BAY1125976_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in LS 180 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the BAY1125976_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TPT1 tumor protein, translationally-controlled 1 0.13097
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0935567
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0891362
PTMA prothymosin, alpha 0.0675844
RPS12 ribosomal protein S12 0.0616813
KRT18 keratin 18, type I 0.0607645
RPL26 ribosomal protein L26 0.0550982
RPS8 ribosomal protein S8 0.0434664
RPS3 ribosomal protein S3 0.0431064
RPL9 ribosomal protein L9 0.0421043
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0417382
FTL ferritin, light polypeptide 0.0377662
RPL12 ribosomal protein L12 0.0360587
RPLP1 ribosomal protein, large, P1 0.0346239
RPL37A ribosomal protein L37a 0.0344748
ACTG1 actin gamma 1 0.0330684
LMO7 LIM domain 7 0.0322853
KLF5 Kruppel-like factor 5 (intestinal) 0.0315833
MYH9 myosin, heavy chain 9, non-muscle 0.0315785
RPS19 ribosomal protein S19 0.0313005
NAP1L1 nucleosome assembly protein 1-like 1 0.0307892
ASPH aspartate beta-hydroxylase 0.0294296
RPLP0 ribosomal protein, large, P0 0.0292151
RPL19 ribosomal protein L19 0.0289685
HSPA8 heat shock 70kDa protein 8 0.0287481
RPL23 ribosomal protein L23 0.0287202
MT2A metallothionein 2A 0.0286677
RPL35A ribosomal protein L35a 0.0276072
RPL34 ribosomal protein L34 0.0275592
RPL31 ribosomal protein L31 0.0266889
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.026275
RPS17 ribosomal protein S17 0.025591
LDHA lactate dehydrogenase A 0.0251156
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0250772
RPL13A ribosomal protein L13a 0.0250026
RPL18 ribosomal protein L18 0.024628
LOC102724023 ES1 protein homolog, mitochondrial 0.0246008
TPI1 triosephosphate isomerase 1 0.02397
RPS24 ribosomal protein S24 0.0236122
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0228171
RPL36 ribosomal protein L36 0.0225678
ISG15 ISG15 ubiquitin-like modifier 0.0223644
ENO1 enolase 1, (alpha) 0.0222005
RACK1 receptor for activated C kinase 1 0.0220423
PLEC plectin 0.0214693
EIF1 eukaryotic translation initiation factor 1 0.0213131
SQSTM1 sequestosome 1 0.021278
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0212732
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0212403
B2M beta-2-microglobulin 0.0211753
KLF6 Kruppel-like factor 6 0.0204299
RPL3 ribosomal protein L3 0.0203135
RPL11 ribosomal protein L11 0.0201968
LAMA4 laminin, alpha 4 0.0201446
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0201203
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0199749
TUBB4B tubulin, beta 4B class IVb 0.0198478
RPL7A ribosomal protein L7a 0.0197882
KRT19 keratin 19, type I 0.019455
SKP1 S-phase kinase-associated protein 1 0.0192689
RPS27A ribosomal protein S27a 0.0192219
RPL7 ribosomal protein L7 0.0186788
DSPP dentin sialophosphoprotein 0.0184214
RPS2 ribosomal protein S2 0.0182247
EXT1 exostosin glycosyltransferase 1 0.0180609
RPS27 ribosomal protein S27 0.0174987
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0174282
RPL30 ribosomal protein L30 0.0173992
RPL37 ribosomal protein L37 0.0172202
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0169029
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.016878
RPL4 ribosomal protein L4 0.0164357
RPLP2 ribosomal protein, large, P2 0.0163257
RPS15A ribosomal protein S15a 0.0162919
NACA nascent polypeptide-associated complex alpha subunit 0.0159398
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) 0.0157689
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0155942
TMSB4X thymosin beta 4, X-linked 0.0155664
S100P S100 calcium binding protein P 0.0155601
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0155135
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.015318
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0151982
ERRFI1 ERBB receptor feedback inhibitor 1 0.015158
SF3B2 splicing factor 3b, subunit 2, 145kDa 0.0147837
AKAP12 A kinase (PRKA) anchor protein 12 0.014768
H1-4 H1.4 linker histone, cluster member 0.0145051
RPS5 ribosomal protein S5 0.0144921
H1-0 H1.0 linker histone 0.0144663
ANXA1 annexin A1 0.01431
MARCHF3 membrane associated ring-CH-type finger 3 0.0142383
IER3 immediate early response 3 0.014181
SRP14 signal recognition particle 14kDa (homologous Alu RNA binding protein) 0.0141351
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.0140075
BRD2 bromodomain containing 2 0.0139933
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0139812
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0137594
LAMB3 laminin, beta 3 0.0137017
VIM vimentin 0.0136837
AFF1 AF4/FMR2 family, member 1 0.0136338
RPL27 ribosomal protein L27 0.013523

decreased expression

Symbol Name Standardized Value
NPSR1 neuropeptide S receptor 1 -0.191899
MUC6 mucin 6, oligomeric mucus/gel-forming -0.144413
GPHN gephyrin -0.113891
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0928392
