BAX Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description BCL2-associated X protein|The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 581)
External Link http://www.ncbi.nlm.nih.gov/gene/581
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372 interacting proteins for BAX from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ABHD12 abhydrolase domain containing 12
ACOT8 acyl-CoA thioesterase 8
ACTB actin, beta
AFG3L2 AFG3-like AAA ATPase 2
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase
ALYREF Aly/REF export factor
ARCN1 archain 1
ARL8A ADP-ribosylation factor-like 8A
ASPH aspartate beta-hydroxylase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
ATP5D ATP synthase, H+ transporting, mitochondrial F1 complex, delta subunit
ATP5F1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d
ATP5J ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F6
ATP5J2 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit F2
ATP5L ATP synthase, H+ transporting, mitochondrial Fo complex, subunit G
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
ATPAF1 ATP synthase mitochondrial F1 complex assembly factor 1
ATXN10 ataxin 10
ATXN2L ataxin 2-like
AUP1 ancient ubiquitous protein 1
AURKB aurora kinase B
BAD BCL2-associated agonist of cell death
BAG2 BCL2-associated athanogene 2
BAG3 BCL2-associated athanogene 3
BAK1 BCL2-antagonist/killer 1
BBC3 BCL2 binding component 3
BCAP31 B-cell receptor-associated protein 31
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough
BECN1 beclin 1, autophagy related
BID BH3 interacting domain death agonist
BNIPL BCL2/adenovirus E1B 19kD interacting protein like
BOK BCL2-related ovarian killer
BSG basigin (Ok blood group)
BZW1 basic leucine zipper and W2 domains 1
C1QBP complement component 1, q subcomponent binding protein
C2ORF47 chromosome 2 open reading frame 47
C3 complement component 3
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CANX calnexin
CAPN1 calpain 1, (mu/I) large subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CBWD6 COBW domain containing 6
CCDC124 coiled-coil domain containing 124
CCDC47 coiled-coil domain containing 47
CCDC85C coiled-coil domain containing 85C
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CCT5 chaperonin containing TCP1, subunit 5 (epsilon)
CCT7 chaperonin containing TCP1, subunit 7 (eta)
CDIPT CDP-diacylglycerol--inositol 3-phosphatidyltransferase
CEPT1 choline/ethanolamine phosphotransferase 1
CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3
CHCHD6 coiled-coil-helix-coiled-coil-helix domain containing 6
CHP1 calcineurin-like EF-hand protein 1
CLPB ClpB homolog, mitochondrial AAA ATPase chaperonin
CLPP caseinolytic mitochondrial matrix peptidase proteolytic subunit
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CLTA clathrin, light chain A
CLU clusterin
COX17 COX17 cytochrome c oxidase copper chaperone
COX4I1 cytochrome c oxidase subunit IV isoform 1
COX5A cytochrome c oxidase subunit Va
COX6C cytochrome c oxidase subunit VIc
CPT2 carnitine palmitoyltransferase 2
CRYAA crystallin, alpha A
CRYAB crystallin, alpha B
CSE1L CSE1 chromosome segregation 1-like (yeast)
CYB5B cytochrome b5 type B (outer mitochondrial membrane)
CYB5R3 cytochrome b5 reductase 3
CYCS cytochrome c, somatic
DAD1 defender against cell death 1
DHCR7 7-dehydrocholesterol reductase
DHRS7 dehydrogenase/reductase (SDR family) member 7
DHRS7B dehydrogenase/reductase (SDR family) member 7B
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJA2 DnaJ (Hsp40) homolog, subfamily A, member 2
DNAJA4 DnaJ (Hsp40) homolog, subfamily A, member 4
DNAJC11 DnaJ (Hsp40) homolog, subfamily C, member 11
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit
EEF1B2 eukaryotic translation elongation factor 1 beta 2
EEF1G eukaryotic translation elongation factor 1 gamma
EEF2 eukaryotic translation elongation factor 2
EGF epidermal growth factor
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4A1 eukaryotic translation initiation factor 4A1
EMD emerin
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
EPRS glutamyl-prolyl-tRNA synthetase
ERLIN2 ER lipid raft associated 2
ERN1 endoplasmic reticulum to nucleus signaling 1
ESYT2 extended synaptotagmin-like protein 2
FAM162A family with sequence similarity 162, member A
FAM186B family with sequence similarity 186, member B
FANCD2 Fanconi anemia, complementation group D2
FANCI Fanconi anemia, complementation group I
FKBP8 FK506 binding protein 8, 38kDa
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GID8 GID complex subunit 8
GIGYF1 GRB10 interacting GYF protein 1
GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3
GSK3B glycogen synthase kinase 3 beta
GTF2B general transcription factor IIB
GTF3C3 general transcription factor IIIC, polypeptide 3, 102kDa
GTF3C5 general transcription factor IIIC, polypeptide 5, 63kDa
HACD3 3-hydroxyacyl-CoA dehydratase 3
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit
HDAC6 histone deacetylase 6
HM13 histocompatibility (minor) 13
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HNRNPK heterogeneous nuclear ribonucleoprotein K
HNRNPM heterogeneous nuclear ribonucleoprotein M
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA4 heat shock 70kDa protein 4
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPBP1 HSPA (heat shock 70kDa) binding protein, cytoplasmic cochaperone 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IARS isoleucyl-tRNA synthetase
IMMT inner membrane protein, mitochondrial
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRAK1 interleukin-1 receptor-associated kinase 1
IRF3 interferon regulatory factor 3
IRS4 insulin receptor substrate 4
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3
KIAA0368 KIAA0368
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KPNB1 karyopherin (importin) beta 1
KRTCAP2 keratinocyte associated protein 2
LAMP1 lysosomal-associated membrane protein 1
LETM1 leucine zipper-EF-hand containing transmembrane protein 1
LMAN1 lectin, mannose-binding, 1
LMAN2 lectin, mannose-binding 2
LRPPRC leucine-rich pentatricopeptide repeat containing
LYPLAL1 lysophospholipase-like 1
M6PR mannose-6-phosphate receptor (cation dependent)
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MEPCE methylphosphate capping enzyme
MLF2 myeloid leukemia factor 2
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMS19 MMS19 nucleotide excision repair homolog (S. cerevisiae)
MOAP1 modulator of apoptosis 1
MTA2 metastasis associated 1 family, member 2
MUC1 mucin 1, cell surface associated
NAP1L1 nucleosome assembly protein 1-like 1
NDUFA13 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 13
NDUFA4 NDUFA4, mitochondrial complex associated
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5
NDUFA8 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 8, 19kDa
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NDUFS3 NADH dehydrogenase (ubiquinone) Fe-S protein 3, 30kDa (NADH-coenzyme Q reductase)
NDUFS7 NADH dehydrogenase (ubiquinone) Fe-S protein 7, 20kDa (NADH-coenzyme Q reductase)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NOMO3 NODAL modulator 3
NUCLEOLIN nucleolin multifunctional protein
NUP205 nucleoporin 205kDa
OSBPL8 oxysterol binding protein-like 8
PABPC1 poly(A) binding protein, cytoplasmic 1
PARK7 parkinson protein 7
PARP1 poly (ADP-ribose) polymerase 1
PCBP1 poly(rC) binding protein 1
PCBP2 poly(rC) binding protein 2
PCNA proliferating cell nuclear antigen
PCYOX1 prenylcysteine oxidase 1
PGRMC1 progesterone receptor membrane component 1
PGRMC2 progesterone receptor membrane component 2
PHB prohibitin
PHB2 prohibitin 2
PHGDH phosphoglycerate dehydrogenase
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNKD paroxysmal nonkinesigenic dyskinesia
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POLR2H polymerase (RNA) II (DNA directed) polypeptide H
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP2R1A protein phosphatase 2, regulatory subunit A, alpha
PPP2R1B protein phosphatase 2, regulatory subunit A, beta
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma
PPP6C protein phosphatase 6, catalytic subunit
PRKCE protein kinase C, epsilon
PRKCZ protein kinase C, zeta
PRKDC protein kinase, DNA-activated, catalytic polypeptide
PSMC3 proteasome (prosome, macropain) 26S subunit, ATPase, 3
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6
PTRH2 peptidyl-tRNA hydrolase 2
PYCARD PYD and CARD domain containing
RAB10 RAB10, member RAS oncogene family
RAB11A RAB11A, member RAS oncogene family
RAB14 RAB14, member RAS oncogene family
RAB1B RAB1B, member RAS oncogene family
RAB21 RAB21, member RAS oncogene family
RAB5C RAB5C, member RAS oncogene family
RAB6A RAB6A, member RAS oncogene family
RAB7A RAB7A, member RAS oncogene family
RAD23A RAD23 homolog A (S. cerevisiae)
RANBP1 RAN binding protein 1
RANBP9 RAN binding protein 9
RBBP4 retinoblastoma binding protein 4
RCN2 reticulocalbin 2, EF-hand calcium binding domain
RFT1 RFT1 homolog (S. cerevisiae)
RNF144B ring finger protein 144B
RPL12 ribosomal protein L12
RPL13 ribosomal protein L13
RPL15 ribosomal protein L15
RPL17 ribosomal protein L17
RPL18 ribosomal protein L18
RPL19 ribosomal protein L19
RPL21 ribosomal protein L21
RPL22 ribosomal protein L22
RPL23 ribosomal protein L23
RPL23A ribosomal protein L23a
RPL26 ribosomal protein L26
RPL27 ribosomal protein L27
RPL29 ribosomal protein L29
RPL3 ribosomal protein L3
RPL35 ribosomal protein L35
RPL36 ribosomal protein L36
RPL4 ribosomal protein L4
RPL5 ribosomal protein L5
RPL6 ribosomal protein L6
RPL7 ribosomal protein L7
RPL8 ribosomal protein L8
RPLP1 ribosomal protein, large, P1
RPLP2 ribosomal protein, large, P2
RPN1 ribophorin I
RPN2 ribophorin II
RPS14 ribosomal protein S14
RPS27 ribosomal protein S27
RPS27A ribosomal protein S27a
RPS28 ribosomal protein S28
RPS3A ribosomal protein S3A
RPS4X ribosomal protein S4, X-linked
RPS6 ribosomal protein S6
RPSA ribosomal protein SA
RUVBL1 RuvB-like AAA ATPase 1
RUVBL2 RuvB-like AAA ATPase 2
SACM1L SAC1 suppressor of actin mutations 1-like (yeast)
SCAMP3 secretory carrier membrane protein 3
SCO2 SCO2 cytochrome c oxidase assembly protein
SDF4 stromal cell derived factor 4
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae)
SEC61B Sec61 beta subunit
SERBP1 SERPINE1 mRNA binding protein 1
SFN stratifin
SFXN1 sideroflexin 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SKP1 S-phase kinase-associated protein 1
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC25A10 solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
SLC25A11 solute carrier family 25 (mitochondrial carrier; oxoglutarate carrier), member 11
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC25A18 solute carrier family 25 (glutamate carrier), member 18
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SMC4 structural maintenance of chromosomes 4
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SMPD3 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SNRPF small nuclear ribonucleoprotein polypeptide F
SPTLC1 serine palmitoyltransferase, long chain base subunit 1
SRPRB signal recognition particle receptor, B subunit
SRSF2 serine/arginine-rich splicing factor 2
SSR1 signal sequence receptor, alpha
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma)
SSR4 signal sequence receptor, delta
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)
STAT2 signal transducer and activator of transcription 2, 113kDa
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STIP1 stress-induced phosphoprotein 1
STOML2 stomatin (EPB72)-like 2
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
SV2A synaptic vesicle glycoprotein 2A
SYNGR1 synaptogyrin 1
SYNJ2BP synaptojanin 2 binding protein
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa
TAGLN2 transgelin 2
TARS2 threonyl-tRNA synthetase 2, mitochondrial (putative)
TBP TATA box binding protein
TCEB1 transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TECR trans-2,3-enoyl-CoA reductase
TFRC transferrin receptor
TIMM10 translocase of inner mitochondrial membrane 10 homolog (yeast)
TIMM23 translocase of inner mitochondrial membrane 23 homolog (yeast)
TIMM50 translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)
TM9SF2 transmembrane 9 superfamily member 2
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED10 transmembrane emp24-like trafficking protein 10 (yeast)
TMED2 transmembrane emp24 domain trafficking protein 2
TMEM109 transmembrane protein 109
TMEM205 transmembrane protein 205
TMEM33 transmembrane protein 33
TMX1 thioredoxin-related transmembrane protein 1
TNPO2 transportin 2
TNPO3 transportin 3
TNS2 tensin 2
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TOMM22 translocase of outer mitochondrial membrane 22 homolog (yeast)
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast)
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TP53 tumor protein p53
TRIM28 tripartite motif containing 28
TTC1 tetratricopeptide repeat domain 1
TUBB tubulin, beta class I
TUBB2A tubulin, beta 2A class IIa
TUBB3 tubulin, beta 3 class III
TUBB4A tubulin, beta 4A class IVa
TUBB4B tubulin, beta 4B class IVb
TUBB6 tubulin, beta 6 class V
TXN thioredoxin
UBC ubiquitin C
UBE2C ubiquitin-conjugating enzyme E2C
UFL1 UFM1-specific ligase 1
UHRF2 ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
UQCRC1 ubiquinol-cytochrome c reductase core protein I
UQCRC2 ubiquinol-cytochrome c reductase core protein II
USMG5 up-regulated during skeletal muscle growth 5 homolog (mouse)
USP7 ubiquitin specific peptidase 7 (herpes virus-associated)
UVRAG UV radiation resistance associated
VAMP3 vesicle-associated membrane protein 3
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
VAT1 vesicle amine transport 1
VCP valosin containing protein
VDAC1 voltage-dependent anion channel 1
VDAC2 voltage-dependent anion channel 2
VIM vimentin
VRK2 vaccinia related kinase 2
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
XPO1 exportin 1
XPO5 exportin 5
XPOT exportin, tRNA
XRCC5 X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining)
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6
YBX1 Y box binding protein 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZMPSTE24 zinc metallopeptidase STE24