BCL10 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description B-cell CLL/lymphoma 10|This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 8915)
External Link http://www.ncbi.nlm.nih.gov/gene/8915
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Genes

60 interacting proteins for BCL10 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
ATM ATM serine/threonine kinase
BCL3 B-cell CLL/lymphoma 3
BIRC2 baculoviral IAP repeat containing 2
BIRC3 baculoviral IAP repeat containing 3
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
C9ORF89 chromosome 9 open reading frame 89
CAMK2G calcium/calmodulin-dependent protein kinase II gamma
CARD10 caspase recruitment domain family, member 10
CARD11 caspase recruitment domain family, member 11
CARD14 caspase recruitment domain family, member 14
CARD9 caspase recruitment domain family, member 9
CASP8 caspase 8, apoptosis-related cysteine peptidase
CASP9 caspase 9, apoptosis-related cysteine peptidase
CDK9 cyclin-dependent kinase 9
CHUK conserved helix-loop-helix ubiquitous kinase
COPS5 COP9 signalosome subunit 5
CSNK1A1 casein kinase 1, alpha 1
DPP4 dipeptidyl-peptidase 4
ELAVL1 ELAV like RNA binding protein 1
FYB FYN binding protein
HIST1H2BF histone cluster 1, H2bf
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IL15RA interleukin 15 receptor, alpha
IRAK1 interleukin-1 receptor-associated kinase 1
KRT33B keratin 33B, type I
MALT1 MALT1 paracaspase
MAP2K7 mitogen-activated protein kinase kinase 7
MAP3K7 mitogen-activated protein kinase kinase kinase 7
MAPK9 mitogen-activated protein kinase 9
MIB2 mindbomb E3 ubiquitin protein ligase 2
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NLRC4 NLR family, CARD domain containing 4
NRF1 nuclear respiratory factor 1
PELI2 pellino E3 ubiquitin protein ligase family member 2
PRKCQ protein kinase C, theta
PRRG4 proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
PYCARD PYD and CARD domain containing
RIPK2 receptor-interacting serine-threonine kinase 2
RNF168 ring finger protein 168, E3 ubiquitin protein ligase
RNF8 ring finger protein 8, E3 ubiquitin protein ligase
RPS27A ribosomal protein S27a
SLC20A1 solute carrier family 20 (phosphate transporter), member 1
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SOCS3 suppressor of cytokine signaling 3
SRSF1 serine/arginine-rich splicing factor 1
TLR4 toll-like receptor 4
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A
TRADD TNFRSF1A-associated via death domain
TRAF2 TNF receptor-associated factor 2
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase
UBC ubiquitin C
UBE2N ubiquitin-conjugating enzyme E2N
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2
USHBP1 Usher syndrome 1C binding protein 1
USP9X ubiquitin specific peptidase 9, X-linked
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase