| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | BAY1125976 perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the BAY1125976_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.227814 |
| ENO1 | enolase 1, (alpha) | 0.124075 |
| ASPH | aspartate beta-hydroxylase | 0.119702 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.116658 |
| LMO7 | LIM domain 7 | 0.106185 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0992104 |
| LDHA | lactate dehydrogenase A | 0.0914525 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0910943 |
| TMSB10 | thymosin beta 10 | 0.0907298 |
| GRAMD1B | GRAM domain containing 1B | 0.0898332 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0896471 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0870199 |
| RPS3 | ribosomal protein S3 | 0.0796891 |
| KRT18 | keratin 18, type I | 0.0769251 |
| PTMA | prothymosin, alpha | 0.0757224 |
| MT2A | metallothionein 2A | 0.0738877 |
| MYOF | myoferlin | 0.0735505 |
| RNF213 | ring finger protein 213 | 0.0728164 |
| DSPP | dentin sialophosphoprotein | 0.0711546 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0711413 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0706055 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0692315 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0684785 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0682717 |
| PKM | pyruvate kinase, muscle | 0.0644531 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0599787 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0565249 |
| RPL37A | ribosomal protein L37a | 0.0545052 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0539567 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0534609 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0534119 |
| RPS8 | ribosomal protein S8 | 0.052619 |
| ACTG1 | actin gamma 1 | 0.0520816 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0520723 |
| STC1 | stanniocalcin 1 | 0.0513973 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0487442 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0485878 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0485591 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0483781 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0477984 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0474029 |
| EFNA5 | ephrin-A5 | 0.0466571 |
| PLEC | plectin | 0.0462409 |
| AHNAK | AHNAK nucleoprotein | 0.0460917 |
| SP100 | SP100 nuclear antigen | 0.0456454 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0455848 |
| B2M | beta-2-microglobulin | 0.0455184 |
| INTS6 | integrator complex subunit 6 | 0.04504 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0444671 |
| MYO1E | myosin IE | 0.0442183 |
| RPLP1 | ribosomal protein, large, P1 | 0.0439298 |
| KRT7 | keratin 7, type II | 0.0425882 |
| TPI1 | triosephosphate isomerase 1 | 0.042491 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | 0.0418028 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0417618 |
| RPL4 | ribosomal protein L4 | 0.0416161 |
| S100A10 | S100 calcium binding protein A10 | 0.0405786 |
| LAMC2 | laminin, gamma 2 | 0.0404443 |
| RPL31 | ribosomal protein L31 | 0.0402899 |
| RPS25 | ribosomal protein S25 | 0.0402422 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0402052 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0400852 |
| SLTM | SAFB-like, transcription modulator | 0.0399711 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0398283 |
| RPS12 | ribosomal protein S12 | 0.0389466 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0385028 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0381325 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0380615 |
| ANXA2 | annexin A2 | 0.0376807 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0371023 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0370033 |
| RPS24 | ribosomal protein S24 | 0.0369099 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0363008 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0355315 |
| RPS17 | ribosomal protein S17 | 0.0354745 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0354525 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.035189 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0351272 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0349876 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0347 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.034592 |
| RPS6 | ribosomal protein S6 | 0.0344336 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.034425 |
| HOMER1 | homer scaffolding protein 1 | 0.0341524 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0339964 |
| RPL7 | ribosomal protein L7 | 0.0337077 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0335387 |
| MCL1 | myeloid cell leukemia 1 | 0.0332998 |
| SMYD3 | SET and MYND domain containing 3 | 0.0327398 |
| RPS27A | ribosomal protein S27a | 0.0326855 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.032412 |
| CPE | carboxypeptidase E | 0.0321121 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0320743 |
| PYGL | phosphorylase, glycogen, liver | 0.0320742 |
| SMAD3 | SMAD family member 3 | 0.0316018 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.031467 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0309434 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0309179 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0305738 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0304536 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.124616 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.101556 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0993783 |
