BAY1125976_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BAY1125976_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.161326
MYH9 myosin, heavy chain 9, non-muscle 0.160251
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.135203
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.131908
MT2A metallothionein 2A 0.0994529
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0854161
VIM vimentin 0.0809966
PTMA prothymosin, alpha 0.0778378
TPM3 tropomyosin 3 0.0756825
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0745994
TMSB10 thymosin beta 10 0.0720909
ENO1 enolase 1, (alpha) 0.072071
CALR calreticulin 0.0693616
FSTL1 follistatin-like 1 0.0675145
ASPH aspartate beta-hydroxylase 0.0668074
TMSB4X thymosin beta 4, X-linked 0.0656968
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0638673
HDAC9 histone deacetylase 9 0.06104
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0608529
AHNAK AHNAK nucleoprotein 0.0582444
NAP1L1 nucleosome assembly protein 1-like 1 0.0574852
STAT1 signal transducer and activator of transcription 1, 91kDa 0.057135
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0562192
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0559845
PLEC plectin 0.0512049
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0510134
NFE2L1 nuclear factor, erythroid 2-like 1 0.0467466
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0456484
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0453281
CENPF centromere protein F, 350/400kDa 0.0443187
RPL37A ribosomal protein L37a 0.0437981
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0434668
DSPP dentin sialophosphoprotein 0.0426451
FLNA filamin A, alpha 0.0422795
RPS3 ribosomal protein S3 0.0414667
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.040901
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0407547
SRRM2 serine/arginine repetitive matrix 2 0.0404722
RPL23 ribosomal protein L23 0.0404341
MSN moesin 0.0396924
SET SET nuclear proto-oncogene 0.0396757
RPL26 ribosomal protein L26 0.0389197
PKM pyruvate kinase, muscle 0.0388347
LDHA lactate dehydrogenase A 0.0384512
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0383498
COL3A1 collagen, type III, alpha 1 0.0383494
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0380318
LMNA lamin A/C 0.0372903
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0372015
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0363633
MPRIP myosin phosphatase Rho interacting protein 0.0357874
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.035688
EEF2 eukaryotic translation elongation factor 2 0.0354897
CAVIN1 caveolae associated protein 1 0.034702
APP amyloid beta (A4) precursor protein 0.0344121
MAP1B microtubule-associated protein 1B 0.0340492
PRRC2C proline-rich coiled-coil 2C 0.0338653
CANX calnexin 0.0328409
SON SON DNA binding protein 0.0326208
SP100 SP100 nuclear antigen 0.0326
RPLP1 ribosomal protein, large, P1 0.032447
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.031982
TPM4 tropomyosin 4 0.0318889
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0318237
RPS12 ribosomal protein S12 0.0316917
RPL35 ribosomal protein L35 0.0314525
RPS8 ribosomal protein S8 0.0311164
EIF1 eukaryotic translation initiation factor 1 0.0310404
RPS19 ribosomal protein S19 0.0300524
CD44 CD44 molecule (Indian blood group) 0.0295751
MKI67 marker of proliferation Ki-67 0.0290794
EXT1 exostosin glycosyltransferase 1 0.0289474
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0288171
RACK1 receptor for activated C kinase 1 0.0283807
TPT1 tumor protein, translationally-controlled 1 0.0281206
RPL12 ribosomal protein L12 0.0275564
ACTG1 actin gamma 1 0.0274967
PDIA3 protein disulfide isomerase family A, member 3 0.0274123
TPI1 triosephosphate isomerase 1 0.0272916
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0272717
RPS6 ribosomal protein S6 0.0268489
RPS17 ribosomal protein S17 0.0266644
RPLP2 ribosomal protein, large, P2 0.0265426
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0261964
SKP1 S-phase kinase-associated protein 1 0.0258691
RPL36 ribosomal protein L36 0.0257959
ALCAM activated leukocyte cell adhesion molecule 0.0257032
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0256597
PRSS23 protease, serine, 23 0.0252885
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0249402
HSPA8 heat shock 70kDa protein 8 0.0247894
MCFD2 multiple coagulation factor deficiency 2 0.024787
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0245234
RPL31 ribosomal protein L31 0.0243014
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0239406
VCL vinculin 0.0238246
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0235765
RPL19 ribosomal protein L19 0.0235249
RPL3 ribosomal protein L3 0.0234359
RPS15A ribosomal protein S15a 0.0230881

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.296694
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.180252
