BAY1125976_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BAY1125976_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.161874
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0833356
RPS12 ribosomal protein S12 0.0765816
RPL36 ribosomal protein L36 0.0538961
RPL26 ribosomal protein L26 0.0521352
RPS3 ribosomal protein S3 0.0511836
ANGPTL4 angiopoietin-like 4 0.0502465
RPS19 ribosomal protein S19 0.0483621
MYH9 myosin, heavy chain 9, non-muscle 0.0474004
TMSB10 thymosin beta 10 0.0455831
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0453582
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0452735
RPL18 ribosomal protein L18 0.0409628
RPL12 ribosomal protein L12 0.0393134
RPL35 ribosomal protein L35 0.0359189
ENO1 enolase 1, (alpha) 0.0352815
NAP1L1 nucleosome assembly protein 1-like 1 0.0350764
RPL23 ribosomal protein L23 0.0345221
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.033318
TPI1 triosephosphate isomerase 1 0.0332562
RPL37A ribosomal protein L37a 0.0325303
RPS27 ribosomal protein S27 0.0307363
PLEC plectin 0.0300523
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0293819
MT1E metallothionein 1E 0.0291287
RPS8 ribosomal protein S8 0.0284216
RPL3 ribosomal protein L3 0.0283487
ZSWIM6 zinc finger, SWIM-type containing 6 0.0278056
SET SET nuclear proto-oncogene 0.0277529
KRT18 keratin 18, type I 0.0268826
BIRC3 baculoviral IAP repeat containing 3 0.0268496
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0265738
SQSTM1 sequestosome 1 0.0262887
CAPRIN2 caprin family member 2 0.0255938
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0252648
TPM3 tropomyosin 3 0.0249615
TMSB4X thymosin beta 4, X-linked 0.0247282
SP100 SP100 nuclear antigen 0.0246703
SRRM2 serine/arginine repetitive matrix 2 0.0242599
EEF1G eukaryotic translation elongation factor 1 gamma 0.0236628
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0229869
RPS17 ribosomal protein S17 0.0222854
RACK1 receptor for activated C kinase 1 0.0213937
RPL31 ribosomal protein L31 0.021185
INTS6 integrator complex subunit 6 0.0210884
RPL13A ribosomal protein L13a 0.0207703
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0203768
PRELID2 PRELI domain containing 2 0.0201038
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0197536
RPS18 ribosomal protein S18 0.019742
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0190376
B2M beta-2-microglobulin 0.0187745
RPL27 ribosomal protein L27 0.018738
PABPN1 poly(A) binding protein, nuclear 1 0.0186279
RPL36A ribosomal protein L36a 0.0185505
RPL7A ribosomal protein L7a 0.0184037
BRD2 bromodomain containing 2 0.0183555
HDAC9 histone deacetylase 9 0.0174837
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0165201
RPS15A ribosomal protein S15a 0.0160517
AREG amphiregulin 0.0160451
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0160138
RPS2 ribosomal protein S2 0.0159635
APLP2 amyloid beta (A4) precursor-like protein 2 0.0158248
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0157735
RPLP2 ribosomal protein, large, P2 0.015691
PLIN2 perilipin 2 0.0155964
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0152246
RPLP1 ribosomal protein, large, P1 0.0152067
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough 0.0151762
MB21D2 Mab-21 domain containing 2 0.0149994
TXNIP thioredoxin interacting protein 0.0147401
ASPH aspartate beta-hydroxylase 0.0147031
RNF213 ring finger protein 213 0.0142215
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 0.0140623
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0139644
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0139533
HSPH1 heat shock 105kDa/110kDa protein 1 0.0138521
RPS6 ribosomal protein S6 0.0137775
HYOU1 hypoxia up-regulated 1 0.0136346
PLK2 polo-like kinase 2 0.0136314
CXCL8 chemokine (C-X-C motif) ligand 8 0.0136062
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.01319
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0131613
AKAP12 A kinase (PRKA) anchor protein 12 0.0131554
HOMER1 homer scaffolding protein 1 0.0131279
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0130285
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0130123
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0129082
RPL7 ribosomal protein L7 0.0128804
MRPL13 mitochondrial ribosomal protein L13 0.0126097
NFE2L1 nuclear factor, erythroid 2-like 1 0.0125939
RPL21 ribosomal protein L21 0.0125717
SVIL supervillin 0.0125264
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0121218
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0120049
TTC3 tetratricopeptide repeat domain 3 0.0119686
RPL19 ribosomal protein L19 0.011947
CXCL5 chemokine (C-X-C motif) ligand 5 0.0119323
EGFR epidermal growth factor receptor 0.0118425

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.3862
TM4SF1 transmembrane 4 L six family member 1 -0.108746
TXNRD1 thioredoxin reductase 1 -0.0882878
