BCL6 Gene Set

Dataset LINCS L1000 CMAP CRISPR Knockout Consensus Signatures
Category transcriptomics
Type gene perturbation
Description B-cell CLL/lymphoma 6|The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Sep 2008] (NCBI Entrez Gene Database, 604)
External Link https://ncbi.nlm.nih.gov/gene/604
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Genes

498 genes differentially expressed following the BCL6 gene perturbation from the LINCS L1000 CMAP CRISPR Knockout Consensus Signatures dataset.

increased expression

Symbol Name Standardized Value
SPRED2 sprouty-related, EVH1 domain containing 2 0.0166148
KRT14 keratin 14, type I 0.014055
KRT15 keratin 15, type I 0.0133983
DLK1 delta-like 1 homolog (Drosophila) 0.0131677
HSPB1 heat shock 27kDa protein 1 0.0125413
KLK10 kallikrein-related peptidase 10 0.0124976
QPCT glutaminyl-peptide cyclotransferase 0.0124819
SIRT3 sirtuin 3 0.0123733
TM4SF1 transmembrane 4 L six family member 1 0.0117321
EMP1 epithelial membrane protein 1 0.0115129
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0109918
HSPA1A heat shock 70kDa protein 1A 0.0109821
CEMIP cell migration inducing protein, hyaluronan binding 0.0109435
KRT5 keratin 5, type II 0.0109153
MALL mal, T-cell differentiation protein-like 0.0105448
TCTA T-cell leukemia translocation altered 0.010408
LCN2 lipocalin 2 0.0103405
SPRR3 small proline-rich protein 3 0.0103055
CCL20 chemokine (C-C motif) ligand 20 0.0101355
AREG amphiregulin 0.0101081
CAPG capping protein (actin filament), gelsolin-like 0.0100448
PDZK1IP1 PDZK1 interacting protein 1 0.0100165
TP53I3 tumor protein p53 inducible protein 3 0.0100034
BHLHE41 basic helix-loop-helix family, member e41 0.00994001
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 0.00973516
IFI27 interferon, alpha-inducible protein 27 0.00972885
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae) 0.00956269
FOLR1 folate receptor 1 (adult) 0.00945972
COL6A3 collagen, type VI, alpha 3 0.00938314
SPRR2B small proline-rich protein 2B 0.00932585
SPRR1B small proline-rich protein 1B 0.00919564
RCAN1 regulator of calcineurin 1 0.00915902
TACSTD2 tumor-associated calcium signal transducer 2 0.00908683
RHCG Rh family, C glycoprotein 0.00905671
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein 0.00891748
ARID4A AT rich interactive domain 4A (RBP1-like) 0.00888994
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.00879656
KLK5 kallikrein-related peptidase 5 0.00878627
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16 0.00871029
TRAF3IP2 TRAF3 interacting protein 2 0.00860186
SPINT2 serine peptidase inhibitor, Kunitz type, 2 0.00858594
PI3 peptidase inhibitor 3, skin-derived 0.00848326
SCGB2A1 secretoglobin, family 2A, member 1 0.00837961
AQP3 aquaporin 3 (Gill blood group) 0.00827336
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.00826708
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 0.00824437
CA12 carbonic anhydrase XII 0.00823112
LY96 lymphocyte antigen 96 0.00820752
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.00819982
MARCKSL1 MARCKS-like 1 0.00816858
KRT6B keratin 6B, type II 0.00806342
SLC18A1 solute carrier family 18 (vesicular monoamine transporter), member 1 0.00802583
WFDC2 WAP four-disulfide core domain 2 0.00795121
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0079475
LY6D lymphocyte antigen 6 complex, locus D 0.00794442
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 0.00791708
CSTA cystatin A (stefin A) 0.00787705
CYBA cytochrome b-245, alpha polypeptide 0.00781974
KRT6A keratin 6A, type II 0.00780449
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.00777336
BIK BCL2-interacting killer (apoptosis-inducing) 0.00772349
CCN2 cellular communication network factor 2 0.00771356
