BCR Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description breakpoint cluster region|A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 613)
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Genes

328 genes differentially expressed following the BCR gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
USH1G Usher syndrome 1G (autosomal recessive) 2.47916
NPAP1 nuclear pore associated protein 1 2.47916
COLEC10 collectin sub-family member 10 (C-type lectin) 2.47916
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.47916
TMEM176A transmembrane protein 176A 2.47916
NXPH4 neurexophilin 4 2.47916
MGAM2 maltase-glucoamylase 2 (putative) 2.47916
SLC35G6 solute carrier family 35, member G6 2.47916
DGAT2L6 diacylglycerol O-acyltransferase 2-like 6 2.47916
SSTR1 somatostatin receptor 1 2.47916
SLC6A1 solute carrier family 6 (neurotransmitter transporter), member 1 2.47916
NR1H4 nuclear receptor subfamily 1, group H, member 4 2.47916
FGF21 fibroblast growth factor 21 2.47916
P2RY6 pyrimidinergic receptor P2Y, G-protein coupled, 6 2.47916
COL19A1 collagen, type XIX, alpha 1 2.47916
PLVAP plasmalemma vesicle associated protein 2.47916
GJA4 gap junction protein, alpha 4, 37kDa 2.47916
GJA3 gap junction protein, alpha 3, 46kDa 2.47916
HRH4 histamine receptor H4 2.47916
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.47916
LURAP1L leucine rich adaptor protein 1-like 2.47916
PDE6C phosphodiesterase 6C, cGMP-specific, cone, alpha prime 2.47916
MYBPC1 myosin binding protein C, slow type 2.47916
OSR2 odd-skipped related transciption factor 2 2.47916
LRRC55 leucine rich repeat containing 55 2.47916
FSCN2 fascin actin-bundling protein 2, retinal 2.47916
ARPP21 cAMP-regulated phosphoprotein, 21kDa 2.47916
CD68 CD68 molecule 2.47916
FOXL2NB FOXL2 neighbor 2.47916
TTLL8 tubulin tyrosine ligase-like family member 8 2.47916
MEIKIN meiotic kinetochore factor 2.47916
NUDT18 nudix (nucleoside diphosphate linked moiety X)-type motif 18 2.47916
COPZ2 coatomer protein complex, subunit zeta 2 2.47916
S100A2 S100 calcium binding protein A2 2.47916
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.47916
PTGER1 prostaglandin E receptor 1 (subtype EP1), 42kDa 2.47916
MT3 metallothionein 3 2.47916
PDE7B phosphodiesterase 7B 2.47916
SLC22A13 solute carrier family 22 (organic anion/urate transporter), member 13 2.47916
BATF basic leucine zipper transcription factor, ATF-like 2.47916
RPE65 retinal pigment epithelium-specific protein 65kDa 2.47916
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 2.47916
KCNMB1 potassium channel subfamily M regulatory beta subunit 1 2.47916
CA6 carbonic anhydrase VI 2.47916
REN renin 2.47916
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 2.47916
NAA11 N(alpha)-acetyltransferase 11, NatA catalytic subunit 2.47916
LOC124900192 uncharacterized LOC124900192 2.47916
CPHXL cytoplasmic polyadenylated homeobox like 2.47916
CHCT1 CHD1 helical C-terminal domain containing 1 2.47916
RTL9 retrotransposon Gag like 9 2.47916
CLXN calaxin 2.47916
PLAAT1 phospholipase A and acyltransferase 1 2.47916
DEPP1 DEPP autophagy regulator 1 2.47916
VSIR V-set immunoregulatory receptor 2.47916
SELE selectin E 2.47916
PTH1R parathyroid hormone 1 receptor 2.47916
CIBAR2 CBY1 interacting BAR domain containing 2 2.47916
SMIM35 small integral membrane protein 35 2.47916
H3C14 H3 clustered histone 14 2.47916
CIMIP4 ciliary microtubule inner protein 4 2.47916
