BAX Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description BCL2-associated X protein|The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 581)
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Genes

356 genes differentially expressed following the BAX gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
KCNK9 potassium channel, two pore domain subfamily K, member 9 3.21362
GPR12 G protein-coupled receptor 12 3.21362
SCGN secretagogin, EF-hand calcium binding protein 3.21362
SP7 Sp7 transcription factor 3.21362
GGN gametogenetin 3.21362
MEP1A meprin A, alpha (PABA peptide hydrolase) 3.21362
SLC46A3 solute carrier family 46, member 3 3.21362
PCDH12 protocadherin 12 3.21362
FGF16 fibroblast growth factor 16 3.21362
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 3.21362
VWA3B von Willebrand factor A domain containing 3B 3.21362
DRD2 dopamine receptor D2 3.21362
POU2AF1 POU class 2 associating factor 1 3.21362
C9ORF57 chromosome 9 open reading frame 57 3.21362
ITPRID1 ITPR interacting domain containing 1 3.21362
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 3.21362
PRH2 proline-rich protein HaeIII subfamily 2 3.21362
GOLGA8R golgin A8 family, member R 3.21362
CTSS cathepsin S 3.21362
SPATA46 spermatogenesis associated 46 3.21362
CFHR5 complement factor H-related 5 3.16783
UGT1A9 UDP glucuronosyltransferase 1 family, polypeptide A9 3.16783
NTRK1 neurotrophic tyrosine kinase, receptor, type 1 3.16783
GLUD2 glutamate dehydrogenase 2 3.16783
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 3.16783
PI16 peptidase inhibitor 16 3.16783
VTN vitronectin 3.16783
SCGB3A1 secretoglobin, family 3A, member 1 3.16783
CD14 CD14 molecule 3.16783
GJA5 gap junction protein, alpha 5, 40kDa 3.16783
RXFP4 relaxin/insulin-like family peptide receptor 4 3.16783
CD93 CD93 molecule 3.16783
SLC26A9 solute carrier family 26 (anion exchanger), member 9 3.16783
GPR55 G protein-coupled receptor 55 3.16783
LAX1 lymphocyte transmembrane adaptor 1 3.16783
PON1 paraoxonase 1 3.16783
PCDHB6 protocadherin beta 6 3.16783
TMEM244 transmembrane protein 244 3.16783
SPP2 secreted phosphoprotein 2, 24kDa 3.16783
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.16783
CRYGC crystallin, gamma C 3.16783
MMP20 matrix metallopeptidase 20 3.16783
IL2RB interleukin 2 receptor, beta 3.16783
MYO1A myosin IA 3.16783
CPLX3 complexin 3 3.16783
SP5 Sp5 transcription factor 3.16783
FAM9B family with sequence similarity 9, member B 3.16783
SFTPB surfactant protein B 3.16783
HCRTR2 hypocretin (orexin) receptor 2 3.16783
SOX14 SRY (sex determining region Y)-box 14 3.16783
GLYAT glycine-N-acyltransferase 3.16783
DDN dendrin 3.16783
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 3.16783
SULT1A4 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4 3.16783
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 3.16783
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.16783
TUBB8 tubulin, beta 8 class VIII 3.16783
ASPG asparaginase 3.16783
LOC102724877 uncharacterized LOC102724877 3.16783
OR9H1 olfactory receptor family 9 subfamily H member 1 pseudogene (gene/pseudogene) 3.16783
OR1C1 olfactory receptor, family 1, subfamily C, member 1 3.16783
SAG S-antigen; retina and pineal gland (arrestin) 3.16783
HSPA6 heat shock 70kDa protein 6 (HSP70B') 3.16783
TSPAN8 tetraspanin 8 3.16783
GPR37L1 G protein-coupled receptor 37 like 1 3.16783
UGT2B7 UDP glucuronosyltransferase 2 family, polypeptide B7 3.16783
VSIG8 V-set and immunoglobulin domain containing 8 3.16783
OSTN osteocrin 3.16783
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 3.16783
PAPOLB poly(A) polymerase beta (testis specific) 3.16783
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 3.16783
H4C14 H4 clustered histone 14 3.16783
POU2AF2 POU class 2 homeobox associating factor 2 3.16783
PPDPFL pancreatic progenitor cell differentiation and proliferation factor like 3.16783
MYOCOS myocilin opposite strand 3.16783
H1-6 H1.6 linker histone, cluster member 3.16783
GPAT3 glycerol-3-phosphate acyltransferase 3 3.16783
GBP3 guanylate binding protein 3 3.16783
GPX6 glutathione peroxidase 6 3.16783
GPX5 glutathione peroxidase 5 3.16783
ZNF683 zinc finger protein 683 3.16783
GDF2 growth differentiation factor 2 3.16783
ZAR1L zygote arrest 1-like 3.16783
NHLRC1 NHL repeat containing E3 ubiquitin protein ligase 1 3.16783
MSX2 msh homeobox 2 3.16783
TMEM235 transmembrane protein 235 3.16783
CATSPER1 cation channel, sperm associated 1 3.16783
ZSWIM2 zinc finger, SWIM-type containing 2 3.16783
TUBA3D tubulin, alpha 3d 3.16783
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 3.16783
CD300LG CD300 molecule-like family member g 3.16783
NKX3-2 NK3 homeobox 2 3.16783
SH3TC1 SH3 domain and tetratricopeptide repeats 1 3.16783
C1QTNF8 C1q and tumor necrosis factor related protein 8 3.16783
LRRC71 leucine rich repeat containing 71 3.16783
CAPN8 calpain 8 3.16783
GTSF1 gametocyte specific factor 1 3.16783
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 3.16783
PLB1 phospholipase B1 3.16783
CLDN22 claudin 22 3.16783
CDSN corneodesmosin 3.16783
CCR3 chemokine (C-C motif) receptor 3 3.16783
PRR4 proline rich 4 (lacrimal) 3.16783
PLCXD3 phosphatidylinositol-specific phospholipase C, X domain containing 3 3.16783
STAP1 signal transducing adaptor family member 1 3.16783
BTNL3 butyrophilin-like 3 3.16783
ITLN1 intelectin 1 (galactofuranose binding) 3.16783
ZXDA zinc finger, X-linked, duplicated A 3.16783
LPAR5 lysophosphatidic acid receptor 5 3.16783
CARD6 caspase recruitment domain family, member 6 3.16783
KRT3 keratin 3, type II 3.16783
TRIM55 tripartite motif containing 55 3.16783
AMER3 APC membrane recruitment protein 3 3.16783
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 3.16783
EVI2A ecotropic viral integration site 2A 3.16783
PATE2 prostate and testis expressed 2 3.16783
GLT6D1 glycosyltransferase 6 domain containing 1 3.16783
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 3.16783
CLCA4 chloride channel accessory 4 3.16783
DUOXA1 dual oxidase maturation factor 1 3.16783
DMTN dematin actin binding protein 3.16783
ZMYND15 zinc finger, MYND-type containing 15 3.16783
POF1B premature ovarian failure, 1B 3.16783
CERKL ceramide kinase-like 3.16783
OR56A4 olfactory receptor, family 56, subfamily A, member 4 3.16783
TAS2R50 taste receptor, type 2, member 50 3.16783
SOWAHA sosondowah ankyrin repeat domain family member A 3.16783
EMX2 empty spiracles homeobox 2 3.16783
C11ORF16 chromosome 11 open reading frame 16 3.16783
SPATA3 spermatogenesis associated 3 3.16783
TCP11X2 t-complex 11 family, X-linked 2 3.16783
APOF apolipoprotein F 3.16783
WFIKKN2 WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2 3.16783
OR7G2 olfactory receptor, family 7, subfamily G, member 2 3.16783
HHATL hedgehog acyltransferase-like 3.16783
RORC RAR-related orphan receptor C 3.16783
NNMT nicotinamide N-methyltransferase 3.16783
GPD1 glycerol-3-phosphate dehydrogenase 1 (soluble) 3.16783
NLRP3 NLR family, pyrin domain containing 3 3.16783
BOD1L2 biorientation of chromosomes in cell division 1-like 2 3.16783
FGB fibrinogen beta chain 3.16783
TBX1 T-box 1 3.16783
TG thyroglobulin 3.16783
GALP galanin-like peptide 3.16783
