BCL3 Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description B-cell CLL/lymphoma 3|This gene is a proto-oncogene candidate. It is identified by its translocation into the immunoglobulin alpha-locus in some cases of B-cell leukemia. The protein encoded by this gene contains seven ankyrin repeats, which are most closely related to those found in I kappa B proteins. This protein functions as a transcriptional co-activator that activates through its association with NF-kappa B homodimers. The expression of this gene can be induced by NF-kappa B, which forms a part of the autoregulatory loop that controls the nuclear residence of p50 NF-kappa B. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 602)
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Genes

356 genes differentially expressed following the BCL3 gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
COL19A1 collagen, type XIX, alpha 1 3.49914
DDN dendrin 3.49914
CCNB3 cyclin B3 3.49914
TBX18 T-box 18 3.49914
UCP3 uncoupling protein 3 (mitochondrial, proton carrier) 3.49914
PAX3 paired box 3 3.49914
PAX5 paired box 5 3.49914
MEI1 meiosis inhibitor 1 3.49914
FOLR3 folate receptor 3 (gamma) 3.49914
GABRA4 gamma-aminobutyric acid (GABA) A receptor, alpha 4 3.49914
HORMAD1 HORMA domain containing 1 3.49914
SLC35G6 solute carrier family 35, member G6 3.49914
RAX retina and anterior neural fold homeobox 3.49914
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 3.49914
AGTR1 angiotensin II receptor, type 1 3.49914
UCN urocortin 3.49914
SLC5A9 solute carrier family 5 (sodium/sugar cotransporter), member 9 3.49914
CHRND cholinergic receptor, nicotinic, delta (muscle) 3.49914
KNG1 kininogen 1 3.49914
SLC46A3 solute carrier family 46, member 3 3.49914
HEATR9 HEAT repeat containing 9 3.49914
IL22RA1 interleukin 22 receptor, alpha 1 3.49914
NUGGC nuclear GTPase, germinal center associated 3.49914
ADAD2 adenosine deaminase domain containing 2 3.49914
SLC23A3 solute carrier family 23, member 3 3.49914
GYS2 glycogen synthase 2 (liver) 3.49914
RTP1 receptor (chemosensory) transporter protein 1 3.49914
SERTM1 serine-rich and transmembrane domain containing 1 3.49914
SPAG8 sperm associated antigen 8 3.49914
RNASE6 ribonuclease, RNase A family, k6 3.49914
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 3.49914
ANXA2R annexin A2 receptor 3.49914
WFDC11 WAP four-disulfide core domain 11 3.49914
NFE2 nuclear factor, erythroid 2 3.49914
KLLN killin, p53-regulated DNA replication inhibitor 3.49914
IL2RB interleukin 2 receptor, beta 3.49914
MMP20 matrix metallopeptidase 20 3.49914
C3ORF22 chromosome 3 open reading frame 22 3.49914
PTGER4 prostaglandin E receptor 4 (subtype EP4) 3.49914
C1ORF141 chromosome 1 open reading frame 141 3.49914
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 3.49914
DLX4 distal-less homeobox 4 3.49914
F2 coagulation factor II (thrombin) 3.49914
CX3CR1 chemokine (C-X3-C motif) receptor 1 3.49914
SOWAHB sosondowah ankyrin repeat domain family member B 3.49914
TCP11 t-complex 11, testis-specific 3.49914
IL17F interleukin 17F 3.49914
SAXO3 stabilizer of axonemal microtubules 3 3.49914
LOC122539214 Zinc finger protein LOC122539214 3.49914
HTD2 hydroxyacyl-thioester dehydratase type 2 3.49914
PNMA8B PNMA family member 8B 3.49914
CES4A carboxylesterase 4A 3.49914
GIPC3 GIPC PDZ domain containing family, member 3 3.49914
SAPCD1 suppressor APC domain containing 1 3.49914
MYH6 myosin, heavy chain 6, cardiac muscle, alpha 3.49914
MGAT4D MGAT4 family, member D 3.49914
PLN phospholamban 3.49914
GUCY1A1 guanylate cyclase 1 soluble subunit alpha 1 3.49914
PLAAT4 phospholipase A and acyltransferase 4 3.49914
