| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/491941 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in BAY 57-1293 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SBSN | suprabasin | 1.39 |
| ZNF263 | zinc finger protein 263 | 1.08 |
| MT1X | metallothionein 1X | 1.06 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.82 |
| COL17A1 | collagen, type XVII, alpha 1 | 0.76 |
| GREB1 | growth regulation by estrogen in breast cancer 1 | 0.64 |
| GID4 | GID complex subunit 4 | 0.62 |
| ANGPTL4 | angiopoietin-like 4 | 0.59 |
| CHKB | choline kinase beta | 0.56 |
| ZNF274 | zinc finger protein 274 | 0.55 |
| ATP5IF1 | ATP synthase inhibitory factor subunit 1 | 0.54 |
| DUOX1 | dual oxidase 1 | 0.54 |
| IP6K1 | inositol hexakisphosphate kinase 1 | 0.52 |
| RPL23A | ribosomal protein L23a | 0.52 |
| BCOR | BCL6 corepressor | 0.52 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.51 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.51 |
| PRDX1 | peroxiredoxin 1 | 0.5 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.47 |
| PREX1 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 | 0.46 |
| SLC39A3 | solute carrier family 39 (zinc transporter), member 3 | 0.45 |
| PARK7 | parkinson protein 7 | 0.44 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 0.44 |
| RPL13 | ribosomal protein L13 | 0.43 |
| LDHA | lactate dehydrogenase A | 0.43 |
| MYBPC2 | myosin binding protein C, fast type | 0.42 |
| RPL27 | ribosomal protein L27 | 0.42 |
| PGAM1 | phosphoglycerate mutase 1 (brain) | 0.42 |
| MT1F | metallothionein 1F | 0.42 |
| UBR7 | ubiquitin protein ligase E3 component n-recognin 7 (putative) | 0.41 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | 0.41 |
| ACTG1 | actin gamma 1 | 0.41 |
| FKBP1A | FK506 binding protein 1A, 12kDa | 0.41 |
| ZNF776 | zinc finger protein 776 | 0.41 |
| PFKFB1 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 | 0.4 |
| MT2A | metallothionein 2A | 0.4 |
| RPL28 | ribosomal protein L28 | 0.39 |
| RPL35 | ribosomal protein L35 | 0.39 |
| GLMP | glycosylated lysosomal membrane protein | 0.38 |
| DOLK | dolichol kinase | 0.38 |
| BCKDK | branched chain ketoacid dehydrogenase kinase | 0.37 |
| FTL | ferritin, light polypeptide | 0.36 |
| SET | SET nuclear proto-oncogene | 0.36 |
| ESAM | endothelial cell adhesion molecule | 0.36 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.36 |
| NEMP2 | nuclear envelope integral membrane protein 2 | 0.35 |
| KIFC3 | kinesin family member C3 | 0.35 |
| CFAP57 | cilia and flagella associated protein 57 | 0.35 |
| ZNF440 | zinc finger protein 440 | 0.35 |
| NIPA2 | non imprinted in Prader-Willi/Angelman syndrome 2 | 0.34 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.34 |
| NOP10 | NOP10 ribonucleoprotein | 0.33 |
| RPAIN | RPA interacting protein | 0.33 |
| CYP27B1 | cytochrome P450, family 27, subfamily B, polypeptide 1 | 0.32 |
| RPS20 | ribosomal protein S20 | 0.32 |
| OBSL1 | obscurin-like 1 | 0.32 |
| USP27X | ubiquitin specific peptidase 27, X-linked | 0.31 |
| RTN3 | reticulon 3 | 0.31 |
| H1-2 | H1.2 linker histone, cluster member | 0.31 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.31 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.31 |
| ZFP1 | ZFP1 zinc finger protein | 0.31 |
| PHLDA2 | pleckstrin homology-like domain, family A, member 2 | 0.31 |
| ICMT | isoprenylcysteine carboxyl methyltransferase | 0.31 |
| HMGB1 | high mobility group box 1 | 0.31 |
| RP9 | retinitis pigmentosa 9 (autosomal dominant) | 0.3 |
| REEP1 | receptor accessory protein 1 | 0.3 |