PSD3 pleckstrin and Sec7 domain containing 3 -0.0762167
DLG1 discs, large homolog 1 (Drosophila) -0.0757545
CD44 CD44 molecule (Indian blood group) -0.0708609
POTEF POTE ankyrin domain family, member F -0.066726
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0666408
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.064124
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0609356
PTMA prothymosin, alpha -0.0602757
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0560022
CENPF centromere protein F, 350/400kDa -0.0524659
VIM vimentin -0.0496001
ACTG1 actin gamma 1 -0.0462015
RTN4 reticulon 4 -0.0442943
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.044256
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0437201
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0426543
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0411647
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0402862
TRIP12 thyroid hormone receptor interactor 12 -0.0400175
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0396554
ZMYND8 zinc finger, MYND-type containing 8 -0.0395154
APP amyloid beta (A4) precursor protein -0.0389264
RPL35A ribosomal protein L35a -0.0388165
EHBP1 EH domain binding protein 1 -0.0373241
RAI1 retinoic acid induced 1 -0.0370332
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) -0.0369361
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0359785
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0356729
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0351764
RAB27B RAB27B, member RAS oncogene family -0.0350075
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0349791
BRWD1 bromodomain and WD repeat domain containing 1 -0.03478
EGR1 early growth response 1 -0.0347118
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0344149
USP34 ubiquitin specific peptidase 34 -0.0341965
BIRC6 baculoviral IAP repeat containing 6 -0.033942
MAP4 microtubule-associated protein 4 -0.0334307
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0333199
RPS23 ribosomal protein S23 -0.0332014
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.033175
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0330239
SLC38A2 solute carrier family 38, member 2 -0.0327851
FBXO11 F-box protein 11 -0.032586
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0319162
PODXL podocalyxin-like -0.031795
LOXL2 lysyl oxidase-like 2 -0.0316306
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0312933
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0310135
WSB1 WD repeat and SOCS box containing 1 -0.0303333
RPL38 ribosomal protein L38 -0.0302426
HLA-B major histocompatibility complex, class I, B -0.0302356
PTK2 protein tyrosine kinase 2 -0.0301764
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0295796
OGA O-GlcNAcase -0.0289973
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0289707
SBF2 SET binding factor 2 -0.0288157
RAB7A RAB7A, member RAS oncogene family -0.0287603
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0279902
MARCHF6 membrane associated ring-CH-type finger 6 -0.0277219
TMEM41B transmembrane protein 41B -0.0277068
MKI67 marker of proliferation Ki-67 -0.0276084
FNIP1 folliculin interacting protein 1 -0.0274036
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0270943
GSK3B glycogen synthase kinase 3 beta -0.027044
KPNB1 karyopherin (importin) beta 1 -0.0264608
SRGN serglycin -0.0263851
CFDP1 craniofacial development protein 1 -0.0261976
RB1CC1 RB1-inducible coiled-coil 1 -0.0260865
ZEB1 zinc finger E-box binding homeobox 1 -0.0259551
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0259095
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0254825
VDAC1 voltage-dependent anion channel 1 -0.0253575
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0252495
GARS1 glycyl-tRNA synthetase 1 -0.0251671
RPS13 ribosomal protein S13 -0.0250751
ZFAND3 zinc finger, AN1-type domain 3 -0.0248869
UPP1 uridine phosphorylase 1 -0.0248442
ADAM17 ADAM metallopeptidase domain 17 -0.0245756
KMT2C lysine (K)-specific methyltransferase 2C -0.0244609
SPRED2 sprouty-related, EVH1 domain containing 2 -0.024399
ZNF292 zinc finger protein 292 -0.0242727
WDR45B WD repeat domain 45B -0.0242269
PUM2 pumilio RNA-binding family member 2 -0.0235229
NCOR1 nuclear receptor corepressor 1 -0.0234146
PRRC2B proline-rich coiled-coil 2B -0.0232466
PGK1 phosphoglycerate kinase 1 -0.0232181
FNBP1 formin binding protein 1 -0.0231576
OLA1 Obg-like ATPase 1 -0.0230329
TMEM123 transmembrane protein 123 -0.022956
ANKRD17 ankyrin repeat domain 17 -0.0228567
NF1 neurofibromin 1 -0.0227644
CMIP c-Maf inducing protein -0.0225084
MIS18BP1 MIS18 binding protein 1 -0.022461
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0223966
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0223851
FTH1 ferritin, heavy polypeptide 1 -0.0223081
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0223006