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 0.00768663
KLK11 kallikrein-related peptidase 11 0.00768384
STC2 stanniocalcin 2 0.00766972
ALCAM activated leukocyte cell adhesion molecule 0.00762029
MAL mal, T-cell differentiation protein 0.00761233
FABP7 fatty acid binding protein 7, brain 0.00759626
ATP5F1E ATP synthase F1 subunit epsilon 0.00750893
ASCL1 achaete-scute family bHLH transcription factor 1 0.00748719
SPRR1A small proline-rich protein 1A 0.00742469
LAMC2 laminin, gamma 2 0.00741645
SMAGP small cell adhesion glycoprotein 0.00741509
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 0.00738464
ZMAT3 zinc finger, matrin-type 3 0.00720801
PEG3 paternally expressed 3 0.00715183
PKP1 plakophilin 1 0.00714521
ETHE1 ethylmalonic encephalopathy 1 0.00712673
SFN stratifin 0.00709683
CLEC11A C-type lectin domain family 11, member A 0.00708914
CTSZ cathepsin Z 0.00708119
UBE2L6 ubiquitin-conjugating enzyme E2L 6 0.00704306
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F 0.00703124
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 0.00701283
TRIM29 tripartite motif containing 29 0.00699681
XIC X chromosome inactivation center 0.00695268
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.00691696
GSTP1 glutathione S-transferase pi 1 0.00689932
TRIB2 tribbles pseudokinase 2 0.00689599
XBP1 X-box binding protein 1 0.00684523
KLK7 kallikrein-related peptidase 7 0.00681036
LEF1 lymphoid enhancer-binding factor 1 0.00680297
PFDN4 prefoldin subunit 4 0.00677564
ARPC3 actin related protein 2/3 complex, subunit 3, 21kDa 0.00677191
MMP1 matrix metallopeptidase 1 0.00674206
C1S complement component 1, s subcomponent 0.00671524
DSG3 desmoglein 3 0.00670771
INAVA innate immunity activator 0.00670006
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.00669948
RPL36 ribosomal protein L36 0.00669503
LBH limb bud and heart development 0.00669071
SLC22A18 solute carrier family 22, member 18 0.00667893
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.00667805
SPINK5 serine peptidase inhibitor, Kazal type 5 0.00663344
ECM1 extracellular matrix protein 1 0.00661591
MTIF2 mitochondrial translational initiation factor 2 0.00661074
NUPR1 nuclear protein, transcriptional regulator, 1 0.00660515
STEAP1 six transmembrane epithelial antigen of the prostate 1 0.00660136
UQCRB ubiquinol-cytochrome c reductase binding protein 0.00658888
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 0.00658877
FXYD3 FXYD domain containing ion transport regulator 3 0.00658867
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 0.00658085
BEX4 brain expressed, X-linked 4 0.00655979
HIST1H2BD histone cluster 1, H2bd 0.00655657
SCEL sciellin 0.00655173
HIST1H2AC histone cluster 1, H2ac 0.00653561
ZBED2 zinc finger, BED-type containing 2 0.00653168
DMAC2L distal membrane arm assembly component 2 like 0.00653152
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.00651605
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.00651047
RIPOR2 RHO family interacting cell polarization regulator 2 0.00649601
RPS27L ribosomal protein S27-like 0.00649056
NT5E 5'-nucleotidase, ecto (CD73) 0.00648824
OXTR oxytocin receptor 0.0064527
APOLD1 apolipoprotein L domain containing 1 0.00645249
MMP7 matrix metallopeptidase 7 0.00643907
CDH2 cadherin 2, type 1, N-cadherin (neuronal) 0.00643459
POU2AF1 POU class 2 associating factor 1 0.00643263
MAMLD1 mastermind-like domain containing 1 0.00643185
MRPL23 mitochondrial ribosomal protein L23 0.00640445
CD200 CD200 molecule 0.00636516
MMP3 matrix metallopeptidase 3 0.00634909
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.00631384
SRC SRC proto-oncogene, non-receptor tyrosine kinase 0.00631088
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1 0.00629588
TGFA transforming growth factor, alpha 0.00627942
THBS2 thrombospondin 2 0.00626718
HOXC6 homeobox C6 0.00626685
AOC1 amine oxidase, copper containing 1 0.00624822
TAOK3 TAO kinase 3 0.00624615
IL6R interleukin 6 receptor 0.00623929
DARS1 aspartyl-tRNA synthetase 1 0.00622223
RNASET2 ribonuclease T2 0.00617473
FXYD2 FXYD domain containing ion transport regulator 2 0.00617164
BBOX1 butyrobetaine (gamma), 2-oxoglutarate dioxygenase (gamma-butyrobetaine hydroxylase) 1 0.00615244
RPS17 ribosomal protein S17 0.00615145
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 0.00614918
CLDN7 claudin 7 0.00614853
SELL selectin L 0.00606247
ITM2C integral membrane protein 2C 0.00605868
TRIM44 tripartite motif containing 44 0.00604875
EPS8 epidermal growth factor receptor pathway substrate 8 0.00602263
BEX1 brain expressed, X-linked 1 0.00601115
MME membrane metallo-endopeptidase 0.005974
SLC16A4 solute carrier family 16, member 4 0.00595758
PKIG protein kinase (cAMP-dependent, catalytic) inhibitor gamma 0.00595145
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.00594892
GM2A GM2 ganglioside activator 0.00593626
ACP5 acid phosphatase 5, tartrate resistant 0.0059361
TPD52L1 tumor protein D52-like 1 0.00593235
FAM171A1 family with sequence similarity 171, member A1 0.00593191
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.00592985
MAST4 microtubule associated serine/threonine kinase family member 4 0.00590116
CHI3L2 chitinase 3-like 2 0.00589573
EMX2 empty spiracles homeobox 2 0.00589319
CSTB cystatin B (stefin B) 0.00588626
SOX10 SRY (sex determining region Y)-box 10 0.00587495
SAMD9 sterile alpha motif domain containing 9 0.00587286
TNIP1 TNFAIP3 interacting protein 1 0.00586743
ISG20 interferon stimulated exonuclease gene 20kDa 0.00583675
RABAC1 Rab acceptor 1 (prenylated) 0.0058206
EGR3 early growth response 3 0.00581084
ASNS asparagine synthetase (glutamine-hydrolyzing) 0.00578901
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6 0.00578511
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 0.00577525
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 0.00577299
CLIC5 chloride intracellular channel 5 0.00576598
HSPB8 heat shock 22kDa protein 8 0.00576182
TTC17 tetratricopeptide repeat domain 17 0.00576161
NFU1 NFU1 iron-sulfur cluster scaffold 0.00572279
S100A10 S100 calcium binding protein A10 0.0057223
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.00570078
PLEKHA5 pleckstrin homology domain containing, family A member 5 0.0056876
S100P S100 calcium binding protein P 0.00568526
SH3YL1 SH3 and SYLF domain containing 1 0.00568466
SMAD2 SMAD family member 2 0.00567735
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 0.00566607
DOK5 docking protein 5 0.00566478
ICAM1 intercellular adhesion molecule 1 0.00566264
PLAUR plasminogen activator, urokinase receptor 0.0056621
DYNLL1 dynein, light chain, LC8-type 1 0.00566167
GMPR guanosine monophosphate reductase 0.00565126
ICAM2 intercellular adhesion molecule 2 0.00564367
STK24 serine/threonine kinase 24 0.00564247
NPC2 Niemann-Pick disease, type C2 0.00563146
ALOX15B arachidonate 15-lipoxygenase, type B 0.00562955
KRT19 keratin 19, type I 0.00562737
CRYAB crystallin, alpha B 0.00562689
ADM adrenomedullin 0.0056194
ADGRE5 adhesion G protein-coupled receptor E5 0.00560362
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.00559632
CD79A CD79a molecule, immunoglobulin-associated alpha 0.00558291
OCRL oculocerebrorenal syndrome of Lowe 0.00557752
TYRP1 tyrosinase-related protein 1 0.0055686
SPRY2 sprouty homolog 2 (Drosophila) 0.0055617
CRYBG1 crystallin beta-gamma domain containing 1 0.00556117
WEE1 WEE1 G2 checkpoint kinase 0.00555642
SORBS2 sorbin and SH3 domain containing 2 0.00555386
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.00554257
BTK Bruton agammaglobulinemia tyrosine kinase 0.00553927
RAB25 RAB25, member RAS oncogene family 0.00552333
COCH cochlin 0.00551935
GAB2 GRB2-associated binding protein 2 0.00551637
DEFB1 defensin, beta 1 0.00550567
GREB1 growth regulation by estrogen in breast cancer 1 0.00549989
RNF170 ring finger protein 170 0.00549309
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 0.00548903
BAMBI BMP and activin membrane-bound inhibitor 0.00546649
ABHD4 abhydrolase domain containing 4 0.00544506
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 0.00543398
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0054262
DAAM1 dishevelled associated activator of morphogenesis 1 0.00539543
ANXA1 annexin A1 0.00538701
IPO13 importin 13 0.00538531
NOTCH3 notch 3 0.00538181
ATP5PD ATP synthase peripheral stalk subunit d 0.00535607
NSG1 neuron specific gene family member 1 0.00535238
B3GNT2 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 0.00534605
KRT16 keratin 16, type I 0.00534243
GRN granulin 0.00534195
ACTA2 actin, alpha 2, smooth muscle, aorta 0.00533956
PTN pleiotrophin 0.00533326
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5 0.00530091
PMEPA1 prostate transmembrane protein, androgen induced 1 0.00529167
ATF3 activating transcription factor 3 0.00528953
RGS10 regulator of G-protein signaling 10 0.00528764
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 0.00528648
GLRX glutaredoxin (thioltransferase) 0.00527911
CAPN3 calpain 3, (p94) 0.00527605
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.00527532
FKBP9 FK506 binding protein 9, 63 kDa 0.00527471
TXLNA taxilin alpha 0.00527324
AK1 adenylate kinase 1 0.00526736
SINHCAF SIN3-HDAC complex associated factor 0.00526615
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.00526501
MAP2K3 mitogen-activated protein kinase kinase 3 0.00525786
ITPKC inositol-trisphosphate 3-kinase C 0.00523529
KLK8 kallikrein-related peptidase 8 0.0052295
YPEL5 yippee-like 5 (Drosophila) 0.00522381

decreased expression

Symbol Name Standardized Value
BMP4 bone morphogenetic protein 4 -0.0141811
S100A8 S100 calcium binding protein A8 -0.0136516
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3 -0.0130833
CLU clusterin -0.012701
TDO2 tryptophan 2,3-dioxygenase -0.0117516
FABP4 fatty acid binding protein 4, adipocyte -0.0114377
ACKR3 atypical chemokine receptor 3 -0.0113356
CA2 carbonic anhydrase II -0.0110476
CXCL14 chemokine (C-X-C motif) ligand 14 -0.0107123
RNPS1 RNA binding protein S1, serine-rich domain -0.0106604
PROM1 prominin 1 -0.0105858
TMSB15A thymosin beta 15a -0.0101174
PRDX2 peroxiredoxin 2 -0.0100549
CD36 CD36 molecule (thrombospondin receptor) -0.0100396
CXCR4 chemokine (C-X-C motif) receptor 4 -0.00998057
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) -0.0098362
CLGN calmegin -0.00936548
NBPF10 neuroblastoma breakpoint family, member 10 -0.00936278
COL4A5 collagen, type IV, alpha 5 -0.00900413
TOX3 TOX high mobility group box family member 3 -0.00897804
BCHE butyrylcholinesterase -0.00892873
RTN1 reticulon 1 -0.00881724
NVL nuclear VCP-like -0.00875578
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.00850482
KIF20A kinesin family member 20A -0.00848274
FASN fatty acid synthase -0.00830057
CCR2 chemokine (C-C motif) receptor 2 -0.00826926
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta -0.00816093
TWIST1 twist family bHLH transcription factor 1 -0.00798589
C8ORF4 chromosome 8 open reading frame 4 -0.00787423
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class) -0.00785354
HMGN5 high mobility group nucleosome binding domain 5 -0.00780432
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 -0.00779564
PTGER4 prostaglandin E receptor 4 (subtype EP4) -0.00778637
LIMCH1 LIM and calponin homology domains 1 -0.00774466
