BCL11B Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description B-cell CLL/lymphoma 11B (zinc finger protein)|This gene encodes a C2H2-type zinc finger protein and is closely related to BCL11A, a gene whose translocation may be associated with B-cell malignancies. Although the specific function of this gene has not been determined, the encoded protein is known to be a transcriptional repressor, and is regulated by the NURD nucleosome remodeling and histone deacetylase complex. Four alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Aug 2013] (NCBI Entrez Gene Database, 64919)
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Genes

322 genes differentially expressed following the BCL11B gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
SCN2B sodium channel, voltage gated, type II beta subunit 4.15988
DMRTC1B DMRT-like family C1B 4.15988
GFAP glial fibrillary acidic protein 4.15988
SSMEM1 serine-rich single-pass membrane protein 1 4.15988
LILRB3 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3 4.15988
ASB10 ankyrin repeat and SOCS box containing 10 4.15988
TUBB1 tubulin, beta 1 class VI 4.15988
BRINP3 bone morphogenetic protein/retinoic acid inducible neural-specific 3 4.15988
UBE2U ubiquitin-conjugating enzyme E2U (putative) 4.15988
DSG4 desmoglein 4 4.15988
WT1 Wilms tumor 1 4.15988
CCDC68 coiled-coil domain containing 68 4.15988
SPAM1 sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding) 4.15988
IL22RA1 interleukin 22 receptor, alpha 1 4.15988
MUC1 mucin 1, cell surface associated 4.15988
FOXA1 forkhead box A1 4.15988
TM4SF1 transmembrane 4 L six family member 1 4.15988
PNMA5 paraneoplastic Ma antigen family member 5 4.15988
TCHH trichohyalin 4.15988
OR10A6 olfactory receptor, family 10, subfamily A, member 6 (gene/pseudogene) 4.15988
ADAMTSL2 ADAMTS-like 2 4.15988
BHLHE40 basic helix-loop-helix family, member e40 4.15988
VCX variable charge, X-linked 4.15988
SPACA5 sperm acrosome associated 5 4.15988
ITIH1 inter-alpha-trypsin inhibitor heavy chain 1 4.15988
SLC22A9 solute carrier family 22 (organic anion transporter), member 9 4.15988
ACRBP acrosin binding protein 4.15988
HRG histidine-rich glycoprotein 4.15988
MNX1 motor neuron and pancreas homeobox 1 4.15988
OR14A2 olfactory receptor, family 14, subfamily A, member 2 4.15988
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 4.15988
MMP20 matrix metallopeptidase 20 4.15988
B3GNT6 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6 4.15988
GMFG glia maturation factor, gamma 4.15988
LCN10 lipocalin 10 4.15988
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 4.15988
CPB1 carboxypeptidase B1 (tissue) 4.15988
DLX4 distal-less homeobox 4 4.15988
PRSS36 protease, serine, 36 4.15988
GMNC geminin coiled-coil domain containing 4.15988
HEPHL1 hephaestin-like 1 4.15988
ANGPTL3 angiopoietin-like 3 4.15988
ZNF492 zinc finger protein 492 4.15988
LOC124901449 uncharacterized LOC124901449 4.15988
RTL5 retrotransposon Gag like 5 4.15988
TMEM275 transmembrane protein 275 4.15988
EIF2S3B eukaryotic translation initiation factor 2 subunit gamma B 4.15988
GBP4 guanylate binding protein 4 4.15988
OPRM1 opioid receptor, mu 1 4.15988
OTOR otoraplin 4.15988
SRGN serglycin 4.15988
PDC phosducin 4.15988
DIPK1C divergent protein kinase domain 1C 4.15988
PPP4R3C protein phosphatase 4 regulatory subunit 3C 4.15988
DNAAF6 dynein axonemal assembly factor 6 4.15988
LOC124906892 uncharacterized LOC124906892 4.15988
LRTM3 leucine rich repeat transmembrane protein 3 4.15988
CATSPERQ catsper channel auxiliary subunit theta 4.15988
PNMA6F PNMA family member 6F 4.15988
LY6S-AS1 LY6S antisense RNA 1 4.15988
CSP2 CS pseudogene 2 4.15988
C1ORF232 chromosome 1 open reading frame 230 4.15988
IQCN IQ motif containing N 4.15988
C1QTNF9B C1q and tumor necrosis factor related protein 9B 4.15988
SAG S-antigen; retina and pineal gland (arrestin) 4.15988
GOLGA6L2 golgin A6 family-like 2 4.15988
NXPE4 neurexophilin and PC-esterase domain family, member 4 4.15988
ZNF436 zinc finger protein 436 4.15988
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 4.15988
ISM2 isthmin 2 4.15988