PLA2G12B phospholipase A2, group XIIB 3.16783
PENK proenkephalin 3.16783
EBI3 Epstein-Barr virus induced 3 3.16783
SOSTDC1 sclerostin domain containing 1 3.16783
RNASE6 ribonuclease, RNase A family, k6 3.16783
OR5AS1 olfactory receptor, family 5, subfamily AS, member 1 3.16783
FGF8 fibroblast growth factor 8 (androgen-induced) 3.16783
PCDHAC2 protocadherin alpha subfamily C, 2 3.16783
KRTAP5-2 keratin associated protein 5-2 3.16783
PRPH peripherin 3.16783
ASTL astacin-like metallo-endopeptidase (M12 family) 3.16783
IL16 interleukin 16 3.16783
PPP1R14D protein phosphatase 1, regulatory (inhibitor) subunit 14D 3.16783
CD244 CD244 molecule, natural killer cell receptor 2B4 3.16783
ZNF831 zinc finger protein 831 3.16783
GREM1 gremlin 1, DAN family BMP antagonist 3.16783
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 3.16783
UNCX UNC homeobox 3.16783
SERPINC1 serpin peptidase inhibitor, clade C (antithrombin), member 1 3.16783
COPS4 COP9 signalosome subunit 4 3.16783
LRRTM1 leucine rich repeat transmembrane neuronal 1 3.0636
MEI1 meiosis inhibitor 1 3.0636
TUBB2B tubulin, beta 2B class IIb 2.99726
HAGHL hydroxyacylglutathione hydrolase-like 2.9436
CMTM2 CKLF-like MARVEL transmembrane domain containing 2 2.85674
SRP72 signal recognition particle 72kDa 2.85674
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 2.85402
TLCD1 TLC domain containing 1 2.79839
PCDH15 protocadherin-related 15 2.71898
FSD1 fibronectin type III and SPRY domain containing 1 2.70415
TGOLN2 trans-golgi network protein 2 2.68157
AUTS2 autism susceptibility candidate 2 2.63899
MBD4 methyl-CpG binding domain protein 4 2.62739
BICRA BRD4 interacting chromatin remodeling complex associated protein 2.57334
ALDH1L1 aldehyde dehydrogenase 1 family, member L1 2.53999
LRRC58 leucine rich repeat containing 58 2.44859
IL18 interleukin 18 2.44417
GLCE glucuronic acid epimerase 2.44417
ANKRD44 ankyrin repeat domain 44 2.44376
BCL7A B-cell CLL/lymphoma 7A 2.42707
TRIM39 tripartite motif containing 39 2.42707
ERGIC3 ERGIC and golgi 3 2.41002
CCDC82 coiled-coil domain containing 82 2.40553
ENOSF1 enolase superfamily member 1 2.39411
CIAO1 cytosolic iron-sulfur assembly component 1 2.36441
CD1D CD1d molecule 2.36441
MARS2 methionyl-tRNA synthetase 2, mitochondrial 2.35597
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 2.33049
ZDHHC3 zinc finger, DHHC-type containing 3 2.32442
NCCRP1 non-specific cytotoxic cell receptor protein 1 homolog (zebrafish) 2.32009
GPR78 G protein-coupled receptor 78 2.32009
NPIPB9 nuclear pore complex interacting protein family, member B9 2.32009
TLK2 tousled-like kinase 2 2.31686
ZNF846 zinc finger protein 846 2.30893
OR14A2 olfactory receptor, family 14, subfamily A, member 2 2.27421
LDHC lactate dehydrogenase C 2.27421
TMEM215 transmembrane protein 215 2.2601
ATAD2B ATPase family, AAA domain containing 2B 2.24309
ZNF703 zinc finger protein 703 2.16272
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 2.15597
ACTG1 actin gamma 1 2.15597
IGSF3 immunoglobulin superfamily, member 3 2.13805
MCL1 myeloid cell leukemia 1 2.11683
MPLKIP M-phase specific PLK1 interacting protein 2.11683
VANGL1 VANGL planar cell polarity protein 1 2.11627
LHX1 LIM homeobox 1 2.11042
TAC3 tachykinin 3 2.08799
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2.08038
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 2.07925
PRKAG2 protein kinase, AMP-activated, gamma 2 non-catalytic subunit 2.07818
DSTYK dual serine/threonine and tyrosine protein kinase 2.06758
SCIMP SLP adaptor and CSK interacting membrane protein 2.06616