DEFB131B defensin beta 131B 3.49914
EPCIP exosomal polycystin 1 interacting protein 3.49914
THSD8 thrombospondin type 1 domain containing 8 3.49914
H3C13 H3 clustered histone 13 3.49914
H4C15 H4 clustered histone 15 3.49914
GREP1 glycine rich extracellular protein 1 3.49914
FYB2 FYN binding protein 2 3.49914
H3C3 H3 clustered histone 3 3.49914
ACP4 acid phosphatase 4 3.49914
H1-8 H1.8 linker histone 3.49914
OTOR otoraplin 3.49914
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 3.49914
SMLR1 small leucine-rich protein 1 3.49914
SIM2 single-minded family bHLH transcription factor 2 3.49914
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 3.49914
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 3.49914
NXPE2 neurexophilin and PC-esterase domain family, member 2 3.49914
LTBP2 latent transforming growth factor beta binding protein 2 3.49914
PCDHB14 protocadherin beta 14 3.49914
PCDHA3 protocadherin alpha 3 3.49914
CAPN14 calpain 14 3.49914
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 3.49914
TBX3 T-box 3 3.49914
RASAL3 RAS protein activator like 3 3.49914
PRR4 proline rich 4 (lacrimal) 3.49914
SLC2A7 solute carrier family 2 (facilitated glucose transporter), member 7 3.49914
TMPRSS4 transmembrane protease, serine 4 3.49914
TMEM40 transmembrane protein 40 3.49914
DOK2 docking protein 2, 56kDa 3.49914
KHDC1L KH homology domain containing 1-like 3.49914
ACE2 angiotensin I converting enzyme 2 3.49914
PNPLA1 patatin-like phospholipase domain containing 1 3.49914
OOSP1 oocyte secreted protein 1, pseudogene 3.49914
CCR3 chemokine (C-C motif) receptor 3 3.49914
KLHL35 kelch-like family member 35 3.49914
RAB7B RAB7B, member RAS oncogene family 3.49914
MAB21L1 mab-21-like 1 (C. elegans) 3.49914
CERS3 ceramide synthase 3 3.49914
SPATA9 spermatogenesis associated 9 3.49914
SLC17A8 solute carrier family 17 (vesicular glutamate transporter), member 8 3.49914
NOX1 NADPH oxidase 1 3.49914
TMEM132E transmembrane protein 132E 3.49914
NT5DC4 5'-nucleotidase domain containing 4 3.49914
STAB1 stabilin 1 3.49914
BLID BH3-like motif containing, cell death inducer 3.49914
ESAM endothelial cell adhesion molecule 3.49914
CD200R1 CD200 receptor 1 3.49914
SMYD1 SET and MYND domain containing 1 3.49914
ZMYND15 zinc finger, MYND-type containing 15 3.49914
AGAP2 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 3.49914
TSPAN32 tetraspanin 32 3.49914
TMEM31 transmembrane protein 31 3.49914
EFCAB3 EF-hand calcium binding domain 3 3.49914
GPR12 G protein-coupled receptor 12 3.49914
SERPINB11 serpin peptidase inhibitor, clade B (ovalbumin), member 11 (gene/pseudogene) 3.49914
PAGE4 P antigen family, member 4 (prostate associated) 3.49914
IRGM immunity-related GTPase family, M 3.49914
SPATA3 spermatogenesis associated 3 3.49914
DSC1 desmocollin 1 3.49914
ISL1 ISL LIM homeobox 1 3.49914
NPFFR1 neuropeptide FF receptor 1 3.49914
KLHL40 kelch-like family member 40 3.49914
CAMK2B calcium/calmodulin-dependent protein kinase II beta 3.49914
SEC14L3 SEC14-like 3 (S. cerevisiae) 3.49914
CYSLTR1 cysteinyl leukotriene receptor 1 3.49914
ANKRD66 ankyrin repeat domain 66 3.49914
PPP1R14C protein phosphatase 1, regulatory (inhibitor) subunit 14C 3.49914
PDZRN4 PDZ domain containing ring finger 4 3.49914
CRYBB3 crystallin, beta B3 3.49914
KLK11 kallikrein-related peptidase 11 3.49914
IBSP integrin-binding sialoprotein 3.49914
AMER2 APC membrane recruitment protein 2 3.49914
GRAP2 GRB2-related adaptor protein 2 3.49914
POU3F2 POU class 3 homeobox 2 3.49914
IL33 interleukin 33 3.49914
ANKRD2 ankyrin repeat domain 2 (stretch responsive muscle) 3.49914
