BAY1125976_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BAY1125976_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VCL vinculin 0.233226
EXT1 exostosin glycosyltransferase 1 0.138696
AKAP12 A kinase (PRKA) anchor protein 12 0.134193
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.129855
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.127345
VIM vimentin 0.116769
PTMA prothymosin, alpha 0.116641
ZSWIM6 zinc finger, SWIM-type containing 6 0.116132
RPL23 ribosomal protein L23 0.113964
TLE4 transducin-like enhancer of split 4 0.106673
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.105447
LSAMP limbic system-associated membrane protein 0.0961185
NALF1 NALCN channel auxiliary factor 1 0.0947176
RPS6 ribosomal protein S6 0.0930699
FMN1 formin 1 0.0927498
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0858749
MYH9 myosin, heavy chain 9, non-muscle 0.0792731
RPL19 ribosomal protein L19 0.0756627
ACTG1 actin gamma 1 0.0741961
TPT1 tumor protein, translationally-controlled 1 0.0718391
RPS3 ribosomal protein S3 0.0702419
NAP1L1 nucleosome assembly protein 1-like 1 0.0679092
RPS12 ribosomal protein S12 0.064676
RPLP1 ribosomal protein, large, P1 0.0646111
RPL37A ribosomal protein L37a 0.0631746
RPL26 ribosomal protein L26 0.0566541
RPL31 ribosomal protein L31 0.0554131
NRG1 neuregulin 1 0.0544755
EIF1 eukaryotic translation initiation factor 1 0.0532545
RPL35A ribosomal protein L35a 0.0532122
SLIT2 slit homolog 2 (Drosophila) 0.0527292
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0523852
MYO1E myosin IE 0.0512557
RACK1 receptor for activated C kinase 1 0.0505032
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0496438
PTPRD protein tyrosine phosphatase, receptor type, D 0.0490668
SRRM2 serine/arginine repetitive matrix 2 0.0484802
CRH corticotropin releasing hormone 0.0484553
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0482711
RPS19 ribosomal protein S19 0.0481276
TMSB10 thymosin beta 10 0.0477233
GLCCI1 glucocorticoid induced 1 0.0475524
SP100 SP100 nuclear antigen 0.0467198
B2M beta-2-microglobulin 0.0466162
NPAS2 neuronal PAS domain protein 2 0.0464436
RPS27 ribosomal protein S27 0.0458218
LIMA1 LIM domain and actin binding 1 0.0455037
TIMP3 TIMP metallopeptidase inhibitor 3 0.0446349
ASPH aspartate beta-hydroxylase 0.0440235
ENO1 enolase 1, (alpha) 0.0438245
TPM4 tropomyosin 4 0.0437784
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0430559
RPS8 ribosomal protein S8 0.0419528
PDLIM5 PDZ and LIM domain 5 0.0419096
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.041739
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0416307
MACF1 microtubule-actin crosslinking factor 1 0.04149
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.04136
RPS17 ribosomal protein S17 0.0408892
IER3 immediate early response 3 0.0408619
RPL36 ribosomal protein L36 0.0404928
THSD4 thrombospondin, type I, domain containing 4 0.0404615
FERMT2 fermitin family member 2 0.040149
SIK2 salt-inducible kinase 2 0.0388511
MCL1 myeloid cell leukemia 1 0.0387733
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.038674
TPM1 tropomyosin 1 (alpha) 0.03853
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0379801
PTPRK protein tyrosine phosphatase, receptor type, K 0.0375815
LPP LIM domain containing preferred translocation partner in lipoma 0.0372114
STK38L serine/threonine kinase 38 like 0.0372057
RPL7 ribosomal protein L7 0.0371202
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.03665
RPS24 ribosomal protein S24 0.0364972
RPLP0 ribosomal protein, large, P0 0.0360589
VMP1 vacuole membrane protein 1 0.0360505
BCAS3 breast carcinoma amplified sequence 3 0.035714
EEF2 eukaryotic translation elongation factor 2 0.0352047
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0351597
SET SET nuclear proto-oncogene 0.0348796
RPL13A ribosomal protein L13a 0.0348325
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0347519
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0347254
HSPA8 heat shock 70kDa protein 8 0.0347024
RIGI RNA sensor RIG-I 0.0345306
RPL34 ribosomal protein L34 0.0342142
TPI1 triosephosphate isomerase 1 0.0341712
INTS6 integrator complex subunit 6 0.0340805
RPS29 ribosomal protein S29 0.0337535
RNF213 ring finger protein 213 0.0337076
RPS14 ribosomal protein S14 0.0336582
RPL7A ribosomal protein L7a 0.033595
FNDC3A fibronectin type III domain containing 3A 0.0334988
RPS25 ribosomal protein S25 0.0334879
RPL4 ribosomal protein L4 0.0331615
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0331599
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0328731
EGR1 early growth response 1 0.0328672
BPTF bromodomain PHD finger transcription factor 0.0325371
RPL35 ribosomal protein L35 0.032396

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.261879
HELZ helicase with zinc finger -0.0699759
MEIS2 Meis homeobox 2 -0.0523033
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0495941
ZNF292 zinc finger protein 292 -0.0408347
NPEPPS aminopeptidase puromycin sensitive -0.0394181
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0377232
LPIN1 lipin 1 -0.0376697
WDR45B WD repeat domain 45B -0.0369719
C1ORF21 chromosome 1 open reading frame 21 -0.0350735
SOS1 son of sevenless homolog 1 (Drosophila) -0.0345274
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0335267
FAM13A family with sequence similarity 13, member A -0.0328866
ADGRG6 adhesion G protein-coupled receptor G6 -0.0323789
FNBP1 formin binding protein 1 -0.031795
MARCHF6 membrane associated ring-CH-type finger 6 -0.0317519
TENT5A terminal nucleotidyltransferase 5A -0.0289166
NAMPT nicotinamide phosphoribosyltransferase -0.0272523
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0269279
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0262539
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0261253
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0257428
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0257009
OGA O-GlcNAcase -0.0253707
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0241448
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0238323
PHIP pleckstrin homology domain interacting protein -0.0228257
BRWD1 bromodomain and WD repeat domain containing 1 -0.022727
ZMYM2 zinc finger, MYM-type 2 -0.0222587
MIS18BP1 MIS18 binding protein 1 -0.0222253
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.0220386
NUP58 nucleoporin 58 -0.021984
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0213686
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.020517
TENT4A terminal nucleotidyltransferase 4A -0.0199579
PDS5B PDS5 cohesin associated factor B -0.0199169
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0197452
CD36 CD36 molecule (thrombospondin receptor) -0.0197084
USP3 ubiquitin specific peptidase 3 -0.0190473
XPO1 exportin 1 -0.0189259
GNG2 guanine nucleotide binding protein (G protein), gamma 2 -0.0188717
LCORL ligand dependent nuclear receptor corepressor-like -0.0187354
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0186958
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0185634
CEP95 centrosomal protein 95kDa -0.0184005
RNF145 ring finger protein 145 -0.0182008
PRTG protogenin -0.0179953
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0179199
SRP54 signal recognition particle 54kDa -0.0178848
FNDC3B fibronectin type III domain containing 3B -0.0178665
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.017709
AOPEP aminopeptidase O (putative) -0.0176468
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0176176
WSB1 WD repeat and SOCS box containing 1 -0.0175537
USP9Y ubiquitin specific peptidase 9, Y-linked -0.0174602
CCNL1 cyclin L1 -0.0173919
PTEN phosphatase and tensin homolog -0.0173863
RFX7 regulatory factor X, 7 -0.0172795
QKI QKI, KH domain containing, RNA binding -0.0172016
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0171941
WAC WW domain containing adaptor with coiled-coil -0.0170889
SSBP2 single-stranded DNA binding protein 2 -0.0168922
INSIG2 insulin induced gene 2 -0.0167206
MEF2A myocyte enhancer factor 2A -0.0165141
FCHSD2 FCH and double SH3 domains 2 -0.0164376
NEK7 NIMA-related kinase 7 -0.0163852
SEC31A SEC31 homolog A (S. cerevisiae) -0.0162854
NDRG1 N-myc downstream regulated 1 -0.0162509
PHF21A PHD finger protein 21A -0.0159602
CDK8 cyclin-dependent kinase 8 -0.0157773
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0157054
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.015554
KCTD3 potassium channel tetramerization domain containing 3 -0.0154624
RTN4 reticulon 4 -0.0154297
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0153226
CDK19 cyclin-dependent kinase 19 -0.0152433
HAND2 heart and neural crest derivatives expressed 2 -0.0151988
ADAM9 ADAM metallopeptidase domain 9 -0.0149147
CDC27 cell division cycle 27 -0.0149146
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0148946
TOB1 transducer of ERBB2, 1 -0.0147379
PCNX1 pecanex 1 -0.0146873
FKBP1A FK506 binding protein 1A, 12kDa -0.014679
SUCO SUN domain containing ossification factor -0.0146031
NBAS neuroblastoma amplified sequence -0.0144918
AUH AU RNA binding protein/enoyl-CoA hydratase -0.0143671
KLHL24 kelch-like family member 24 -0.0142822
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.014281
PCDH9 protocadherin 9 -0.0141982
KMT2C lysine (K)-specific methyltransferase 2C -0.0140467
ZNF148 zinc finger protein 148 -0.0140466
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0140217
MED23 mediator complex subunit 23 -0.0139001
PIBF1 progesterone immunomodulatory binding factor 1 -0.0138956
NKTR natural killer cell triggering receptor -0.013895
PTK2 protein tyrosine kinase 2 -0.0138799
MXI1 MAX interactor 1, dimerization protein -0.01387
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0138549
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0138506
GPC5 glypican 5 -0.0137808