BCR Gene Set

Dataset KEA Substrates of Kinases
Category physical interactions
Type kinase
Description breakpoint cluster region|A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 613)
External Link http://www.ncbi.nlm.nih.gov/gene/613
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10 substrates of the kinase BCR from the curated KEA Substrates of Kinases dataset.

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
CRK v-crk avian sarcoma virus CT10 oncogene homolog
DLG1 discs, large homolog 1 (Drosophila)
FAS Fas cell surface death receptor
FES FES proto-oncogene, tyrosine kinase
HCK HCK proto-oncogene, Src family tyrosine kinase
HNF1A HNF1 homeobox A
MLLT4 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta