BHMT Gene Set

Dataset CM4AI KOLF21J CRISPRi Gene Perturbation Atlas
Category transcriptomics
Type gene perturbation
Description betaine--homocysteine S-methyltransferase|This gene encodes a cytosolic enzyme that catalyzes the conversion of betaine and homocysteine to dimethylglycine and methionine, respectively. Defects in this gene could lead to hyperhomocyst(e)inemia, but such a defect has not yet been observed. [provided by RefSeq, Jul 2008] (NCBI Entrez Gene Database, 635)
Similar Terms
Downloads & Tools

Genes

325 genes differentially expressed following the BHMT gene perturbation from the CM4AI KOLF21J CRISPRi Gene Perturbation Atlas.

increased expression

Symbol Name Standardized Value
WEE2 WEE1 homolog 2 (S. pombe) 2.9015
MILR1 mast cell immunoglobulin-like receptor 1 2.9015
HES4 hes family bHLH transcription factor 4 2.9015
NCF1 neutrophil cytosolic factor 1 2.9015
NOD2 nucleotide-binding oligomerization domain containing 2 2.9015
RRAD Ras-related associated with diabetes 2.9015
AADACL4 arylacetamide deacetylase-like 4 2.9015
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 2.9015
MTTP microsomal triglyceride transfer protein 2.9015
DSG3 desmoglein 3 2.9015
GDNF glial cell derived neurotrophic factor 2.9015
EPPIN epididymal peptidase inhibitor 2.9015
TRIM15 tripartite motif containing 15 2.9015
NDRG1 N-myc downstream regulated 1 2.9015
FOXL1 forkhead box L1 2.9015
PLEKHG7 pleckstrin homology domain containing, family G (with RhoGef domain) member 7 2.9015
IL4I1 interleukin 4 induced 1 2.9015
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 2.9015
NOTO notochord homeobox 2.9015
SLC5A1 solute carrier family 5 (sodium/glucose cotransporter), member 1 2.9015
SCG2 secretogranin II 2.9015
OR4F17 olfactory receptor, family 4, subfamily F, member 17 2.9015
PPBP pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) 2.9015
GABRA6 gamma-aminobutyric acid (GABA) A receptor, alpha 6 2.9015
SFXN3 sideroflexin 3 2.9015
FABP12 fatty acid binding protein 12 2.9015
CLEC5A C-type lectin domain family 5, member A 2.9015
LRRIQ4 leucine-rich repeats and IQ motif containing 4 2.9015
HBB hemoglobin, beta 2.9015
BHMT2 betaine--homocysteine S-methyltransferase 2 2.9015
ATOH1 atonal homolog 1 (Drosophila) 2.9015
ADH6 alcohol dehydrogenase 6 (class V) 2.9015
CPLX4 complexin 4 2.9015
VCL vinculin 2.9015
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.9015
OR2AJ1 olfactory receptor, family 2, subfamily AJ, member 1 2.9015
LRRC10B leucine rich repeat containing 10B 2.9015
TAL2 T-cell acute lymphocytic leukemia 2 2.9015
MYOM3 myomesin 3 2.9015
ALPK2 alpha-kinase 2 2.9015
PECAM1 platelet/endothelial cell adhesion molecule 1 2.9015
LYNX1 Ly6/neurotoxin 1 2.9015
ARSF arylsulfatase F 2.9015
C12ORF71 chromosome 12 open reading frame 71 2.9015
THRSP thyroid hormone responsive 2.9015
IQCF1 IQ motif containing F1 2.9015
GMFG glia maturation factor, gamma 2.9015
TMC3 transmembrane channel-like 3 2.9015
SYCP2 synaptonemal complex protein 2 2.9015
SPMAP1 sperm microtubule associated protein 1 2.9015
ROPN1L rhophilin associated tail protein 1-like 2.9015
ROPN1B rhophilin associated tail protein 1B 2.9015
OPRM1 opioid receptor, mu 1 2.9015
CXCL13 chemokine (C-X-C motif) ligand 13 2.9015
RD3 retinal degeneration 3 2.9015
C9ORF43 chromosome 9 open reading frame 43 2.9015
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 2.9015
TTR transthyretin 2.9015
CMKLR1 chemerin chemokine-like receptor 1 2.9015
ARL14EPL ADP-ribosylation factor-like 14 effector protein-like 2.9015
PTH1R parathyroid hormone 1 receptor 2.9015
STING1 stimulator of interferon response cGAMP interactor 1 2.9015
SPMIP1 sperm microtubule inner protein 1 2.9015
SPMIP9 sperm microtubule inner protein 9 2.9015
MYMK myomaker, myoblast fusion factor 2.9015
MUCL3 mucin like 3 2.9015
CFAP276 cilia and flagella associated protein 276 2.9015
MEIOSIN meiosis initiator 2.9015
CATSPERZ catsper channel auxiliary subunit zeta 2.9015
DIPK1C divergent protein kinase domain 1C 2.9015
CABCOCO1 ciliary associated calcium binding coiled-coil 1 2.9015
PMIS2 PMIS2 transmembrane protein 2.9015
SDR16C5 short chain dehydrogenase/reductase family 16C, member 5 2.9015
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 2.9015
LRIT3 leucine-rich repeat, immunoglobulin-like and transmembrane domains 3 2.9015
AKR1D1 aldo-keto reductase family 1, member D1 2.9015
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 2.9015
EDAR ectodysplasin A receptor 2.9015
C1ORF87 chromosome 1 open reading frame 87 2.9015
DMP1 dentin matrix acidic phosphoprotein 1 2.9015
PRB2 proline-rich protein BstNI subfamily 2 2.9015
NAMPT nicotinamide phosphoribosyltransferase 2.9015
CD300LG CD300 molecule-like family member g 2.9015
ATP13A5 ATPase type 13A5 2.9015
HAPLN2 hyaluronan and proteoglycan link protein 2 2.9015
IL5 interleukin 5 2.9015
LRRN4CL LRRN4 C-terminal like 2.9015
BEST2 bestrophin 2 2.9015
ASIC4 acid sensing (proton gated) ion channel family member 4 2.9015
GPR85 G protein-coupled receptor 85 2.9015
TAS1R1 taste receptor, type 1, member 1 2.9015
GJD2 gap junction protein, delta 2, 36kDa 2.9015
C1QL2 complement component 1, q subcomponent-like 2 2.9015
CFAP45 cilia and flagella associated protein 45 2.9015
RUNX3 runt-related transcription factor 3 2.9015
NHLRC4 NHL repeat containing 4 2.9015
FAM3D family with sequence similarity 3, member D 2.9015
SPACA5 sperm acrosome associated 5 2.9015
CXCR2 chemokine (C-X-C motif) receptor 2 2.9015
PCDHGA4 protocadherin gamma subfamily A, 4 2.9015
ALOXE3 arachidonate lipoxygenase 3 2.9015
FCN3 ficolin (collagen/fibrinogen domain containing) 3 2.9015
ECM1 extracellular matrix protein 1 2.9015
C17ORF99 chromosome 17 open reading frame 99 2.9015
HOPX HOP homeobox 2.9015
GOLGA6C golgin A6 family, member C 2.9015
TBC1D26 TBC1 domain family, member 26 2.9015
ALOX15B arachidonate 15-lipoxygenase, type B 2.9015
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 2.9015
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 2.9015
ACKR2 atypical chemokine receptor 2 2.9015
CTXN2 cortexin 2 2.9015
IL9R interleukin 9 receptor 2.9015
GH2 growth hormone 2 2.9015
GLT6D1 glycosyltransferase 6 domain containing 1 2.9015
CYP2C19 cytochrome P450, family 2, subfamily C, polypeptide 19 2.9015
ZP1 zona pellucida glycoprotein 1 (sperm receptor) 2.9015
TRIM55 tripartite motif containing 55 2.9015
LRRC36 leucine rich repeat containing 36 2.9015
PTGIR prostaglandin I2 (prostacyclin) receptor (IP) 2.9015
BPIFB4 BPI fold containing family B, member 4 2.9015
CXCR6 chemokine (C-X-C motif) receptor 6 2.9015
CALHM1 calcium homeostasis modulator 1 2.9015
LYG2 lysozyme G-like 2 2.9015
EFCAB9 EF-hand calcium binding domain 9 2.9015
TDRD10 tudor domain containing 10 2.9015
EXTL1 exostosin-like glycosyltransferase 1 2.9015
LAIR1 leukocyte-associated immunoglobulin-like receptor 1 2.9015
ACCSL 1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)-like 2.9015
TREH trehalase (brush-border membrane glycoprotein) 2.9015
CSF3R colony stimulating factor 3 receptor (granulocyte) 2.9015
ARHGAP20 Rho GTPase activating protein 20 2.9015
APOH apolipoprotein H (beta-2-glycoprotein I) 2.9015
HUS1B HUS1 checkpoint homolog b (S. pombe) 2.9015
MBOAT4 membrane bound O-acyltransferase domain containing 4 2.9015
TTBK1 tau tubulin kinase 1 2.9015
KCNJ13 potassium channel, inwardly rectifying subfamily J, member 13 2.9015
WFDC11 WAP four-disulfide core domain 11 2.9015
TECTB tectorin beta 2.9015
TTC22 tetratricopeptide repeat domain 22 2.9015
TXNDC17 thioredoxin domain containing 17 2.9015
FGF4 fibroblast growth factor 4 2.9015
SETD6 SET domain containing 6 2.9015
CH25H cholesterol 25-hydroxylase 2.9015
CNGB1 cyclic nucleotide gated channel beta 1 2.9015
WFDC13 WAP four-disulfide core domain 13 2.9015
ZNF835 zinc finger protein 835 2.9015
GJC2 gap junction protein, gamma 2, 47kDa 2.9015
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type 2.9015
SPON2 spondin 2, extracellular matrix protein 2.9015
RTP1 receptor (chemosensory) transporter protein 1 2.9015
RXRG retinoid X receptor, gamma 2.9015
HES2 hes family bHLH transcription factor 2 2.9015
RIIAD1 regulatory subunit of type II PKA R-subunit (RIIa) domain containing 1 2.9015
GOLGA8R golgin A8 family, member R 2.9015
SLC10A6 solute carrier family 10 (sodium/bile acid cotransporter), member 6 2.9015
GBX1 gastrulation brain homeobox 1 2.9015
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.9015
CD8A CD8a molecule 2.9015
PLA2G12B phospholipase A2, group XIIB 2.9015
OTOP3 otopetrin 3 2.9015
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 2.9015
CTSF cathepsin F 2.9015
SLC25A31 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 31 2.9015
NMBR neuromedin B receptor 2.9015
MSMP microseminoprotein, prostate associated 2.9015
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 2.9015
LPA lipoprotein, Lp(a) 2.9015
RP1 retinitis pigmentosa 1 (autosomal dominant) 2.9015
GCSAML germinal center-associated, signaling and motility-like 2.9015
OR4M2 olfactory receptor, family 4, subfamily M, member 2 2.9015
TMEM52B transmembrane protein 52B 2.9015
PCDHAC2 protocadherin alpha subfamily C, 2 2.9015
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 2.9015
BRD1 bromodomain containing 1 2.86126
ZC3H11A zinc finger CCCH-type containing 11A 2.83001
ACKR3 atypical chemokine receptor 3 2.83001
ANAPC2 anaphase promoting complex subunit 2 2.83001
EML2 echinoderm microtubule associated protein like 2 2.73242
TMEM70 transmembrane protein 70 2.70805
PLBD2 phospholipase B domain containing 2 2.70056
NDUFB6 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 6, 17kDa 2.69302
H1-1 H1.1 linker histone, cluster member 2.66704
EPHB1 EPH receptor B1 2.65779
LOC730098 uncharacterized LOC730098 2.65779
KDM3A lysine (K)-specific demethylase 3A 2.60646
CCN2 cellular communication network factor 2 2.59931
ATF7IP2 activating transcription factor 7 interacting protein 2 2.57008
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 2.53336
AMBP alpha-1-microglobulin/bikunin precursor 2.52179
TECTA tectorin alpha 2.52179
SVBP small vasohibin binding protein 2.50058
MEGF10 multiple EGF-like-domains 10 2.48548
KPNA1 karyopherin alpha 1 (importin alpha 5) 2.47711
FNDC3B fibronectin type III domain containing 3B 2.42971
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 2.41274
LPAR6 lysophosphatidic acid receptor 6 2.3535
PDCD6IP programmed cell death 6 interacting protein 2.31495
MRPL1 mitochondrial ribosomal protein L1 2.31056
CLEC4G C-type lectin domain family 4, member G 2.30269
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.30128
GREM1 gremlin 1, DAN family BMP antagonist 2.30128
PCDHB9 protocadherin beta 9 2.30128
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 2.28613
JCAD junctional cadherin 5 associated 2.28366
SMYD3 SET and MYND domain containing 3 2.26481
KANK2 KN motif and ankyrin repeat domains 2 2.25304
SYNPR synaptoporin 2.25205
RPS23 ribosomal protein S23 2.22212
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2 2.21431
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 2.1793
RPS19 ribosomal protein S19 2.1793
EFNA4 ephrin-A4 2.16487
RTL4 retrotransposon Gag like 4 2.14056
POLR1B polymerase (RNA) I polypeptide B, 128kDa 2.10248
GATA4 GATA binding protein 4 2.09485
FABP3 fatty acid binding protein 3, muscle and heart 2.09405
HERPUD2 HERPUD family member 2 2.08817
NPHP4 nephronophthisis 4 2.08713
WNK2 WNK lysine deficient protein kinase 2 2.06621
EIF3I eukaryotic translation initiation factor 3, subunit I 2.06149
LCOR ligand dependent nuclear receptor corepressor 2.05021
UBE2E1 ubiquitin-conjugating enzyme E2E 1 2.03658
CSMD3 CUB and Sushi multiple domains 3 2.03498
ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 2.03498
HAPSTR1 HUWE1 associated protein modifying stress responses 2.03498
YPEL2 yippee-like 2 (Drosophila) 2.0341
CCDC51 coiled-coil domain containing 51 2.01052
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.01052
DBN1 drebrin 1 2.01
SELENOH selenoprotein H 2.00906
ARHGAP32 Rho GTPase activating protein 32 2.00551

decreased expression

Symbol Name Standardized Value
INPP5J inositol polyphosphate-5-phosphatase J -2.9015
ZNF226 zinc finger protein 226 -2.9015
ADPRHL1 ADP-ribosylhydrolase like 1 -2.9015
SMIM36 small integral membrane protein 36 -2.9015
BTBD18 BTB (POZ) domain containing 18 -2.9015
FAM110D family with sequence similarity 110, member D -2.9015
MMP28 matrix metallopeptidase 28 -2.9015
SNX2 sorting nexin 2 -2.9015
HTRA1 HtrA serine peptidase 1 -2.9015
TAS2R31 taste receptor, type 2, member 31 -2.9015
TSHR thyroid stimulating hormone receptor -2.9015
NIPAL2 NIPA-like domain containing 2 -2.86813
TMEM138 transmembrane protein 138 -2.86813
BARX1 BARX homeobox 1 -2.86019
ZBTB42 zinc finger and BTB domain containing 42 -2.86019
LTBP2 latent transforming growth factor beta binding protein 2 -2.86019
UAP1L1 UDP-N-acetylglucosamine pyrophosphorylase 1 like 1 -2.86019
LRRC63 leucine rich repeat containing 63 -2.86019
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.86019
LY6G5C lymphocyte antigen 6 complex, locus G5C -2.86019
CFAP299 cilia and flagella associated protein 299 -2.86019
BNC1 basonuclin 1 -2.86019
VXN vexin -2.86019
ENTPD2 ectonucleoside triphosphate diphosphohydrolase 2 -2.86019
CFAP73 cilia and flagella associated protein 73 -2.86019
TEKTIP1 tektin bundle interacting protein 1 -2.86019
SERPIND1 serpin peptidase inhibitor, clade D (heparin cofactor), member 1 -2.86019
SDS serine dehydratase -2.86019
ATP10B ATPase, class V, type 10B -2.86019
CXCR4 chemokine (C-X-C motif) receptor 4 -2.86019
ATP6V0A2 ATPase, H+ transporting, lysosomal V0 subunit a2 -2.78922
REL v-rel avian reticuloendotheliosis viral oncogene homolog -2.78238
RHBG Rh family, B glycoprotein (gene/pseudogene) -2.71914
AP3B2 adaptor-related protein complex 3, beta 2 subunit -2.71808
COL6A3 collagen, type VI, alpha 3 -2.70374
TVP23B trans-golgi network vesicle protein 23 homolog B (S. cerevisiae) -2.56205
A2M alpha-2-macroglobulin -2.53336
VSTM4 V-set and transmembrane domain containing 4 -2.53336
RRN3 RRN3 RNA polymerase I transcription factor homolog (S. cerevisiae) -2.44618
OVGP1 oviductal glycoprotein 1, 120kDa -2.44338
BRINP2 bone morphogenetic protein/retinoic acid inducible neural-specific 2 -2.44338
CCDC81 coiled-coil domain containing 81 -2.44338
MAK16 MAK16 homolog (S. cerevisiae) -2.42973
LEPROTL1 leptin receptor overlapping transcript-like 1 -2.41026
KTN1 kinectin 1 (kinesin receptor) -2.37281
C1ORF198 chromosome 1 open reading frame 198 -2.34853
RAB43 RAB43, member RAS oncogene family -2.33403
FMN2 formin 2 -2.31643
TYW5 tRNA-yW synthesizing protein 5 -2.31643
TAF10 TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa -2.31169
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -2.31169
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 -2.30269
MFSD2B major facilitator superfamily domain containing 2B -2.30207
ZNF660-ZNF197 ZNF660-ZNF197 readthrough -2.28613
PCDHGA6 protocadherin gamma subfamily A, 6 -2.27733
REC114 REC114 meiotic recombination protein -2.27733
GNG7 guanine nucleotide binding protein (G protein), gamma 7 -2.27575
EXOG endo/exonuclease (5'-3'), endonuclease G-like -2.26647
ELP1 elongator acetyltransferase complex subunit 1 -2.2661
RANGRF RAN guanine nucleotide release factor -2.2661
HTRA3 HtrA serine peptidase 3 -2.25459
TMEM154 transmembrane protein 154 -2.24753
ATG5 autophagy related 5 -2.23992
OMA1 OMA1 zinc metallopeptidase -2.20574
HYI hydroxypyruvate isomerase (putative) -2.20474
PPIL6 peptidylprolyl isomerase (cyclophilin)-like 6 -2.18927
RBM43 RNA binding motif protein 43 -2.18927
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 -2.17615
UBE2C ubiquitin-conjugating enzyme E2C -2.17423
TPT1 tumor protein, translationally-controlled 1 -2.16637
MEI4 meiosis-specific 4 homolog (S. cerevisiae) -2.13405
GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D -2.13405
NTMT1 N-terminal Xaa-Pro-Lys N-methyltransferase 1 -2.12158
DMAP1 DNA methyltransferase 1 associated protein 1 -2.11696
ZGRF1 zinc finger, GRF-type containing 1 -2.11582
SLC16A10 solute carrier family 16 (aromatic amino acid transporter), member 10 -2.09365
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -2.08817
FRMD5 FERM domain containing 5 -2.08713
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 -2.06078
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 -2.05272
RNF2 ring finger protein 2 -2.05021
H1-10 H1.10 linker histone -2.04477
NID1 nidogen 1 -2.03685
PARD6A par-6 family cell polarity regulator alpha -2.03659
RB1 retinoblastoma 1 -2.03498
ATXN7 ataxin 7 -2.03498
FAM53A family with sequence similarity 53, member A -2.03498
DST dystonin -2.0349
VWDE von Willebrand factor D and EGF domains -2.03323
TTF2 transcription termination factor, RNA polymerase II -2.01953
BCAR3 breast cancer anti-estrogen resistance 3 -2.00906
MERTK MER proto-oncogene, tyrosine kinase -2.00394
PSRC1 proline/serine-rich coiled-coil 1 -2.00083