BAY1125976_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BAY1125976_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.155414
COL11A1 collagen, type XI, alpha 1 0.141508
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.103197
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0961991
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0951412
TMSB10 thymosin beta 10 0.0866452
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0842488
RPS12 ribosomal protein S12 0.0811
RPS6 ribosomal protein S6 0.0798219
RPL23 ribosomal protein L23 0.0714065
RPS8 ribosomal protein S8 0.0699717
MYH9 myosin, heavy chain 9, non-muscle 0.0628888
ENO1 enolase 1, (alpha) 0.062631
RPS16 ribosomal protein S16 0.0620951
TPT1 tumor protein, translationally-controlled 1 0.0573145
COL5A2 collagen, type V, alpha 2 0.0525555
RPS3 ribosomal protein S3 0.0487138
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0485777
RPS19 ribosomal protein S19 0.0463045
TMSB4X thymosin beta 4, X-linked 0.045761
RPL37A ribosomal protein L37a 0.0453873
RPLP1 ribosomal protein, large, P1 0.043049
RPL31 ribosomal protein L31 0.0426239
NAP1L1 nucleosome assembly protein 1-like 1 0.0420633
SRRM2 serine/arginine repetitive matrix 2 0.0410027
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0408241
RPLP2 ribosomal protein, large, P2 0.0407373
ASPH aspartate beta-hydroxylase 0.0395084
CALR calreticulin 0.0392794
RPL12 ribosomal protein L12 0.0388904
EEF2 eukaryotic translation elongation factor 2 0.0388371
CENPF centromere protein F, 350/400kDa 0.0376088
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0373831
RACK1 receptor for activated C kinase 1 0.0370095
STMN1 stathmin 1 0.0365575
ACTG1 actin gamma 1 0.0361202
RPS2 ribosomal protein S2 0.0355073
RPL11 ribosomal protein L11 0.0353663
RPL4 ribosomal protein L4 0.0348785
RPS5 ribosomal protein S5 0.0339053
RPS17 ribosomal protein S17 0.0337086
RPL3 ribosomal protein L3 0.033672
RPS27 ribosomal protein S27 0.0334795
PTMA prothymosin, alpha 0.0329515
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0326401
CKAP2 cytoskeleton associated protein 2 0.0326175
NACA nascent polypeptide-associated complex alpha subunit 0.0323574
RPL37 ribosomal protein L37 0.0317279
EIF1 eukaryotic translation initiation factor 1 0.0317156
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0313602
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0310608
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0310518
MACF1 microtubule-actin crosslinking factor 1 0.0310229
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.030446
CANX calnexin 0.0300993
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0298543
RPS4X ribosomal protein S4, X-linked 0.02963
RPL9 ribosomal protein L9 0.029334
AKAP12 A kinase (PRKA) anchor protein 12 0.0291305
RPL7 ribosomal protein L7 0.0291121
RNF213 ring finger protein 213 0.0287247
RPL18 ribosomal protein L18 0.0281777
RPL7A ribosomal protein L7a 0.0277916
PCDH9 protocadherin 9 0.0275589
VCL vinculin 0.0273054
SET SET nuclear proto-oncogene 0.0272488
RAI1 retinoic acid induced 1 0.0268638
AHNAK AHNAK nucleoprotein 0.0266448
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0263411
FN1 fibronectin 1 0.0262956
GPX4 glutathione peroxidase 4 0.0261908
SNX6 sorting nexin 6 0.0259886
RPLP0 ribosomal protein, large, P0 0.0259202
NDRG1 N-myc downstream regulated 1 0.0258906
MKI67 marker of proliferation Ki-67 0.0255665
LOC102724023 ES1 protein homolog, mitochondrial 0.0254458
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0251911
EEF1G eukaryotic translation elongation factor 1 gamma 0.0249548
RAD21 RAD21 homolog (S. pombe) 0.0246398
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0245674
MCL1 myeloid cell leukemia 1 0.0245406
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0243532
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0243377
DOCK5 dedicator of cytokinesis 5 0.0242721
HMGA2 high mobility group AT-hook 2 0.0242296
DOCK1 dedicator of cytokinesis 1 0.0240377
EGFR epidermal growth factor receptor 0.0238742
RPS24 ribosomal protein S24 0.0236542
FTL ferritin, light polypeptide 0.0234891
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0234042
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0230458
RPL30 ribosomal protein L30 0.0227936
HYOU1 hypoxia up-regulated 1 0.022778
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0227023
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0225874
LMO7 LIM domain 7 0.0225156
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0224882
PGK1 phosphoglycerate kinase 1 0.022276
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0221962
RPL36A ribosomal protein L36a 0.0221875

decreased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.169807
CDH10 cadherin 10, type 2 (T2-cadherin) -0.134508
ZNF292 zinc finger protein 292 -0.104313
ZFAND3 zinc finger, AN1-type domain 3 -0.102819