GPRC6A G protein-coupled receptor, class C, group 6, member A 3.49914
ACTR3C ARP3 actin-related protein 3 homolog C (yeast) 3.49914
ZNF831 zinc finger protein 831 3.49914
ZPLD1 zona pellucida-like domain containing 1 3.49914
GPBAR1 G protein-coupled bile acid receptor 1 3.49914
POU4F3 POU class 4 homeobox 3 3.49914
ELANE elastase, neutrophil expressed 3.49914
GOLGA8H golgin A8 family, member H 3.49914
NUTM2F NUT family member 2F 3.49914
CROCC2 ciliary rootlet coiled-coil, rootletin family member 2 3.49914
TRIM7 tripartite motif containing 7 3.49914
CDCP2 CUB domain containing protein 2 3.49914
KCNK4 potassium channel, two pore domain subfamily K, member 4 3.49914
NLRP14 NLR family, pyrin domain containing 14 3.49914
ALOX15B arachidonate 15-lipoxygenase, type B 3.49914
DEFB134 defensin, beta 134 3.49914
CHRM4 cholinergic receptor, muscarinic 4 3.49914
SLC34A1 solute carrier family 34 (type II sodium/phosphate cotransporter), member 1 3.49914
ORM1 orosomucoid 1 3.49914
WNT4 wingless-type MMTV integration site family, member 4 3.49914
RBBP8NL RBBP8 N-terminal like 3.49914
SUN3 Sad1 and UNC84 domain containing 3 3.49914
LRRC31 leucine rich repeat containing 31 3.49914
CD70 CD70 molecule 3.47705
SLC30A10 solute carrier family 30, member 10 3.47705
PLPPR4 phospholipid phosphatase related 4 3.14951
SLC16A6 solute carrier family 16, member 6 3.11812
CD38 CD38 molecule 3.11812
COQ5 coenzyme Q5 homolog, methyltransferase (S. cerevisiae) 3.08085
ENPEP glutamyl aminopeptidase (aminopeptidase A) 3.00701
CACNA1F calcium channel, voltage-dependent, L type, alpha 1F subunit 2.99778
FKBP7 FK506 binding protein 7 2.97277
ELOF1 elongation factor 1 homolog (S. cerevisiae) 2.76226
C3ORF18 chromosome 3 open reading frame 18 2.66842
COL9A3 collagen, type IX, alpha 3 2.65475
EYA4 EYA transcriptional coactivator and phosphatase 4 2.65284
SULF1 sulfatase 1 2.62891
DKKL1 dickkopf-like 1 2.59318
NFKBIL1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 2.58058
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 2.57892
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 2.57431
ZNF709 zinc finger protein 709 2.57133
PPP4R3A protein phosphatase 4 regulatory subunit 3A 2.56472
PRKCZ protein kinase C, zeta 2.56472
SARNP SAP domain containing ribonucleoprotein 2.54207
ESCO1 establishment of sister chromatid cohesion N-acetyltransferase 1 2.52364
TIMCC TIM double twin CX3C motif chaperone 2.50247
KASH5 KASH domain containing 5 2.4978
ETNPPL ethanolamine-phosphate phospho-lyase 2.4978
RIBC1 RIB43A domain with coiled-coils 1 2.4978
CYTIP cytohesin 1 interacting protein 2.4978
LRRK2 leucine-rich repeat kinase 2 2.4978
BBLN bublin coiled coil protein 2.4978
ENO1 enolase 1, (alpha) 2.4978
PKP1 plakophilin 1 2.4978
TMPPE transmembrane protein with metallophosphoesterase domain 2.48499
ZNF280B zinc finger protein 280B 2.45483
GALR3 galanin receptor 3 2.44406
EPHB2 EPH receptor B2 2.4347
EGLN2 egl-9 family hypoxia-inducible factor 2 2.40496
UBA5 ubiquitin-like modifier activating enzyme 5 2.38962
ARGLU1 arginine and glutamate rich 1 2.3845
RBM15 RNA binding motif protein 15 2.3745
ZNF493 zinc finger protein 493 2.37216
RPL26L1 ribosomal protein L26-like 1 2.34894
SH3PXD2A SH3 and PX domains 2A 2.32598
C2ORF80 chromosome 2 open reading frame 80 2.32463
CHIC2 cysteine-rich hydrophobic domain 2 2.31476
TAFA3 TAFA chemokine like family member 3 2.31381
PHB1 prohibitin 1 2.31219
COX6C cytochrome c oxidase subunit VIc 2.30078
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae) 2.28323
USHBP1 Usher syndrome 1C binding protein 1 2.28323
EXOSC7 exosome component 7 2.26645
STUM stum, mechanosensory transduction mediator homolog 2.23808
