BAY1125976_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BAY1125976_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.138209
MT2A metallothionein 2A 0.132011
RPS12 ribosomal protein S12 0.0911591
TPT1 tumor protein, translationally-controlled 1 0.0706515
RPS3 ribosomal protein S3 0.0682276
PLEC plectin 0.0675415
RPL37A ribosomal protein L37a 0.0603011
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0589072
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.058113
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.056863
TMSB10 thymosin beta 10 0.054742
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0501614
NAP1L1 nucleosome assembly protein 1-like 1 0.0499027
RPL26 ribosomal protein L26 0.0496628
RPS19 ribosomal protein S19 0.0491111
ENO1 enolase 1, (alpha) 0.0484885
RPS8 ribosomal protein S8 0.0448424
RPL31 ribosomal protein L31 0.0424264
ANGPTL4 angiopoietin-like 4 0.0399795
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0397219
RPL12 ribosomal protein L12 0.0394189
RPL13A ribosomal protein L13a 0.0386878
VCL vinculin 0.0386374
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0385398
DSCAM Down syndrome cell adhesion molecule 0.0378214
RPL37 ribosomal protein L37 0.0357262
ASPH aspartate beta-hydroxylase 0.0354676
TPM3 tropomyosin 3 0.0347203
RPL36 ribosomal protein L36 0.0341489
RPS17 ribosomal protein S17 0.0337063
TMSB4X thymosin beta 4, X-linked 0.0329013
ANXA1 annexin A1 0.0318255
RPLP2 ribosomal protein, large, P2 0.0304127
RPS27A ribosomal protein S27a 0.0300567
SRRM2 serine/arginine repetitive matrix 2 0.0299693
SET SET nuclear proto-oncogene 0.029959
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0298118
NUMA1 nuclear mitotic apparatus protein 1 0.029626
RACK1 receptor for activated C kinase 1 0.0295833
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0292269
RPLP1 ribosomal protein, large, P1 0.0289002
RPL7A ribosomal protein L7a 0.0287041
RPS25 ribosomal protein S25 0.0285791
TOP1 topoisomerase (DNA) I 0.0285241
SQSTM1 sequestosome 1 0.0281669
RPL35 ribosomal protein L35 0.0278672
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0277418
RPL19 ribosomal protein L19 0.027655
EHBP1L1 EH domain binding protein 1-like 1 0.0274868
CLU clusterin 0.0273823
MBNL1 muscleblind-like splicing regulator 1 0.0269026
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0264018
RPS2 ribosomal protein S2 0.025481
SMAD3 SMAD family member 3 0.0253688
DUSP6 dual specificity phosphatase 6 0.0252885
RPL9 ribosomal protein L9 0.0250117
RPS15A ribosomal protein S15a 0.0243442
MT1E metallothionein 1E 0.0237115
RPL3 ribosomal protein L3 0.0236067
RPL23 ribosomal protein L23 0.0235956
RRBP1 ribosome binding protein 1 0.0232198
SAMD9 sterile alpha motif domain containing 9 0.0230789
CD9 CD9 molecule 0.0230018
ADM adrenomedullin 0.0229725
RPS27 ribosomal protein S27 0.0227171
RPS24 ribosomal protein S24 0.0224317
ARGLU1 arginine and glutamate rich 1 0.0223882
RPL7 ribosomal protein L7 0.0222898
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0222823
EIF5B eukaryotic translation initiation factor 5B 0.0222074
NACA nascent polypeptide-associated complex alpha subunit 0.0221569
CAVIN1 caveolae associated protein 1 0.0220806
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 0.021599
HSPA1A heat shock 70kDa protein 1A 0.0215158
RPS14 ribosomal protein S14 0.0208175
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0207561
HSPA8 heat shock 70kDa protein 8 0.0206513
IRS2 insulin receptor substrate 2 0.0204906
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0194035
HLA-B major histocompatibility complex, class I, B 0.0192483
RPS4X ribosomal protein S4, X-linked 0.0190621
RPL4 ribosomal protein L4 0.0188797
HYOU1 hypoxia up-regulated 1 0.0185209
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0183117
ATP5MK ATP synthase membrane subunit k 0.0182307
CTNND1 catenin (cadherin-associated protein), delta 1 0.0179131
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0177498
RPL27 ribosomal protein L27 0.0175976
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0174673
CTTN cortactin 0.0174045
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.017328
RBM25 RNA binding motif protein 25 0.0172532
CAPRIN2 caprin family member 2 0.0169464
PTMA prothymosin, alpha 0.0168711
LOC102724023 ES1 protein homolog, mitochondrial 0.0166685
NFE2L1 nuclear factor, erythroid 2-like 1 0.0164368
FAM107B family with sequence similarity 107, member B 0.0163903
PDIA3 protein disulfide isomerase family A, member 3 0.0163652
SKP1 S-phase kinase-associated protein 1 0.0163496
ERRFI1 ERBB receptor feedback inhibitor 1 0.0163385

decreased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.348188
STC1 stanniocalcin 1 -0.160783
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.154027