FGL2 fibrinogen-like 2 -0.0077389
CAV1 caveolin 1, caveolae protein, 22kDa -0.00767845
FEN1 flap structure-specific endonuclease 1 -0.00765865
TPD52 tumor protein D52 -0.00765687
CHN1 chimerin 1 -0.00763817
PDPK1 3-phosphoinositide dependent protein kinase 1 -0.00753767
CDC20 cell division cycle 20 -0.0075218
CSRP3 cysteine and glycine-rich protein 3 (cardiac LIM protein) -0.00751671
BPHL biphenyl hydrolase-like (serine hydrolase) -0.00751151
SAP30 Sin3A-associated protein, 30kDa -0.00747633
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase -0.00746759
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 -0.00743008
CCR1 chemokine (C-C motif) receptor 1 -0.00741757
LCP1 lymphocyte cytosolic protein 1 (L-plastin) -0.00741054
CD14 CD14 molecule -0.00741052
IL10RA interleukin 10 receptor, alpha -0.00738887
SNCA synuclein, alpha (non A4 component of amyloid precursor) -0.00737605
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 -0.00733158
RPA3 replication protein A3, 14kDa -0.00722564
ACTG2 actin, gamma 2, smooth muscle, enteric -0.00716965
RXRA retinoid X receptor, alpha -0.00713933
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.00710295
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.00705475
MNDA myeloid cell nuclear differentiation antigen -0.0069995
CD40 CD40 molecule, TNF receptor superfamily member 5 -0.00688588
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 -0.00688246
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 -0.00686849
MEX3D mex-3 RNA binding family member D -0.00681685
APMAP adipocyte plasma membrane associated protein -0.00678811
MCM2 minichromosome maintenance complex component 2 -0.00674629
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 -0.00673662
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) -0.00673164
RTL8C retrotransposon Gag like 8C -0.00670779
TSPAN12 tetraspanin 12 -0.00669283
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0066713
F13A1 coagulation factor XIII, A1 polypeptide -0.00666759
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.00666221
CHN2 chimerin 2 -0.00666137
CCL8 chemokine (C-C motif) ligand 8 -0.00665853
QKI QKI, KH domain containing, RNA binding -0.00664816
TUBG1 tubulin, gamma 1 -0.00664624
S100A9 S100 calcium binding protein A9 -0.00664391
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2 -0.00663837
SYNM synemin, intermediate filament protein -0.00658423
PRC1 protein regulator of cytokinesis 1 -0.00657684
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) -0.00656856
FAM13A family with sequence similarity 13, member A -0.00654294
PTCH1 patched 1 -0.00653033
CALD1 caldesmon 1 -0.00651044
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.00650449
NXN nucleoredoxin -0.00647853
PDGFRL platelet-derived growth factor receptor-like -0.00645503
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like) -0.00643965
UGT2B15 UDP glucuronosyltransferase 2 family, polypeptide B15 -0.00641643
PRKACB protein kinase, cAMP-dependent, catalytic, beta -0.00641478
ADH1C alcohol dehydrogenase 1C (class I), gamma polypeptide -0.0064084
RRM2 ribonucleotide reductase M2 -0.00636142
POGLUT2 protein O-glucosyltransferase 2 -0.00635053
FOXF1 forkhead box F1 -0.00629007
MPDZ multiple PDZ domain protein -0.00628579
GCLC glutamate-cysteine ligase, catalytic subunit -0.00628444
MARCO macrophage receptor with collagenous structure -0.00628147
NQO2 NAD(P)H dehydrogenase, quinone 2 -0.00624833
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -0.00624671
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.00623413
FGFR2 fibroblast growth factor receptor 2 -0.00623179
CADPS2 Ca++-dependent secretion activator 2 -0.00621324
HELLS helicase, lymphoid-specific -0.00620851
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide -0.00619087
TGFB1 transforming growth factor, beta 1 -0.00614314
GAS1 growth arrest-specific 1 -0.00614091
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.00613861
GOLM1 golgi membrane protein 1 -0.00613462
HK1 hexokinase 1 -0.00608628
PFKM phosphofructokinase, muscle -0.00606483
MCM6 minichromosome maintenance complex component 6 -0.00602637
C6 complement component 6 -0.00602103
CPS1 carbamoyl-phosphate synthase 1, mitochondrial -0.00600654
GUCY1A3 guanylate cyclase 1, soluble, alpha 3 -0.00599178
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.00597792
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.00597661
CRIP2 cysteine-rich protein 2 -0.00597348
QDPR quinoid dihydropteridine reductase -0.0059519
CYP2C8 cytochrome P450, family 2, subfamily C, polypeptide 8 -0.00594264
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15 -0.00593944
TMEM47 transmembrane protein 47 -0.00593026
SORBS1 sorbin and SH3 domain containing 1 -0.00592593
RUNX3 runt-related transcription factor 3 -0.00589806
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -0.00587237
CCL5 chemokine (C-C motif) ligand 5 -0.00586306
MAN1C1 mannosidase, alpha, class 1C, member 1 -0.00586008
NUP85 nucleoporin 85kDa -0.00584567
ELOVL5 ELOVL fatty acid elongase 5 -0.00584347
DEGS1 delta(4)-desaturase, sphingolipid 1 -0.00581636
MCM3 minichromosome maintenance complex component 3 -0.00579909
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) -0.00576463
PDE3B phosphodiesterase 3B, cGMP-inhibited -0.00576366
FUT9 fucosyltransferase 9 (alpha (1,3) fucosyltransferase) -0.00576117
MBL2 mannose-binding lectin (protein C) 2, soluble -0.00574959
ADIPOQ adiponectin, C1Q and collagen domain containing -0.00574188
ADO 2-aminoethanethiol (cysteamine) dioxygenase -0.00573896
RAD23B RAD23 homolog B (S. cerevisiae) -0.00573705
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -0.00573193
HOXA5 homeobox A5 -0.00572569
PAX6 paired box 6 -0.00571264
DEK DEK proto-oncogene -0.00571255
FSD1 fibronectin type III and SPRY domain containing 1 -0.00570624
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.00570402
NMU neuromedin U -0.00569808
UBE2I ubiquitin-conjugating enzyme E2I -0.00569003
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.00567909
GLUL glutamate-ammonia ligase -0.00566578
SIKE1 suppressor of IKBKE 1 -0.0056641
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -0.00566108
SRRM2 serine/arginine repetitive matrix 2 -0.0056547
G6PD glucose-6-phosphate dehydrogenase -0.00564309
ASPN asporin -0.00562691
COLEC12 collectin sub-family member 12 -0.00561493
CAV2 caveolin 2 -0.00560013
LYZ lysozyme -0.00559098
CCDC47 coiled-coil domain containing 47 -0.00559069
MTTP microsomal triglyceride transfer protein -0.00558165
DKC1 dyskeratosis congenita 1, dyskerin -0.00557925
GLO1 glyoxalase I -0.00557007
DNAAF5 dynein, axonemal, assembly factor 5 -0.00556079
CCL2 chemokine (C-C motif) ligand 2 -0.00556002
REEP1 receptor accessory protein 1 -0.0055558
APOF apolipoprotein F -0.0055475
CROCCP2 ciliary rootlet coiled-coil, rootletin pseudogene 2 -0.00554381
SDC2 syndecan 2 -0.0055173
METRN meteorin, glial cell differentiation regulator -0.00550604
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.00550011
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.00549278
SLC38A1 solute carrier family 38, member 1 -0.00549188
SHMT1 serine hydroxymethyltransferase 1 (soluble) -0.00548775
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 -0.00548234
TMEM106C transmembrane protein 106C -0.00548058
MAP7 microtubule-associated protein 7 -0.00547978
CYP39A1 cytochrome P450, family 39, subfamily A, polypeptide 1 -0.00547133
HMG20B high mobility group 20B -0.00547046
