domain containing 11
ZFP64 ZFP64 zinc finger protein
ZHX1 zinc fingers and homeoboxes 1
ZNF121 zinc finger protein 121
ZNF768 zinc finger protein 768