BBC3 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description BCL2 binding component 3|This gene encodes a member of the BCL-2 family of proteins. This family member belongs to the BH3-only pro-apoptotic subclass. The protein cooperates with direct activator proteins to induce mitochondrial outer membrane permeabilization and apoptosis. It can bind to anti-apoptotic Bcl-2 family members to induce mitochondrial dysfunction and caspase activation. Because of its pro-apoptotic role, this gene is a potential drug target for cancer therapy and for tissue injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011] (NCBI Entrez Gene Database, 27113)
External Link http://www.ncbi.nlm.nih.gov/gene/27113
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Genes

66 interacting proteins for BBC3 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ALB albumin
AP4E1 adaptor-related protein complex 4, epsilon 1 subunit
APOA1 apolipoprotein A-I
APOA2 apolipoprotein A-II
APOA4 apolipoprotein A-IV
APOC1 apolipoprotein C-I
APOC3 apolipoprotein C-III
APOE apolipoprotein E
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough
BNC1 basonuclin 1
CABLES1 Cdk5 and Abl enzyme substrate 1
CAMTA1 calmodulin binding transcription activator 1
CEP44 centrosomal protein 44kDa
CHUK conserved helix-loop-helix ubiquitous kinase
CLCA2 chloride channel accessory 2
CNOT1 CCR4-NOT transcription complex, subunit 1
CROT carnitine O-octanoyltransferase
DCC DCC netrin 1 receptor
DGKG diacylglycerol kinase, gamma 90kDa
DICER1 dicer 1, ribonuclease type III
DMD dystrophin
F2 coagulation factor II (thrombin)
GCN1L1 GCN1 general control of amino-acid synthesis 1-like 1 (yeast)
GRAP2 GRB2-related adaptor protein 2
HBA2 hemoglobin, alpha 2
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
JARID2 jumonji, AT rich interactive domain 2
KIAA1551 KIAA1551
KRT1 keratin 1, type II
KRT10 keratin 10, type I
LAT linker for activation of T cells
LDB3 LIM domain binding 3
MCL1 myeloid cell leukemia 1
MYL4 myosin, light chain 4, alkali; atrial, embryonic
MYLK3 myosin light chain kinase 3
NLRC4 NLR family, CARD domain containing 4
NPHS1 nephrosis 1, congenital, Finnish type (nephrin)
PALB2 partner and localizer of BRCA2
PCED1B PC-esterase domain containing 1B
PDZRN4 PDZ domain containing ring finger 4
PEG3 paternally expressed 3
PRSS1 protease, serine, 1 (trypsin 1)
QTRTD1 queuine tRNA-ribosyltransferase domain containing 1
RANBP3 RAN binding protein 3
SCN5A sodium channel, voltage gated, type V alpha subunit
SETX senataxin
SGOL2 shugoshin-like 2 (S. pombe)
SLA2 Src-like-adaptor 2
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC9A8 solute carrier family 9, subfamily A (NHE8, cation proton antiporter 8), member 8
SORBS3 sorbin and SH3 domain containing 3
SPAST spastin
SPATA31A7 SPATA31 subfamily A, member 7
THRAP3 thyroid hormone receptor associated protein 3
TIAM1 T-cell lymphoma invasion and metastasis 1
TLN2 talin 2
TRAPPC11 trafficking protein particle complex 11
TTN titin