BCL10 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description B-cell CLL/lymphoma 10|This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8915)
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Genes

312 genes differentially expressed following the BCL10 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
NRN1 neuritin 1 2.77914
OR51A7 olfactory receptor, family 51, subfamily A, member 7 2.77914
CX3CL1 chemokine (C-X3-C motif) ligand 1 2.77914
PRMT3 protein arginine methyltransferase 3 2.77914
NXPH3 neurexophilin 3 2.77914
ZEB2 zinc finger E-box binding homeobox 2 2.77914
TM4SF1 transmembrane 4 L six family member 1 2.77914
PCDHGB3 protocadherin gamma subfamily B, 3 2.77914
PEAR1 platelet endothelial aggregation receptor 1 2.77914
AFM afamin 2.77914
ASPDH aspartate dehydrogenase domain containing 2.77914
IGFL4 IGF-like family member 4 2.77914
LIPH lipase, member H 2.77914
WEE2 WEE1 homolog 2 (S. pombe) 2.77914
PIGZ phosphatidylinositol glycan anchor biosynthesis, class Z 2.77914
TMPRSS11D transmembrane protease, serine 11D 2.77914
IL4I1 interleukin 4 induced 1 2.77914
ZNF285 zinc finger protein 285 2.77914
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 2.77914
AGTR1 angiotensin II receptor, type 1 2.77914
PDE6A phosphodiesterase 6A, cGMP-specific, rod, alpha 2.77914
COLEC10 collectin sub-family member 10 (C-type lectin) 2.77914
NME8 NME/NM23 family member 8 2.77914
LMO2 LIM domain only 2 (rhombotin-like 1) 2.77914
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5 2.77914
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.77914
C1ORF146 chromosome 1 open reading frame 146 2.77914
KHDC3L KH domain containing 3-like, subcortical maternal complex member 2.77914
PSCA prostate stem cell antigen 2.77914
CPB2 carboxypeptidase B2 (plasma) 2.77914
DLX4 distal-less homeobox 4 2.77914
CCDC38 coiled-coil domain containing 38 2.77914
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.77914
S100A2 S100 calcium binding protein A2 2.77914
C11ORF87 chromosome 11 open reading frame 87 2.77914
REN renin 2.77914
DIRAS2 DIRAS family, GTP-binding RAS-like 2 2.77914
CSMD3 CUB and Sushi multiple domains 3 2.77914
EPHX4 epoxide hydrolase 4 2.77914
C6ORF58 chromosome 6 open reading frame 58 2.77914
HSD3B1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 2.77914
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 2.77914
GFAP glial fibrillary acidic protein 2.77914
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 2.77914
FNDC7 fibronectin type III domain containing 7 2.77914
NEU4 sialidase 4 2.77914
ABI3BP ABI family, member 3 (NESH) binding protein 2.77914
SPMIP11 sperm microtubule inner protein 11 2.77914
GOLGA6L7 golgin A6 family like 7 2.77914
GBP6 guanylate binding protein family, member 6 2.77914
CADM2 cell adhesion molecule 2 2.77914
GOLGA6L10 golgin A6 family-like 10 2.77914
RHCG Rh family, C glycoprotein 2.77914
FRG2C FSHD region gene 2 family, member C 2.77914
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa 2.77914
MUSTN1 musculoskeletal, embryonic nuclear protein 1 2.77914
LRTM3 leucine rich repeat transmembrane protein 3 2.77914
SQOR sulfide quinone oxidoreductase 2.77914
VSIR V-set immunoregulatory receptor 2.77914