KLRB1 killer cell lectin-like receptor subfamily B, member 1 -0.00544956
USP10 ubiquitin specific peptidase 10 -0.00543291
SLBP stem-loop binding protein -0.00543141
CCDC86 coiled-coil domain containing 86 -0.00542214
STK10 serine/threonine kinase 10 -0.0054201
ARPP19 cAMP-regulated phosphoprotein, 19kDa -0.0054175
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -0.00540852
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 -0.00540618
HOXB6 homeobox B6 -0.00540509
NPTX1 neuronal pentraxin I -0.00540321
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A -0.00540067
NUP54 nucleoporin 54kDa -0.00539799
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.00538417
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase -0.00538
ROR2 receptor tyrosine kinase-like orphan receptor 2 -0.00536777
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -0.00535913
NEUROD1 neuronal differentiation 1 -0.0053431
CKAP4 cytoskeleton-associated protein 4 -0.00533175
ALDH1B1 aldehyde dehydrogenase 1 family, member B1 -0.00533043
DSE dermatan sulfate epimerase -0.00532211
CHRDL1 chordin-like 1 -0.0053173
C9 complement component 9 -0.00531515
U2AF1 U2 small nuclear RNA auxiliary factor 1 -0.00530951
GINS1 GINS complex subunit 1 (Psf1 homolog) -0.00530908
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.00530847
GFAP glial fibrillary acidic protein -0.00529196
GPM6A glycoprotein M6A -0.00528771
PKIA protein kinase (cAMP-dependent, catalytic) inhibitor alpha -0.00528639
H2AX H2A.X variant histone -0.00528197
LAMA4 laminin, alpha 4 -0.00527256
CNR1 cannabinoid receptor 1 (brain) -0.00526294
SDF4 stromal cell derived factor 4 -0.00526266
ABHD17A abhydrolase domain containing 17A -0.00525674
HILPDA hypoxia inducible lipid droplet-associated -0.00524996
ANXA10 annexin A10 -0.00524984
ORC1 origin recognition complex, subunit 1 -0.00524536
POMZP3 POM121 and ZP3 fusion -0.00524013
GJA1 gap junction protein, alpha 1, 43kDa -0.00523701
GINS2 GINS complex subunit 2 (Psf2 homolog) -0.00520743
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 -0.00520154
IKZF1 IKAROS family zinc finger 1 (Ikaros) -0.00519192
HMGB3 high mobility group box 3 -0.00519061
PRRC1 proline-rich coiled-coil 1 -0.00519028
WSB1 WD repeat and SOCS box containing 1 -0.00518334
CD320 CD320 molecule -0.00517401
TMPRSS4 transmembrane protease, serine 4 -0.00517295
HHEX hematopoietically expressed homeobox -0.00517216
DPYD dihydropyrimidine dehydrogenase -0.00517202
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) -0.00516063
TXNIP thioredoxin interacting protein -0.00516019
PRPF19 pre-mRNA processing factor 19 -0.00511888
CP ceruloplasmin (ferroxidase) -0.00511703
CERS2 ceramide synthase 2 -0.00511214
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.00510986
PRPS1 phosphoribosyl pyrophosphate synthetase 1 -0.0051043
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 -0.00510331
PRPF4 pre-mRNA processing factor 4 -0.00510213
NLGN4X neuroligin 4, X-linked -0.0050756
FZD2 frizzled class receptor 2 -0.00507556
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -0.0050715
SPARCL1 SPARC-like 1 (hevin) -0.00507102
PTGIS prostaglandin I2 (prostacyclin) synthase -0.005069
TMC5 transmembrane channel-like 5 -0.00506594
CFHR4 complement factor H-related 4 -0.00505803
KLHL23 kelch-like family member 23 -0.00505697
USPL1 ubiquitin specific peptidase like 1 -0.00505219
FBP1 fructose-1,6-bisphosphatase 1 -0.00505036
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0050437
MECOM MDS1 and EVI1 complex locus -0.00504346
PIP prolactin-induced protein -0.00503875
WASL Wiskott-Aldrich syndrome-like -0.00503111
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.00503053
MT3 metallothionein 3 -0.00502906
PHGDH phosphoglycerate dehydrogenase -0.00500918