| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | BAY1125976 perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the BAY1125976_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SAMD4A | sterile alpha motif domain containing 4A | 0.117226 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.111745 |
| LMO7 | LIM domain 7 | 0.0857948 |
| EGFR | epidermal growth factor receptor | 0.078243 |
| STC1 | stanniocalcin 1 | 0.0690024 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0662107 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0615463 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0560328 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0530052 |
| PLEC | plectin | 0.0506334 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | 0.0490575 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0489712 |
| SMAD3 | SMAD family member 3 | 0.0485451 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.048473 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0481287 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0469289 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0465486 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0465312 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0427588 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0423977 |
| KYNU | kynureninase | 0.0422568 |
| HOMER1 | homer scaffolding protein 1 | 0.0418545 |
| MYO1E | myosin IE | 0.0415388 |
| IGF1R | insulin-like growth factor 1 receptor | 0.039877 |
| KCNH8 | potassium channel, voltage gated eag related subfamily H, member 8 | 0.0391821 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0390547 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0390173 |
| MMP1 | matrix metallopeptidase 1 | 0.0386707 |
| ATP11A | ATPase, class VI, type 11A | 0.038541 |
| ANXA1 | annexin A1 | 0.0381522 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0378292 |
| FAM107B | family with sequence similarity 107, member B | 0.0371757 |
| SVIL | supervillin | 0.0366405 |
| STEAP4 | STEAP family member 4 | 0.0366208 |
| CNKSR3 | CNKSR family member 3 | 0.035993 |
| FMN1 | formin 1 | 0.0358838 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0353874 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0351855 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0340561 |
| INTS6 | integrator complex subunit 6 | 0.0334189 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0334182 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0333848 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.0333165 |
| KIF13B | kinesin family member 13B | 0.0331626 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.032862 |
| ANO6 | anoctamin 6 | 0.0320125 |
| FAM110C | family with sequence similarity 110, member C | 0.0311584 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0309652 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0305185 |
| TJP1 | tight junction protein 1 | 0.0304773 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0302182 |
| STK17A | serine/threonine kinase 17a | 0.0301213 |
| HECTD1 | HECT domain containing E3 ubiquitin protein ligase 1 | 0.0299592 |
| STK10 | serine/threonine kinase 10 | 0.0295135 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0294284 |
| TOP1 | topoisomerase (DNA) I | 0.0291894 |
| EGR1 | early growth response 1 | 0.0291005 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0281446 |
| NABP1 | nucleic acid binding protein 1 | 0.0278057 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0278026 |
| RASA2 | RAS p21 protein activator 2 | 0.0276735 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0276386 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0276191 |
| NIBAN2 | niban apoptosis regulator 2 | 0.0273028 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0271157 |
| LAMA4 | laminin, alpha 4 | 0.0269751 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | 0.0269519 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0269216 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0268188 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0266046 |
| TBC1D15 | TBC1 domain family, member 15 | 0.0265409 |
| DUSP16 | dual specificity phosphatase 16 | 0.0259725 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0258466 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0253964 |
| YTHDC1 | YTH domain containing 1 | 0.0253904 |
| SPAG9 | sperm associated antigen 9 | 0.025251 |
| EPB41L5 | erythrocyte membrane protein band 4.1 like 5 | 0.0251888 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0243457 |
| CYTH1 | cytohesin 1 | 0.0243414 |
| ITPRID2 | ITPR interacting domain containing 2 | 0.0242876 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.024209 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | 0.0241804 |
| SNX9 | sorting nexin 9 | 0.0240598 |
| PHF3 | PHD finger protein 3 | 0.0240286 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.023872 |
| FOSL2 | FOS-like antigen 2 | 0.0237796 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0237059 |
| NPTN | neuroplastin | 0.0236949 |
| DUSP5 | dual specificity phosphatase 5 | 0.0236675 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0236215 |
| SLTM | SAFB-like, transcription modulator | 0.0235196 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0235002 |
| FRY | furry homolog (Drosophila) | 0.0233437 |
| RDH13 | retinol dehydrogenase 13 (all-trans/9-cis) | 0.023237 |
| RDH10 | retinol dehydrogenase 10 (all-trans) | 0.0230198 |
| DUSP6 | dual specificity phosphatase 6 | 0.0225764 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0225047 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0222662 |
| NSMCE2 | non-SMC element 2, MMS21 homolog (S. cerevisiae) | 0.0221078 |
| RAB31 | RAB31, member RAS oncogene family | 0.0219919 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.077802 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0775838 |
| FN1 | fibronectin 1 | -0.0626318 |
| TMSB10 | thymosin beta 10 | -0.0611824 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0591833 |
| FTL | ferritin, light polypeptide | -0.0571809 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0557404 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | -0.0547469 |
| HLA-B | major histocompatibility complex, class I, B | -0.0530069 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0514015 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0488075 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0451686 |
| ATOSA | atos homolog A | -0.0438818 |
| VIM | vimentin | -0.0424282 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0420217 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0408627 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | -0.0407177 |
| TXNRD1 | thioredoxin reductase 1 | -0.0397823 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0389846 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0386307 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0383908 |
| B2M | beta-2-microglobulin | -0.0371901 |
| SLC24A3 | solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 | -0.0370116 |
| RPL19 | ribosomal protein L19 | -0.0343875 |
| TXNIP | thioredoxin interacting protein | -0.0335625 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0335327 |
| PTMA | prothymosin, alpha | -0.0331536 |
| ZNF638 | zinc finger protein 638 | -0.0322163 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0319931 |
| NLGN1 | neuroligin 1 | -0.0312568 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0311995 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0309893 |
| KIAA1217 | KIAA1217 | -0.0309451 |
| RNF213 | ring finger protein 213 | -0.0308267 |
| RPS19 | ribosomal protein S19 | -0.0306302 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0306195 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | -0.0302605 |
| FBXL20 | F-box and leucine-rich repeat protein 20 | -0.0300484 |
| WASF2 | WAS protein family, member 2 | -0.0290763 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0287653 |
| RFX7 | regulatory factor X, 7 | -0.0286057 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.0284593 |
| FOXP1 | forkhead box P1 | -0.0280774 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0280082 |
| CERS6 | ceramide synthase 6 | -0.0278049 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0276394 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0273986 |
| SBF2 | SET binding factor 2 | -0.0269673 |
| RAD51B | RAD51 paralog B | -0.0267186 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0265124 |
| ITGA3 | integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) | -0.0264629 |
| PARD3 | par-3 family cell polarity regulator | -0.0264592 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0262765 |
| H3-3B | H3.3 histone B | -0.02602 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0259853 |
| MARCHF7 | membrane associated ring-CH-type finger 7 | -0.0259764 |
| MYOF | myoferlin | -0.02595 |
| FOXO3 | forkhead box O3 | -0.0259252 |
| DENND1A | DENN/MADD domain containing 1A | -0.0258524 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0256629 |
| ASPH | aspartate beta-hydroxylase | -0.0256319 |
| DOCK9 | dedicator of cytokinesis 9 | -0.0254969 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0253577 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0251296 |
| GPC6 | glypican 6 | -0.0250219 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0249459 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0247912 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0246288 |
| SSH2 | slingshot protein phosphatase 2 | -0.0243851 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0242054 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0241233 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | -0.0240641 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0238014 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0235719 |
| ANXA2 | annexin A2 | -0.0235373 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0235265 |
| RBCK1 | RanBP-type and C3HC4-type zinc finger containing 1 | -0.0234203 |
| SETD5 | SET domain containing 5 | -0.0232761 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0232427 |
| RBM47 | RNA binding motif protein 47 | -0.0231076 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0230694 |
| SENP6 | SUMO1/sentrin specific peptidase 6 | -0.0229858 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0228953 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0228202 |
| BPTF | bromodomain PHD finger transcription factor | -0.0227474 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.0227354 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | -0.0226881 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0224602 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | -0.0223189 |
| USP53 | ubiquitin specific peptidase 53 | -0.0220994 |
| SRPK2 | SRSF protein kinase 2 | -0.0220972 |
| PLS3 | plastin 3 | -0.0214149 |
| TNPO1 | transportin 1 | -0.0213919 |
| CSTB | cystatin B (stefin B) | -0.0212305 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0211454 |
| ACTN1 | actinin, alpha 1 | -0.0211144 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0210999 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0210835 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0210358 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0209575 |