KBTBD13 kelch repeat and BTB (POZ) domain containing 13 4.15988
TSSK4 testis-specific serine kinase 4 4.15988
HLX H2.0-like homeobox 4.15988
CD79A CD79a molecule, immunoglobulin-associated alpha 4.15988
OVOL3 ovo-like zinc finger 3 4.15988
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3 4.15988
SRPK3 SRSF protein kinase 3 4.15988
XKRX XK, Kell blood group complex subunit-related, X-linked 4.15988
IMPG1 interphotoreceptor matrix proteoglycan 1 4.15988
LTA lymphotoxin alpha 4.15988
PLEK2 pleckstrin 2 4.15988
ALG10B ALG10B, alpha-1,2-glucosyltransferase 4.15988
C7ORF57 chromosome 7 open reading frame 57 4.15988
SASH3 SAM and SH3 domain containing 3 4.15988
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 4.15988
PF4V1 platelet factor 4 variant 1 4.15988
CHIT1 chitinase 1 (chitotriosidase) 4.15988
LMOD2 leiomodin 2 (cardiac) 4.15988
CAGE1 cancer antigen 1 4.15988
IRGM immunity-related GTPase family, M 4.15988
APOC4 apolipoprotein C-IV 4.15988
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 4.15988
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 4.15988
AKNAD1 AKNA domain containing 1 4.15988
ADAM2 ADAM metallopeptidase domain 2 4.15988
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 4.15988
CDHR5 cadherin-related family member 5 4.15988
C11ORF96 chromosome 11 open reading frame 96 4.15988
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 4.15988
EDN2 endothelin 2 4.15988
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 4.15988
TCEA3 transcription elongation factor A (SII), 3 4.15988
PALMD palmdelphin 4.15988
SEC14L3 SEC14-like 3 (S. cerevisiae) 4.15988
KISS1 KiSS-1 metastasis-suppressor 4.15988
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 4.15988
GOLGA8K golgin A8 family, member K 4.15988
CNGB1 cyclic nucleotide gated channel beta 1 4.15988
CLEC18B C-type lectin domain family 18, member B 4.15988
DKK1 dickkopf WNT signaling pathway inhibitor 1 4.15988
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 4.15988
CTRB1 chymotrypsinogen B1 4.15988
PENK proenkephalin 4.15988
CRHBP corticotropin releasing hormone binding protein 4.15988
SYNGR4 synaptogyrin 4 4.15988
B4GALNT1 beta-1,4-N-acetyl-galactosaminyl transferase 1 4.15988
SLC4A1 solute carrier family 4 (anion exchanger), member 1 (Diego blood group) 4.15988
LOC124901872 uncharacterized LOC124901872 4.15988
IGF2 insulin-like growth factor 2 4.15988
COL6A5 collagen, type VI, alpha 5 4.15988
CNGB3 cyclic nucleotide gated channel beta 3 4.15988
PLA2G4E phospholipase A2, group IVE 4.15988
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 4.15988
IFNE interferon, epsilon 4.15988
MT1M metallothionein 1M 4.15988
PPY pancreatic polypeptide 4.15988
OR14A16 olfactory receptor, family 14, subfamily A, member 16 4.15988
XCR1 chemokine (C motif) receptor 1 4.15988
GRAPL GRB2-related adaptor protein-like 4.15988
LST1 leukocyte specific transcript 1 4.15988
RERGL RERG/RAS-like 4.15988
PATE2 prostate and testis expressed 2 4.15988
AQP10 aquaporin 10 4.15988
SLC51B solute carrier family 51, beta subunit 4.15988
MSANTD1 Myb/SANT-like DNA-binding domain containing 1 4.15988
HTR4 5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled 4.15988
SPNS3 spinster homolog 3 (Drosophila) 4.15988
CCNO cyclin O 4.15988
AGBL4 ATP/GTP binding protein-like 4 4.15988
BIN2 bridging integrator 2 4.15988
RTN4RL1 reticulon 4 receptor-like 1 4.15988
GPR87 G protein-coupled receptor 87 4.09593
IDNK idnK, gluconokinase homolog (E. coli) 3.73155
SCTR secretin receptor 3.37871
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 3.37454
SNRK SNF related kinase 3.21255
FOXI3 forkhead box I3 3.19851
METTL15 methyltransferase like 15 3.19851
CCL25 chemokine (C-C motif) ligand 25 3.19851
NCR3LG1 natural killer cell cytotoxicity receptor 3 ligand 1 3.19851
FOXP2 forkhead box P2 3.19851
PALD1 phosphatase domain containing, paladin 1 3.18423
PPFIA3 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 3 3.04759
ANKRD52 ankyrin repeat domain 52 2.81712
ZSCAN32 zinc finger and SCAN domain containing 32 2.79034
RBMXL1 RNA binding motif protein, X-linked-like 1 2.71138