GPRASP3 G protein-coupled receptor associated sorting protein family member 3 2.77914
SPMIP10 sperm microtubule inner protein 10 2.77914
SPMIP9 sperm microtubule inner protein 9 2.77914
PNMA6F PNMA family member 6F 2.77914
LRRC8C-DT LRRC8C divergent transcript 2.77914
RPS21-DT RPS21 divergent transcript 2.77914
H2BC4 H2B clustered histone 4 2.77914
C20ORF204 chromosome 20 open reading frame 204 2.77914
ACP7 acid phosphatase 7, tartrate resistant (putative) 2.77914
EZHIP EZH inhibitory protein 2.77914
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 2.77914
ASB4 ankyrin repeat and SOCS box containing 4 2.77914
ARMCX5-GPRASP2 ARMCX5-GPRASP2 readthrough 2.77914
C1ORF162 chromosome 1 open reading frame 162 2.77914
CXCL16 chemokine (C-X-C motif) ligand 16 2.77914
LDHAL6B lactate dehydrogenase A-like 6B 2.77914
ERVFRD-1 endogenous retrovirus group FRD, member 1 2.77914
IRF8 interferon regulatory factor 8 2.77914
CFAP99 cilia and flagella associated protein 99 2.77914
SLC35D3 solute carrier family 35, member D3 2.77914
ACTL8 actin-like 8 2.77914
CPNE5 copine V 2.77914
CDK3 cyclin-dependent kinase 3 2.77914
TLR2 toll-like receptor 2 2.77914
TLR7 toll-like receptor 7 2.77914
HTR3E 5-hydroxytryptamine (serotonin) receptor 3E, ionotropic 2.77914
ZNF680 zinc finger protein 680 2.77914
TAS1R1 taste receptor, type 1, member 1 2.77914
DDTL D-dopachrome tautomerase-like 2.77914
SAMD14 sterile alpha motif domain containing 14 2.77914
PGLYRP1 peptidoglycan recognition protein 1 2.77914
MS4A13 membrane-spanning 4-domains, subfamily A, member 13 2.77914
GJD3 gap junction protein, delta 3, 31.9kDa 2.77914
MYH11 myosin, heavy chain 11, smooth muscle 2.77914
HHEX hematopoietically expressed homeobox 2.77914
LPAR5 lysophosphatidic acid receptor 5 2.77914
MRLN myoregulin 2.77914
TCEA3 transcription elongation factor A (SII), 3 2.77914
CT55 cancer/testis antigen 55 2.77914
CRYBB3 crystallin, beta B3 2.77914
DCLK3 doublecortin-like kinase 3 2.77914
TDRD10 tudor domain containing 10 2.77914
C10ORF71 chromosome 10 open reading frame 71 2.77914
SPATA4 spermatogenesis associated 4 2.77914
MAMLD1 mastermind-like domain containing 1 2.77914
LRRC43 leucine rich repeat containing 43 2.77914
NPPA natriuretic peptide A 2.77914
ECM1 extracellular matrix protein 1 2.77914
KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase) 2.77914
OR13A1 olfactory receptor, family 13, subfamily A, member 1 2.77914
PKLR pyruvate kinase, liver and RBC 2.77914
CPO carboxypeptidase O 2.77914
ZP2 zona pellucida glycoprotein 2 (sperm receptor) 2.77914
C17ORF107 chromosome 17 open reading frame 107 2.77914
TIGIT T cell immunoreceptor with Ig and ITIM domains 2.77914
ALAS2 5'-aminolevulinate synthase 2 2.77914
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 2.77914
IL1A interleukin 1, alpha 2.77914
FBXL22 F-box and leucine-rich repeat protein 22 2.77914
GPR150 G protein-coupled receptor 150 2.77914
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.77914
OPTC opticin 2.77914
DDI1 DNA-damage inducible 1 homolog 1 (S. cerevisiae) 2.77914
HLA-DMB major histocompatibility complex, class II, DM beta 2.77914
MGP matrix Gla protein 2.77914
TM4SF19 transmembrane 4 L six family member 19 2.77914
NPY2R neuropeptide Y receptor Y2 2.77914
SYT5 synaptotagmin V 2.77914
LDLRAD2 low density lipoprotein receptor class A domain containing 2 2.77914
CCNI2 cyclin I family, member 2 2.77914
ZNF843 zinc finger protein 843 2.77914
MSR1 macrophage scavenger receptor 1 2.77914
HLA-DQA2 major histocompatibility complex, class II, DQ alpha 2 2.77914
MAML2 mastermind-like 2 (Drosophila) 2.77914
CTSF cathepsin F 2.77914
DAPL1 death associated protein-like 1 2.77914
OR4D1 olfactory receptor, family 4, subfamily D, member 1 2.77914
PSG9 pregnancy specific beta-1-glycoprotein 9 2.77914
MOS v-mos Moloney murine sarcoma viral oncogene homolog 2.77914
TRHR thyrotropin-releasing hormone receptor 2.77914
RGPD5 RANBP2-like and GRIP domain containing 5 2.77914
PRSS21 protease, serine, 21 (testisin) 2.77914
HRG histidine-rich glycoprotein 2.77914
FRMPD2 FERM and PDZ domain containing 2 2.77914
TPH1 tryptophan hydroxylase 1 2.77914
MEIG1 meiosis/spermiogenesis associated 1 2.77914
TGM3 transglutaminase 3 2.77914
EYA4 EYA transcriptional coactivator and phosphatase 4 2.77914
PGM5 phosphoglucomutase 5 2.77914
GPRC5A G protein-coupled receptor, class C, group 5, member A 2.77914
ASCL2 achaete-scute family bHLH transcription factor 2 2.77914
AHSG alpha-2-HS-glycoprotein 2.77914
RDH16 retinol dehydrogenase 16 (all-trans) 2.77914
AZU1 azurocidin 1 2.77914
BTBD19 BTB (POZ) domain containing 19 2.77914
AGBL4 ATP/GTP binding protein-like 4 2.77914
PCDHGA12 protocadherin gamma subfamily A, 12 2.77914
SPINK14 serine peptidase inhibitor, Kazal type 14 (putative) 2.77914
MYO16 myosin XVI 2.77914
LST1 leukocyte specific transcript 1 2.77914
OVCH2 ovochymase 2 (gene/pseudogene) 2.77914
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.77914
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 2.77914
WFDC10A WAP four-disulfide core domain 10A 2.77914
KIAA1755 KIAA1755 2.77914
EMCN endomucin 2.77914
LRRC31 leucine rich repeat containing 31 2.77914
BIN2 bridging integrator 2 2.77914
STAP1 signal transducing adaptor family member 1 2.77914
ITIH2 inter-alpha-trypsin inhibitor heavy chain 2 2.77914
MROH2A maestro heat-like repeat family member 2A 2.77914
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 2.68684
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1 2.67561
LECT2 leukocyte cell-derived chemotaxin 2 2.64517
NACAD NAC alpha domain containing 2.64517
SEC31B SEC31 homolog B (S. cerevisiae) 2.63872
MMP21 matrix metallopeptidase 21 2.59212
TAPBPL TAP binding protein-like 2.59212
NAT14 N-acetyltransferase 14 (GCN5-related, putative) 2.53342
MAP3K4-AS1 MAP3K4 antisense RNA 1 2.50564
BMP8B bone morphogenetic protein 8b 2.48093
PEMT phosphatidylethanolamine N-methyltransferase 2.39995
PDZD8 PDZ domain containing 8 2.38219
SLC16A13 solute carrier family 16, member 13 2.36532
MPIG6B megakaryocyte and platelet inhibitory receptor G6b 2.36532
REP15 RAB15 effector protein 2.36532
RRM2 ribonucleotide reductase M2 2.35595
C8ORF34 chromosome 8 open reading frame 34 2.35397
AIF1 allograft inflammatory factor 1 2.34119
RBM11 RNA binding motif protein 11 2.3269
ANO4 anoctamin 4 2.31803
AMIGO2 adhesion molecule with Ig-like domain 2 2.30746
GSTO2 glutathione S-transferase omega 2 2.30445
