BI-3406_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BI-3406 perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BI-3406_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.109453
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0789673
NDRG1 N-myc downstream regulated 1 0.0691237
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0646499
SQSTM1 sequestosome 1 0.0625132
B2M beta-2-microglobulin 0.0614596
PTMA prothymosin, alpha 0.0590225
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0586765
AKAP12 A kinase (PRKA) anchor protein 12 0.0573864
CSTB cystatin B (stefin B) 0.0533462
TPM4 tropomyosin 4 0.0533352
LDHA lactate dehydrogenase A 0.0423977
EEF2 eukaryotic translation elongation factor 2 0.0391801
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0379596
FTL ferritin, light polypeptide 0.0373059
ZFP36L1 ZFP36 ring finger protein-like 1 0.0371197
RACK1 receptor for activated C kinase 1 0.0341583
UBC ubiquitin C 0.0319815
RPL23 ribosomal protein L23 0.0312787
GOLGA4 golgin A4 0.0301622
VIM vimentin 0.0301621
ENO1 enolase 1, (alpha) 0.0290708
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0290593
DDIT4 DNA-damage-inducible transcript 4 0.0289481
RPS8 ribosomal protein S8 0.0257654
RPL37A ribosomal protein L37a 0.0257282
RPS3 ribosomal protein S3 0.0254723
EIF1 eukaryotic translation initiation factor 1 0.0251863
IFITM3 interferon induced transmembrane protein 3 0.0251436
RPL12 ribosomal protein L12 0.0251401
S100A6 S100 calcium binding protein A6 0.0251376
MT2A metallothionein 2A 0.0237649
RPS6 ribosomal protein S6 0.0236939
RPS12 ribosomal protein S12 0.0228143
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0227091
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.022336
TPM3 tropomyosin 3 0.0221009
CALR calreticulin 0.0220442
NAP1L1 nucleosome assembly protein 1-like 1 0.0218795
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0210011
LOC112694756 uncharaterized LOC112694756 0.020248
PKM pyruvate kinase, muscle 0.020001
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0199214
SOX9 SRY (sex determining region Y)-box 9 0.019921
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0197218
RPLP1 ribosomal protein, large, P1 0.019525
BHLHE40 basic helix-loop-helix family, member e40 0.0193254
FLNA filamin A, alpha 0.0190515
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0190056
SRRM2 serine/arginine repetitive matrix 2 0.0186931
MYH9 myosin, heavy chain 9, non-muscle 0.0186063
RHOBTB3 Rho-related BTB domain containing 3 0.0184734
FAM107B family with sequence similarity 107, member B 0.0183031
EZR ezrin 0.018169
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0181044
NFE2L1 nuclear factor, erythroid 2-like 1 0.0178049
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0177861
HILPDA hypoxia inducible lipid droplet-associated 0.0176259
STC1 stanniocalcin 1 0.0172067
OPTN optineurin 0.01718
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0171313
ADM adrenomedullin 0.0169996
RPL26 ribosomal protein L26 0.0169795
LAPTM4A lysosomal protein transmembrane 4 alpha 0.0169732
PDIA3 protein disulfide isomerase family A, member 3 0.0169423
MXI1 MAX interactor 1, dimerization protein 0.0168968
RPL35A ribosomal protein L35a 0.01682
SEPTIN7 septin 7 0.0167643
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0164003
RPS19 ribosomal protein S19 0.0160896
RPL11 ribosomal protein L11 0.0159739
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0159655
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0158575
RPL36 ribosomal protein L36 0.0157809
RND3 Rho family GTPase 3 0.0157612
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0157434
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0157424
ARRDC3 arrestin domain containing 3 0.0156966
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0154258
FOSL1 FOS-like antigen 1 0.0154
YBX1 Y box binding protein 1 0.0152843
HLA-A major histocompatibility complex, class I, A 0.0152589
RPS2 ribosomal protein S2 0.0152572
RIOK3 RIO kinase 3 0.0151639
RPS27 ribosomal protein S27 0.0150679
LOXL2 lysyl oxidase-like 2 0.0150608
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0150488
RPS27A ribosomal protein S27a 0.0149517
TPI1 triosephosphate isomerase 1 0.0149208
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0148875
RNMT RNA (guanine-7-) methyltransferase 0.0147708
LGALS1 lectin, galactoside-binding, soluble, 1 0.0146721
S100A11 S100 calcium binding protein A11 0.01463
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0146224
RPL31 ribosomal protein L31 0.0146142
FGFR1 fibroblast growth factor receptor 1 0.0145357
AHNAK2 AHNAK nucleoprotein 2 0.0145162
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0143034
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.014231
TPT1 tumor protein, translationally-controlled 1 0.0141276

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.154888
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.120229
NAV1 neuron navigator 1 -0.0854301
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0847964
CDH13 cadherin 13 -0.0763163
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0712416
COL5A1 collagen, type V, alpha 1 -0.0701038
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0647671
PLAT plasminogen activator, tissue -0.0638089
COL8A1 collagen, type VIII, alpha 1 -0.0628601
FN1 fibronectin 1 -0.0489722
SLC39A11 solute carrier family 39, member 11 -0.0484201
PODXL podocalyxin-like -0.0455392
ABI3BP ABI family, member 3 (NESH) binding protein -0.0446072
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0410698
AUTS2 autism susceptibility candidate 2 -0.0410528
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0380305
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0369323
SUCNR1 succinate receptor 1 -0.0350489
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0344482
EFNA5 ephrin-A5 -0.0312664
GLIS3 GLIS family zinc finger 3 -0.0286128
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0275843
DGKG diacylglycerol kinase, gamma 90kDa -0.0275238
FBXL7 F-box and leucine-rich repeat protein 7 -0.0274239
FRMD4A FERM domain containing 4A -0.0263089
CUX1 cut-like homeobox 1 -0.0262806
RIGI RNA sensor RIG-I -0.0246103
PDE4D phosphodiesterase 4D, cAMP-specific -0.0245001
ZBTB20 zinc finger and BTB domain containing 20 -0.0231628
EGFR epidermal growth factor receptor -0.0230664
JAZF1 JAZF zinc finger 1 -0.0226676
FLT1 fms-related tyrosine kinase 1 -0.0222512
COL5A2 collagen, type V, alpha 2 -0.0216833
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0216524
CYTH3 cytohesin 3 -0.0214659
PRSS23 protease, serine, 23 -0.0212481
MAP1B microtubule-associated protein 1B -0.020849
MX2 MX dynamin-like GTPase 2 -0.0206453
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0199921
RUNX1 runt-related transcription factor 1 -0.0190832
VEGFC vascular endothelial growth factor C -0.0190046
SDCCAG8 serologically defined colon cancer antigen 8 -0.0189653
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0187444
LOX lysyl oxidase -0.0186696
MRPS6 mitochondrial ribosomal protein S6 -0.0186051
SORBS2 sorbin and SH3 domain containing 2 -0.0184273
TPM1 tropomyosin 1 (alpha) -0.0182384
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0180585
MSI2 musashi RNA-binding protein 2 -0.0180569
COL1A2 collagen, type I, alpha 2 -0.0180238
PDE10A phosphodiesterase 10A -0.0179551
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.017951
TNS3 tensin 3 -0.0179095
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.0175235
MT1X metallothionein 1X -0.0174566
MBD5 methyl-CpG binding domain protein 5 -0.0170714
LDLRAD4 low density lipoprotein receptor class A domain containing 4 -0.0170531
MED13L mediator complex subunit 13-like -0.0169998
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.016627
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0164138
SP3 Sp3 transcription factor -0.0162731
PRELID2 PRELI domain containing 2 -0.0162211
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0161549
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) -0.0160631
SRPK2 SRSF protein kinase 2 -0.0158378
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0154594
DOCK5 dedicator of cytokinesis 5 -0.0153492
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0151958
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0151664
PBX3 pre-B-cell leukemia homeobox 3 -0.015054
RNF213 ring finger protein 213 -0.0149287
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0148445
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0147879
IPO9 importin 9 -0.0145463
DKK1 dickkopf WNT signaling pathway inhibitor 1 -0.0144554
CEP112 centrosomal protein 112kDa -0.0144486
KIAA1549L KIAA1549-like -0.014417
PCDH7 protocadherin 7 -0.0144042
RNF144A ring finger protein 144A -0.0142143
NLGN4Y neuroligin 4, Y-linked -0.0142056
FBN1 fibrillin 1 -0.0140475
SMYD3 SET and MYND domain containing 3 -0.0140408
MACF1 microtubule-actin crosslinking factor 1 -0.0138792
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0138604
DIRAS3 DIRAS family, GTP-binding RAS-like 3 -0.0136379
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0135762
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0135168
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0133556
COPA coatomer protein complex, subunit alpha -0.0132349
CD99 CD99 molecule -0.0130851
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0130554
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0128738
SCLT1 sodium channel and clathrin linker 1 -0.0127866
EHBP1 EH domain binding protein 1 -0.0126212
RASAL2 RAS protein activator like 2 -0.0124261
MEIS2 Meis homeobox 2 -0.012341
WWTR1 WW domain containing transcription regulator 1 -0.0123379
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0123122
DCLK2 doublecortin-like kinase 2 -0.0123045