BAY1125976_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BAY1125976_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.256827
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.158418
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.13394
MYH9 myosin, heavy chain 9, non-muscle 0.123196
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.10485
RPS3 ribosomal protein S3 0.0833204
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0764184
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0673161
NAP1L1 nucleosome assembly protein 1-like 1 0.0510664
RPL37A ribosomal protein L37a 0.0509127
RPS12 ribosomal protein S12 0.0491139
RPL23 ribosomal protein L23 0.0472353
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0464091
PLEC plectin 0.0448938
LAMC2 laminin, gamma 2 0.0445236
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0423732
HMGB2 high mobility group box 2 0.0421885
RPS17 ribosomal protein S17 0.0403
ENO1 enolase 1, (alpha) 0.0395596
RACK1 receptor for activated C kinase 1 0.0384277
RPLP1 ribosomal protein, large, P1 0.0383866
RPL9 ribosomal protein L9 0.038229
FTL ferritin, light polypeptide 0.0375953
RPS19 ribosomal protein S19 0.0372225
TPM3 tropomyosin 3 0.0347288
MT2A metallothionein 2A 0.0346589
LAMB3 laminin, beta 3 0.0344901
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.033146
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0308701
CALR calreticulin 0.0305011
RPS8 ribosomal protein S8 0.0304828
RPL13A ribosomal protein L13a 0.029945
EIF1 eukaryotic translation initiation factor 1 0.0297727
RPLP2 ribosomal protein, large, P2 0.0296408
RPL3 ribosomal protein L3 0.0293693
RPL4 ribosomal protein L4 0.0281457
HSPA8 heat shock 70kDa protein 8 0.0278821
PTMA prothymosin, alpha 0.0271507
DSPP dentin sialophosphoprotein 0.026611
TMSB4X thymosin beta 4, X-linked 0.0265309
TPT1 tumor protein, translationally-controlled 1 0.026453
RPL31 ribosomal protein L31 0.0264009
EEF2 eukaryotic translation elongation factor 2 0.0259572
RPL7 ribosomal protein L7 0.0257195
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0242348
RPL12 ribosomal protein L12 0.0241845
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0236505
RPL36 ribosomal protein L36 0.0235795
RPL19 ribosomal protein L19 0.0235387
RPL26 ribosomal protein L26 0.0234708
EEF1G eukaryotic translation elongation factor 1 gamma 0.0230254
BRD2 bromodomain containing 2 0.0226501
RPL37 ribosomal protein L37 0.0226141
SLC38A1 solute carrier family 38, member 1 0.0223986
TACSTD2 tumor-associated calcium signal transducer 2 0.0223894
SKP1 S-phase kinase-associated protein 1 0.0222336
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0215799
RPL35 ribosomal protein L35 0.0215128
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0211454
RPSA ribosomal protein SA 0.0210842
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0209994
NACA nascent polypeptide-associated complex alpha subunit 0.0208223
RPL7A ribosomal protein L7a 0.0203879
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein) 0.0203188
RPL18 ribosomal protein L18 0.0203134
RPS27 ribosomal protein S27 0.0201825
VIM vimentin 0.0201233
RPS14 ribosomal protein S14 0.019814
ANXA1 annexin A1 0.0195858
APLP2 amyloid beta (A4) precursor-like protein 2 0.0195318
HDGF hepatoma-derived growth factor 0.0194786
SET SET nuclear proto-oncogene 0.0193888
RPL27 ribosomal protein L27 0.0187759
DDIT4 DNA-damage-inducible transcript 4 0.0187553
RPL5 ribosomal protein L5 0.0185123
RPS6 ribosomal protein S6 0.018425
KRT18 keratin 18, type I 0.0180425
GPX4 glutathione peroxidase 4 0.0174705
SRRM2 serine/arginine repetitive matrix 2 0.0174299
RPS2 ribosomal protein S2 0.0170996
HYOU1 hypoxia up-regulated 1 0.0167556
PDIA4 protein disulfide isomerase family A, member 4 0.0165532
RPS25 ribosomal protein S25 0.0165383
CANX calnexin 0.0165047
RPS29 ribosomal protein S29 0.0164306
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0163679
TPI1 triosephosphate isomerase 1 0.0162477
PEG10 paternally expressed 10 0.0161692
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0161385
ATF4 activating transcription factor 4 0.0160615
PDIA3 protein disulfide isomerase family A, member 3 0.016024
MSN moesin 0.0157227
G0S2 G0/G1 switch 2 0.0155161
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0154049
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0153185
PRRC2C proline-rich coiled-coil 2C 0.0151522
RPLP0 ribosomal protein, large, P0 0.0150776
RPL36A ribosomal protein L36a 0.0148209
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0147467
RPL11 ribosomal protein L11 0.0143485

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.160004
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.149082
POTEF POTE ankyrin domain family, member F -0.109086
LPP LIM domain containing preferred translocation partner in lipoma -0.104579
