BAY1125976_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BAY1125976 perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BAY1125976_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.191257
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0979973
TMSB10 thymosin beta 10 0.0838477
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0753879
MT2A metallothionein 2A 0.0727526
ZSWIM6 zinc finger, SWIM-type containing 6 0.064362
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0607489
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0579408
PTMA prothymosin, alpha 0.0528465
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0483529
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0469115
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0418622
ADM adrenomedullin 0.0392746
RPS12 ribosomal protein S12 0.0370794
RPL11 ribosomal protein L11 0.036565
PKM pyruvate kinase, muscle 0.0363357
RPLP1 ribosomal protein, large, P1 0.0363035
RPL37A ribosomal protein L37a 0.0360683
RPS6 ribosomal protein S6 0.0354378
TGFBI transforming growth factor, beta-induced, 68kDa 0.0352116
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0346645
RPL26 ribosomal protein L26 0.0341864
B2M beta-2-microglobulin 0.033654
CALR calreticulin 0.0326448
ANGPTL4 angiopoietin-like 4 0.0321807
RPS17 ribosomal protein S17 0.0308231
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0307096
TMSB4X thymosin beta 4, X-linked 0.0304193
NAP1L1 nucleosome assembly protein 1-like 1 0.0301056
ENO1 enolase 1, (alpha) 0.0297192
RPL12 ribosomal protein L12 0.0295459
APLP2 amyloid beta (A4) precursor-like protein 2 0.029185
CD44 CD44 molecule (Indian blood group) 0.0290378
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0285817
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0283394
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0281248
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0275207
CTNND1 catenin (cadherin-associated protein), delta 1 0.0274802
WWOX WW domain containing oxidoreductase 0.0266599
FAT1 FAT atypical cadherin 1 0.0265299
IGFBP7 insulin-like growth factor binding protein 7 0.0265268
RPL31 ribosomal protein L31 0.0264765
RPL3 ribosomal protein L3 0.026148
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0260453
PLEC plectin 0.0259268
ASPH aspartate beta-hydroxylase 0.0255952
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0253613
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0247445
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) 0.0245694
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0235862
RPL13A ribosomal protein L13a 0.0234301
RPS8 ribosomal protein S8 0.0233805
RPL35 ribosomal protein L35 0.0231006
RPL5 ribosomal protein L5 0.0228408
TPI1 triosephosphate isomerase 1 0.0228217
TPM3 tropomyosin 3 0.0226708
EMP1 epithelial membrane protein 1 0.022604
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.022321
ANKRD12 ankyrin repeat domain 12 0.0221539
RPS19 ribosomal protein S19 0.0221245
EXT1 exostosin glycosyltransferase 1 0.0221199
RAD21 RAD21 homolog (S. pombe) 0.0218013
CSNK1A1 casein kinase 1, alpha 1 0.0215537
HILPDA hypoxia inducible lipid droplet-associated 0.021396
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0213934
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.021353
HSPA8 heat shock 70kDa protein 8 0.0213424
PRELID2 PRELI domain containing 2 0.021332
RPS27A ribosomal protein S27a 0.0212576
RPLP2 ribosomal protein, large, P2 0.0210943
NFE2L1 nuclear factor, erythroid 2-like 1 0.0208809
LGALS3 lectin, galactoside-binding, soluble, 3 0.0208605
SKP1 S-phase kinase-associated protein 1 0.0207863
RPL34 ribosomal protein L34 0.0206624
FAM53C family with sequence similarity 53, member C 0.020588
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0204456
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0203211
LDHA lactate dehydrogenase A 0.0202099
TIMP3 TIMP metallopeptidase inhibitor 3 0.0201859
RPS14 ribosomal protein S14 0.0199951
VCL vinculin 0.0198442
LMO7 LIM domain 7 0.0197572
RPL37 ribosomal protein L37 0.0197372
RPS2 ribosomal protein S2 0.0196672
CLIC4 chloride intracellular channel 4 0.0196604
FTL ferritin, light polypeptide 0.0192928
CCND1 cyclin D1 0.0192483
SETBP1 SET binding protein 1 0.0192271
S100A10 S100 calcium binding protein A10 0.0191083
RPL36 ribosomal protein L36 0.0190869
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0190241
TXNRD1 thioredoxin reductase 1 0.0188373
RPL23 ribosomal protein L23 0.0186121
BRD2 bromodomain containing 2 0.0184484
RPS15A ribosomal protein S15a 0.0184245
CALD1 caldesmon 1 0.0183702
RPS25 ribosomal protein S25 0.0182343
EPS8 epidermal growth factor receptor pathway substrate 8 0.0182104
HYOU1 hypoxia up-regulated 1 0.0182018
RAB2A RAB2A, member RAS oncogene family 0.0180198

decreased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 -0.311099
IGFBP3 insulin-like growth factor binding protein 3 -0.157521
