BAY1125976_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BAY1125976_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.159104
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.158324
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0883542
MYH9 myosin, heavy chain 9, non-muscle 0.0855944
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0838711
EIF1 eukaryotic translation initiation factor 1 0.0816405
KRT18 keratin 18, type I 0.0768457
TMC5 transmembrane channel-like 5 0.0637415
HYOU1 hypoxia up-regulated 1 0.0624393
DSPP dentin sialophosphoprotein 0.0606569
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0600124
TMSB4X thymosin beta 4, X-linked 0.0520255
ANXA1 annexin A1 0.0492837
FTL ferritin, light polypeptide 0.0480313
LMO7 LIM domain 7 0.0465172
B2M beta-2-microglobulin 0.0438479
PGK1 phosphoglycerate kinase 1 0.0432935
AGR2 anterior gradient 2 0.0419046
MBNL2 muscleblind-like splicing regulator 2 0.0411113
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0400518
TXNRD1 thioredoxin reductase 1 0.0394979
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.03863
ENO1 enolase 1, (alpha) 0.0377885
GOLGA4 golgin A4 0.0377485
AKAP9 A kinase (PRKA) anchor protein 9 0.0377251
PDIA4 protein disulfide isomerase family A, member 4 0.0366885
KRT19 keratin 19, type I 0.0348742
EMP1 epithelial membrane protein 1 0.0339162
PLEC plectin 0.033147
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0331064
RPS6 ribosomal protein S6 0.0330479
TPI1 triosephosphate isomerase 1 0.032659
PDIA3 protein disulfide isomerase family A, member 3 0.0324357
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0321908
KDM3A lysine (K)-specific demethylase 3A 0.0303835
SET SET nuclear proto-oncogene 0.0303072
HSPA8 heat shock 70kDa protein 8 0.0298782
GCLC glutamate-cysteine ligase, catalytic subunit 0.0295514
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0281729
CALR calreticulin 0.0280395
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0280388
AHNAK AHNAK nucleoprotein 0.0276303
RAD21 RAD21 homolog (S. pombe) 0.0274622
IQGAP1 IQ motif containing GTPase activating protein 1 0.0267707
AGR3 anterior gradient 3 0.0260739
EZR ezrin 0.0259749
RRBP1 ribosome binding protein 1 0.0257889
GDA guanine deaminase 0.0255116
RPL4 ribosomal protein L4 0.0253328
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0252728
RPL23 ribosomal protein L23 0.0251505
CANX calnexin 0.0251477
NFE2L1 nuclear factor, erythroid 2-like 1 0.0245927
LOC112694756 uncharaterized LOC112694756 0.0236224
AKAP13 A kinase (PRKA) anchor protein 13 0.0234546
H1-0 H1.0 linker histone 0.0231604
PNRC1 proline-rich nuclear receptor coactivator 1 0.0228743
SFTPA2 surfactant protein A2 0.0228143
TMF1 TATA element modulatory factor 1 0.0223833
RPS19 ribosomal protein S19 0.0220506
HDLBP high density lipoprotein binding protein 0.0220224
BAIAP2L1 BAI1-associated protein 2-like 1 0.0219986
ASPH aspartate beta-hydroxylase 0.021663
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0213302
EXPH5 exophilin 5 0.0213201
GOLGB1 golgin B1 0.0211566
ARF1 ADP-ribosylation factor 1 0.0208668
SRPRA SRP receptor subunit alpha 0.0207781
RPL7 ribosomal protein L7 0.0204628
RPS8 ribosomal protein S8 0.0202822
RPL18 ribosomal protein L18 0.020242
EEF2 eukaryotic translation elongation factor 2 0.0200422
FTH1 ferritin, heavy polypeptide 1 0.0200409
MANF mesencephalic astrocyte-derived neurotrophic factor 0.0197648
TMED2 transmembrane emp24 domain trafficking protein 2 0.0197477
NUPR1 nuclear protein, transcriptional regulator, 1 0.0196939
LAMB3 laminin, beta 3 0.0196848
RPL3 ribosomal protein L3 0.019659
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0196142
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0195705
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.019323
LDHA lactate dehydrogenase A 0.0192063
COPB2 coatomer protein complex, subunit beta 2 (beta prime) 0.0191397
RPLP1 ribosomal protein, large, P1 0.018755
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0185055
LMAN1 lectin, mannose-binding, 1 0.0184875
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0184433
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0182703
HLA-E major histocompatibility complex, class I, E 0.0181785
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0181243
DST dystonin 0.0179582
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0179155
SLC38A1 solute carrier family 38, member 1 0.0177936
PTMA prothymosin, alpha 0.0177394
TXNIP thioredoxin interacting protein 0.0174242
MXI1 MAX interactor 1, dimerization protein 0.0173184
RPS15A ribosomal protein S15a 0.0170237
ITPRID2 ITPR interacting domain containing 2 0.0169611
SERINC1 serine incorporator 1 0.0168059
TES testin LIM domain protein 0.0167822

decreased expression

Symbol Name Standardized Value
GMDS GDP-mannose 4,6-dehydratase -0.284047
NPSR1 neuropeptide S receptor 1 -0.273365