MFAP1 microfibrillar-associated protein 1 2.2307
SLC36A1 solute carrier family 36 (proton/amino acid symporter), member 1 2.22506
INTS15 integrator complex subunit 15 2.21539
THBS2 thrombospondin 2 2.19358
RAN RAN, member RAS oncogene family 2.1922
CLPTM1 cleft lip and palate associated transmembrane protein 1 2.18846
PPP1R35 protein phosphatase 1, regulatory subunit 35 2.17021
MLST8 MTOR associated protein, LST8 homolog (S. cerevisiae) 2.15915
CENPX centromere protein X 2.15893
VMA22 vacuolar ATPase assembly factor VMA22 2.12821
PHF7 PHD finger protein 7 2.11643
WDR41 WD repeat domain 41 2.11258
DRAXIN dorsal inhibitory axon guidance protein 2.10602
HDLBP high density lipoprotein binding protein 2.10602
CCNDBP1 cyclin D-type binding-protein 1 2.10032
MFSD12 major facilitator superfamily domain containing 12 2.09744
S1PR3 sphingosine-1-phosphate receptor 3 2.09555
ZNF398 zinc finger protein 398 2.0922
ELMO1 engulfment and cell motility 1 2.0922
KIFBP kinesin family binding protein 2.0902
PODNL1 podocan-like 1 2.0802
MIOS missing oocyte, meiosis regulator, homolog (Drosophila) 2.07172
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 2.06368
TATDN3 TatD DNase domain containing 3 2.06315
CYB5R2 cytochrome b5 reductase 2 2.0431
ZNFX1 zinc finger, NFX1-type containing 1 2.0356
KIF1B kinesin family member 1B 2.01035

decreased expression

Symbol Name Standardized Value
BICRA BRD4 interacting chromatin remodeling complex associated protein -3.49914
JPH2 junctophilin 2 -3.49914
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -3.49914
INHBA inhibin, beta A -3.49914
CERS6 ceramide synthase 6 -3.49914
NCF2 neutrophil cytosolic factor 2 -3.49914
STMN2 stathmin 2 -3.49914
GHRL ghrelin/obestatin prepropeptide -3.49914
ZNF76 zinc finger protein 76 -3.49914
RCSD1 RCSD domain containing 1 -3.49914
EBF3 early B-cell factor 3 -3.49407
GP1BA glycoprotein Ib (platelet), alpha polypeptide -3.49407
PLA2G4B phospholipase A2, group IVB (cytosolic) -3.49407
TACSTD2 tumor-associated calcium signal transducer 2 -3.49407
SLC22A25 solute carrier family 22, member 25 -3.49407
LOC114841035 uncharacterized LOC114841035 -3.49407
PLB1 phospholipase B1 -3.49407
ERVFRD-1 endogenous retrovirus group FRD, member 1 -3.49407
TMEM217 transmembrane protein 217 -3.49407
S100A2 S100 calcium binding protein A2 -3.49407
AFTPH aftiphilin -3.49407
IQCJ IQ motif containing J -3.49407
PFKFB1 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 -3.49407
ACTG2 actin, gamma 2, smooth muscle, enteric -3.49407
C2CD2L C2CD2-like -3.49407
TLE6 transducin-like enhancer of split 6 -3.49407
HPX hemopexin -3.49407
CNGA4 cyclic nucleotide gated channel alpha 4 -3.49407
GCKR glucokinase (hexokinase 4) regulator -3.49407
PCDHA13 protocadherin alpha 13 -3.49407
P2RX1 purinergic receptor P2X, ligand gated ion channel, 1 -3.49407
CTXN2 cortexin 2 -3.49407
RPS21-DT RPS21 divergent transcript -3.49407
KLHL10 kelch-like family member 10 -3.49407
FAM240C family with sequence similarity 240 member C -3.49407
ETV3L ets variant 3-like -3.49407
MISP3 MISP family member 3 -3.49407
C22ORF31 chromosome 22 open reading frame 31 -3.49407
ALX4 ALX homeobox 4 -3.49407
ACSL5 acyl-CoA synthetase long-chain family member 5 -3.49407
CDHR1 cadherin-related family member 1 -3.49407
GOLGA6L10 golgin A6 family-like 10 -3.49407
ADGRA2 adhesion G protein-coupled receptor A2 -3.38071
SLC67A1 solute carrier family 67 member 1 -3.38071
IFT70B intraflagellar transport 70B -3.38071
PRPH2 peripherin 2 (retinal degeneration, slow) -3.38071
EXOC3L2 exocyst complex component 3-like 2 -3.38071
JHY junctional cadherin complex regulator -3.17882
