BI-3406_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description BI-3406 perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the BI-3406_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
B2M beta-2-microglobulin 0.123829
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.121242
LCN2 lipocalin 2 0.11073
EPSTI1 epithelial stromal interaction 1 (breast) 0.0998185
RNF213 ring finger protein 213 0.0961021
SMAD3 SMAD family member 3 0.0911598
C6ORF132 chromosome 6 open reading frame 132 0.08528
PKM pyruvate kinase, muscle 0.0822508
ANXA2 annexin A2 0.0805622
MX1 MX dynamin-like GTPase 1 0.0788207
LMO7 LIM domain 7 0.0768281
IFI6 interferon, alpha-inducible protein 6 0.0750795
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0731292
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0713017
AREG amphiregulin 0.0658812
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.06408
SP100 SP100 nuclear antigen 0.0626772
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0585051
STS steroid sulfatase (microsomal), isozyme S 0.0584637
MX2 MX dynamin-like GTPase 2 0.0580276
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0563604
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0556773
RIGI RNA sensor RIG-I 0.0556367
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0533998
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0527076
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.052132
AKAP13 A kinase (PRKA) anchor protein 13 0.0519592
EFNB2 ephrin-B2 0.0504234
MSI2 musashi RNA-binding protein 2 0.0500444
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0493281
TMC5 transmembrane channel-like 5 0.0490696
ETV6 ets variant 6 0.0483365
LYZ lysozyme 0.0480886
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0479599
MYO1E myosin IE 0.0478826
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0477263
ITGA6 integrin, alpha 6 0.0455728
GMDS GDP-mannose 4,6-dehydratase 0.0451784
ARHGAP26 Rho GTPase activating protein 26 0.0448183
EPHB2 EPH receptor B2 0.0444511
ASPH aspartate beta-hydroxylase 0.0435638
VCL vinculin 0.0427679
FAT1 FAT atypical cadherin 1 0.0404351
BCL2L1 BCL2-like 1 0.0398887
GCLC glutamate-cysteine ligase, catalytic subunit 0.0398736
PTMA prothymosin, alpha 0.0392545
DIAPH1 diaphanous-related formin 1 0.0387182
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0382934
UBC ubiquitin C 0.0381548
ZSWIM6 zinc finger, SWIM-type containing 6 0.0377125
LPP LIM domain containing preferred translocation partner in lipoma 0.0367773
RABGAP1L RAB GTPase activating protein 1-like 0.0365158
RPL23 ribosomal protein L23 0.0360622
SRRM2 serine/arginine repetitive matrix 2 0.0358198
TM4SF19 transmembrane 4 L six family member 19 0.0356341
RSAD2 radical S-adenosyl methionine domain containing 2 0.0353529
SHB Src homology 2 domain containing adaptor protein B 0.0351542
RPL7L1 ribosomal protein L7-like 1 0.0347562
LOC102724023 ES1 protein homolog, mitochondrial 0.0347306
TSHZ2 teashirt zinc finger homeobox 2 0.0346033
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0344759
MCL1 myeloid cell leukemia 1 0.0344671
IFI27 interferon, alpha-inducible protein 27 0.0344544
MYH9 myosin, heavy chain 9, non-muscle 0.0340054
ZNFX1 zinc finger, NFX1-type containing 1 0.0338138
DSPP dentin sialophosphoprotein 0.0337459
ACTG1 actin gamma 1 0.0333674
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0332686
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0330997
SEPTIN9 septin 9 0.0329534
ACTN4 actinin, alpha 4 0.0328127
ENO1 enolase 1, (alpha) 0.0326855
EEF2 eukaryotic translation elongation factor 2 0.0326802
FTL ferritin, light polypeptide 0.0325258
CATSPERB catsper channel auxiliary subunit beta 0.0322574
INTS6 integrator complex subunit 6 0.031911
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0317931
PMP22 peripheral myelin protein 22 0.0309801
MCU mitochondrial calcium uniporter 0.0308552
APP amyloid beta (A4) precursor protein 0.0305468
RBM47 RNA binding motif protein 47 0.030132
CTNND1 catenin (cadherin-associated protein), delta 1 0.0300384
