BCL2 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description B-cell CLL/lymphoma 2|This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 596)
External Link http://www.ncbi.nlm.nih.gov/gene/596
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Genes

128 interacting proteins for BCL2 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1
AKT1 v-akt murine thymoma viral oncogene homolog 1
AMBRA1 autophagy/beclin-1 regulator 1
ATG12 autophagy related 12
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
AVEN apoptosis, caspase activation inhibitor
BAD BCL2-associated agonist of cell death
BAG1 BCL2-associated athanogene
BAG3 BCL2-associated athanogene 3
BAG4 BCL2-associated athanogene 4
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCAP31 B-cell receptor-associated protein 31
BCL2L1 BCL2-like 1
BCL2L10 BCL2-like 10 (apoptosis facilitator)
BCL2L11 BCL2-like 11 (apoptosis facilitator)
BCL2L14 BCL2-like 14 (apoptosis facilitator)
BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough
BCLAF1 BCL2-associated transcription factor 1
BECN1 beclin 1, autophagy related
BECN2 beclin 2
BFAR bifunctional apoptosis regulator
BID BH3 interacting domain death agonist
BIK BCL2-interacting killer (apoptosis-inducing)
BLID BH3-like motif containing, cell death inducer
BLK BLK proto-oncogene, Src family tyrosine kinase
BMF Bcl2 modifying factor
BNIP1 BCL2/adenovirus E1B 19kDa interacting protein 1
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BNIPL BCL2/adenovirus E1B 19kD interacting protein like
BRCA1 breast cancer 1, early onset
CALR calreticulin
CAPN2 calpain 2, (m/II) large subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP8 caspase 8, apoptosis-related cysteine peptidase
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CHUK conserved helix-loop-helix ubiquitous kinase
CISD2 CDGSH iron sulfur domain 2
CPT1A carnitine palmitoyltransferase 1A (liver)
CRYAB crystallin, alpha B
CUL3 cullin 3
CYCS cytochrome c, somatic
DAPK1 death-associated protein kinase 1
DYNLL1 dynein, light chain, LC8-type 1
EPHB2 EPH receptor B2
FKBP8 FK506 binding protein 8, 38kDa
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
HRAS Harvey rat sarcoma viral oncogene homolog
HRK harakiri, BCL2 interacting protein
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA1B heat shock 70kDa protein 1B
HSPA9 heat shock 70kDa protein 9 (mortalin)
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
IRS1 insulin receptor substrate 1
IRS2 insulin receptor substrate 2
ITM2B integral membrane protein 2B
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KEAP1 kelch-like ECH-associated protein 1
KRAS Kirsten rat sarcoma viral oncogene homolog
LMNB1 lamin B1
MAPK1 mitogen-activated protein kinase 1
MAPK11 mitogen-activated protein kinase 11
MAPK14 mitogen-activated protein kinase 14
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MCL1 myeloid cell leukemia 1
MDM4 MDM4, p53 regulator
MEX3D mex-3 RNA binding family member D
MOAP1 modulator of apoptosis 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAF1 nuclear assembly factor 1 ribonucleoprotein
NLRP1 NLR family, pyrin domain containing 1
NMT2 N-myristoyltransferase 2
NR4A1 nuclear receptor subfamily 4, group A, member 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PARK2 parkin RBR E3 ubiquitin protein ligase
PARP1 poly (ADP-ribose) polymerase 1
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PKMYT1 protein kinase, membrane associated tyrosine/threonine 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PML promyelocytic leukemia
PPID peptidylprolyl isomerase D
PPIF peptidylprolyl isomerase F
PPP1CA protein phosphatase 1, catalytic subunit, alpha isozyme
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme
PPP2CA protein phosphatase 2, catalytic subunit, alpha isozyme
PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
PPP2R5A protein phosphatase 2, regulatory subunit B', alpha
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKCA protein kinase C, alpha
PSEN1 presenilin 1
PTK2 protein tyrosine kinase 2
PXN paxillin
PYCARD PYD and CARD domain containing
RAD9A RAD9 homolog A (S. pombe)
RAF1 Raf-1 proto-oncogene, serine/threonine kinase
RBX1 ring-box 1, E3 ubiquitin protein ligase
RHEB Ras homolog enriched in brain
RRAS related RAS viral (r-ras) oncogene homolog
RTN4 reticulon 4
SERPINB8 serpin peptidase inhibitor, clade B (ovalbumin), member 8
SF1 splicing factor 1
SIVA1 SIVA1, apoptosis-inducing factor
SMN2 survival of motor neuron 2, centromeric
SOD1 superoxide dismutase 1, soluble
SPNS1 spinster homolog 1 (Drosophila)
SQSTM1 sequestosome 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TP53 tumor protein p53
TP53AIP1 tumor protein p53 regulated apoptosis inducing protein 1
TP53BP2 tumor protein p53 binding protein 2
UBC ubiquitin C
UVRAG UV radiation resistance associated
VDAC1 voltage-dependent anion channel 1
VRK2 vaccinia related kinase 2