C3ORF85 chromosome 3 open reading frame 85 2.47916
SMIM32 small integral membrane protein 32 2.47916
LITAFD LITAF domain containing 2.47916
C1ORF232 chromosome 1 open reading frame 230 2.47916
CIMIP3 ciliary microtubule inner protein 3 2.47916
LOC124903233 uncharacterized LOC124903233 2.47916
RAMACL RNA guanine-7 methyltransferase activating subunit like 2.47916
GREP1 glycine rich extracellular protein 1 2.47916
RAG2 recombination activating gene 2 2.47916
CLDN14 claudin 14 2.47916
CD300LF CD300 molecule-like family member f 2.47916
ANXA10 annexin A10 2.47916
OR51B5 olfactory receptor, family 51, subfamily B, member 5 2.47916
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 2.47916
IL31RA interleukin 31 receptor A 2.47916
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.47916
PTGDR2 prostaglandin D2 receptor 2 2.47916
CLDN9 claudin 9 2.47916
PCDHB11 protocadherin beta 11 2.47916
TLE6 transducin-like enhancer of split 6 2.47916
GOLGA7B golgin A7 family, member B 2.47916
GZMM granzyme M (lymphocyte met-ase 1) 2.47916
SLC45A2 solute carrier family 45, member 2 2.47916
SIM1 single-minded family bHLH transcription factor 1 2.47916
CFAP97 cilia and flagella associated protein 97 2.47916
SMLR1 small leucine-rich protein 1 2.47916
TMPRSS7 transmembrane protease, serine 7 2.47916
LY6K lymphocyte antigen 6 complex, locus K 2.47916
PNPLA1 patatin-like phospholipase domain containing 1 2.47916
ADPRH ADP-ribosylarginine hydrolase 2.47916
CREB3L3 cAMP responsive element binding protein 3-like 3 2.47916
SLC9A4 solute carrier family 9, subfamily A (NHE4, cation proton antiporter 4), member 4 2.47916
DNAI2 dynein, axonemal, intermediate chain 2 2.47916
TMIGD3 transmembrane and immunoglobulin domain containing 3 2.47916
DEFB4A defensin, beta 4A 2.47916
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.47916
TRADD TNFRSF1A-associated via death domain 2.47916
NPFFR1 neuropeptide FF receptor 1 2.47916
CD52 CD52 molecule 2.47916
MEFV Mediterranean fever 2.47916
ISL2 ISL LIM homeobox 2 2.47916
CHSY3 chondroitin sulfate synthase 3 2.47916
TIPE2 TNF alpha induced protein 8 like 2 2.47916
ZNF80 zinc finger protein 80 2.47916
ADAM2 ADAM metallopeptidase domain 2 2.47916
BPIFB1 BPI fold containing family B, member 1 2.47916
ACSM5 acyl-CoA synthetase medium-chain family member 5 2.47916
PRSS53 protease, serine, 53 2.47916
PDCD1 programmed cell death 1 2.47916
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin) 2.47916
APOF apolipoprotein F 2.47916
DACT3 dishevelled-binding antagonist of beta-catenin 3 2.47916
EBF3 early B-cell factor 3 2.47916
CCDC159 coiled-coil domain containing 159 2.47916
FNDC1 fibronectin type III domain containing 1 2.47916
MR1 major histocompatibility complex, class I-related 2.47916
CNGB3 cyclic nucleotide gated channel beta 3 2.47916
IGF2 insulin-like growth factor 2 2.47916
TM4SF19 transmembrane 4 L six family member 19 2.47916
CLEC18A C-type lectin domain family 18, member A 2.47916
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 2.47916
SLC17A6 solute carrier family 17 (vesicular glutamate transporter), member 6 2.47916
BTG4 B-cell translocation gene 4 2.47916
GOLGA8H golgin A8 family, member H 2.47916
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.47916
DMRTB1 DMRT-like family B with proline-rich C-terminal, 1 2.47916
CFH complement factor H 2.47916
NLRP14 NLR family, pyrin domain containing 14 2.47916
GAS2L2 growth arrest-specific 2 like 2 2.47916
GPR150 G protein-coupled receptor 150 2.47916
LY96 lymphocyte antigen 96 2.47916
TAPBPL TAP binding protein-like 2.47916
TF transferrin 2.47916
RBM20 RNA binding motif protein 20 2.47916
NTN5 netrin 5 2.47916
NR5A1 nuclear receptor subfamily 5, group A, member 1 2.47916
F13B coagulation factor XIII, B polypeptide 2.47916
DAW1 dynein assembly factor with WDR repeat domains 1 2.47916
MYLK2 myosin light chain kinase 2 2.47916
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 2.47916
BCL2A1 BCL2-related protein A1 2.47916
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.47916
SLC10A5 solute carrier family 10, member 5 2.47916
CTRL chymotrypsin-like 2.47916
LY6G6D lymphocyte antigen 6 complex, locus G6D 2.47916
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.47916
AQP10 aquaporin 10 2.47916
PTPN7 protein tyrosine phosphatase, non-receptor type 7 2.47916
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.47916
TGM6 transglutaminase 6 2.47916
OR51I2 olfactory receptor, family 51, subfamily I, member 2 2.47916
PRSS21 protease, serine, 21 (testisin) 2.47916
OR10G8 olfactory receptor, family 10, subfamily G, member 8 2.47916
DCST1 DC-STAMP domain containing 1 2.47916
CHRDL1 chordin-like 1 2.47916
HES2 hes family bHLH transcription factor 2 2.47916
RGR retinal G protein coupled receptor 2.47916
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 2.47916
LDHC lactate dehydrogenase C 2.47916
EPO erythropoietin 2.47916
C9ORF50 chromosome 9 open reading frame 50 2.47916
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 2.47916
HIC1 hypermethylated in cancer 1 2.47916
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial 2.47916
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 2.47916
ANKRD33 ankyrin repeat domain 33 2.47916
NAA30 N(alpha)-acetyltransferase 30, NatC catalytic subunit 2.42859
RASGRF1 Ras protein-specific guanine nucleotide-releasing factor 1 2.39934
BHLHE40 basic helix-loop-helix family, member e40 2.39934
GTF2A1L general transcription factor IIA, 1-like 2.39934
EFHB EF-hand domain family, member B 2.39934
ERAS ES cell expressed Ras 2.38941
DARS1 aspartyl-tRNA synthetase 1 2.38941
CLTRN collectrin, amino acid transport regulator 2.38207
MACC1 metastasis associated in colon cancer 1 2.38207
RTL8B retrotransposon Gag like 8B 2.38113
CAMSAP3 calmodulin regulated spectrin-associated protein family, member 3 2.37395
GTF2F1 general transcription factor IIF, polypeptide 1, 74kDa 2.36818
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 2.36401
TRPS1 trichorhinophalangeal syndrome I 2.31847
CCDC92 coiled-coil domain containing 92 2.31809
NLRP10 NLR family, pyrin domain containing 10 2.3046
PECAM1 platelet/endothelial cell adhesion molecule 1 2.3046
LRP1B low density lipoprotein receptor-related protein 1B 2.3046
CCDC80 coiled-coil domain containing 80 2.28768
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit 2.28455
WTAP Wilms tumor 1 associated protein 2.27605
PERP PERP, TP53 apoptosis effector 2.26645
WDR76 WD repeat domain 76 2.24522
STOX2 storkhead box 2 2.20554
B3GALT5 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 2.17903
ATG13 autophagy related 13 2.17682
WARS2 tryptophanyl tRNA synthetase 2, mitochondrial 2.17682
EIF3M eukaryotic translation initiation factor 3, subunit M 2.16187
TAGLN transgelin 2.15341
AP2M1 adaptor-related protein complex 2, mu 1 subunit 2.15101
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.1501
FANCM Fanconi anemia, complementation group M 2.12039
LSM2 LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) 2.10646
SOCS4 suppressor of cytokine signaling 4 2.10474
SLC9A9 solute carrier family 9, subfamily A (NHE9, cation proton antiporter 9), member 9 2.1035
DOCK6 dedicator of cytokinesis 6 2.09186
KLRB1 killer cell lectin-like receptor subfamily B, member 1 2.0896
PAQR3 progestin and adipoQ receptor family member III 2.0829
ATP5PF ATP synthase peripheral stalk subunit F6 2.0766
SIT1 signaling threshold regulating transmembrane adaptor 1 2.05988
ARRDC1 arrestin domain containing 1 2.05988
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 2.05764
POLR2D polymerase (RNA) II (DNA directed) polypeptide D 2.05555
ZSWIM9 zinc finger SWIM-type containing 9 2.05551
TBRG1 transforming growth factor beta regulator 1 2.05144
UPP2 uridine phosphorylase 2 2.03503
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 2.02307
PIP4P1 phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 2.02236
SPINK5 serine peptidase inhibitor, Kazal type 5 2.02148
ATF7 activating transcription factor 7 2.0181
CLEC4A C-type lectin domain family 4, member A 2.0169
ZNF165 zinc finger protein 165 2.00925
ARID3B AT rich interactive domain 3B (BRIGHT-like) 2.00863
KLF7 Kruppel-like factor 7 (ubiquitous) 2.00399

decreased expression

Symbol Name Standardized Value
FKBP4 FK506 binding protein 4, 59kDa -2.47916
PCDHB5 protocadherin beta 5 -2.47916
RCN3 reticulocalbin 3, EF-hand calcium binding domain -2.47916
MANBA mannosidase, beta A, lysosomal -2.47916
ZNF23 zinc finger protein 23 -2.47916
FRMPD2 FERM and PDZ domain containing 2 -2.47916
PLAGL1 pleiomorphic adenoma gene-like 1 -2.47916
SVIL supervillin -2.47916
PAWR PRKC, apoptosis, WT1, regulator -2.47916
TFF3 trefoil factor 3 (intestinal) -2.47916
C5AR1 complement component 5a receptor 1 -2.47916
ZDHHC8 zinc finger, DHHC-type containing 8 -2.47916
SYNDIG1L synapse differentiation inducing 1-like -2.47916
LOC124904542 uncharacterized LOC124904542 -2.47916
DHFR2 dihydrofolate reductase 2 -2.47916
ATL1 atlastin GTPase 1 -2.47916
RETREG1 reticulophagy regulator 1 -2.47916
MYLK4 myosin light chain kinase family, member 4 -2.47916
AGFG1 ArfGAP with FG repeats 1 -2.47916
MOG myelin oligodendrocyte glycoprotein -2.47916
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 -2.46523
BCAS1 breast carcinoma amplified sequence 1 -2.38941
CASR calcium-sensing receptor -2.38941
INCA1 inhibitor of CDK, cyclin A1 interacting protein 1 -2.38941
PLXNA4 plexin A4 -2.38941
C1QL1 complement component 1, q subcomponent-like 1 -2.38006
SERGEF secretion regulating guanine nucleotide exchange factor -2.36041
MAEA macrophage erythroblast attacher -2.34698
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -2.34698
ZRANB1 zinc finger, RAN-binding domain containing 1 -2.34698
ACADVL acyl-CoA dehydrogenase, very long chain -2.3413
TMEM242 transmembrane protein 242 -2.32539
RERG RAS-like, estrogen-regulated, growth inhibitor -2.32539
ACE angiotensin I converting enzyme -2.32539
SLC14A2 solute carrier family 14 (urea transporter), member 2 -2.32539
CNOT6 CCR4-NOT transcription complex, subunit 6 -2.31809
AP4B1 adaptor-related protein complex 4, beta 1 subunit -2.3085
FBXO48 F-box protein 48 -2.3085
NCF2 neutrophil cytosolic factor 2 -2.3046
SHLD2 shieldin complex subunit 2 -2.3046