CEMIP cell migration inducing protein, hyaluronan binding -0.0914657
GMDS GDP-mannose 4,6-dehydratase -0.0894396
NALF1 NALCN channel auxiliary factor 1 -0.0892429
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0803806
TNS4 tensin 4 -0.0729409
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0715831
ITGA6 integrin, alpha 6 -0.068062
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0648339
FLNB filamin B, beta -0.0631707
GREB1L growth regulation by estrogen in breast cancer-like -0.0621105
PPARG peroxisome proliferator-activated receptor gamma -0.0609727
ANTXR2 anthrax toxin receptor 2 -0.060184
ANXA2 annexin A2 -0.0574009
PTEN phosphatase and tensin homolog -0.0520134
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0494234
CALB1 calbindin 1, 28kDa -0.0483969
RNF43 ring finger protein 43 -0.0475085
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0471047
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.046109
MED13L mediator complex subunit 13-like -0.0452475
CADPS Ca++-dependent secretion activator -0.0447059
CD46 CD46 molecule, complement regulatory protein -0.0437657
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0433338
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.042778
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0421199
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0420102
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0419297
BIRC6 baculoviral IAP repeat containing 6 -0.0412909
NCOR1 nuclear receptor corepressor 1 -0.0411798
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0407388
ZFAND3 zinc finger, AN1-type domain 3 -0.0403129
PATJ PATJ crumbs cell polarity complex component -0.0398654
PIGR polymeric immunoglobulin receptor -0.0396918
RNF217 ring finger protein 217 -0.0396917
ALCAM activated leukocyte cell adhesion molecule -0.0392689
CCSER1 coiled-coil serine-rich protein 1 -0.0390264
PRSS3 protease, serine, 3 -0.0384082
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0382133
FTH1 ferritin, heavy polypeptide 1 -0.0379357
TBC1D5 TBC1 domain family, member 5 -0.0376843
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0375553
NFIA nuclear factor I/A -0.0372382
SBF2 SET binding factor 2 -0.0367917
GOLGA4 golgin A4 -0.0366246
ESYT2 extended synaptotagmin-like protein 2 -0.0362527
FOXO1 forkhead box O1 -0.0362341
KDM4C lysine (K)-specific demethylase 4C -0.035543
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0353891
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0350922
NRXN3 neurexin 3 -0.0350318
PARD3 par-3 family cell polarity regulator -0.0348054
PTPRK protein tyrosine phosphatase, receptor type, K -0.0346943
PTBP3 polypyrimidine tract binding protein 3 -0.0346785
MSI2 musashi RNA-binding protein 2 -0.034497
SMYD3 SET and MYND domain containing 3 -0.0343916
RREB1 ras responsive element binding protein 1 -0.0343769
MBD5 methyl-CpG binding domain protein 5 -0.0340333
FHIT fragile histidine triad -0.0339991
ABHD2 abhydrolase domain containing 2 -0.0332984
MAML2 mastermind-like 2 (Drosophila) -0.0328056
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0326885
MECOM MDS1 and EVI1 complex locus -0.0325924
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0323933
PDE4D phosphodiesterase 4D, cAMP-specific -0.0322898
FAT1 FAT atypical cadherin 1 -0.0319263
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0317032
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0313248
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0308991
DLG1 discs, large homolog 1 (Drosophila) -0.0308527
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0305097
JMJD1C jumonji domain containing 1C -0.0303901
ACTN4 actinin, alpha 4 -0.030337
MON2 MON2 homolog (S. cerevisiae) -0.0302382
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0301207
INSIG1 insulin induced gene 1 -0.0299399
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.02972
SAMD5 sterile alpha motif domain containing 5 -0.0294298
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0292772
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0292695
KDM7A lysine (K)-specific demethylase 7A -0.0291165
CCNY cyclin Y -0.0290768
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0289959
RIN2 Ras and Rab interactor 2 -0.0289526
ZNF292 zinc finger protein 292 -0.0287539
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0286856
ITGB4 integrin, beta 4 -0.028598
FOXP1 forkhead box P1 -0.0282016
PTPRR protein tyrosine phosphatase, receptor type, R -0.0280256
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.028024
TRIM2 tripartite motif containing 2 -0.0275026
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 -0.0274376
LPP LIM domain containing preferred translocation partner in lipoma -0.0271322
FOSL1 FOS-like antigen 1 -0.0270615
SETD5 SET domain containing 5 -0.0267793
ARHGAP26 Rho GTPase activating protein 26 -0.0267287
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0266404