BCL2L1 Gene Set

Dataset MSigDB Cancer Gene Co-expression Modules
Category transcriptomics
Type co-expressed gene
Description BCL2-like 1|The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Two alternatively spliced transcript variants, which encode distinct isoforms, have been reported. The longer isoform acts as an apoptotic inhibitor and the shorter form acts as an apoptotic activator. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 598)
External Link http://www.broadinstitute.org/gsea/msigdb/cards/GCM_BCL2L1
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Genes

35 co-expressed genes for BCL2L1 from the MSigDB Cancer Gene Co-expression Modules dataset.

Symbol Name
AAAS achalasia, adrenocortical insufficiency, alacrimia
ASB3 ankyrin repeat and SOCS box containing 3
BAZ2A bromodomain adjacent to zinc finger domain, 2A
BCL2L1 BCL2-like 1
BOD1L1 biorientation of chromosomes in cell division 1-like 1
BRPF3 bromodomain and PHD finger containing, 3
CHTOP chromatin target of PRMT1
COMMD9 COMM domain containing 9
CS citrate synthase
CSRNP2 cysteine-serine-rich nuclear protein 2
DFFA DNA fragmentation factor, 45kDa, alpha polypeptide
EPT1 ethanolaminephosphotransferase 1
FOXO3 forkhead box O3
GSPT1 G1 to S phase transition 1
GTPBP1 GTP binding protein 1
ISCA1 iron-sulfur cluster assembly 1
KDM3B lysine (K)-specific demethylase 3B
MEPCE methylphosphate capping enzyme
NF2 neurofibromin 2 (merlin)
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
PAFAH1B2 platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (30kDa)
PHF2 PHD finger protein 2
PRKRA protein kinase, interferon-inducible double stranded RNA dependent activator
PRRC2B proline-rich coiled-coil 2B
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1
RAN RAN, member RAS oncogene family
RNF41 ring finger protein 41, E3 ubiquitin protein ligase
RTN4 reticulon 4
TAF9B TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31kDa
TMEM120A transmembrane protein 120A
TNPO2 transportin 2
TRIM33 tripartite motif containing 33
UBE2E3 ubiquitin-conjugating enzyme E2E 3
WNK1 WNK lysine deficient protein kinase 1
ZNF529 zinc finger protein 529