| ENC1 | ectodermal-neural cortex 1 (with BTB domain) | 0.3 |
| EIF5A | eukaryotic translation initiation factor 5A | 0.3 |
| AP4M1 | adaptor-related protein complex 4, mu 1 subunit | 0.3 |
| SEL1L3 | sel-1 suppressor of lin-12-like 3 (C. elegans) | 0.3 |
| RWDD1 | RWD domain containing 1 | 0.3 |
| RPL7A | ribosomal protein L7a | 0.3 |
| RBM3 | RNA binding motif (RNP1, RRM) protein 3 | 0.3 |
| PSPH | phosphoserine phosphatase | 0.29 |
| ALDH1L2 | aldehyde dehydrogenase 1 family, member L2 | 0.29 |
| GPSM2 | G-protein signaling modulator 2 | 0.29 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.29 |
| RPL3 | ribosomal protein L3 | 0.29 |
| ZBTB12 | zinc finger and BTB domain containing 12 | 0.29 |
| ANKEF1 | ankyrin repeat and EF-hand domain containing 1 | 0.29 |
| ZNF761 | zinc finger protein 761 | 0.29 |
| ANKRD39 | ankyrin repeat domain 39 | 0.28 |
| ELOC | elongin C | 0.28 |
| TMEM39B | transmembrane protein 39B | 0.28 |
| MDH1 | malate dehydrogenase 1, NAD (soluble) | 0.28 |
| FABP5 | fatty acid binding protein 5 (psoriasis-associated) | 0.28 |
| SLC2A4RG | SLC2A4 regulator | 0.28 |
| BCO2 | beta-carotene oxygenase 2 | 0.27 |
| SNRPC | small nuclear ribonucleoprotein polypeptide C | 0.27 |
| C5ORF30 | chromosome 5 open reading frame 30 | 0.27 |
| GTF2IRD1 | GTF2I repeat domain containing 1 | 0.27 |
| B3GNTL1 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 | 0.27 |
| AP3M2 | adaptor-related protein complex 3, mu 2 subunit | 0.27 |
| BTBD3 | BTB (POZ) domain containing 3 | 0.26 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.26 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.26 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.26 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.26 |
| Symbol | Name | Standardized Value |
|---|---|---|
| ZG16B | zymogen granule protein 16B | -0.93 |
| MERTK | MER proto-oncogene, tyrosine kinase | -0.76 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | -0.56 |
| GRID1 | glutamate receptor, ionotropic, delta 1 | -0.53 |
| CKM | creatine kinase, muscle | -0.5 |
| SPPL2B | signal peptide peptidase like 2B | -0.49 |
| SOCS2 | suppressor of cytokine signaling 2 | -0.48 |
| GRHL1 | grainyhead-like 1 (Drosophila) | -0.47 |
| ANKRD22 | ankyrin repeat domain 22 | -0.47 |
| PLEKHH2 | pleckstrin homology domain containing, family H (with MyTH4 domain) member 2 | -0.46 |
| FRMPD3 | FERM and PDZ domain containing 3 | -0.46 |
| THBS2 | thrombospondin 2 | -0.45 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | -0.44 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.44 |
| NOTCH3 | notch 3 | -0.42 |
| P3H2 | prolyl 3-hydroxylase 2 | -0.42 |
| CYB5A | cytochrome b5 type A (microsomal) | -0.42 |
| CEP68 | centrosomal protein 68kDa | -0.41 |
| BCL2L12 | BCL2-like 12 (proline rich) | -0.41 |
| UBAP1 | ubiquitin associated protein 1 | -0.4 |
| FBXO17 | F-box protein 17 | -0.4 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.4 |
| PEA15 | phosphoprotein enriched in astrocytes 15 | -0.39 |
| PPP1R2 | protein phosphatase 1, regulatory (inhibitor) subunit 2 | -0.39 |
| RPE | ribulose-5-phosphate-3-epimerase | -0.39 |
| USF2 | upstream transcription factor 2, c-fos interacting | -0.38 |
| ZNF691 | zinc finger protein 691 | -0.37 |
| F5 | coagulation factor V (proaccelerin, labile factor) | -0.37 |
| NKAPD1 | NKAP domain containing 1 | -0.37 |
| TNFRSF12A | tumor necrosis factor receptor superfamily, member 12A | -0.37 |
| DUSP14 | dual specificity phosphatase 14 | -0.36 |
| RHOD | ras homolog family member D | -0.36 |
| ZNF12 | zinc finger protein 12 | -0.36 |
