| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | BAY1125976 perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the BAY1125976_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.129431 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.115999 |
| PM20D1 | peptidase M20 domain containing 1 | 0.103665 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0955978 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0762592 |
| TPM3 | tropomyosin 3 | 0.0716496 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.070658 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.06059 |
| TPI1 | triosephosphate isomerase 1 | 0.0492407 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0454634 |
| RPL3 | ribosomal protein L3 | 0.0434543 |
| ASPH | aspartate beta-hydroxylase | 0.0431589 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0421827 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0413086 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0403589 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0394049 |
| RPL26 | ribosomal protein L26 | 0.0371797 |
| RPL23 | ribosomal protein L23 | 0.0351267 |
| RPL18 | ribosomal protein L18 | 0.0335807 |
| HYOU1 | hypoxia up-regulated 1 | 0.0322569 |
| TMSB10 | thymosin beta 10 | 0.030438 |
| RPS12 | ribosomal protein S12 | 0.0300196 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0294741 |
| RPL4 | ribosomal protein L4 | 0.0287096 |
| RPS3 | ribosomal protein S3 | 0.0267952 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.026724 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0257946 |
| FGB | fibrinogen beta chain | 0.0248539 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0248317 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0242484 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0242397 |
| PLEC | plectin | 0.0242289 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0234103 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0231964 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0226045 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0223265 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0222359 |
| RPS17 | ribosomal protein S17 | 0.0217969 |
| RPS15A | ribosomal protein S15a | 0.0210681 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0209867 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0207654 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0207595 |
| H1-2 | H1.2 linker histone, cluster member | 0.0200492 |
| RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) | 0.0196884 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0195378 |
| SET | SET nuclear proto-oncogene | 0.0195 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.0194739 |
| RPL13A | ribosomal protein L13a | 0.019408 |
| SIK3 | SIK family kinase 3 | 0.0191939 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0188888 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0187908 |
| RPS19 | ribosomal protein S19 | 0.01877 |
| RPL7 | ribosomal protein L7 | 0.0187691 |
| ANXA1 | annexin A1 | 0.0187473 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0186433 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0185065 |
| CLU | clusterin | 0.018247 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0181307 |
| CALR | calreticulin | 0.0180971 |
| SKP1 | S-phase kinase-associated protein 1 | 0.0179771 |
| CUL3 | cullin 3 | 0.0179155 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0177816 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0174343 |
| RPS18 | ribosomal protein S18 | 0.0172106 |
| AHR | aryl hydrocarbon receptor | 0.0170669 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0166188 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0166135 |
| SON | SON DNA binding protein | 0.0164128 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0162163 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0161257 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0159828 |
| RPL37A | ribosomal protein L37a | 0.0158925 |
| FAM107B | family with sequence similarity 107, member B | 0.0158664 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0156306 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0155838 |
| RBM25 | RNA binding motif protein 25 | 0.0155106 |
| AHNAK | AHNAK nucleoprotein | 0.015496 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.015369 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.015309 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0150923 |
| BRD2 | bromodomain containing 2 | 0.0150897 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0150846 |
| PFDN2 | prefoldin subunit 2 | 0.0150109 |
| GPX4 | glutathione peroxidase 4 | 0.0149277 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.014701 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0143823 |
| HNRNPH3 | heterogeneous nuclear ribonucleoprotein H3 (2H9) | 0.0142526 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0142111 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0141972 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0140408 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | 0.0140404 |
| RNF145 | ring finger protein 145 | 0.0139247 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0137512 |
| RACK1 | receptor for activated C kinase 1 | 0.0136805 |
| RPL36 | ribosomal protein L36 | 0.0136193 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0135413 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0135213 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0134432 |