HDAC9 histone deacetylase 9 -0.0972475
TSC22D2 TSC22 domain family, member 2 -0.0959411
TRPS1 trichorhinophalangeal syndrome I -0.0912292
PGAP1 post-GPI attachment to proteins 1 -0.0892105
PHIP pleckstrin homology domain interacting protein -0.0849085
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.080135
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0703307
SAMD4A sterile alpha motif domain containing 4A -0.0624261
SPAG9 sperm associated antigen 9 -0.0622612
SRP54 signal recognition particle 54kDa -0.0611852
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) -0.057802
STRN3 striatin, calmodulin binding protein 3 -0.0567384
PLPP1 phospholipid phosphatase 1 -0.0564013
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0553914
KMT2C lysine (K)-specific methyltransferase 2C -0.0541169
CHD1 chromodomain helicase DNA binding protein 1 -0.0527686
BMPR1A bone morphogenetic protein receptor, type IA -0.0486607
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0486366
TTC28 tetratricopeptide repeat domain 28 -0.0484202
CDC73 cell division cycle 73 -0.0482278
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 -0.0470974
RERE arginine-glutamic acid dipeptide (RE) repeats -0.04683
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0458571
NTM neurotrimin -0.0450553
YES1 YES proto-oncogene 1, Src family tyrosine kinase -0.0446662
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0444969
KMT2E lysine (K)-specific methyltransferase 2E -0.0440939
TOX thymocyte selection-associated high mobility group box -0.0436761
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D -0.0429477
ZEB2 zinc finger E-box binding homeobox 2 -0.0420732
ADGRL2 adhesion G protein-coupled receptor L2 -0.0415583
ANKRD33B ankyrin repeat domain 33B -0.041356
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0409834
ENAH enabled homolog (Drosophila) -0.0408501
GLS2 glutaminase 2 (liver, mitochondrial) -0.0405126
PRR16 proline rich 16 -0.0398643
PHF21A PHD finger protein 21A -0.0397095
FAM171B family with sequence similarity 171, member B -0.0396719
FNDC3A fibronectin type III domain containing 3A -0.0393455
RASAL2 RAS protein activator like 2 -0.039318
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.038993
FNDC3B fibronectin type III domain containing 3B -0.0388684
PUM2 pumilio RNA-binding family member 2 -0.0386945
RBM20 RNA binding motif protein 20 -0.0383287
SRPK2 SRSF protein kinase 2 -0.0380419
PRKD1 protein kinase D1 -0.0377236
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0377155
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.036827
SHROOM3 shroom family member 3 -0.0360558
ZNF217 zinc finger protein 217 -0.0359436
GARS1 glycyl-tRNA synthetase 1 -0.03594
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0359147
ADGRL3 adhesion G protein-coupled receptor L3 -0.0346814
MRPS6 mitochondrial ribosomal protein S6 -0.0341889
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0340949
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0335023
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0334531
USP25 ubiquitin specific peptidase 25 -0.0334268
THBS1 thrombospondin 1 -0.0332514
NCOR1 nuclear receptor corepressor 1 -0.0332322
RCOR1 REST corepressor 1 -0.0332022
CDH4 cadherin 4, type 1, R-cadherin (retinal) -0.0331501
PRTG protogenin -0.0322678
NCAM2 neural cell adhesion molecule 2 -0.031529
NCOA2 nuclear receptor coactivator 2 -0.0311036
CELF2 CUGBP, Elav-like family member 2 -0.0309836
JMJD1C jumonji domain containing 1C -0.0301189
RFX7 regulatory factor X, 7 -0.0299522
PUM1 pumilio RNA-binding family member 1 -0.0298524
PTK2 protein tyrosine kinase 2 -0.0297869
ACTN4 actinin, alpha 4 -0.0290466
FOXO3 forkhead box O3 -0.0288517
SLC44A5 solute carrier family 44, member 5 -0.0288143
RHEB Ras homolog enriched in brain -0.0285221
PEG10 paternally expressed 10 -0.0284047
IARS1 isoleucyl-tRNA synthetase 1 -0.0279908
GNAS GNAS complex locus -0.0277502
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0273533
MED13L mediator complex subunit 13-like -0.0273035
CHD7 chromodomain helicase DNA binding protein 7 -0.0272054
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0267714
LPIN2 lipin 2 -0.0266519
CAMTA1 calmodulin binding transcription activator 1 -0.0264954
MAP4 microtubule-associated protein 4 -0.0264451
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0262166
TNRC6B trinucleotide repeat containing 6B -0.02616
SSH2 slingshot protein phosphatase 2 -0.0260656
NFIA nuclear factor I/A -0.0260653
SETD5 SET domain containing 5 -0.0258663
LATS2 large tumor suppressor kinase 2 -0.0256731
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.025624
NHSL1 NHS-like 1 -0.0253514
WDR43 WD repeat domain 43 -0.0251742
FCHSD2 FCH and double SH3 domains 2 -0.0251543
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0250632
MTF2 metal response element binding transcription factor 2 -0.0249097