| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | BAY1125976 perturbation in NCI-H23 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the BAY1125976_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.255109 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.187986 |
| TPI1 | triosephosphate isomerase 1 | 0.118082 |
| TPM3 | tropomyosin 3 | 0.103112 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.100915 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0963134 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0938975 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0747992 |
| RPS3 | ribosomal protein S3 | 0.0729814 |
| KRT18 | keratin 18, type I | 0.0664325 |
| TPM2 | tropomyosin 2 (beta) | 0.0631878 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0622046 |
| VIM | vimentin | 0.0604656 |
| TMSB10 | thymosin beta 10 | 0.0526138 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0517748 |
| SET | SET nuclear proto-oncogene | 0.0516952 |
| ENO1 | enolase 1, (alpha) | 0.0507722 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0499778 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0496848 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0473553 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0471351 |
| RPS12 | ribosomal protein S12 | 0.0445958 |
| PTMA | prothymosin, alpha | 0.0423355 |
| RPL37A | ribosomal protein L37a | 0.0405564 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0396373 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0385267 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0380902 |
| RPL3 | ribosomal protein L3 | 0.0377014 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0374439 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0370602 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0358782 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.0356684 |
| BRD2 | bromodomain containing 2 | 0.0348579 |
| RPS17 | ribosomal protein S17 | 0.0347987 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0340166 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0338562 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0336448 |
| RPS8 | ribosomal protein S8 | 0.0320753 |
| HYOU1 | hypoxia up-regulated 1 | 0.031945 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0318428 |
| CHD4 | chromodomain helicase DNA binding protein 4 | 0.0311997 |
| PTMS | parathymosin | 0.0306873 |
| IPO7 | importin 7 | 0.0305894 |
| TLN1 | talin 1 | 0.0303704 |
| RPL23 | ribosomal protein L23 | 0.0293015 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0288718 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0288696 |
| RPS27 | ribosomal protein S27 | 0.0287215 |
| CANX | calnexin | 0.0281549 |
| RPL26 | ribosomal protein L26 | 0.0281362 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0278294 |
| GOLGB1 | golgin B1 | 0.0276695 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0276324 |
| RPS19 | ribosomal protein S19 | 0.0275858 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0265885 |
| RPS4X | ribosomal protein S4, X-linked | 0.0263882 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0263796 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0263611 |
| PLEC | plectin | 0.02631 |
| FKBP4 | FK506 binding protein 4, 59kDa | 0.0262496 |
| HDGF | hepatoma-derived growth factor | 0.0261747 |
| CALR | calreticulin | 0.0259514 |
| DSPP | dentin sialophosphoprotein | 0.0253197 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0253185 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.025134 |
| TSR1 | TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) | 0.0250982 |
| MSH6 | mutS homolog 6 | 0.0247477 |
| XPOT | exportin, tRNA | 0.0240042 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0239009 |
| COPA | coatomer protein complex, subunit alpha | 0.0234225 |
| RPL35 | ribosomal protein L35 | 0.0232028 |
| SUPT6H | suppressor of Ty 6 homolog (S. cerevisiae) | 0.0228995 |
| RPL36 | ribosomal protein L36 | 0.022642 |
| DST | dystonin | 0.022149 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0220694 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0220374 |
| YBX1 | Y box binding protein 1 | 0.0220068 |
| SNRNP200 | small nuclear ribonucleoprotein 200kDa (U5) | 0.0219128 |
| ASPH | aspartate beta-hydroxylase | 0.0218871 |
| RPL18 | ribosomal protein L18 | 0.0215033 |
| SYNCRIP | synaptotagmin binding, cytoplasmic RNA interacting protein | 0.0214592 |
| PKM | pyruvate kinase, muscle | 0.0209706 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0207872 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0205642 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | 0.0205062 |
| RPS2 | ribosomal protein S2 | 0.0200208 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0197064 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0195752 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0195349 |
| CRY1 | cryptochrome circadian clock 1 | 0.019454 |
| MT2A | metallothionein 2A | 0.0193895 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0190893 |
| RPL4 | ribosomal protein L4 | 0.0187265 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0184907 |
| NARS1 | asparaginyl-tRNA synthetase 1 | 0.0183658 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0182676 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0181617 |
| CEP250 | centrosomal protein 250kDa | 0.0181195 |
| IER2 | immediate early response 2 | 0.018111 |
| RPL27 | ribosomal protein L27 | 0.018085 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.193848 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0825554 |
| EGR1 | early growth response 1 | -0.07492 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.071631 |
| MCL1 | myeloid cell leukemia 1 | -0.0695008 |
| OSMR | oncostatin M receptor | -0.0634828 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0562666 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0549204 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0536551 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0533524 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.049474 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0450356 |
| RAD51B | RAD51 paralog B | -0.0437608 |
| EXOC4 | exocyst complex component 4 | -0.0437354 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0389484 |
| IGF2 | insulin-like growth factor 2 | -0.0370856 |
| PTK2 | protein tyrosine kinase 2 | -0.0359487 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0354408 |
| SNX9 | sorting nexin 9 | -0.0349905 |
| HMGA2 | high mobility group AT-hook 2 | -0.034989 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0348724 |
| NF1 | neurofibromin 1 | -0.0341314 |
| FBXO11 | F-box protein 11 | -0.0338964 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0337829 |
| GRAMD1B | GRAM domain containing 1B | -0.0337359 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0329407 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0324428 |
| SBF2 | SET binding factor 2 | -0.031918 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0318491 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0313731 |
| CCNL1 | cyclin L1 | -0.030708 |
| NABP1 | nucleic acid binding protein 1 | -0.0301768 |
| RPS21 | ribosomal protein S21 | -0.0296305 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | -0.029185 |
| DNAH14 | dynein, axonemal, heavy chain 14 | -0.0287774 |
| BCAS3 | breast carcinoma amplified sequence 3 | -0.0286993 |
| USP34 | ubiquitin specific peptidase 34 | -0.028602 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0284386 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0284237 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0283829 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0281909 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0281003 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.027858 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.027373 |
| RTN4 | reticulon 4 | -0.0273063 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0272173 |
| ATG7 | autophagy related 7 | -0.0253816 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0248005 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0247461 |
| RPL35A | ribosomal protein L35a | -0.0242145 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0241917 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0241037 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0240645 |
| RPL38 | ribosomal protein L38 | -0.0237435 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0237281 |
| CCDC91 | coiled-coil domain containing 91 | -0.0234988 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0232333 |
| PCNX1 | pecanex 1 | -0.0224547 |
| ZNF638 | zinc finger protein 638 | -0.0221384 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0218801 |
| EXOC6B | exocyst complex component 6B | -0.0217376 |
| CDK17 | cyclin-dependent kinase 17 | -0.0216046 |
| SMYD3 | SET and MYND domain containing 3 | -0.0215315 |
| CSGALNACT1 | chondroitin sulfate N-acetylgalactosaminyltransferase 1 | -0.0211789 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0210982 |
| GATAD2B | GATA zinc finger domain containing 2B | -0.0209341 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | -0.0207992 |
| TMEM131 | transmembrane protein 131 | -0.020333 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0201781 |
| THOC2 | THO complex 2 | -0.0198525 |
| DENND1A | DENN/MADD domain containing 1A | -0.0197971 |
| PHIP | pleckstrin homology domain interacting protein | -0.0197108 |
| RASAL2 | RAS protein activator like 2 | -0.0194022 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0193695 |
| ATXN1 | ataxin 1 | -0.0191645 |
| RSRC1 | arginine/serine-rich coiled-coil 1 | -0.0190156 |
| FMNL2 | formin-like 2 | -0.0188777 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0188362 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0185151 |
| CMSS1 | cms1 ribosomal small subunit homolog (yeast) | -0.0184826 |
| MMP12 | matrix metallopeptidase 12 | -0.0184529 |
| TFDP2 | transcription factor Dp-2 (E2F dimerization partner 2) | -0.0183443 |
| PUM2 | pumilio RNA-binding family member 2 | -0.018289 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0182661 |
| PDE10A | phosphodiesterase 10A | -0.0180168 |
| MED13L | mediator complex subunit 13-like | -0.0178702 |
| BBX | bobby sox homolog (Drosophila) | -0.0176418 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0175597 |
| TLK1 | tousled-like kinase 1 | -0.0175422 |
| PNPT1 | polyribonucleotide nucleotidyltransferase 1 | -0.0175295 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0174819 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0174506 |
| TAOK1 | TAO kinase 1 | -0.0173867 |
| CUX1 | cut-like homeobox 1 | -0.0173749 |
| RPS15 | ribosomal protein S15 | -0.017179 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0171697 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0170087 |
| PHF21A | PHD finger protein 21A | -0.0169915 |
| CAPZA1 | capping protein (actin filament) muscle Z-line, alpha 1 | -0.0169662 |
| ZNF292 | zinc finger protein 292 | -0.0169631 |