| PTMS | parathymosin | 0.0133418 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0133347 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.456217 |
| IGF2 | insulin-like growth factor 2 | -0.14851 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.139352 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.136809 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.133075 |
| VIM | vimentin | -0.126589 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.119792 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.105614 |
| GRAMD1B | GRAM domain containing 1B | -0.0999115 |
| ACTG1 | actin gamma 1 | -0.0983169 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0980954 |
| POTEF | POTE ankyrin domain family, member F | -0.0975553 |
| CMIP | c-Maf inducing protein | -0.0913003 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0885126 |
| FTL | ferritin, light polypeptide | -0.0672456 |
| MT2A | metallothionein 2A | -0.0668477 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.064306 |
| RPL35A | ribosomal protein L35a | -0.061046 |
| EGR1 | early growth response 1 | -0.0602281 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0580927 |
| TXNRD1 | thioredoxin reductase 1 | -0.0564974 |
| MCL1 | myeloid cell leukemia 1 | -0.055097 |
| S100A10 | S100 calcium binding protein A10 | -0.0525954 |
| PYGL | phosphorylase, glycogen, liver | -0.0519969 |
| RPS21 | ribosomal protein S21 | -0.0480134 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0466122 |
| OSMR | oncostatin M receptor | -0.0459931 |
| FMNL2 | formin-like 2 | -0.0446967 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0414471 |
| AK1 | adenylate kinase 1 | -0.0409718 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0404253 |
| RPS23 | ribosomal protein S23 | -0.0402254 |
| HLA-B | major histocompatibility complex, class I, B | -0.0399231 |
| DOCK5 | dedicator of cytokinesis 5 | -0.039152 |
| RPS15 | ribosomal protein S15 | -0.0386183 |
| IER3 | immediate early response 3 | -0.0375158 |
| TPM4 | tropomyosin 4 | -0.0366788 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0357679 |
| ERBIN | erbb2 interacting protein | -0.0351525 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0351237 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0348422 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0346091 |
| RPS13 | ribosomal protein S13 | -0.0345616 |
| PFN1 | profilin 1 | -0.0342105 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0339959 |
| BICC1 | BicC family RNA binding protein 1 | -0.0338957 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0337659 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0336742 |
| USP34 | ubiquitin specific peptidase 34 | -0.0331019 |
| RAD51B | RAD51 paralog B | -0.0328782 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0325395 |
| SVIL | supervillin | -0.0324912 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0324452 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0320389 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0318122 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0317112 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0316375 |
| HDAC9 | histone deacetylase 9 | -0.0315691 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0310046 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0307515 |
| RPS29 | ribosomal protein S29 | -0.0306799 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0304458 |
| NDRG1 | N-myc downstream regulated 1 | -0.030146 |
| NAV3 | neuron navigator 3 | -0.029975 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0295039 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0294944 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0290752 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0290542 |
| SNX9 | sorting nexin 9 | -0.0287086 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0286335 |
| GLIS3 | GLIS family zinc finger 3 | -0.0285329 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0282877 |
| RPL38 | ribosomal protein L38 | -0.0282697 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0282609 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0281001 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.0280371 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | -0.0271741 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.0269256 |
| RASAL2 | RAS protein activator like 2 | -0.0267974 |
| CFDP1 | craniofacial development protein 1 | -0.0267248 |
| NRG1 | neuregulin 1 | -0.0267117 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.026643 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0260275 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0259577 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0258214 |
| UBC | ubiquitin C | -0.0249936 |
| HMGA1 | high mobility group AT-hook 1 | -0.0248678 |
| RAB31 | RAB31, member RAS oncogene family | -0.0248529 |
| IL6 | interleukin 6 | -0.0247828 |
| RHOA | ras homolog family member A | -0.0247802 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0243737 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | -0.0243546 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0241948 |
| PCNX4 | pecanex 4 | -0.0241311 |
| HMOX1 | heme oxygenase 1 | -0.0240718 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0240115 |
| RPS8 | ribosomal protein S8 | -0.0238927 |
| CUX1 | cut-like homeobox 1 | -0.0237988 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0236097 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0235995 |
