BDNF Gene Set

Dataset Pathway Commons Protein-Protein Interactions
Category physical interactions
Type interacting protein
Description brain-derived neurotrophic factor|The protein encoded by this gene is a member of the nerve growth factor family. It is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. Expression of this gene is reduced in both Alzheimer's and Huntington disease patients. This gene may play a role in the regulation of stress response and in the biology of mood disorders. Multiple transcript variants encoding distinct isoforms have been described for this gene. [provided by RefSeq, Jan 2009] (NCBI Entrez Gene Database, 627)
External Link http://www.ncbi.nlm.nih.gov/gene/627
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Genes

52 interacting proteins for BDNF from the Pathway Commons Protein-Protein Interactions dataset.

Symbol Name
ADAM17 ADAM metallopeptidase domain 17
AGO3 argonaute RISC catalytic component 3
APP amyloid beta (A4) precursor protein
CADPS2 Ca++-dependent secretion activator 2
CASP6 caspase 6, apoptosis-related cysteine peptidase
CDC42 cell division cycle 42
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CHEK2 checkpoint kinase 2
CPE carboxypeptidase E
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CTNND1 catenin (cadherin-associated protein), delta 1
DYNLT1 dynein, light chain, Tctex-type 1
EHD4 EH-domain containing 4
ELAVL1 ELAV like RNA binding protein 1
ESR1 estrogen receptor 1
F11R F11 receptor
FRS2 fibroblast growth factor receptor substrate 2
FRS3 fibroblast growth factor receptor substrate 3
GAB1 GRB2-associated binding protein 1
GRB2 growth factor receptor-bound protein 2
INPP5K inositol polyphosphate-5-phosphatase K
JUNB jun B proto-oncogene
MAPK10 mitogen-activated protein kinase 10
MAPK8 mitogen-activated protein kinase 8
MAPK9 mitogen-activated protein kinase 9
MBTPS1 membrane-bound transcription factor peptidase, site 1
MMP3 matrix metallopeptidase 3
MMP7 matrix metallopeptidase 7
NCAM1 neural cell adhesion molecule 1
NOS3 nitric oxide synthase 3 (endothelial cell)
NTF3 neurotrophin 3
NTF4 neurotrophin 4
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PLCG1 phospholipase C, gamma 1
PLG plasminogen
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
RAP1A RAP1A, member of RAS oncogene family
RAP1B RAP1B, member of RAS oncogene family
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RIT1 Ras-like without CAAX 1
RIT2 Ras-like without CAAX 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SORT1 sortilin 1
SOS1 son of sevenless homolog 1 (Drosophila)
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TP53 tumor protein p53