| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/10200390 |
| Similar Terms | |
| Downloads & Tools |
200 proteins with high or low expression in BAY 61-3606 relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ICAM5 | intercellular adhesion molecule 5, telencephalin | 2.39 |
| F5 | coagulation factor V (proaccelerin, labile factor) | 2.32 |
| CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.92 |
| GDF15 | growth differentiation factor 15 | 1.89 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 1.78 |
| AXIN2 | axin 2 | 1.76 |
| CCDC130 | coiled-coil domain containing 130 | 1.52 |
| TMUB1 | transmembrane and ubiquitin-like domain containing 1 | 1.5 |
| NDOR1 | NADPH dependent diflavin oxidoreductase 1 | 1.49 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 1.46 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 1.46 |
| AREG | amphiregulin | 1.46 |
| MSX1 | msh homeobox 1 | 1.43 |
| KMT2B | lysine (K)-specific methyltransferase 2B | 1.42 |
| FBXL8 | F-box and leucine-rich repeat protein 8 | 1.37 |
| CLK1 | CDC-like kinase 1 | 1.37 |
| NGRN | neugrin, neurite outgrowth associated | 1.36 |
| CDC37 | cell division cycle 37 | 1.35 |
| SESN2 | sestrin 2 | 1.35 |
| PLD6 | phospholipase D family, member 6 | 1.34 |
| ZNF624 | zinc finger protein 624 | 1.29 |
| SIRT7 | sirtuin 7 | 1.29 |
| PER2 | period circadian clock 2 | 1.28 |
| FBXL6 | F-box and leucine-rich repeat protein 6 | 1.27 |
| SGSH | N-sulfoglucosamine sulfohydrolase | 1.26 |
| ATF3 | activating transcription factor 3 | 1.22 |
| POLR1D | polymerase (RNA) I polypeptide D, 16kDa | 1.18 |
| SYTL1 | synaptotagmin-like 1 | 1.18 |
| NAXD | NAD(P)HX dehydratase | 1.17 |
| PPP2R3C | protein phosphatase 2, regulatory subunit B'', gamma | 1.16 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | 1.16 |
| RNASE4 | ribonuclease, RNase A family, 4 | 1.16 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 1.15 |
| BTBD3 | BTB (POZ) domain containing 3 | 1.12 |
| LARGE2 | LARGE xylosyl- and glucuronyltransferase 2 | 1.12 |
| SPPL2B | signal peptide peptidase like 2B | 1.11 |
| C1QTNF3 | C1q and tumor necrosis factor related protein 3 | 1.11 |
| WDR90 | WD repeat domain 90 | 1.11 |
| KLHL17 | kelch-like family member 17 | 1.1 |
| CDCA5 | cell division cycle associated 5 | 1.06 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 1.06 |
| TTC13 | tetratricopeptide repeat domain 13 | 1.05 |
| CCNT2 | cyclin T2 | 1.05 |
| TMEM128 | transmembrane protein 128 | 1.04 |
| MTG2 | mitochondrial ribosome-associated GTPase 2 | 1.03 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | 1.03 |
| CCDC158 | coiled-coil domain containing 158 | 1.02 |
| TP53 | tumor protein p53 | 1.0 |
| COASY | CoA synthase | 1.0 |
| CLK3 | CDC-like kinase 3 | 0.99 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 0.99 |
| PRG4 | proteoglycan 4 | 0.99 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.98 |
| ARVCF | armadillo repeat gene deleted in velocardiofacial syndrome | 0.98 |
| RHOD | ras homolog family member D | 0.98 |
| RUBCN | rubicon autophagy regulator | 0.97 |
| SLC30A1 | solute carrier family 30 (zinc transporter), member 1 | 0.97 |
| CRY2 | cryptochrome circadian clock 2 | 0.97 |
| ZNF629 | zinc finger protein 629 | 0.97 |
| COL14A1 | collagen, type XIV, alpha 1 | 0.97 |
| NRXN3 | neurexin 3 | 0.94 |
| E2F7 | E2F transcription factor 7 | 0.94 |
| SRA1 | steroid receptor RNA activator 1 | 0.94 |
| HBA1 | hemoglobin, alpha 1 | 0.94 |
| TMED3 | transmembrane emp24 protein transport domain containing 3 | 0.93 |
| CDK9 | cyclin-dependent kinase 9 | 0.92 |
| ENTPD2 | ectonucleoside triphosphate diphosphohydrolase 2 | 0.92 |
| PGBD2 | piggyBac transposable element derived 2 | 0.9 |
| SBNO2 | strawberry notch homolog 2 (Drosophila) | 0.89 |
| WDR81 | WD repeat domain 81 | 0.88 |
| CFAP58 | cilia and flagella associated protein 58 | 0.88 |
| DPP7 | dipeptidyl-peptidase 7 | 0.88 |
| GAS6 | growth arrest-specific 6 | 0.88 |
| PML | promyelocytic leukemia | 0.88 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.87 |
| ECHDC3 | enoyl CoA hydratase domain containing 3 | 0.86 |
| FRMD8 | FERM domain containing 8 | 0.86 |
| PHLDA3 | pleckstrin homology-like domain, family A, member 3 | 0.85 |
| CLK4 | CDC-like kinase 4 | 0.85 |
| MBLAC2 | metallo-beta-lactamase domain containing 2 | 0.85 |
| MDM1 | Mdm1 nuclear protein homolog (mouse) | 0.85 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | 0.84 |
| SETD5 | SET domain containing 5 | 0.84 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.83 |
| MRM2 | mitochondrial rRNA methyltransferase 2 | 0.82 |
| ITPRIP | inositol 1,4,5-trisphosphate receptor interacting protein | 0.82 |
| CES2 | carboxylesterase 2 | 0.81 |
| TNPO2 | transportin 2 | 0.81 |
| SETD6 | SET domain containing 6 | 0.81 |
| VTN | vitronectin | 0.81 |
| EAF1 | ELL associated factor 1 | 0.81 |
| DALRD3 | DALR anticodon binding domain containing 3 | 0.81 |
| RWDD2B | RWD domain containing 2B | 0.8 |
| PRR14 | proline rich 14 | 0.79 |
| SLC27A3 | solute carrier family 27 (fatty acid transporter), member 3 | 0.79 |
| IRS2 | insulin receptor substrate 2 | 0.78 |
| NPDC1 | neural proliferation, differentiation and control, 1 | 0.78 |
| JAG1 | jagged 1 | 0.78 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.77 |
| STK19 | serine/threonine kinase 19 | 0.77 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CREBZF | CREB/ATF bZIP transcription factor | -4.74 |
| PRKCH | protein kinase C, eta | -2.69 |
| RNF115 | ring finger protein 115 | -2.55 |
| MT2A | metallothionein 2A | -2.44 |
| KIAA1107 | KIAA1107 | -2.26 |
| JPT1 | Jupiter microtubule associated homolog 1 | -2.2 |
| NABP1 | nucleic acid binding protein 1 | -1.91 |
| CDC25C | cell division cycle 25C | -1.83 |
| PHLPP1 | PH domain and leucine rich repeat protein phosphatase 1 | -1.77 |
| HOXA9 | homeobox A9 | -1.75 |
| SYTL3 | synaptotagmin-like 3 | -1.64 |
| EXO1 | exonuclease 1 | -1.63 |
| MAGEF1 | melanoma antigen family F1 | -1.63 |
| CDC25B | cell division cycle 25B | -1.62 |
| RCAN3 | RCAN family member 3 | -1.62 |
| RRM2 | ribonucleotide reductase M2 | -1.58 |
| VWA1 | von Willebrand factor A domain containing 1 | -1.57 |
| NES | nestin | -1.56 |
| STK17B | serine/threonine kinase 17b | -1.54 |
| CDKN3 | cyclin-dependent kinase inhibitor 3 | -1.53 |
| TTLL5 | tubulin tyrosine ligase-like family member 5 | -1.53 |
| IFT22 | intraflagellar transport 22 | -1.53 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | -1.51 |
| GRB7 | growth factor receptor-bound protein 7 | -1.5 |
| RAD51AP1 | RAD51 associated protein 1 | -1.5 |
| ZNF814 | zinc finger protein 814 | -1.49 |
| CEP55 | centrosomal protein 55kDa | -1.47 |
| PXMP4 | peroxisomal membrane protein 4, 24kDa | -1.46 |
| IVNS1ABP | influenza virus NS1A binding protein | -1.44 |
| ODC1 | ornithine decarboxylase 1 | -1.44 |
| SGSM1 | small G protein signaling modulator 1 | -1.43 |
| ARHGAP19 | Rho GTPase activating protein 19 | -1.43 |