PYGO2 pygopus family PHD finger 2 2.29225
ZNG1E Zn regulated GTPase metalloprotein activator 1E 2.29225
CINP cyclin-dependent kinase 2 interacting protein 2.29207
MAP1LC3B2 microtubule-associated protein 1 light chain 3 beta 2 2.27836
DNAH14 dynein, axonemal, heavy chain 14 2.27707
ORMDL1 ORMDL sphingolipid biosynthesis regulator 1 2.20111
PLOD1 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 2.19302
TXLNG taxilin gamma 2.18805
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 2.18023
NPR1 natriuretic peptide receptor 1 2.16121
CA11 carbonic anhydrase XI 2.14487
PPP4R3B protein phosphatase 4 regulatory subunit 3B 2.14267
KCNT2 potassium channel, sodium activated subfamily T, member 2 2.13486
USP31 ubiquitin specific peptidase 31 2.09238
POP7 processing of precursor 7, ribonuclease P/MRP subunit (S. cerevisiae) 2.08866
SNX24 sorting nexin 24 2.06446

decreased expression

Symbol Name Standardized Value
TTLL9 tubulin tyrosine ligase-like family member 9 -2.77914
FSTL3 follistatin-like 3 (secreted glycoprotein) -2.77914
TNRC18 trinucleotide repeat containing 18 -2.77914
PEX11A peroxisomal biogenesis factor 11 alpha -2.77914
ARMCX6 armadillo repeat containing, X-linked 6 -2.77914
CARD14 caspase recruitment domain family, member 14 -2.77914
ENPP6 ectonucleotide pyrophosphatase/phosphodiesterase 6 -2.77914
CATSPERQ catsper channel auxiliary subunit theta -2.77914
EVPL envoplakin -2.77914
TAS2R30 taste receptor, type 2, member 30 -2.77914
PRB3 proline-rich protein BstNI subfamily 3 -2.77914
SH2D7 SH2 domain containing 7 -2.77914
SYTL5 synaptotagmin-like 5 -2.77914
SYNDIG1L synapse differentiation inducing 1-like -2.77914
GLIS1 GLIS family zinc finger 1 -2.77914
HMX2 H6 family homeobox 2 -2.77914
GRPR gastrin-releasing peptide receptor -2.77914
ZNF230 zinc finger protein 230 -2.77914
SLC23A1 solute carrier family 23 (ascorbic acid transporter), member 1 -2.77914
GPR20 G protein-coupled receptor 20 -2.77914
CD38 CD38 molecule -2.77914
GABRA2 gamma-aminobutyric acid (GABA) A receptor, alpha 2 -2.77914
KCNJ8 potassium channel, inwardly rectifying subfamily J, member 8 -2.77914
TCEANC transcription elongation factor A (SII) N-terminal and central domain containing -2.77914
GNA12 guanine nucleotide binding protein (G protein) alpha 12 -2.77914
CMKLR1 chemerin chemokine-like receptor 1 -2.77914
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -2.77914
NBPF10 neuroblastoma breakpoint family, member 10 -2.77914
GLB1L2 galactosidase, beta 1-like 2 -2.77914
POM121L2 POM121 transmembrane nucleoporin-like 2 -2.77914
SMIM17 small integral membrane protein 17 -2.77914
RNF208 ring finger protein 208 -2.77914
SPMIP6 sperm microtubule inner protein 6 -2.77914
ADCY10 adenylate cyclase 10 (soluble) -2.77914
CCDC177 coiled-coil domain containing 177 -2.77914
LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 -2.77914
SCIMP SLP adaptor and CSK interacting membrane protein -2.77914
CALHM2 calcium homeostasis modulator 2 -2.77914
PGF placental growth factor -2.77914
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit -2.77914
DXO decapping exoribonuclease -2.77914
TIGD6 tigger transposable element derived 6 -2.77914
