BI-3406_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BI-3406 perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BI-3406_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.0672212
VCL vinculin 0.0642134
B2M beta-2-microglobulin 0.0546662
EEF2 eukaryotic translation elongation factor 2 0.0534985
PDE10A phosphodiesterase 10A 0.0497787
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0432263
ASPH aspartate beta-hydroxylase 0.0402072
MCL1 myeloid cell leukemia 1 0.0377132
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0374298
SRRM2 serine/arginine repetitive matrix 2 0.0366853
RPS8 ribosomal protein S8 0.0366683
IGFBP3 insulin-like growth factor binding protein 3 0.0362731
RACK1 receptor for activated C kinase 1 0.03622
FAT1 FAT atypical cadherin 1 0.0338132
IFI6 interferon, alpha-inducible protein 6 0.0333403
ANTXR1 anthrax toxin receptor 1 0.0317729
RPL23 ribosomal protein L23 0.031772
EGFR epidermal growth factor receptor 0.0310056
FN1 fibronectin 1 0.0308672
RPS3 ribosomal protein S3 0.030833
NPAS2 neuronal PAS domain protein 2 0.0298404
HMGA2 high mobility group AT-hook 2 0.0283953
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0281889
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0272066
HSPA8 heat shock 70kDa protein 8 0.0270165
SP100 SP100 nuclear antigen 0.026876
RIGI RNA sensor RIG-I 0.0268338
EXOC4 exocyst complex component 4 0.026601
MYO1E myosin IE 0.0263531
RPL11 ribosomal protein L11 0.0260307
TRIO trio Rho guanine nucleotide exchange factor 0.0259304
LDHA lactate dehydrogenase A 0.0259058
CEMIP cell migration inducing protein, hyaluronan binding 0.0258955
SVIL supervillin 0.0255932
RPL7 ribosomal protein L7 0.0249287
TM4SF1 transmembrane 4 L six family member 1 0.0233084
PDLIM5 PDZ and LIM domain 5 0.0227726
LMO7 LIM domain 7 0.0227666
PRELID2 PRELI domain containing 2 0.0227178
MACF1 microtubule-actin crosslinking factor 1 0.0226715
RPS27 ribosomal protein S27 0.0224294
ATXN1 ataxin 1 0.0223823
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0223015
SOX4 SRY (sex determining region Y)-box 4 0.0221088
LOC112694756 uncharaterized LOC112694756 0.0221064
COL5A2 collagen, type V, alpha 2 0.0220985
NALF1 NALCN channel auxiliary factor 1 0.0220937
DSPP dentin sialophosphoprotein 0.0217826
FTL ferritin, light polypeptide 0.0213687
RPL3 ribosomal protein L3 0.0212032
MRTFA myocardin related transcription factor A 0.0207763
EXT1 exostosin glycosyltransferase 1 0.0207449
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.020581
INTS6 integrator complex subunit 6 0.0205005
SAMD4A sterile alpha motif domain containing 4A 0.0204178
FTH1 ferritin, heavy polypeptide 1 0.0203288
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0202783
CDH13 cadherin 13 0.020254
RPS19 ribosomal protein S19 0.0200428
MYOF myoferlin 0.020002
JMJD1C jumonji domain containing 1C 0.0200001
HLA-A major histocompatibility complex, class I, A 0.0199069
KYNU kynureninase 0.0198931
MX1 MX dynamin-like GTPase 1 0.0198592
SIK2 salt-inducible kinase 2 0.0195299
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0193725
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0190276
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0188613
MT2A metallothionein 2A 0.0188456
TXNRD1 thioredoxin reductase 1 0.0188385
AHNAK AHNAK nucleoprotein 0.0188197
CSNK1A1 casein kinase 1, alpha 1 0.0187726
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0187655
KTN1 kinectin 1 (kinesin receptor) 0.0186621
SMAD3 SMAD family member 3 0.0185622
APLP2 amyloid beta (A4) precursor-like protein 2 0.0185467
EZR ezrin 0.018512
SMYD3 SET and MYND domain containing 3 0.0184546
CLIP1 CAP-GLY domain containing linker protein 1 0.0184397
EGR1 early growth response 1 0.0183464
PSEN1 presenilin 1 0.0182246
FLNB filamin B, beta 0.0181836
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0181734
NACA nascent polypeptide-associated complex alpha subunit 0.0180616
LAMB3 laminin, beta 3 0.0177895
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0176691
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0175982
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0175919
MAP7 microtubule-associated protein 7 0.0171799
TPI1 triosephosphate isomerase 1 0.0171737
HOMER1 homer scaffolding protein 1 0.0171216
CTBP2 C-terminal binding protein 2 0.0169742
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0165586
PCBP2 poly(rC) binding protein 2 0.0164305
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0164023
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0163475
PTPRE protein tyrosine phosphatase, receptor type, E 0.0162361
RABGAP1L RAB GTPase activating protein 1-like 0.0161449
PGK1 phosphoglycerate kinase 1 0.0160733
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0160505

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.187124
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.120972
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0999584
HELZ helicase with zinc finger -0.0900397
