BAY1125976_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BAY1125976_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.311099
HDAC9 histone deacetylase 9 0.13325
MT2A metallothionein 2A 0.120457
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.103621
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.100173
RPS12 ribosomal protein S12 0.0932575
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.08521
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0807734
NAP1L1 nucleosome assembly protein 1-like 1 0.0800154
RPL37A ribosomal protein L37a 0.0792653
ENO1 enolase 1, (alpha) 0.0744706
SQSTM1 sequestosome 1 0.068989
VIM vimentin 0.0654405
RPS3 ribosomal protein S3 0.0609268
RPS8 ribosomal protein S8 0.0571973
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.056876
RPS6 ribosomal protein S6 0.0557854
RPL23 ribosomal protein L23 0.0555752
ZSWIM6 zinc finger, SWIM-type containing 6 0.0546576
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0538623
RPL26 ribosomal protein L26 0.0538519
B2M beta-2-microglobulin 0.0536206
TPT1 tumor protein, translationally-controlled 1 0.0506268
LDHA lactate dehydrogenase A 0.050037
TMSB10 thymosin beta 10 0.0469424
RPLP2 ribosomal protein, large, P2 0.0451766
RPL7A ribosomal protein L7a 0.0450283
RPS19 ribosomal protein S19 0.0442611
RPS17 ribosomal protein S17 0.0434329
ASPH aspartate beta-hydroxylase 0.0432513
CALR calreticulin 0.0431294
IER3 immediate early response 3 0.0418197
RPL3 ribosomal protein L3 0.0385576
RPL13A ribosomal protein L13a 0.0381856
RPLP1 ribosomal protein, large, P1 0.0375632
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0370172
FTL ferritin, light polypeptide 0.0365441
RPL12 ribosomal protein L12 0.035508
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0354557
RPS2 ribosomal protein S2 0.0350668
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0350191
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0345851
BRD2 bromodomain containing 2 0.0344857
TMSB4X thymosin beta 4, X-linked 0.0343399
RACK1 receptor for activated C kinase 1 0.0340001
RPL31 ribosomal protein L31 0.0338792
RPL35 ribosomal protein L35 0.0338666
RPL36 ribosomal protein L36 0.0335961
RPL7 ribosomal protein L7 0.0330458
EIF1 eukaryotic translation initiation factor 1 0.0329327
RPL4 ribosomal protein L4 0.0327321
RPS14 ribosomal protein S14 0.0326162
GOLGB1 golgin B1 0.0322436
RPL36A ribosomal protein L36a 0.031503
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0313288
HLA-E major histocompatibility complex, class I, E 0.0313025
LOC112694756 uncharaterized LOC112694756 0.0312125
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0311643
RPS15A ribosomal protein S15a 0.0303989
RPS4X ribosomal protein S4, X-linked 0.0300633
RPL9 ribosomal protein L9 0.0297876
RPS27 ribosomal protein S27 0.0297092
EEF2 eukaryotic translation elongation factor 2 0.0296425
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0294938
AKAP12 A kinase (PRKA) anchor protein 12 0.0288914
RPS10 ribosomal protein S10 0.0288323
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0287069
IER2 immediate early response 2 0.0286802
PDIA3 protein disulfide isomerase family A, member 3 0.028598
INTS6 integrator complex subunit 6 0.0284726
NFE2L1 nuclear factor, erythroid 2-like 1 0.0282396
HLA-A major histocompatibility complex, class I, A 0.0282163
GADD45B growth arrest and DNA-damage-inducible, beta 0.0273829
TPI1 triosephosphate isomerase 1 0.0272308
NACA nascent polypeptide-associated complex alpha subunit 0.0269403
SP100 SP100 nuclear antigen 0.0267961
ADM adrenomedullin 0.0267486
RPL27A ribosomal protein L27a 0.0258352
RPL19 ribosomal protein L19 0.0255642
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.0254918
CREB5 cAMP responsive element binding protein 5 0.025294
ANGPTL4 angiopoietin-like 4 0.0249718
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0248414
HSPA8 heat shock 70kDa protein 8 0.0248375
LOC102724023 ES1 protein homolog, mitochondrial 0.0247489
RND3 Rho family GTPase 3 0.0246431
EEF1G eukaryotic translation elongation factor 1 gamma 0.0246164
RPL11 ribosomal protein L11 0.0245732
RPL37 ribosomal protein L37 0.0245148
RPL5 ribosomal protein L5 0.0242202
PKM pyruvate kinase, muscle 0.0238722
RPL10A ribosomal protein L10a 0.0238674
TPM3 tropomyosin 3 0.0237005
PLIN2 perilipin 2 0.0232629
RPL27 ribosomal protein L27 0.0230954
FAM107B family with sequence similarity 107, member B 0.0225995
HILPDA hypoxia inducible lipid droplet-associated 0.0214166
RPS25 ribosomal protein S25 0.0212085
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0210748
RCN1 reticulocalbin 1, EF-hand calcium binding domain 0.021026

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.120365
FNDC3B fibronectin type III domain containing 3B -0.109024
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.105666
