BAY1125976_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BAY1125976_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.148912
VIM vimentin 0.119343
RPS6 ribosomal protein S6 0.0919327
RPS12 ribosomal protein S12 0.086749
RPL37A ribosomal protein L37a 0.0811568
ENO1 enolase 1, (alpha) 0.0808369
RPL26 ribosomal protein L26 0.0756961
RPL31 ribosomal protein L31 0.0734335
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0709089
RPS8 ribosomal protein S8 0.070295
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0656276
RPS3 ribosomal protein S3 0.0652325
RPS17 ribosomal protein S17 0.0607997
RPS19 ribosomal protein S19 0.0582544
RPS27 ribosomal protein S27 0.0541034
RPL9 ribosomal protein L9 0.0509968
RPLP1 ribosomal protein, large, P1 0.0496048
MYH9 myosin, heavy chain 9, non-muscle 0.049326
NAP1L1 nucleosome assembly protein 1-like 1 0.0479652
RPL3 ribosomal protein L3 0.0472271
RPL7A ribosomal protein L7a 0.0463091
RPL23 ribosomal protein L23 0.0459417
SH3KBP1 SH3-domain kinase binding protein 1 0.0454547
TPM3 tropomyosin 3 0.0451844
PTMA prothymosin, alpha 0.0443986
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0437212
PKM pyruvate kinase, muscle 0.043472
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0430209
TPT1 tumor protein, translationally-controlled 1 0.0419619
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0402762
RPL36A ribosomal protein L36a 0.0391478
SRRM2 serine/arginine repetitive matrix 2 0.0391132
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.038646
RPS14 ribosomal protein S14 0.0373896
MT2A metallothionein 2A 0.0373552
LSAMP limbic system-associated membrane protein 0.0371685
COL5A2 collagen, type V, alpha 2 0.0367299
SET SET nuclear proto-oncogene 0.0367299
EEF2 eukaryotic translation elongation factor 2 0.0366427
RPL19 ribosomal protein L19 0.0354798
P3H2 prolyl 3-hydroxylase 2 0.0339649
RACK1 receptor for activated C kinase 1 0.0334482
RPL35 ribosomal protein L35 0.03244
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0321897
RPLP2 ribosomal protein, large, P2 0.0319908
AKAP12 A kinase (PRKA) anchor protein 12 0.0318924
EXT1 exostosin glycosyltransferase 1 0.0316119
TPI1 triosephosphate isomerase 1 0.030739
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0305785
RPL12 ribosomal protein L12 0.0304165
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0303609
SQSTM1 sequestosome 1 0.0299609
RPL36 ribosomal protein L36 0.0299368
RPL27 ribosomal protein L27 0.028676
RPS15A ribosomal protein S15a 0.0286546
RPS27A ribosomal protein S27a 0.0280009
SOX4 SRY (sex determining region Y)-box 4 0.0278801
RPL37 ribosomal protein L37 0.0276437
RPL4 ribosomal protein L4 0.0275193
SMOC1 SPARC related modular calcium binding 1 0.0266682
KRT19 keratin 19, type I 0.0265455
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0261526
RPL7 ribosomal protein L7 0.0260065
EEF1G eukaryotic translation elongation factor 1 gamma 0.025925
RPS25 ribosomal protein S25 0.0257419
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0252283
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0252026
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0249208
MAP7 microtubule-associated protein 7 0.024584
NACA nascent polypeptide-associated complex alpha subunit 0.0243503
HSPA8 heat shock 70kDa protein 8 0.0242197
RPL13A ribosomal protein L13a 0.0241874
RPS2 ribosomal protein S2 0.0232918
RPL35A ribosomal protein L35a 0.0231792
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0227069
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0226965
RPL18 ribosomal protein L18 0.022248
RPS29 ribosomal protein S29 0.021216
RPL34 ribosomal protein L34 0.0211205
NFE2L1 nuclear factor, erythroid 2-like 1 0.0209028
RPL5 ribosomal protein L5 0.0206085
ANGPTL4 angiopoietin-like 4 0.0205903
PDIA3 protein disulfide isomerase family A, member 3 0.0204738
RPS4X ribosomal protein S4, X-linked 0.0202221
EEF1B2 eukaryotic translation elongation factor 1 beta 2 0.0201132
PRKN parkin RBR E3 ubiquitin protein ligase 0.0200301
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0197935
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0197932
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0194536
RPL21 ribosomal protein L21 0.0190625
GOLGB1 golgin B1 0.0188627
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0187195
LOC102724023 ES1 protein homolog, mitochondrial 0.0185296
NRXN3 neurexin 3 0.0182401
RAB3B RAB3B, member RAS oncogene family 0.0180703
PDLIM5 PDZ and LIM domain 5 0.0180056
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0179883
MSN moesin 0.0179275
CREB3L2 cAMP responsive element binding protein 3-like 2 0.0179008
FAM107B family with sequence similarity 107, member B 0.0176458

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.239029
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.199243
EFNA5 ephrin-A5 -0.15407
NAMPT nicotinamide phosphoribosyltransferase -0.1528
FN1 fibronectin 1 -0.100176
ELL2 elongation factor, RNA polymerase II, 2 -0.0876015