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.147116
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.118762
NDRG1 N-myc downstream regulated 1 -0.11417
LOX lysyl oxidase -0.103565
DLG1 discs, large homolog 1 (Drosophila) -0.100596
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0894722
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0757445
LOXL2 lysyl oxidase-like 2 -0.0749942
UBC ubiquitin C -0.0744611
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0549924
ABI3BP ABI family, member 3 (NESH) binding protein -0.0534429
PODXL podocalyxin-like -0.0533894
TRIO trio Rho guanine nucleotide exchange factor -0.0517837
AUTS2 autism susceptibility candidate 2 -0.0500303
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0489997
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0484914
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0474594
COL8A1 collagen, type VIII, alpha 1 -0.0462625
MSI2 musashi RNA-binding protein 2 -0.0452047
FTH1 ferritin, heavy polypeptide 1 -0.0451492
COL1A2 collagen, type I, alpha 2 -0.0422026
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0400618
CD109 CD109 molecule -0.0397363
FBN1 fibrillin 1 -0.039072
THBS2 thrombospondin 2 -0.0375524
SOD2 superoxide dismutase 2, mitochondrial -0.036731
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.036411
ELL2 elongation factor, RNA polymerase II, 2 -0.0354268
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.035197
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0337317
GOLGA4 golgin A4 -0.0331975
BHLHE40 basic helix-loop-helix family, member e40 -0.0331854
CD99 CD99 molecule -0.0329893
RUNX1 runt-related transcription factor 1 -0.0326291
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0323865
MRPS6 mitochondrial ribosomal protein S6 -0.0319835
FOSL1 FOS-like antigen 1 -0.0318691
SUCNR1 succinate receptor 1 -0.0316715
TPM1 tropomyosin 1 (alpha) -0.0302258
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0302055
HELZ helicase with zinc finger -0.0301358
MEIS2 Meis homeobox 2 -0.0301141
EPAS1 endothelial PAS domain protein 1 -0.0300559
RTN4 reticulon 4 -0.0298361
SH3BP5 SH3-domain binding protein 5 (BTK-associated) -0.0294725
KDM5B lysine (K)-specific demethylase 5B -0.0293813
OGA O-GlcNAcase -0.0290509
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0279689
FNDC3B fibronectin type III domain containing 3B -0.0279524
RNF24 ring finger protein 24 -0.0271271
DCLK2 doublecortin-like kinase 2 -0.0270772
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0270562
PFN1 profilin 1 -0.02657
HILPDA hypoxia inducible lipid droplet-associated -0.0261648
MT1X metallothionein 1X -0.0260687
MMP12 matrix metallopeptidase 12 -0.0259505
ZBTB20 zinc finger and BTB domain containing 20 -0.0256899
TAGLN2 transgelin 2 -0.0255368
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0251624
ADAM9 ADAM metallopeptidase domain 9 -0.0250825
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0248769
ZNF207 zinc finger protein 207 -0.0245435
WTAP Wilms tumor 1 associated protein -0.0245374
C1D C1D nuclear receptor corepressor -0.0242873
DPYSL3 dihydropyrimidinase-like 3 -0.0241427
TAPBP TAP binding protein (tapasin) -0.0238287
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0237343
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0236585
INSIG2 insulin induced gene 2 -0.0233988
ADAM17 ADAM metallopeptidase domain 17 -0.0233364
SOX9 SRY (sex determining region Y)-box 9 -0.0230321
MYADM myeloid-associated differentiation marker -0.0221485
NPEPPS aminopeptidase puromycin sensitive -0.0217282
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.021687
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0215998
ANXA2 annexin A2 -0.021584
LPCAT2 lysophosphatidylcholine acyltransferase 2 -0.0213934
TGFB1 transforming growth factor, beta 1 -0.0212658
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0212329
INSIG1 insulin induced gene 1 -0.0212305
MXI1 MAX interactor 1, dimerization protein -0.0212083
SSBP2 single-stranded DNA binding protein 2 -0.0211893
ADM adrenomedullin -0.0209829
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0208259
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0205929
BIRC6 baculoviral IAP repeat containing 6 -0.0205701
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0203376
KCTD9 potassium channel tetramerization domain containing 9 -0.0203145
MARCHF6 membrane associated ring-CH-type finger 6 -0.0203049
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 -0.0202533
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0200189
SORBS2 sorbin and SH3 domain containing 2 -0.0198735
POTEF POTE ankyrin domain family, member F -0.0198463
GARS1 glycyl-tRNA synthetase 1 -0.0197834
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0196446
SLC38A1 solute carrier family 38, member 1 -0.0195551
MEF2D myocyte enhancer factor 2D -0.0192918
NFIX nuclear factor I/X (CCAAT-binding transcription factor) -0.0191845