SMIM3 small integral membrane protein 3 2.68551
GON4L gon-4-like (C. elegans) 2.59647
WDR72 WD repeat domain 72 2.55447
FHIP1B FHF complex subunit HOOK interacting protein 1B 2.50122
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.4713
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2.41797
TEX261 testis expressed 261 2.40719
PAQR9 progestin and adipoQ receptor family member IX 2.38736
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 2.38736
B4GALNT4 beta-1,4-N-acetyl-galactosaminyl transferase 4 2.36676
SHOX short stature homeobox 2.34624
CDHR4 cadherin-related family member 4 2.34438
GGT1 gamma-glutamyltransferase 1 2.28982
RBM33 RNA binding motif protein 33 2.26554
FNDC4 fibronectin type III domain containing 4 2.25095
SON SON DNA binding protein 2.24422
TYW3 tRNA-yW synthesizing protein 3 homolog (S. cerevisiae) 2.22391
PEX5L peroxisomal biogenesis factor 5-like 2.15378
GGA1 golgi-associated, gamma adaptin ear containing, ARF binding protein 1 2.14288
ARMCX2 armadillo repeat containing, X-linked 2 2.13199
FASTKD1 FAST kinase domains 1 2.12878
RAD51C RAD51 paralog C 2.1272
NR2C2 nuclear receptor subfamily 2, group C, member 2 2.12274
OPA1 optic atrophy 1 (autosomal dominant) 2.09181
MYO10 myosin X 2.0863
METTL9 methyltransferase like 9 2.08478
TOB1 transducer of ERBB2, 1 2.07943
LPCAT2 lysophosphatidylcholine acyltransferase 2 2.07349
CAPN5 calpain 5 2.06206
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 2.06047
ZNF510 zinc finger protein 510 2.05161
PKNOX2 PBX/knotted 1 homeobox 2 2.04921
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2.04858
KIF15 kinesin family member 15 2.04684
CCDC3 coiled-coil domain containing 3 2.04309
EXD2 exonuclease 3'-5' domain containing 2 2.04309
ANP32A acidic (leucine-rich) nuclear phosphoprotein 32 family, member A 2.02726
ATP2A3 ATPase, Ca++ transporting, ubiquitous 2.02708
STARD10 StAR-related lipid transfer (START) domain containing 10 2.02612
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2.02612
RMI2 RecQ mediated genome instability 2 2.02375
KCNK2 potassium channel, two pore domain subfamily K, member 2 2.02375
SLC49A3 solute carrier family 49 member 3 2.02375
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 2.02375
ASB2 ankyrin repeat and SOCS box containing 2 2.02375
CRTC1 CREB regulated transcription coactivator 1 2.0117

decreased expression

Symbol Name Standardized Value
FMO5 flavin containing monooxygenase 5 -4.15988
HYAL3 hyaluronoglucosaminidase 3 -4.15988
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -4.15988
STAB2 stabilin 2 -4.15988
NBPF10 neuroblastoma breakpoint family, member 10 -4.15988
TLR2 toll-like receptor 2 -4.15988
FLNC filamin C, gamma -4.15988
ZFP3 ZFP3 zinc finger protein -4.02641
ARG1 arginase 1 -4.02641
OR8D4 olfactory receptor, family 8, subfamily D, member 4 -4.02641
ITK IL2-inducible T-cell kinase -4.02641
GABRB2 gamma-aminobutyric acid (GABA) A receptor, beta 2 -4.02641
LDHAL6A lactate dehydrogenase A-like 6A -4.02641
ZNF99 zinc finger protein 99 -4.02641
IRX3 iroquois homeobox 3 -4.02641
RNASE6 ribonuclease, RNase A family, k6 -4.02641
SGCA sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein) -4.02641
NWD1 NACHT and WD repeat domain containing 1 -4.02641
LRRC63 leucine rich repeat containing 63 -4.02641
RASA4B RAS p21 protein activator 4B -4.02641
ASCL2 achaete-scute family bHLH transcription factor 2 -4.02641
LHCGR luteinizing hormone/choriogonadotropin receptor -4.02641
TRIM55 tripartite motif containing 55 -4.02641
APBB3 amyloid beta (A4) precursor protein-binding, family B, member 3 -4.02641
OSTN osteocrin -4.02641
CD28 CD28 molecule -4.02641
CSDC2 cold shock domain containing C2, RNA binding -4.02641
MYH7B myosin, heavy chain 7B, cardiac muscle, beta -4.02641
SLC25A34 solute carrier family 25, member 34 -4.02641
H3C14 H3 clustered histone 14 -4.02641
GPR146 G protein-coupled receptor 146 -4.02641
SYT15B synaptotagmin 15B -4.02641
OTP orthopedia homeobox -4.02641
UPK1A uroplakin 1A -4.02641
MYL10 myosin, light chain 10, regulatory -4.02641
GTF2A1L general transcription factor IIA, 1-like -4.02641