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0804357
MEIS2 Meis homeobox 2 -0.0717291
SYT1 synaptotagmin I -0.0649306
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0606817
COL1A1 collagen, type I, alpha 1 -0.0601436
FNBP1 formin binding protein 1 -0.0596418
PTPRD protein tyrosine phosphatase, receptor type, D -0.0537253
LSAMP limbic system-associated membrane protein -0.0525597
MEF2A myocyte enhancer factor 2A -0.0524638
FAM13A family with sequence similarity 13, member A -0.0516773
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0500137
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0484944
NPEPPS aminopeptidase puromycin sensitive -0.0461427
SOS1 son of sevenless homolog 1 (Drosophila) -0.0453317
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0450313
LPIN1 lipin 1 -0.0448511
LMNA lamin A/C -0.0440312
PTMA prothymosin, alpha -0.043466
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0421288
SPAG9 sperm associated antigen 9 -0.0414584
ZNF292 zinc finger protein 292 -0.0412072
WDR45B WD repeat domain 45B -0.0411304
KDM3A lysine (K)-specific demethylase 3A -0.0403444
PTK2 protein tyrosine kinase 2 -0.0396812
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0375729
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0368639
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0368049
NREP neuronal regeneration related protein -0.0352355
PRKCA protein kinase C, alpha -0.0351897
NAMPT nicotinamide phosphoribosyltransferase -0.0350525
OGA O-GlcNAcase -0.0345761
MED13 mediator complex subunit 13 -0.0345304
COL3A1 collagen, type III, alpha 1 -0.034448
TNRC6B trinucleotide repeat containing 6B -0.0339062
NCAM2 neural cell adhesion molecule 2 -0.0333728
DTNA dystrobrevin, alpha -0.0329787
IGF1R insulin-like growth factor 1 receptor -0.0327706
FMN1 formin 1 -0.0326954
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0324117
SEC31A SEC31 homolog A (S. cerevisiae) -0.0323803
MBNL2 muscleblind-like splicing regulator 2 -0.0319331
SCN9A sodium channel, voltage gated, type IX alpha subunit -0.0313302
MSI2 musashi RNA-binding protein 2 -0.031017
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0306425
ACBD3 acyl-CoA binding domain containing 3 -0.0301224
CD36 CD36 molecule (thrombospondin receptor) -0.029813
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0292633
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.029146
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0290691
ADGRG6 adhesion G protein-coupled receptor G6 -0.0287783
TRIB2 tribbles pseudokinase 2 -0.028615
ZMYM2 zinc finger, MYM-type 2 -0.0285367
GOLGA4 golgin A4 -0.0285028
DPH6 diphthamine biosynthesis 6 -0.0283787
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0279247
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0278066
RPL38 ribosomal protein L38 -0.0277783
MARCHF6 membrane associated ring-CH-type finger 6 -0.0277282
CDC27 cell division cycle 27 -0.0277164
HIP1 huntingtin interacting protein 1 -0.0273005
USP3 ubiquitin specific peptidase 3 -0.0270627
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 -0.0269952
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0269876
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.026716
NAP1L1 nucleosome assembly protein 1-like 1 -0.0266676
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.026659
GLG1 golgi glycoprotein 1 -0.0265519
QKI QKI, KH domain containing, RNA binding -0.0260865
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0258259
APP amyloid beta (A4) precursor protein -0.0253608
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0249991
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0247286
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0243684
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) -0.0242582
FBXL20 F-box and leucine-rich repeat protein 20 -0.0240857
BIRC6 baculoviral IAP repeat containing 6 -0.0238901
EYA1 EYA transcriptional coactivator and phosphatase 1 -0.0237521
RPL19 ribosomal protein L19 -0.0234183
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0232937
WSB1 WD repeat and SOCS box containing 1 -0.0231404
LCORL ligand dependent nuclear receptor corepressor-like -0.022973
SEPTIN9 septin 9 -0.0226211
RNF145 ring finger protein 145 -0.0225877
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0224952
KDM5B lysine (K)-specific demethylase 5B -0.0224342
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 -0.0223786
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0223472
HAND2 heart and neural crest derivatives expressed 2 -0.0222549
ANKRD17 ankyrin repeat domain 17 -0.0221395
LRRC7 leucine rich repeat containing 7 -0.021868
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0215294
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0215015
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0213055
MON2 MON2 homolog (S. cerevisiae) -0.0212206
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -0.0211342
SETD5 SET domain containing 5 -0.0211249