NAMPT nicotinamide phosphoribosyltransferase -0.104303
SOD2 superoxide dismutase 2, mitochondrial -0.102012
UGCG UDP-glucose ceramide glucosyltransferase -0.0787212
PDE10A phosphodiesterase 10A -0.0767301
FRMD4A FERM domain containing 4A -0.0741192
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0701111
ZNF292 zinc finger protein 292 -0.0682826
ZFAND3 zinc finger, AN1-type domain 3 -0.0679967
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0660545
GLIS3 GLIS family zinc finger 3 -0.0658871
OGA O-GlcNAcase -0.065419
ELL2 elongation factor, RNA polymerase II, 2 -0.0654097
ZMYND8 zinc finger, MYND-type containing 8 -0.0644266
RTN4 reticulon 4 -0.0633448
UBC ubiquitin C -0.0619637
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0618631
NDRG1 N-myc downstream regulated 1 -0.0570659
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0565925
CADM1 cell adhesion molecule 1 -0.0554348
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0545251
NAV2 neuron navigator 2 -0.0541892
ATP13A3 ATPase type 13A3 -0.0531224
VCAN versican -0.0519667
DST dystonin -0.0517074
PCBP2 poly(rC) binding protein 2 -0.0507003
DLG1 discs, large homolog 1 (Drosophila) -0.0497854
COL6A3 collagen, type VI, alpha 3 -0.049186
IGFBP3 insulin-like growth factor binding protein 3 -0.0487279
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0477164
SBF2 SET binding factor 2 -0.045499
ANLN anillin, actin binding protein -0.0450345
RBM39 RNA binding motif protein 39 -0.0448354
RAI14 retinoic acid induced 14 -0.0439896
BICC1 BicC family RNA binding protein 1 -0.0432438
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0429814
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0421581
DIAPH2 diaphanous-related formin 2 -0.0418305
WSB1 WD repeat and SOCS box containing 1 -0.0409732
NPEPPS aminopeptidase puromycin sensitive -0.0407673
CDK19 cyclin-dependent kinase 19 -0.0405803
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0403956
TNS3 tensin 3 -0.0403797
VMP1 vacuole membrane protein 1 -0.0393948
CD44 CD44 molecule (Indian blood group) -0.039315
TMEM123 transmembrane protein 123 -0.0392528
PHF21A PHD finger protein 21A -0.0391545
THOC2 THO complex 2 -0.0390248
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0388719
TENT5A terminal nucleotidyltransferase 5A -0.0377272
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0366722
BIRC6 baculoviral IAP repeat containing 6 -0.036609
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0360903
DIAPH3 diaphanous-related formin 3 -0.0359918
LCORL ligand dependent nuclear receptor corepressor-like -0.0355347
PTBP3 polypyrimidine tract binding protein 3 -0.0354403
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0353309
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.03532
COL1A1 collagen, type I, alpha 1 -0.035064
TAPBP TAP binding protein (tapasin) -0.0347139
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0343712
QKI QKI, KH domain containing, RNA binding -0.0342719
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0337819
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.033687
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0328167
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0327289
KDM3A lysine (K)-specific demethylase 3A -0.0326071
NT5C2 5'-nucleotidase, cytosolic II -0.0325254
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0316976
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.031286
BRWD3 bromodomain and WD repeat domain containing 3 -0.0309425
FOXO3 forkhead box O3 -0.0306446
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0304938
ERBIN erbb2 interacting protein -0.0300888
WDFY1 WD repeat and FYVE domain containing 1 -0.0299859
GNAS GNAS complex locus -0.0299364
TSC22D2 TSC22 domain family, member 2 -0.0298814
PHIP pleckstrin homology domain interacting protein -0.0298436
RAB6A RAB6A, member RAS oncogene family -0.0296352
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0295807
DEK DEK proto-oncogene -0.0293949
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0292313
KMT2E lysine (K)-specific methyltransferase 2E -0.0291943
BBX bobby sox homolog (Drosophila) -0.0291794
KIF13A kinesin family member 13A -0.0290583
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0286077
ARF4 ADP-ribosylation factor 4 -0.0284652
KIF4A kinesin family member 4A -0.0282856
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0276543
CD2AP CD2-associated protein -0.027532
CCNL1 cyclin L1 -0.027449
ZNF207 zinc finger protein 207 -0.0273895
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0272245
FNIP1 folliculin interacting protein 1 -0.0271954
ARID1B AT rich interactive domain 1B (SWI1-like) -0.027154
WAC WW domain containing adaptor with coiled-coil -0.0270916
WDR45B WD repeat domain 45B -0.0269207
MARCHF6 membrane associated ring-CH-type finger 6 -0.026887