TTC16 tetratricopeptide repeat domain 16 -4.02641
TMPRSS4 transmembrane protease, serine 4 -4.02641
PLCZ1 phospholipase C, zeta 1 -4.02641
SPEF2 sperm flagellar 2 -4.02641
H4C6 H4 clustered histone 6 -3.89281
H2BC8 H2B clustered histone 8 -3.89281
RFXAP regulatory factor X-associated protein -3.68603
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -3.37871
BCORL1 BCL6 corepressor-like 1 -3.37871
C18ORF32 chromosome 18 open reading frame 32 -3.36013
RAB40B RAB40B, member RAS oncogene family -3.33227
PDK2 pyruvate dehydrogenase kinase, isozyme 2 -3.19851
SUMO1 small ubiquitin-like modifier 1 -3.13592
LOC124904942 uncharacterized LOC124904942 -3.13577
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7 -3.01753
NADSYN1 NAD synthetase 1 -2.99529
DEF6 differentially expressed in FDCP 6 homolog (mouse) -2.95592
MED30 mediator complex subunit 30 -2.93459
NAT2 N-acetyltransferase 2 (arylamine N-acetyltransferase) -2.78046
PLA2G4B phospholipase A2, group IVB (cytosolic) -2.78046
TIGD6 tigger transposable element derived 6 -2.78046
HCLS1 hematopoietic cell-specific Lyn substrate 1 -2.78046
ZSCAN22 zinc finger and SCAN domain containing 22 -2.78046
SV2B synaptic vesicle glycoprotein 2B -2.78046
TNS2 tensin 2 -2.78046
EPSTI1 epithelial stromal interaction 1 (breast) -2.78046
ZNF215 zinc finger protein 215 -2.77737
OR3A2 olfactory receptor, family 3, subfamily A, member 2 -2.77737
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -2.74182
KRABD3 KRAB domain containing 3 -2.67029
NOL4 nucleolar protein 4 -2.65843
FICD FIC domain containing -2.63481
CILP2 cartilage intermediate layer protein 2 -2.59663
KIAA1671 KIAA1671 -2.57476
LRP5 low density lipoprotein receptor-related protein 5 -2.46221
ADAM22 ADAM metallopeptidase domain 22 -2.45122
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) -2.44516
LIMK1 LIM domain kinase 1 -2.4444
NDUFA5 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 5 -2.38834
TNPO1 transportin 1 -2.37324
SELENBP1 selenium binding protein 1 -2.35956
SEC61B Sec61 beta subunit -2.35177
LRRC45 leucine rich repeat containing 45 -2.33923
H2BC17 H2B clustered histone 17 -2.29703
SMARCA2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 -2.2964
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) -2.27053
CDNF cerebral dopamine neurotrophic factor -2.26554
WBP2NL WBP2 N-terminal like -2.26554
AQP5 aquaporin 5 -2.26554
TMEM221 transmembrane protein 221 -2.26554
UQCC5 ubiquinol-cytochrome c reductase complex assembly factor 5 -2.25489
ATXN1L ataxin 1-like -2.25133
GABRQ gamma-aminobutyric acid (GABA) A receptor, theta -2.25133
TMEM117 transmembrane protein 117 -2.24679
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta -2.23429
DPY19L1 dpy-19-like 1 (C. elegans) -2.21137
HFE hemochromatosis -2.2083
CEP55 centrosomal protein 55kDa -2.198
LRRC39 leucine rich repeat containing 39 -2.19759
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) -2.19759
ASIC1 acid sensing (proton gated) ion channel 1 -2.19759
PCYT2 phosphate cytidylyltransferase 2, ethanolamine -2.16912
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 -2.15081
DIO2 deiodinase, iodothyronine, type II -2.13773
MKX mohawk homeobox -2.13773
NAV1 neuron navigator 1 -2.13163
CCNB2 cyclin B2 -2.12915
PDE1A phosphodiesterase 1A, calmodulin-dependent -2.12878
ZC3H11A zinc finger CCCH-type containing 11A -2.12274
CASR calcium-sensing receptor -2.12274
NHLH2 nescient helix loop helix 2 -2.12274
PDLIM4 PDZ and LIM domain 4 -2.09975
CCDC91 coiled-coil domain containing 91 -2.05917
MAST2 microtubule associated serine/threonine kinase 2 -2.05872
ZNF577 zinc finger protein 577 -2.05232
CTPS1 CTP synthase 1 -2.05161
PDHX pyruvate dehydrogenase complex, component X -2.04713
IRF1 interferon regulatory factor 1 -2.0301
PSMD8 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 -2.02726
ASXL2 additional sex combs like transcriptional regulator 2 -2.02612
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -2.02375
WNK2 WNK lysine deficient protein kinase 2 -2.02375
RAB17 RAB17, member RAS oncogene family -2.02375
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -2.02375