KLF4 Kruppel-like factor 4 (gut) -2.77914
CAMK2A calcium/calmodulin-dependent protein kinase II alpha -2.77914
ALPK3 alpha-kinase 3 -2.74021
TLE2 transducin-like enhancer of split 2 -2.65465
RHBDL1 rhomboid, veinlet-like 1 (Drosophila) -2.65465
USP27X ubiquitin specific peptidase 27, X-linked -2.65465
USF1 upstream transcription factor 1 -2.65465
DUSP22 dual specificity phosphatase 22 -2.57457
ADH4 alcohol dehydrogenase 4 (class II), pi polypeptide -2.57457
GSTM4 glutathione S-transferase mu 4 -2.57457
ZNF160 zinc finger protein 160 -2.55564
ING4 inhibitor of growth family, member 4 -2.50254
NSRP1 nuclear speckle splicing regulatory protein 1 -2.45993
MACROH2A1 macroH2A.1 histone -2.45794
C7ORF25 chromosome 7 open reading frame 25 -2.45791
SERTAD4 SERTA domain containing 4 -2.45791
PLAAT5 phospholipase A and acyltransferase 5 -2.45791
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.45791
ARHGAP33 Rho GTPase activating protein 33 -2.45047
PACSIN1 protein kinase C and casein kinase substrate in neurons 1 -2.37516
EXOC8 exocyst complex component 8 -2.37011
FUCA1 fucosidase, alpha-L- 1, tissue -2.37011
NXPE3 neurexophilin and PC-esterase domain family, member 3 -2.35595
GLMN glomulin, FKBP associated protein -2.34119
PFKP phosphofructokinase, platelet -2.33839
CDCA7L cell division cycle associated 7-like -2.33839
SMYD2 SET and MYND domain containing 2 -2.31997
WRAP53 WD repeat containing, antisense to TP53 -2.31997
DVL1 dishevelled segment polarity protein 1 -2.31803
MAP3K15 mitogen-activated protein kinase kinase kinase 15 -2.31607
MIF4GD MIF4G domain containing -2.30981
SPRY2 sprouty homolog 2 (Drosophila) -2.29207
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 -2.27707
LZTS1 leucine zipper, putative tumor suppressor 1 -2.25922
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2 -2.24827
CCDC102A coiled-coil domain containing 102A -2.24367
LOC107985101 uncharacterized LOC107985101 -2.24367
ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 -2.24367
MTHFSD methenyltetrahydrofolate synthetase domain containing -2.24009
GON4L gon-4-like (C. elegans) -2.23241
ANKRD54 ankyrin repeat domain 54 -2.22455
PIGV phosphatidylinositol glycan anchor biosynthesis, class V -2.22384
CDIP1 cell death-inducing p53 target 1 -2.19302
RPS28 ribosomal protein S28 -2.19063
ENTPD4 ectonucleoside triphosphate diphosphohydrolase 4 -2.16136
HASPIN histone H3 associated protein kinase -2.14564
HHLA1 HERV-H LTR-associating 1 -2.14487
GABARAPL1 GABA(A) receptor-associated protein like 1 -2.14267
COL12A1 collagen, type XII, alpha 1 -2.13486
GNAS GNAS complex locus -2.13304
TICAM2 toll-like receptor adaptor molecule 2 -2.12489
SOGA3 SOGA family member 3 -2.12455
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -2.05835
RNF150 ring finger protein 150 -2.05279
TRIM21 tripartite motif containing 21 -2.03647
PHC2 polyhomeotic homolog 2 (Drosophila) -2.03051
C8ORF82 chromosome 8 open reading frame 82 -2.02502
CHM choroideremia (Rab escort protein 1) -2.02502
PACS1 phosphofurin acidic cluster sorting protein 1 -2.01695
ALKBH8 alkB, alkylation repair homolog 8 (E. coli) -2.01462
EIF4A2 eukaryotic translation initiation factor 4A2 -2.01191
ZNF106 zinc finger protein 106 -2.00567