LIMCH1 LIM and calponin homology domains 1 -0.0902127
NDRG1 N-myc downstream regulated 1 -0.0804835
SAMD4A sterile alpha motif domain containing 4A -0.0742203
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0696379
FNDC3B fibronectin type III domain containing 3B -0.0653467
IGFBP3 insulin-like growth factor binding protein 3 -0.0641931
ACTG1 actin gamma 1 -0.0605067
NPEPPS aminopeptidase puromycin sensitive -0.0585308
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0583084
TRIO trio Rho guanine nucleotide exchange factor -0.0561805
UBC ubiquitin C -0.0555697
EFNA5 ephrin-A5 -0.052767
FBXO32 F-box protein 32 -0.0482015
PTK2 protein tyrosine kinase 2 -0.0479646
FN1 fibronectin 1 -0.0476155
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0466291
CD2AP CD2-associated protein -0.045853
LMO7 LIM domain 7 -0.045167
ERBIN erbb2 interacting protein -0.0449331
TMEM165 transmembrane protein 165 -0.0440368
MYO6 myosin VI -0.0435766
ITCH itchy E3 ubiquitin protein ligase -0.0406996
TSC22D2 TSC22 domain family, member 2 -0.0406311
TM4SF1 transmembrane 4 L six family member 1 -0.0400361
FAM3C family with sequence similarity 3, member C -0.0397243
GRB10 growth factor receptor-bound protein 10 -0.038286
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0373615
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0367418
CCND1 cyclin D1 -0.0359423
S100A10 S100 calcium binding protein A10 -0.0359235
NAV2 neuron navigator 2 -0.0356108
ZBTB20 zinc finger and BTB domain containing 20 -0.0338679
F3 coagulation factor III (thromboplastin, tissue factor) -0.0330714
LY6E lymphocyte antigen 6 complex, locus E -0.0324517
RBM47 RNA binding motif protein 47 -0.0316298
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.031356
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0313175
RCOR1 REST corepressor 1 -0.0307171
EXT1 exostosin glycosyltransferase 1 -0.0306674
SOX4 SRY (sex determining region Y)-box 4 -0.0304838
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0302904
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0301702
STRN3 striatin, calmodulin binding protein 3 -0.0299826
KMT2C lysine (K)-specific methyltransferase 2C -0.0295376
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0290229
MDK midkine (neurite growth-promoting factor 2) -0.028836
KDM5B lysine (K)-specific demethylase 5B -0.0284402
FTH1 ferritin, heavy polypeptide 1 -0.0281718
UBE2H ubiquitin-conjugating enzyme E2H -0.0272155
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0270136
ANTXR2 anthrax toxin receptor 2 -0.0268695
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0264146
AKAP13 A kinase (PRKA) anchor protein 13 -0.0263014
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.026161
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0259663
TMEM123 transmembrane protein 123 -0.0255843
MARCHF6 membrane associated ring-CH-type finger 6 -0.0252036
RAI14 retinoic acid induced 14 -0.0250747
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0248485
ADAM9 ADAM metallopeptidase domain 9 -0.024422
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0242882
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0241
WSB1 WD repeat and SOCS box containing 1 -0.0240306
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0238879
PATJ PATJ crumbs cell polarity complex component -0.0238605
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0234155
NF1 neurofibromin 1 -0.0233358
MCTP2 multiple C2 domains, transmembrane 2 -0.0232549
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0228941
ANXA2 annexin A2 -0.0228218
CAPN2 calpain 2, (m/II) large subunit -0.0226969
MAML2 mastermind-like 2 (Drosophila) -0.0226122
MAP4 microtubule-associated protein 4 -0.0225743
DSG2 desmoglein 2 -0.0224118
FBXO34 F-box protein 34 -0.0222379
CDCP1 CUB domain containing protein 1 -0.0220145
ATXN1 ataxin 1 -0.0217697
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0216106
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0213879
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 -0.0213753
HLA-B major histocompatibility complex, class I, B -0.0213612
RPS21 ribosomal protein S21 -0.0211528
SVIL supervillin -0.0210467
RASA2 RAS p21 protein activator 2 -0.0210364
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0208885
ZFAND3 zinc finger, AN1-type domain 3 -0.020873
OSMR oncostatin M receptor -0.0207597
CTSB cathepsin B -0.0207035
OCLN occludin -0.0205968
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.0202484
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0201687
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0200277
WASF2 WAS protein family, member 2 -0.0198327
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0198232
RHOA ras homolog family member A -0.0196009
BBX bobby sox homolog (Drosophila) -0.0195113