CDH13 cadherin 13 -0.137237
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.112396
F3 coagulation factor III (thromboplastin, tissue factor) -0.0977565
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0915238
EGFR epidermal growth factor receptor -0.0857751
NDRG1 N-myc downstream regulated 1 -0.0825613
COL1A2 collagen, type I, alpha 2 -0.0786541
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0760248
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.075606
NRXN3 neurexin 3 -0.0725008
LOX lysyl oxidase -0.0704391
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0652722
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.062032
SOD2 superoxide dismutase 2, mitochondrial -0.0595501
TNS3 tensin 3 -0.0582861
DPYD dihydropyrimidine dehydrogenase -0.0563989
GOLGA4 golgin A4 -0.0560338
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0549967
CALU calumenin -0.0546438
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0537158
STC1 stanniocalcin 1 -0.0528674
COL1A1 collagen, type I, alpha 1 -0.0494999
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0487655
NAMPT nicotinamide phosphoribosyltransferase -0.0483579
IL6 interleukin 6 -0.0468739
TMEM165 transmembrane protein 165 -0.0463614
TM4SF1 transmembrane 4 L six family member 1 -0.0455415
KAZN kazrin, periplakin interacting protein -0.0453308
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0436948
POTEF POTE ankyrin domain family, member F -0.0436871
DNAH11 dynein, axonemal, heavy chain 11 -0.0416429
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0415593
LMAN1 lectin, mannose-binding, 1 -0.0412095
MAP1B microtubule-associated protein 1B -0.0411618
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0411332
SEC31A SEC31 homolog A (S. cerevisiae) -0.0393885
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0388449
FNIP1 folliculin interacting protein 1 -0.0384324
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0383279
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0366304
ZMYND8 zinc finger, MYND-type containing 8 -0.0364927
GARS1 glycyl-tRNA synthetase 1 -0.0363286
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0362578
KMT2E lysine (K)-specific methyltransferase 2E -0.0356608
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0355488
COL6A1 collagen, type VI, alpha 1 -0.0352677
ATP13A3 ATPase type 13A3 -0.0350699
CDK13 cyclin-dependent kinase 13 -0.0348407
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0348236
HIPK2 homeodomain interacting protein kinase 2 -0.0341553
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0341437
MACF1 microtubule-actin crosslinking factor 1 -0.0335814
UBC ubiquitin C -0.0335591
TENT5A terminal nucleotidyltransferase 5A -0.0334925
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0329466
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0328438
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0326207
LOXL2 lysyl oxidase-like 2 -0.0319063
AHNAK AHNAK nucleoprotein -0.0317254
ARF4 ADP-ribosylation factor 4 -0.0312952
JARID2 jumonji, AT rich interactive domain 2 -0.030924
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.030881
MON2 MON2 homolog (S. cerevisiae) -0.030838
HLA-C major histocompatibility complex, class I, C -0.0307397
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0305793
LPP LIM domain containing preferred translocation partner in lipoma -0.0302064
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0298963
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.029886
ANKRD28 ankyrin repeat domain 28 -0.0292969
NAV2 neuron navigator 2 -0.0289207
WSB1 WD repeat and SOCS box containing 1 -0.0288802
ATXN1 ataxin 1 -0.0284128
EXOC4 exocyst complex component 4 -0.0282513
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0281226
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0278265
FTH1 ferritin, heavy polypeptide 1 -0.0277766
ZFAND3 zinc finger, AN1-type domain 3 -0.0277698
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0276897
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0276683
MT1X metallothionein 1X -0.0272052
PRRC1 proline-rich coiled-coil 1 -0.0263987
PSD3 pleckstrin and Sec7 domain containing 3 -0.0263111
CUL1 cullin 1 -0.0261523
CCNI cyclin I -0.0258829
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0256923
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0255524
MBD5 methyl-CpG binding domain protein 5 -0.025197
ITCH itchy E3 ubiquitin protein ligase -0.025007
COL5A2 collagen, type V, alpha 2 -0.0247699
SLC38A2 solute carrier family 38, member 2 -0.0245005
NF1 neurofibromin 1 -0.0244946
SPAG9 sperm associated antigen 9 -0.0244564
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.024332
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0243195
TNNC1 troponin C type 1 (slow) -0.02383
SKIC3 SKI3 subunit of superkiller complex -0.0235436
MORF4L2 mortality factor 4 like 2 -0.0234256
ANKRD17 ankyrin repeat domain 17 -0.0234022