MAML2 mastermind-like 2 (Drosophila) -0.190902
POTEF POTE ankyrin domain family, member F -0.107997
CEMIP cell migration inducing protein, hyaluronan binding -0.0951762
TNIK TRAF2 and NCK interacting kinase -0.0789649
FLNB filamin B, beta -0.0771026
EHBP1 EH domain binding protein 1 -0.074101
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.0670531
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0622717
RUNX1 runt-related transcription factor 1 -0.0609166
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0605079
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0605076
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0603515
CDK6 cyclin-dependent kinase 6 -0.0588428
LPP LIM domain containing preferred translocation partner in lipoma -0.0585599
C6ORF132 chromosome 6 open reading frame 132 -0.0554307
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0547933
TRPS1 trichorhinophalangeal syndrome I -0.0532623
ARHGAP32 Rho GTPase activating protein 32 -0.0530269
INTS6 integrator complex subunit 6 -0.0517896
ANXA2 annexin A2 -0.0455452
ATXN1 ataxin 1 -0.0455079
DLG1 discs, large homolog 1 (Drosophila) -0.0454783
MBNL1 muscleblind-like splicing regulator 1 -0.0452461
YAP1 Yes-associated protein 1 -0.0448552
PRKCA protein kinase C, alpha -0.044433
SAMD12 sterile alpha motif domain containing 12 -0.0442015
EXOC4 exocyst complex component 4 -0.0437887
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0430159
BCL2L1 BCL2-like 1 -0.0421003
VEGFA vascular endothelial growth factor A -0.0419692
FAT1 FAT atypical cadherin 1 -0.0419098
FRMD5 FERM domain containing 5 -0.0409414
FNDC3B fibronectin type III domain containing 3B -0.039893
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0395225
CATSPERB catsper channel auxiliary subunit beta -0.0389093
CTBP2 C-terminal binding protein 2 -0.0387817
MCU mitochondrial calcium uniporter -0.0382183
DENND1A DENN/MADD domain containing 1A -0.0380744
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.038049
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.037852
ANKRD11 ankyrin repeat domain 11 -0.0378068
CUX1 cut-like homeobox 1 -0.0364787
SLC38A2 solute carrier family 38, member 2 -0.0361891
WARS1 tryptophanyl-tRNA synthetase 1 -0.0361781
RAD51B RAD51 paralog B -0.0361503
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0356859
ZCCHC7 zinc finger, CCHC domain containing 7 -0.035676
JUP junction plakoglobin -0.0355804
EGR1 early growth response 1 -0.0349394
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0347441
VCL vinculin -0.0344829
ANO1 anoctamin 1, calcium activated chloride channel -0.0344166
TCF12 transcription factor 12 -0.0343616
POF1B premature ovarian failure, 1B -0.0338983
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0336908
MECOM MDS1 and EVI1 complex locus -0.0336552
CCNL1 cyclin L1 -0.0328663
AUTS2 autism susceptibility candidate 2 -0.0324977
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 -0.032429
UBAP2 ubiquitin associated protein 2 -0.0324168
MTUS1 microtubule associated tumor suppressor 1 -0.0323615
PHF14 PHD finger protein 14 -0.0322691
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0320444
UBASH3B ubiquitin associated and SH3 domain containing B -0.0320104
KLHL29 kelch-like family member 29 -0.0310919
SH3RF1 SH3 domain containing ring finger 1 -0.0309096
KDM4C lysine (K)-specific demethylase 4C -0.0307173
FBXO11 F-box protein 11 -0.0305916
CAMKMT calmodulin-lysine N-methyltransferase -0.0300851
CMIP c-Maf inducing protein -0.0299674
RAB7A RAB7A, member RAS oncogene family -0.02956
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0292135
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0291805
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0290233
DIAPH2 diaphanous-related formin 2 -0.0289638
TMEM123 transmembrane protein 123 -0.0285655
PTPRG protein tyrosine phosphatase, receptor type, G -0.0285455
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0284778
PTPRK protein tyrosine phosphatase, receptor type, K -0.0284625
PALLD palladin, cytoskeletal associated protein -0.028271
SHB Src homology 2 domain containing adaptor protein B -0.0281652
NFIB nuclear factor I/B -0.0279929
RCOR1 REST corepressor 1 -0.0277702
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0276061
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.0273904
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0270924
TNS4 tensin 4 -0.02705
MED13 mediator complex subunit 13 -0.0269723
PKP4 plakophilin 4 -0.0269475
FAF1 Fas (TNFRSF6) associated factor 1 -0.0266147
LAMA5 laminin, alpha 5 -0.0265333
VMP1 vacuole membrane protein 1 -0.0262894
CCND1 cyclin D1 -0.0260433
ETV6 ets variant 6 -0.0256584
SULF2 sulfatase 2 -0.0254582
OSBPL10 oxysterol binding protein-like 10 -0.0254514
FGD4 FYVE, RhoGEF and PH domain containing 4 -0.0250818
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.024934