UPB1 ureidopropionase, beta -2.3046
MGAM maltase-glucoamylase -2.3046
PRRT4 proline-rich transmembrane protein 4 -2.3046
NOD2 nucleotide-binding oligomerization domain containing 2 -2.3046
TMPRSS6 transmembrane protease, serine 6 -2.3046
SPMIP3 sperm microtubule inner protein 3 -2.3046
GDPD4 glycerophosphodiester phosphodiesterase domain containing 4 -2.3046
TMIE transmembrane inner ear -2.3046
TP73 tumor protein p73 -2.3046
RXFP1 relaxin/insulin-like family peptide receptor 1 -2.3046
SCN7A sodium channel, voltage gated, type VII alpha subunit -2.3046
NPPC natriuretic peptide C -2.3046
DDTL D-dopachrome tautomerase-like -2.3046
SYT15 synaptotagmin XV -2.3046
RGPD5 RANBP2-like and GRIP domain containing 5 -2.3046
PTH2 parathyroid hormone 2 -2.3046
EPHA10 EPH receptor A10 -2.3046
PLAC8 placenta-specific 8 -2.3046
MOS v-mos Moloney murine sarcoma viral oncogene homolog -2.3046
SCNN1D sodium channel, non voltage gated 1 delta subunit -2.3046
SLA Src-like-adaptor -2.3046
ZNF675 zinc finger protein 675 -2.3046
DES desmin -2.3046
PSMD13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 13 -2.3046
HIPK4 homeodomain interacting protein kinase 4 -2.3046
KCNA2 potassium channel, voltage gated shaker related subfamily A, member 2 -2.3046
USP35 ubiquitin specific peptidase 35 -2.3046
FGFR1 fibroblast growth factor receptor 1 -2.3046
SLC5A11 solute carrier family 5 (sodium/inositol cotransporter), member 11 -2.3046
YTHDC1 YTH domain containing 1 -2.29683
ILK integrin-linked kinase -2.29179
MAZ MYC-associated zinc finger protein (purine-binding transcription factor) -2.25028
IQSEC1 IQ motif and Sec7 domain 1 -2.24733
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 -2.23665
RAB33B RAB33B, member RAS oncogene family -2.23431
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -2.22193
FAM228B family with sequence similarity 228, member B -2.20913
VAC14 Vac14 homolog (S. cerevisiae) -2.19976
ING2 inhibitor of growth family, member 2 -2.16655
NDST2 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2 -2.1621
SNX9 sorting nexin 9 -2.16187
KCNV2 potassium channel, voltage gated modifier subfamily V, member 2 -2.16187
LRP1 low density lipoprotein receptor-related protein 1 -2.16187
XKR9 XK, Kell blood group complex subunit-related family, member 9 -2.16187
LDHD lactate dehydrogenase D -2.15972
PPP4R1 protein phosphatase 4, regulatory subunit 1 -2.15557
CACNB3 calcium channel, voltage-dependent, beta 3 subunit -2.1457
JUNB jun B proto-oncogene -2.1457
GPNMB glycoprotein (transmembrane) nmb -2.1457
TLCD3B TLC domain containing 3B -2.13924
NEK5 NIMA-related kinase 5 -2.10776
CCDC183 coiled-coil domain containing 183 -2.10646
C17ORF67 chromosome 17 open reading frame 67 -2.0797
C10ORF88 chromosome 10 open reading frame 88 -2.07533
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 -2.05608
PIMREG PICALM interacting mitotic regulator -2.05409
NHLH2 nescient helix loop helix 2 -2.04706
TSN translin -2.04706
INAVA innate immunity activator -2.04675
TACR3 tachykinin receptor 3 -2.03697
UVRAG UV radiation resistance associated -2.03434
USE1 unconventional SNARE in the ER 1 homolog (S. cerevisiae) -2.03347
METTL26 methyltransferase like 26 -2.02687
FNTA farnesyltransferase, CAAX box, alpha -2.02457
CD24 CD24 molecule -2.02356
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain -2.02148
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -2.01906