GDA guanine deaminase -0.081145
TM4SF1 transmembrane 4 L six family member 1 -0.0791453
TFPI2 tissue factor pathway inhibitor 2 -0.0748452
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0724805
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0698276
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 -0.0662802
SPAG9 sperm associated antigen 9 -0.0652793
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0642259
IGFBP3 insulin-like growth factor binding protein 3 -0.059057
LIMCH1 LIM and calponin homology domains 1 -0.0588521
OGA O-GlcNAcase -0.0577185
TRIO trio Rho guanine nucleotide exchange factor -0.0560148
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.055663
RTN4 reticulon 4 -0.055656
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.053466
NPAS2 neuronal PAS domain protein 2 -0.0533697
RBM39 RNA binding motif protein 39 -0.0527006
BIRC6 baculoviral IAP repeat containing 6 -0.0491637
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0491089
NEK7 NIMA-related kinase 7 -0.0477039
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 -0.045061
TXNRD1 thioredoxin reductase 1 -0.0443719
AGFG1 ArfGAP with FG repeats 1 -0.0424563
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0421501
PDE10A phosphodiesterase 10A -0.0414183
PUM2 pumilio RNA-binding family member 2 -0.0390803
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0388399
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0381188
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0380958
PDE4D phosphodiesterase 4D, cAMP-specific -0.0373078
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0365397
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.036005
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0358548
KMT2C lysine (K)-specific methyltransferase 2C -0.0357498
WDR45B WD repeat domain 45B -0.035241
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0350904
GNAS GNAS complex locus -0.0350396
COL4A5 collagen, type IV, alpha 5 -0.0346357
USP3 ubiquitin specific peptidase 3 -0.0346183
SRPK2 SRSF protein kinase 2 -0.0345725
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.034366
TRA2A transformer 2 alpha homolog (Drosophila) -0.0343502
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0339527
SOD2 superoxide dismutase 2, mitochondrial -0.0339514
KDM3A lysine (K)-specific demethylase 3A -0.0334374
SMYD3 SET and MYND domain containing 3 -0.033409
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.033384
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0333649
OSMR oncostatin M receptor -0.0332683
ADGRD1 adhesion G protein-coupled receptor D1 -0.0331641
EPB41L3 erythrocyte membrane protein band 4.1-like 3 -0.0330119
NF1 neurofibromin 1 -0.0327777
NALF1 NALCN channel auxiliary factor 1 -0.0320422
MARCHF6 membrane associated ring-CH-type finger 6 -0.0315266
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0313335
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0311274
LAMA1 laminin, alpha 1 -0.0309189
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0307988
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0306886
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0302425
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0300719
FNDC3B fibronectin type III domain containing 3B -0.0300506
RAB1A RAB1A, member RAS oncogene family -0.0299912
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked -0.029438
TENT5A terminal nucleotidyltransferase 5A -0.0293124
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0290522
FTH1 ferritin, heavy polypeptide 1 -0.0287152
NUP58 nucleoporin 58 -0.0284916
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0284178
HELZ helicase with zinc finger -0.0283544
WAC WW domain containing adaptor with coiled-coil -0.028251
BRWD3 bromodomain and WD repeat domain containing 3 -0.0281371
GOLGA4 golgin A4 -0.0281363
TGFBI transforming growth factor, beta-induced, 68kDa -0.0280856
DOCK4 dedicator of cytokinesis 4 -0.0279801
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0276293
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.027391
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa -0.0273126
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0270837
AVL9 AVL9 homolog (S. cerevisiase) -0.0267852
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0266142
COL4A6 collagen, type IV, alpha 6 -0.0265262
NCOA7 nuclear receptor coactivator 7 -0.026515
NRCAM neuronal cell adhesion molecule -0.026482
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0263898
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0263266
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0262347
PDGFA platelet-derived growth factor alpha polypeptide -0.0262129
GARS1 glycyl-tRNA synthetase 1 -0.0261661
CDC73 cell division cycle 73 -0.0261524
FAM13A family with sequence similarity 13, member A -0.02597
OLA1 Obg-like ATPase 1 -0.0258953
RUNX1 runt-related transcription factor 1 -0.0258646
RAP1B RAP1B, member of RAS oncogene family -0.0258595