PDE4D phosphodiesterase 4D, cAMP-specific -0.124191
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.121073
MTSS1 metastasis suppressor 1 -0.11766
IGF2 insulin-like growth factor 2 -0.0992759
NDRG1 N-myc downstream regulated 1 -0.0913267
DPYD dihydropyrimidine dehydrogenase -0.0898701
RAI14 retinoic acid induced 14 -0.0842309
RPS21 ribosomal protein S21 -0.0763956
FLNB filamin B, beta -0.0732707
PODXL podocalyxin-like -0.0727032
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0712634
POTEF POTE ankyrin domain family, member F -0.0712525
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0699035
SULF1 sulfatase 1 -0.0690599
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0674843
MEF2A myocyte enhancer factor 2A -0.0651935
PALLD palladin, cytoskeletal associated protein -0.0625293
ITCH itchy E3 ubiquitin protein ligase -0.0615623
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0587825
PTK2 protein tyrosine kinase 2 -0.057183
PSD3 pleckstrin and Sec7 domain containing 3 -0.0568606
THSD4 thrombospondin, type I, domain containing 4 -0.0558725
AKAP13 A kinase (PRKA) anchor protein 13 -0.0551694
HSPG2 heparan sulfate proteoglycan 2 -0.0526129
FTH1 ferritin, heavy polypeptide 1 -0.0522793
ZMYND8 zinc finger, MYND-type containing 8 -0.0520428
TRIO trio Rho guanine nucleotide exchange factor -0.0493695
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0489195
CEMIP cell migration inducing protein, hyaluronan binding -0.0489063
MACF1 microtubule-actin crosslinking factor 1 -0.0488953
HMGA2 high mobility group AT-hook 2 -0.0488142
SOD2 superoxide dismutase 2, mitochondrial -0.048297
CD44 CD44 molecule (Indian blood group) -0.0452681
UTRN utrophin -0.0447974
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.043936
DOCK9 dedicator of cytokinesis 9 -0.0435292
ALCAM activated leukocyte cell adhesion molecule -0.0430959
MDK midkine (neurite growth-promoting factor 2) -0.0424416
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0422986
RABGAP1L RAB GTPase activating protein 1-like -0.0421228
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0415108
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0414623
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0401808
PLS3 plastin 3 -0.0396338
OSMR oncostatin M receptor -0.0389622
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0388691
BCAR3 breast cancer anti-estrogen resistance 3 -0.0387239
S100A10 S100 calcium binding protein A10 -0.0384588
MAML2 mastermind-like 2 (Drosophila) -0.0384365
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0381515
FOXP1 forkhead box P1 -0.0378639
RASAL2 RAS protein activator like 2 -0.0373171
LY6E lymphocyte antigen 6 complex, locus E -0.0369442
LAMC2 laminin, gamma 2 -0.0362238
ABI3BP ABI family, member 3 (NESH) binding protein -0.0354419
LRRC8C leucine rich repeat containing 8 family, member C -0.0351447
EXOC4 exocyst complex component 4 -0.0350693
SMYD3 SET and MYND domain containing 3 -0.0350566
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0338158
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0337215
AOPEP aminopeptidase O (putative) -0.033277
TGM2 transglutaminase 2 -0.0331759
UBC ubiquitin C -0.0329792
CYB5R3 cytochrome b5 reductase 3 -0.0321838
DUSP4 dual specificity phosphatase 4 -0.032066
ANTXR2 anthrax toxin receptor 2 -0.0318675
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0312723
SLC35F3 solute carrier family 35, member F3 -0.031131
LMO7 LIM domain 7 -0.0309693
ZEB1 zinc finger E-box binding homeobox 1 -0.0308288
CMIP c-Maf inducing protein -0.0305084
RBM39 RNA binding motif protein 39 -0.0304059
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.03014
DGKH diacylglycerol kinase, eta -0.0296348
CDK6 cyclin-dependent kinase 6 -0.0296275
JMJD1C jumonji domain containing 1C -0.0296049
FOXO1 forkhead box O1 -0.0294847
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0292661
UBE2H ubiquitin-conjugating enzyme E2H -0.0288324
CD99 CD99 molecule -0.0287266
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0286637
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0286145
MT1X metallothionein 1X -0.0285653
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0283132
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0282171
EXT1 exostosin glycosyltransferase 1 -0.0281757
MYOF myoferlin -0.0281118
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.027991
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0278437
LAMA5 laminin, alpha 5 -0.0276483
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0276186
SH3PXD2A SH3 and PX domains 2A -0.0274289
RAP1B RAP1B, member of RAS oncogene family -0.0274115
PCDH1 protocadherin 1 -0.0272253
TSC22D1 TSC22 domain family, member 1 -0.0269503
SNX9 sorting nexin 9 -0.0269344
RCOR1 REST corepressor 1 -0.0268065