| TMEM165 | transmembrane protein 165 | -0.076542 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0763465 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0758668 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.057715 |
| FAM13A | family with sequence similarity 13, member A | -0.0443736 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | -0.044173 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0431349 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0426434 |
| TSC22D2 | TSC22 domain family, member 2 | -0.04258 |
| RUNX1 | runt-related transcription factor 1 | -0.0416118 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0401878 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0398622 |
| CCNL1 | cyclin L1 | -0.0388269 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0361517 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0351329 |
| UVRAG | UV radiation resistance associated | -0.0348658 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0347062 |
| NGLY1 | N-glycanase 1 | -0.0346501 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | -0.0344984 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0341055 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0337267 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0329874 |
| WDR45B | WD repeat domain 45B | -0.0326901 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0322959 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0319747 |
| PDE8A | phosphodiesterase 8A | -0.0301455 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0299488 |
| HELZ | helicase with zinc finger | -0.029095 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0290012 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0285601 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0282393 |
| GPC6 | glypican 6 | -0.0270658 |
| RNF145 | ring finger protein 145 | -0.0268906 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0264968 |
| SNX9 | sorting nexin 9 | -0.0261877 |
| TPD52 | tumor protein D52 | -0.0246607 |
| KDM6A | lysine (K)-specific demethylase 6A | -0.024523 |
| OSMR | oncostatin M receptor | -0.0242681 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0237894 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0236734 |
| NPTN | neuroplastin | -0.0228871 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0228486 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0225272 |
| INSIG2 | insulin induced gene 2 | -0.0224893 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0224089 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0223716 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0221164 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0218479 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0213404 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0210956 |
| SRP54 | signal recognition particle 54kDa | -0.020439 |
| CES1 | carboxylesterase 1 | -0.0202545 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0201351 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0199357 |
| DTNA | dystrobrevin, alpha | -0.0198912 |
| NUP58 | nucleoporin 58 | -0.0197951 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0197342 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0195241 |
| USP3 | ubiquitin specific peptidase 3 | -0.0193123 |
| OGA | O-GlcNAcase | -0.01923 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0192129 |
| ZNF292 | zinc finger protein 292 | -0.0191203 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.018787 |
| GK | glycerol kinase | -0.0183816 |
| EGR1 | early growth response 1 | -0.0183453 |
| RASA2 | RAS p21 protein activator 2 | -0.0182866 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0182017 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0172819 |
| FBXL5 | F-box and leucine-rich repeat protein 5 | -0.017255 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | -0.017224 |
| FOSL1 | FOS-like antigen 1 | -0.017204 |
| MAP4K3 | mitogen-activated protein kinase kinase kinase kinase 3 | -0.0171288 |
| RNF24 | ring finger protein 24 | -0.017078 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0162592 |
| ARL5B | ADP-ribosylation factor-like 5B | -0.0162568 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0162526 |
| PTEN | phosphatase and tensin homolog | -0.0162151 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0160827 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0159779 |
| SYN3 | synapsin III | -0.0158592 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0153785 |
| PPP3R1 | protein phosphatase 3, regulatory subunit B, alpha | -0.0151272 |
| SAMD5 | sterile alpha motif domain containing 5 | -0.0150395 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0149466 |
| ARL8B | ADP-ribosylation factor-like 8B | -0.0149175 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0146061 |
| EP300 | E1A binding protein p300 | -0.0145072 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0144715 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.014467 |
| PDPK1 | 3-phosphoinositide dependent protein kinase 1 | -0.014455 |
| TFG | TRK-fused gene | -0.0144541 |
| ATP13A3 | ATPase type 13A3 | -0.0143089 |
| ATP11B | ATPase, class VI, type 11B | -0.0141745 |
| MYO1B | myosin IB | -0.014171 |
| PPP1R15B | protein phosphatase 1, regulatory subunit 15B | -0.0141664 |
| PCNX1 | pecanex 1 | -0.0141503 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0141219 |
