BAY1125976_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in A-427 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the BAY1125976_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.187973
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.18201
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.160111
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.131248
PDE4D phosphodiesterase 4D, cAMP-specific 0.117893
VIM vimentin 0.109253
ASPH aspartate beta-hydroxylase 0.106718
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.106296
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.104008
TPI1 triosephosphate isomerase 1 0.1009
TPM3 tropomyosin 3 0.0971255
ANXA1 annexin A1 0.0936819
ENO1 enolase 1, (alpha) 0.0755097
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0703908
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.07034
RRM2 ribonucleotide reductase M2 0.0639164
HSPA8 heat shock 70kDa protein 8 0.0639015
NAP1L1 nucleosome assembly protein 1-like 1 0.0624056
MTAP methylthioadenosine phosphorylase 0.0616084
HMGA2 high mobility group AT-hook 2 0.0607244
IPO7 importin 7 0.0596623
MYH9 myosin, heavy chain 9, non-muscle 0.0596127
PDGFC platelet derived growth factor C 0.0573684
TMSB10 thymosin beta 10 0.0564676
CALR calreticulin 0.0557909
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0555284
YAP1 Yes-associated protein 1 0.0549849
PCDH7 protocadherin 7 0.0537915
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0536961
ACTG1 actin gamma 1 0.0520822
ERRFI1 ERBB receptor feedback inhibitor 1 0.0516725
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0516315
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.051051
AHNAK AHNAK nucleoprotein 0.0508005
BIRC3 baculoviral IAP repeat containing 3 0.0506774
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0496596
RPL3 ribosomal protein L3 0.0495152
SRRM2 serine/arginine repetitive matrix 2 0.0487641
ADIPOR2 adiponectin receptor 2 0.0462621
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0459563
NEBL nebulette 0.0459543
DPYD dihydropyrimidine dehydrogenase 0.0451139
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0439796
AREG amphiregulin 0.0436328
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0432823
SLC38A2 solute carrier family 38, member 2 0.0429351
MMP12 matrix metallopeptidase 12 0.0422885
EZR ezrin 0.041936
HDAC9 histone deacetylase 9 0.0417993
SET SET nuclear proto-oncogene 0.0407253
NFE2L1 nuclear factor, erythroid 2-like 1 0.0381418
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0373034
RPS12 ribosomal protein S12 0.0371406
EHBP1 EH domain binding protein 1 0.0358628
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0348961
CANX calnexin 0.0346424
EIF1 eukaryotic translation initiation factor 1 0.0336003
MKI67 marker of proliferation Ki-67 0.032941
NFE2L2 nuclear factor, erythroid 2-like 2 0.0326378
GJA1 gap junction protein, alpha 1, 43kDa 0.032596
INTS6 integrator complex subunit 6 0.0325902
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.032505
ZSWIM6 zinc finger, SWIM-type containing 6 0.032338
DENND5A DENN/MADD domain containing 5A 0.0321006
XPOT exportin, tRNA 0.0319792
AKAP12 A kinase (PRKA) anchor protein 12 0.0315409
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0311397
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0308981
TMEM41B transmembrane protein 41B 0.0303671
TPT1 tumor protein, translationally-controlled 1 0.0303512
PTMA prothymosin, alpha 0.0302436
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0301137
RPL4 ribosomal protein L4 0.0298972
SMC1A structural maintenance of chromosomes 1A 0.0296046
WWOX WW domain containing oxidoreductase 0.0295784
LOC102724023 ES1 protein homolog, mitochondrial 0.0291708
RPL37A ribosomal protein L37a 0.0288387
HSPA4 heat shock 70kDa protein 4 0.0285132
SFPQ splicing factor proline/glutamine-rich 0.0284464
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0282654
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0278514
LOC112694756 uncharaterized LOC112694756 0.0274873
CLTC clathrin, heavy chain (Hc) 0.0273175
CPNE1 copine I 0.0270826
DSCAM Down syndrome cell adhesion molecule 0.02705
BRCA1 breast cancer 1, early onset 0.0268976
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0267832
ZNF146 zinc finger protein 146 0.0267383
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0263402
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0263354
WNK1 WNK lysine deficient protein kinase 1 0.0262536
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0261423
SMYD3 SET and MYND domain containing 3 0.0259289
TCP1 t-complex 1 0.0258948
DSPP dentin sialophosphoprotein 0.0258625
RPS17 ribosomal protein S17 0.0256845
TM9SF3 transmembrane 9 superfamily member 3 0.025479
RABGAP1L RAB GTPase activating protein 1-like 0.0254274
MAP1B microtubule-associated protein 1B 0.0254268
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0253876

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.238277
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.107954
FTL ferritin, light polypeptide -0.0778566
PCBP2 poly(rC) binding protein 2 -0.0665332
BIRC6 baculoviral IAP repeat containing 6 -0.064371
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0641035
ATP5F1B ATP synthase F1 subunit beta -0.0639743
RASAL2 RAS protein activator like 2 -0.0637462
MGAT4C MGAT4 family, member C -0.0601033
PFN1 profilin 1 -0.0596636
RPL35A ribosomal protein L35a -0.0420652
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0403902
HMGA1 high mobility group AT-hook 1 -0.0396209
MED13L mediator complex subunit 13-like -0.0393642
HSPB1 heat shock 27kDa protein 1 -0.0385281
ZNF292 zinc finger protein 292 -0.0368436
POTEF POTE ankyrin domain family, member F -0.0354279
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0352476
RAB1A RAB1A, member RAS oncogene family -0.0351433
CCNL1 cyclin L1 -0.0347832
SYT1 synaptotagmin I -0.0347446
PUM2 pumilio RNA-binding family member 2 -0.0345227
FBXO11 F-box protein 11 -0.0338143
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0333047
TNRC6B trinucleotide repeat containing 6B -0.0331915
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0331426
S100A6 S100 calcium binding protein A6 -0.032972
ARHGAP12 Rho GTPase activating protein 12 -0.0328274
TSC22D2 TSC22 domain family, member 2 -0.0326657
RPS15 ribosomal protein S15 -0.0325274
KLHL24 kelch-like family member 24 -0.0317511
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -0.0309572
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0308381
WDR45B WD repeat domain 45B -0.0301696
VPS8 vacuolar protein sorting 8 homolog (S. cerevisiae) -0.029757
ZNF804A zinc finger protein 804A -0.0295267
MON2 MON2 homolog (S. cerevisiae) -0.029341
CDK19 cyclin-dependent kinase 19 -0.0292647
OXR1 oxidation resistance 1 -0.0287136
GSK3B glycogen synthase kinase 3 beta -0.0286655
RPL8 ribosomal protein L8 -0.028473
BTG3 BTG family, member 3 -0.0282645
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0281867
PARD3 par-3 family cell polarity regulator -0.0281154
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0281046
QKI QKI, KH domain containing, RNA binding -0.028025
AP3S1 adaptor-related protein complex 3, sigma 1 subunit -0.0276574
RBM39 RNA binding motif protein 39 -0.026921
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0258204
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa -0.0253868
MARCHF6 membrane associated ring-CH-type finger 6 -0.0253035
KMT2E lysine (K)-specific methyltransferase 2E -0.0250698
BRWD3 bromodomain and WD repeat domain containing 3 -0.0246904
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0240271
THOC2 THO complex 2 -0.0239611
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0238139
BCAS3 breast carcinoma amplified sequence 3 -0.0236095
AKAP9 A kinase (PRKA) anchor protein 9 -0.023443
COG5 component of oligomeric golgi complex 5 -0.023143
BRWD1 bromodomain and WD repeat domain containing 1 -0.0229959
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0229418
ZMYM2 zinc finger, MYM-type 2 -0.0227599
CNRIP1 cannabinoid receptor interacting protein 1 -0.0226882
FUS FUS RNA binding protein -0.0226278
CXADR coxsackie virus and adenovirus receptor -0.0224273
YBX1 Y box binding protein 1 -0.0223857
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0223018
MBNL1 muscleblind-like splicing regulator 1 -0.0219951
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0219655
RPS21 ribosomal protein S21 -0.0219587
PER1 period circadian clock 1 -0.0218853
FBXL20 F-box and leucine-rich repeat protein 20 -0.0217844
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0216653
PACS1 phosphofurin acidic cluster sorting protein 1 -0.021565
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0215556
HELZ helicase with zinc finger -0.0213302
CAMKMT calmodulin-lysine N-methyltransferase -0.0213096
ATP11B ATPase, class VI, type 11B -0.0211563
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0211461
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0209801
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0208352
NPEPPS aminopeptidase puromycin sensitive -0.020649
PHIP pleckstrin homology domain interacting protein -0.0205542
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0205279
PIBF1 progesterone immunomodulatory binding factor 1 -0.0202806
HLA-A major histocompatibility complex, class I, A -0.0202214
TAPBP TAP binding protein (tapasin) -0.0201315
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0199898
HMGB1 high mobility group box 1 -0.0198395
TRA2A transformer 2 alpha homolog (Drosophila) -0.0198038
PFN2 profilin 2 -0.0197738
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0197434
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0197395
FOXM1 forkhead box M1 -0.0197017
SESN2 sestrin 2 -0.0194593
VAT1 vesicle amine transport 1 -0.0193527
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0192887
WDR43 WD repeat domain 43 -0.0192785
PCNX1 pecanex 1 -0.0192542
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.019165