| DONSON | downstream neighbor of SON | -1.43 |
| RAD51 | RAD51 recombinase | -1.43 |
| LZTS1 | leucine zipper, putative tumor suppressor 1 | -1.39 |
| ATXN2 | ataxin 2 | -1.34 |
| ZNF584 | zinc finger protein 584 | -1.33 |
| RTN4R | reticulon 4 receptor | -1.33 |
| NOTCH3 | notch 3 | -1.3 |
| CEP97 | centrosomal protein 97kDa | -1.3 |
| KIAA0586 | KIAA0586 | -1.29 |
| ZRANB1 | zinc finger, RAN-binding domain containing 1 | -1.28 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -1.28 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -1.28 |
| CCNF | cyclin F | -1.27 |
| FBXL3 | F-box and leucine-rich repeat protein 3 | -1.26 |
| ATAD5 | ATPase family, AAA domain containing 5 | -1.26 |
| MCM8 | minichromosome maintenance complex component 8 | -1.24 |
| PSRC1 | proline/serine-rich coiled-coil 1 | -1.24 |
| DIAPH3 | diaphanous-related formin 3 | -1.23 |
| NDC80 | NDC80 kinetochore complex component | -1.23 |
| BRCA1 | breast cancer 1, early onset | -1.23 |
| CCDC138 | coiled-coil domain containing 138 | -1.23 |
| HAUS7 | HAUS augmin-like complex, subunit 7 | -1.23 |
| ZCCHC2 | zinc finger, CCHC domain containing 2 | -1.22 |
| BSDC1 | BSD domain containing 1 | -1.22 |
| NECTIN3 | nectin cell adhesion molecule 3 | -1.21 |
| ATXN7L3B | ataxin 7-like 3B | -1.21 |
| SHROOM1 | shroom family member 1 | -1.21 |
| HELLS | helicase, lymphoid-specific | -1.2 |
| ZGRF1 | zinc finger, GRF-type containing 1 | -1.2 |
| ADGRF1 | adhesion G protein-coupled receptor F1 | -1.2 |
| NUF2 | NUF2, NDC80 kinetochore complex component | -1.2 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -1.18 |
| RNF187 | ring finger protein 187 | -1.18 |
| CDCA7 | cell division cycle associated 7 | -1.17 |
| TCF12 | transcription factor 12 | -1.17 |
| HAS3 | hyaluronan synthase 3 | -1.17 |
| PRELID1 | PRELI domain containing 1 | -1.17 |
| CCNB2 | cyclin B2 | -1.17 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -1.16 |
| POLQ | polymerase (DNA directed), theta | -1.15 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -1.15 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | -1.15 |
| TMUB2 | transmembrane and ubiquitin-like domain containing 2 | -1.15 |
| MDM4 | MDM4, p53 regulator | -1.15 |
| TTC31 | tetratricopeptide repeat domain 31 | -1.13 |
| C1ORF226 | chromosome 1 open reading frame 226 | -1.13 |
| ZKSCAN8 | zinc finger with KRAB and SCAN domains 8 | -1.13 |
| CCPG1 | cell cycle progression 1 | -1.13 |
| TULP4 | tubby like protein 4 | -1.12 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -1.11 |
| REXO5 | RNA exonuclease 5 | -1.11 |
| PHLPP2 | PH domain and leucine rich repeat protein phosphatase 2 | -1.11 |
| ZNF799 | zinc finger protein 799 | -1.11 |
| FAR2 | fatty acyl CoA reductase 2 | -1.11 |
| PTTG1 | pituitary tumor-transforming 1 | -1.11 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -1.11 |
| KNL1 | kinetochore scaffold 1 | -1.1 |
| GAS2L3 | growth arrest-specific 2 like 3 | -1.1 |
| MEF2A | myocyte enhancer factor 2A | -1.1 |
| APOL2 | apolipoprotein L, 2 | -1.1 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -1.1 |
| FAM111B | family with sequence similarity 111, member B | -1.1 |
| CCDC14 | coiled-coil domain containing 14 | -1.1 |
| C6ORF62 | chromosome 6 open reading frame 62 | -1.09 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -1.09 |
| UBE2J1 | ubiquitin-conjugating enzyme E2, J1 | -1.09 |
| STIL | SCL/TAL1 interrupting locus | -1.09 |
| SYTL4 | synaptotagmin-like 4 | -1.08 |