IGSF10 immunoglobulin superfamily, member 10 2.06616
CYS1 cystin 1 2.06616
PRAP1 proline-rich acidic protein 1 2.06616
YPEL4 yippee-like 4 (Drosophila) 2.06616
ADAM33 ADAM metallopeptidase domain 33 2.06616
PGM5 phosphoglucomutase 5 2.06616
EGR2 early growth response 2 2.06616
PHF21B PHD finger protein 21B 2.06191
ATP11A ATPase, class VI, type 11A 2.01153
ZNF483 zinc finger protein 483 2.01153
ACIN1 apoptotic chromatin condensation inducer 1 2.00047

decreased expression

Symbol Name Standardized Value
IFT70A intraflagellar transport 70A -3.21362
IGSF22 immunoglobulin superfamily, member 22 -3.21362
LRRTM2 leucine rich repeat transmembrane neuronal 2 -3.21362
CCDC68 coiled-coil domain containing 68 -3.21362
PKD2L1 polycystic kidney disease 2-like 1 -3.21362
SQLE squalene epoxidase -3.21362
SLC51B solute carrier family 51, beta subunit -3.21362
TEX19 testis expressed 19 -3.21362
KCNE2 potassium channel, voltage gated subfamily E regulatory beta subunit 2 -3.16783
BAX BCL2-associated X protein -3.16783
UXT ubiquitously-expressed, prefoldin-like chaperone -3.16783
ASGR2 asialoglycoprotein receptor 2 -3.16783
GAD1 glutamate decarboxylase 1 (brain, 67kDa) -3.16783
NRSN1 neurensin 1 -3.16783
ICAM5 intercellular adhesion molecule 5, telencephalin -3.16783
BMP5 bone morphogenetic protein 5 -3.16783
SDSL serine dehydratase-like -3.16783
LRRC38 leucine rich repeat containing 38 -3.16783
MMP3 matrix metallopeptidase 3 -3.16783
RGPD3 RANBP2-like and GRIP domain containing 3 -3.16783
TRPV3 transient receptor potential cation channel, subfamily V, member 3 -3.16783
PTGFR prostaglandin F receptor (FP) -3.16783
CCDC198 coiled-coil domain containing 198 -3.16783
CCN5 cellular communication network factor 5 -3.16783
ZNF524 zinc finger protein 524 -3.16783
FRG2C FSHD region gene 2 family, member C -3.16783
APOBEC3H apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3H -3.16783
CNTN6 contactin 6 -3.16783
SHC4 SHC (Src homology 2 domain containing) family, member 4 -3.16783
C1QTNF1 C1q and tumor necrosis factor related protein 1 -3.16783
SLC9A2 solute carrier family 9, subfamily A (NHE2, cation proton antiporter 2), member 2 -3.16783
NXPE1 neurexophilin and PC-esterase domain family, member 1 -3.16783
PCDHA3 protocadherin alpha 3 -3.16783
RNF17 ring finger protein 17 -3.16783
ALPK2 alpha-kinase 2 -3.16783
RFPL3 ret finger protein-like 3 -3.16783
SLITRK1 SLIT and NTRK-like family, member 1 -3.16783
DQX1 DEAQ box RNA-dependent ATPase 1 -3.16783
RSPH10B2 radial spoke head 10 homolog B2 (Chlamydomonas) -3.16783
SERPINB4 serpin peptidase inhibitor, clade B (ovalbumin), member 4 -3.16783
DND1 DND microRNA-mediated repression inhibitor 1 -3.16783
C16ORF78 chromosome 16 open reading frame 78 -3.16783
AMN amnion associated transmembrane protein -3.16783
RNF121 ring finger protein 121 -3.16783
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 -3.16783
RELN reelin -3.16783
CFP complement factor properdin -3.16783
CFAP47 cilia and flagella associated protein 47 -3.16783
NLRC5 NLR family, CARD domain containing 5 -3.1496
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 -3.08903
TENT5A terminal nucleotidyltransferase 5A -3.07321
COL7A1 collagen, type VII, alpha 1 -3.03903
FAM194C family with sequence similarity 149 member C -3.03903
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -3.03903
DNAAF2 dynein, axonemal, assembly factor 2 -3.00994
C9ORF40 chromosome 9 open reading frame 40 -2.99726
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.85674
MANF mesencephalic astrocyte-derived neurotrophic factor -2.83172