FAM81A family with sequence similarity 81, member A -3.16978
MMD monocyte to macrophage differentiation-associated -3.14415
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) -3.00555
PCSK9 proprotein convertase subtilisin/kexin type 9 -2.96356
PDE4C phosphodiesterase 4C, cAMP-specific -2.92248
WWC2 WW and C2 domain containing 2 -2.90428
MAN2A2 mannosidase, alpha, class 2A, member 2 -2.85914
ZRANB1 zinc finger, RAN-binding domain containing 1 -2.85203
TSPAN14 tetraspanin 14 -2.81872
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -2.81872
NF2 neurofibromin 2 (merlin) -2.81872
CSRNP1 cysteine-serine-rich nuclear protein 1 -2.79214
MYBBP1A MYB binding protein (P160) 1a -2.7747
RGS3 regulator of G-protein signaling 3 -2.76068
USP25 ubiquitin specific peptidase 25 -2.5807
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -2.56747
NIPAL1 NIPA-like domain containing 1 -2.56747
GNPTG N-acetylglucosamine-1-phosphate transferase, gamma subunit -2.52364
SAMD10 sterile alpha motif domain containing 10 -2.50714
KLK6 kallikrein-related peptidase 6 -2.42588
C1QTNF12 C1q and TNF related 12 -2.42588
IFI27 interferon, alpha-inducible protein 27 -2.42588
GRB2 growth factor receptor-bound protein 2 -2.41024
MRM3 mitochondrial rRNA methyltransferase 3 -2.39722
SREBF1 sterol regulatory element binding transcription factor 1 -2.39203
CUTA cutA divalent cation tolerance homolog (E. coli) -2.38808
PCDHGA5 protocadherin gamma subfamily A, 5 -2.3845
CES3 carboxylesterase 3 -2.3845
FCGBP Fc fragment of IgG binding protein -2.3845
C5ORF58 chromosome 5 open reading frame 58 -2.37216
MYO18B myosin XVIIIB -2.37216
KIAA0319L KIAA0319-like -2.35982
RASL10B RAS-like, family 10, member B -2.32598
TRAM1L1 translocation associated membrane protein 1-like 1 -2.31476
ERICH5 glutamate-rich 5 -2.31476
COL8A1 collagen, type VIII, alpha 1 -2.31476
TPP2 tripeptidyl peptidase II -2.29908
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) -2.28323
SND1 staphylococcal nuclease and tudor domain containing 1 -2.28186
CCDC163 CCDC163 homolog -2.28186
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta -2.28186
CC2D1A coiled-coil and C2 domain containing 1A -2.2718
BOLA1 bolA family member 1 -2.2717
USP12 ubiquitin specific peptidase 12 -2.26838
RPRM reprimo, TP53 dependent G2 arrest mediator candidate -2.24287
VTI1A vesicle transport through interaction with t-SNAREs 1A -2.23469
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -2.23469
INSL3 insulin-like 3 (Leydig cell) -2.21207
IQSEC2 IQ motif and Sec7 domain 2 -2.18847
MARS1 methionyl-tRNA synthetase 1 -2.18338
IKZF1 IKAROS family zinc finger 1 (Ikaros) -2.18143
MAP7D3 MAP7 domain containing 3 -2.16803
S100A6 S100 calcium binding protein A6 -2.15915
LCAT lecithin-cholesterol acyltransferase -2.15731
PHETA2 PH domain containing endocytic trafficking adaptor 2 -2.15731
SOS2 son of sevenless homolog 2 (Drosophila) -2.14938
RABGAP1L RAB GTPase activating protein 1-like -2.12821
RERE arginine-glutamic acid dipeptide (RE) repeats -2.11517
MEX3A mex-3 RNA binding family member A -2.11258
DCAF11 DDB1 and CUL4 associated factor 11 -2.10115
THOC2 THO complex 2 -2.09744
STS steroid sulfatase (microsomal), isozyme S -2.09744
LMNB1 lamin B1 -2.09744
MSN moesin -2.08656
ETV6 ets variant 6 -2.07853
KLHL9 kelch-like family member 9 -2.07224
WDCP WD repeat and coiled coil containing -2.06331
EIF4ENIF1 eukaryotic translation initiation factor 4E nuclear import factor 1 -2.05619
ASNS asparagine synthetase (glutamine-hydrolyzing) -2.0356
CAVIN3 caveolae associated protein 3 -2.0254
ZBTB39 zinc finger and BTB domain containing 39 -2.01854