| RNF115 | ring finger protein 115 | -0.36 |
| CCNDBP1 | cyclin D-type binding-protein 1 | -0.36 |
| IL6ST | interleukin 6 signal transducer | -0.35 |
| CHN1 | chimerin 1 | -0.35 |
| HMCN1 | hemicentin 1 | -0.35 |
| TRMO | tRNA methyltransferase O | -0.35 |
| ZSWIM3 | zinc finger, SWIM-type containing 3 | -0.34 |
| PEX19 | peroxisomal biogenesis factor 19 | -0.34 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.34 |
| KMT5C | lysine methyltransferase 5C | -0.34 |
| HGH1 | HGH1 homolog (S. cerevisiae) | -0.33 |
| F13A1 | coagulation factor XIII, A1 polypeptide | -0.33 |
| SGSH | N-sulfoglucosamine sulfohydrolase | -0.33 |
| ATOX1 | antioxidant 1 copper chaperone | -0.33 |
| LGALSL | lectin, galactoside-binding-like | -0.33 |
| BLOC1S2 | biogenesis of lysosomal organelles complex-1, subunit 2 | -0.33 |
| CYTH3 | cytohesin 3 | -0.32 |
| BTG3 | BTG family, member 3 | -0.32 |
| SHROOM3 | shroom family member 3 | -0.32 |
| MYL3 | myosin, light chain 3, alkali; ventricular, skeletal, slow | -0.32 |
| GPANK1 | G patch domain and ankyrin repeats 1 | -0.32 |
| TYK2 | tyrosine kinase 2 | -0.32 |
| ABHD17C | abhydrolase domain containing 17C | -0.31 |
| CSNK1G3 | casein kinase 1, gamma 3 | -0.31 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.31 |
| SLC66A2 | solute carrier family 66 member 2 | -0.3 |
| GPD1 | glycerol-3-phosphate dehydrogenase 1 (soluble) | -0.3 |
| CADPS2 | Ca++-dependent secretion activator 2 | -0.3 |
| MYH11 | myosin, heavy chain 11, smooth muscle | -0.3 |
| DAPK1 | death-associated protein kinase 1 | -0.3 |
| CEBPZOS | CEBPZ opposite strand | -0.3 |
| CCN1 | cellular communication network factor 1 | -0.29 |
| YAP1 | Yes-associated protein 1 | -0.29 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.29 |
| IKBKG | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma | -0.29 |
| UBL5 | ubiquitin-like 5 | -0.29 |
| SLC16A6 | solute carrier family 16, member 6 | -0.29 |
| ZNF205 | zinc finger protein 205 | -0.29 |
| SLC38A2 | solute carrier family 38, member 2 | -0.29 |
| PAH | phenylalanine hydroxylase | -0.29 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.29 |
| CDC37 | cell division cycle 37 | -0.29 |
| SLC35A3 | solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 | -0.28 |
| ARL4A | ADP-ribosylation factor-like 4A | -0.28 |
| POLR2J | polymerase (RNA) II (DNA directed) polypeptide J, 13.3kDa | -0.28 |
| SLC16A7 | solute carrier family 16 (monocarboxylate transporter), member 7 | -0.28 |
| AZGP1 | alpha-2-glycoprotein 1, zinc-binding | -0.28 |
| INTU | inturned planar cell polarity protein | -0.28 |
| KLHDC10 | kelch domain containing 10 | -0.27 |
| PLEKHA7 | pleckstrin homology domain containing, family A member 7 | -0.27 |
| ALS2CL | ALS2 C-terminal like | -0.27 |
| SNX24 | sorting nexin 24 | -0.27 |
| ZRSR2 | zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 | -0.27 |
| TCOF1 | Treacher Collins-Franceschetti syndrome 1 | -0.27 |
| PALM3 | paralemmin 3 | -0.27 |
| TNKS2 | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2 | -0.27 |
| PLXNB1 | plexin B1 | -0.27 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | -0.27 |
| SNAP47 | synaptosomal-associated protein, 47kDa | -0.27 |
| FOXJ3 | forkhead box J3 | -0.27 |
| GPRC5B | G protein-coupled receptor, class C, group 5, member B | -0.27 |
| ZNF319 | zinc finger protein 319 | -0.27 |
| DTNA | dystrobrevin, alpha | -0.27 |
| HCFC2 | host cell factor C2 | -0.26 |
| GKAP1 | G kinase anchoring protein 1 | -0.26 |
| ERVMER34-1 | endogenous retrovirus group MER34, member 1 | -0.26 |