RAB27B RAB27B, member RAS oncogene family -2.81539
GDAP1L1 ganglioside induced differentiation associated protein 1-like 1 -2.62658
PEX7 peroxisomal biogenesis factor 7 -2.60515
OLFML1 olfactomedin-like 1 -2.57334
TECTA tectorin alpha -2.57334
RSPH1 radial spoke head 1 homolog (Chlamydomonas) -2.57334
SAT2 spermidine/spermine N1-acetyltransferase family member 2 -2.57334
NPIPB2 nuclear pore complex interacting protein family member B2 -2.57334
CSMD3 CUB and Sushi multiple domains 3 -2.57334
CALD1 caldesmon 1 -2.55253
SCRN3 secernin 3 -2.54929
PXDN peroxidasin -2.53984
NPIPA1 nuclear pore complex interacting protein family, member A1 -2.49537
MARCHF6 membrane associated ring-CH-type finger 6 -2.48503
UBA1 ubiquitin-like modifier activating enzyme 1 -2.47943
RPP30 ribonuclease P/MRP 30kDa subunit -2.47644
TRAF4 TNF receptor-associated factor 4 -2.46367
PRSS53 protease, serine, 53 -2.45403
POU2F3 POU class 2 homeobox 3 -2.45403
ARHGEF15 Rho guanine nucleotide exchange factor (GEF) 15 -2.45403
LIMA1 LIM domain and actin binding 1 -2.44417
STIM1 stromal interaction molecule 1 -2.42765
KCTD2 potassium channel tetramerization domain containing 2 -2.42707
LSR lipolysis stimulated lipoprotein receptor -2.40553
MCM4 minichromosome maintenance complex component 4 -2.40553
PPP6R3 protein phosphatase 6, regulatory subunit 3 -2.40553
TNS2 tensin 2 -2.38571
FAM229A family with sequence similarity 229, member A -2.38571
TUB tubby bipartite transcription factor -2.38229
SEC23IP SEC23 interacting protein -2.38019
AARSD1 alanyl-tRNA synthetase domain containing 1 -2.38019
ZNF723 zinc finger protein 723 -2.38019
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 -2.35955
TEX14 testis expressed 14 -2.3572
API5 apoptosis inhibitor 5 -2.3255
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 -2.32442
NOTCH2NLA notch 2 N-terminal like A -2.28747
KLHDC1 kelch domain containing 1 -2.24621
LSAMP limbic system-associated membrane protein -2.24309
NFIA nuclear factor I/A -2.22615
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -2.20975
C1QBP complement component 1, q subcomponent binding protein -2.20975
MPP1 membrane protein, palmitoylated 1, 55kDa -2.20975
DDX50 DEAD (Asp-Glu-Ala-Asp) box polypeptide 50 -2.18446
SRSF7 serine/arginine-rich splicing factor 7 -2.18324
TAF6 TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa -2.17816
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -2.17577
ADD2 adducin 2 (beta) -2.13917
FOSL2 FOS-like antigen 2 -2.13124
TRMT61B tRNA methyltransferase 61B -2.12755
USP20 ubiquitin specific peptidase 20 -2.12271
NAPRT nicotinate phosphoribosyltransferase -2.12271
FTL ferritin, light polypeptide -2.12271
SHARPIN SHANK-associated RH domain interactor -2.11683
LUC7L LUC7-like (S. cerevisiae) -2.11232
MYO15B myosin XVB -2.09594
RBMS1 RNA binding motif, single stranded interacting protein 1 -2.08799
KLHL2 kelch-like family member 2 -2.07507
TSR2 TSR2, 20S rRNA accumulation, homolog (S. cerevisiae) -2.06851
EPCAM epithelial cell adhesion molecule -2.06851
TEK TEK tyrosine kinase, endothelial -2.06616
MRPS17 mitochondrial ribosomal protein S17 -2.06283
IL6ST interleukin 6 signal transducer -2.04504
DAAM2 dishevelled associated activator of morphogenesis 2 -2.02009
ISG20L2 interferon stimulated exonuclease gene 20kDa-like 2 -2.0175
TMEM248 transmembrane protein 248 -2.0175
USP43 ubiquitin specific peptidase 43 -2.01245
SLC71A1 solute carrier family 71 member 1 -2.01153
YY2 YY2 transcription factor -2.01027
CXCL14 chemokine (C-X-C motif) ligand 14 -2.01027
PIGB phosphatidylinositol glycan anchor biosynthesis, class B -2.00535