BCL2L11 Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description BCL2-like 11 (apoptosis facilitator)|The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jun 2013] (NCBI Entrez Gene Database, 10018)
External Link http://www.ncbi.nlm.nih.gov/gene/10018
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Genes

54 interacting proteins for BCL2L11 from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
AKT1 v-akt murine thymoma viral oncogene homolog 1
APP amyloid beta (A4) precursor protein
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
AURKA aurora kinase A
AURKB aurora kinase B
BAD BCL2-associated agonist of cell death
BAG3 BCL2-associated athanogene 3
BAK1 BCL2-antagonist/killer 1
BAX BCL2-associated X protein
BBC3 BCL2 binding component 3
BCL2 B-cell CLL/lymphoma 2
BCL2A1 BCL2-related protein A1
BCL2L1 BCL2-like 1
BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough
BID BH3 interacting domain death agonist
BTK Bruton agammaglobulinemia tyrosine kinase
BTRC beta-transducin repeat containing E3 ubiquitin protein ligase
CASP3 caspase 3, apoptosis-related cysteine peptidase
CD302 CD302 molecule
CDK1 cyclin-dependent kinase 1
CISH cytokine inducible SH2-containing protein
CUL2 cullin 2
DYNLL1 dynein, light chain, LC8-type 1
DYNLL2 dynein, light chain, LC8-type 2
DYNLRB1 dynein, light chain, roadblock-type 1
FBXW11 F-box and WD repeat domain containing 11
FEM1C fem-1 homolog c (C. elegans)
FGL1 fibrinogen-like 1
GNB2L1 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1
GTF2I general transcription factor IIi
HSPA4 heat shock 70kDa protein 4
MAPK1 mitogen-activated protein kinase 1
MAPK10 mitogen-activated protein kinase 10
MAPK3 mitogen-activated protein kinase 3
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MCL1 myeloid cell leukemia 1
MEX3D mex-3 RNA binding family member D
MIF macrophage migration inhibitory factor (glycosylation-inhibiting factor)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NDRG1 N-myc downstream regulated 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
RIOK3 RIO kinase 3
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast)
TRIM2 tripartite motif containing 2
UBC ubiquitin C
UBQLN2 ubiquilin 2
VDAC1 voltage-dependent anion channel 1
VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta