| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | BAY1125976 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the BAY1125976_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| DSPP | dentin sialophosphoprotein | 0.0750647 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0746796 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0744548 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0587016 |
| C3 | complement component 3 | 0.0581882 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0531308 |
| RPL3 | ribosomal protein L3 | 0.0518653 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0511991 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0416895 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.036758 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0366355 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0340697 |
| TF | transferrin | 0.0323822 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0317174 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.031653 |
| RPS12 | ribosomal protein S12 | 0.0303176 |
| KYNU | kynureninase | 0.0301857 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0296861 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0284229 |
| VCL | vinculin | 0.0283079 |
| PLIN2 | perilipin 2 | 0.0275482 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0261702 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0260885 |
| USP47 | ubiquitin specific peptidase 47 | 0.0256146 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0251159 |
| JAK1 | Janus kinase 1 | 0.0238076 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0235826 |
| VEGFA | vascular endothelial growth factor A | 0.0230651 |
| RPS2 | ribosomal protein S2 | 0.0229575 |
| RPL21 | ribosomal protein L21 | 0.0227507 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0227177 |
| SET | SET nuclear proto-oncogene | 0.0225283 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0208448 |
| CRY1 | cryptochrome circadian clock 1 | 0.0208341 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0200604 |
| RPL37A | ribosomal protein L37a | 0.0199521 |
| DTNA | dystrobrevin, alpha | 0.019841 |
| OPTN | optineurin | 0.0198372 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0189069 |
| RPS15A | ribosomal protein S15a | 0.0185919 |
| DNAJC12 | DnaJ (Hsp40) homolog, subfamily C, member 12 | 0.0185777 |
| KLF10 | Kruppel-like factor 10 | 0.0185073 |
| RIGI | RNA sensor RIG-I | 0.0179661 |
| ATF4 | activating transcription factor 4 | 0.0178054 |
| DIAPH1 | diaphanous-related formin 1 | 0.0177984 |
| AFDN | afadin, adherens junction formation factor | 0.0174651 |
| RPS18 | ribosomal protein S18 | 0.0174509 |
| RPS7 | ribosomal protein S7 | 0.0173888 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0173436 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0172781 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0171406 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0170987 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0170166 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0166056 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0164817 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0159343 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0158575 |
| STC2 | stanniocalcin 2 | 0.0158039 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0154837 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0150782 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0149887 |
| SIK3 | SIK family kinase 3 | 0.0148651 |
| CLIC4 | chloride intracellular channel 4 | 0.014825 |
| KMT5B | lysine methyltransferase 5B | 0.0143278 |
| JMY | junction mediating and regulatory protein, p53 cofactor | 0.0143039 |
| FILIP1L | filamin A interacting protein 1-like | 0.014247 |
| FAM13A | family with sequence similarity 13, member A | 0.0142196 |
| ADAR | adenosine deaminase, RNA-specific | 0.0141425 |
| EFNA5 | ephrin-A5 | 0.0138084 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0137624 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0137167 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0136618 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0136324 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0135098 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0133926 |
| TMF1 | TATA element modulatory factor 1 | 0.0133602 |
| CUL3 | cullin 3 | 0.0133444 |
| DYRK1A | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A | 0.0132157 |
| PNN | pinin, desmosome associated protein | 0.0131751 |
| PAPOLA | poly(A) polymerase alpha | 0.013091 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0130459 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.012986 |
| FOSL2 | FOS-like antigen 2 | 0.0129231 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0129219 |
| CCDC6 | coiled-coil domain containing 6 | 0.0128833 |
| ALPK2 | alpha-kinase 2 | 0.0128377 |
| RPL26 | ribosomal protein L26 | 0.0128063 |
| FHL2 | four and a half LIM domains 2 | 0.0127698 |
| RASA2 | RAS p21 protein activator 2 | 0.0127591 |
| RAD23B | RAD23 homolog B (S. cerevisiae) | 0.0126674 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0126319 |
| HBS1L | HBS1-like translational GTPase | 0.0126298 |
| BRD2 | bromodomain containing 2 | 0.0125808 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.012545 |
| GLIS3 | GLIS family zinc finger 3 | 0.0125218 |
| PRELID2 | PRELI domain containing 2 | 0.0124503 |
| RNF213 | ring finger protein 213 | 0.0124095 |
| UGT2B7 | UDP glucuronosyltransferase 2 family, polypeptide B7 | 0.0123591 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.0123104 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0120936 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.23461 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.180317 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.149239 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.135679 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.129852 |
| GPC3 | glypican 3 | -0.128541 |
| EHBP1 | EH domain binding protein 1 | -0.126922 |
| APOB | apolipoprotein B | -0.125483 |
| IGF2 | insulin-like growth factor 2 | -0.124134 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.122756 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.114374 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.111658 |
| APOA2 | apolipoprotein A-II | -0.103417 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0977096 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0938557 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0846809 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0820672 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0819798 |
| FRMD5 | FERM domain containing 5 | -0.0800052 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0780451 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0772811 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0744798 |
| NHSL1 | NHS-like 1 | -0.0731877 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0713165 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0698212 |
| FTL | ferritin, light polypeptide | -0.068683 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0684697 |
| RASGRF2 | Ras protein-specific guanine nucleotide-releasing factor 2 | -0.0680402 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0649529 |
| FN1 | fibronectin 1 | -0.0646265 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.062715 |
| UBC | ubiquitin C | -0.0595048 |
| CNKSR3 | CNKSR family member 3 | -0.0594788 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0589467 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0588571 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | -0.0583789 |
| A2M | alpha-2-macroglobulin | -0.0578405 |
| RPS27A | ribosomal protein S27a | -0.0575888 |
| ITGA1 | integrin, alpha 1 | -0.0553157 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0547902 |
| TRIM26 | tripartite motif containing 26 | -0.0547103 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0538223 |
| RPS24 | ribosomal protein S24 | -0.0527281 |
| GNAS | GNAS complex locus | -0.0506702 |
| CTSB | cathepsin B | -0.0497038 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0494161 |
| ROCK2 | Rho-associated, coiled-coil containing protein kinase 2 | -0.049098 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0485216 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0483254 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0468481 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0434445 |
| TMEM123 | transmembrane protein 123 | -0.0430697 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.043058 |
| ASPH | aspartate beta-hydroxylase | -0.0421136 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0419713 |
| OSBPL10 | oxysterol binding protein-like 10 | -0.0419109 |
| APOE | apolipoprotein E | -0.041551 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0405249 |
| ZFHX3 | zinc finger homeobox 3 | -0.0399761 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | -0.0393948 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0391747 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0388691 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0386189 |
| FMNL2 | formin-like 2 | -0.0385204 |
| RAI14 | retinoic acid induced 14 | -0.0383919 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0382684 |
| GK | glycerol kinase | -0.0377403 |
| PARD3 | par-3 family cell polarity regulator | -0.0372001 |
| HMGA1 | high mobility group AT-hook 1 | -0.0370166 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0363859 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0360216 |
| STK39 | serine threonine kinase 39 | -0.0359202 |
| ATXN1 | ataxin 1 | -0.0354407 |
| IER3 | immediate early response 3 | -0.0353894 |
| MSI2 | musashi RNA-binding protein 2 | -0.0350967 |
| RAPGEF5 | Rap guanine nucleotide exchange factor (GEF) 5 | -0.0348488 |
| RPL35A | ribosomal protein L35a | -0.03447 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0340619 |
| RPL34 | ribosomal protein L34 | -0.0336719 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.033513 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.033027 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0328491 |
| OSMR | oncostatin M receptor | -0.0328097 |
| RPL11 | ribosomal protein L11 | -0.0326923 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0324592 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0319975 |
| USP34 | ubiquitin specific peptidase 34 | -0.0312357 |
| LYZ | lysozyme | -0.031201 |
| GDF15 | growth differentiation factor 15 | -0.0310207 |
| ATP10A | ATPase, class V, type 10A | -0.031007 |
| SDC4 | syndecan 4 | -0.0309759 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0306516 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0302004 |
| GLG1 | golgi glycoprotein 1 | -0.0301943 |
| CP | ceruloplasmin (ferroxidase) | -0.0300889 |
| VMP1 | vacuole membrane protein 1 | -0.0299865 |
| DOCK5 | dedicator of cytokinesis 5 | -0.029961 |
| RPLP1 | ribosomal protein, large, P1 | -0.0297284 |
| MALRD1 | MAM and LDL receptor class A domain containing 1 | -0.029308 |
| BCL2L1 | BCL2-like 1 | -0.0292817 |