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0300261
HKDC1 hexokinase domain containing 1 0.0299189
VMP1 vacuole membrane protein 1 0.0298679
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0296621
PARP9 poly (ADP-ribose) polymerase family, member 9 0.0295779
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0292883
LIMA1 LIM domain and actin binding 1 0.0292491
MACF1 microtubule-actin crosslinking factor 1 0.0291872
DST dystonin 0.0290336
CTBP2 C-terminal binding protein 2 0.0283424
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0281819
ATP11A ATPase, class VI, type 11A 0.0280546
TPM3 tropomyosin 3 0.0278211
SOX9 SRY (sex determining region Y)-box 9 0.0275028
EXT1 exostosin glycosyltransferase 1 0.0274251
TSC22D1 TSC22 domain family, member 1 0.0272445
MLPH melanophilin 0.0270896
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0269498

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0799786
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0755656
TPT1 tumor protein, translationally-controlled 1 -0.0592254
MBNL2 muscleblind-like splicing regulator 2 -0.0502528
NDRG1 N-myc downstream regulated 1 -0.044091
SEC31A SEC31 homolog A (S. cerevisiae) -0.0417828
COG6 component of oligomeric golgi complex 6 -0.040712
BTBD9 BTB (POZ) domain containing 9 -0.0395098
H1-0 H1.0 linker histone -0.0381268
RNF149 ring finger protein 149 -0.0365389
AHI1 Abelson helper integration site 1 -0.0342603
ACBD3 acyl-CoA binding domain containing 3 -0.0340524
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0337198
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0336017
TTC3 tetratricopeptide repeat domain 3 -0.0334436
GOLGA4 golgin A4 -0.0330691
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0315223
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0311681
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0308151
MORF4L2 mortality factor 4 like 2 -0.0297199
RBM39 RNA binding motif protein 39 -0.0286461
ZMYM2 zinc finger, MYM-type 2 -0.0281605
UFM1 ubiquitin-fold modifier 1 -0.0280491
RAB1A RAB1A, member RAS oncogene family -0.027548
FNIP1 folliculin interacting protein 1 -0.0267171
SEC24D SEC24 family member D -0.0264842
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0264332
SBF2 SET binding factor 2 -0.0262496
KDM3A lysine (K)-specific demethylase 3A -0.0254676
TMEM263 transmembrane protein 263 -0.0246156
PDIA3 protein disulfide isomerase family A, member 3 -0.0242522
PTEN phosphatase and tensin homolog -0.0242055
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0234615
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0233778
ESYT2 extended synaptotagmin-like protein 2 -0.0231608
P4HB prolyl 4-hydroxylase, beta polypeptide -0.023087
MCTP2 multiple C2 domains, transmembrane 2 -0.0225686
CANX calnexin -0.0223916
FNDC3A fibronectin type III domain containing 3A -0.0221538
AGR2 anterior gradient 2 -0.0221488
USP3 ubiquitin specific peptidase 3 -0.0218081
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0215741
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0214622
GOLGB1 golgin B1 -0.0213789
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0209488
HELZ helicase with zinc finger -0.0208035
MON2 MON2 homolog (S. cerevisiae) -0.0207605
COG5 component of oligomeric golgi complex 5 -0.0206488
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.020502
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0204871
SEC24A SEC24 family member A -0.020127
FNDC3B fibronectin type III domain containing 3B -0.0200639
WDR45B WD repeat domain 45B -0.0198185
PPP1CB protein phosphatase 1, catalytic subunit, beta isozyme -0.0196624
TMPRSS4 transmembrane protease, serine 4 -0.0196452
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0194786
DENND4C DENN/MADD domain containing 4C -0.0194281
COPB1 coatomer protein complex, subunit beta 1 -0.0194146
CALU calumenin -0.0194119
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0193543
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0192149
GOLGA2 golgin A2 -0.0190918
SUCO SUN domain containing ossification factor -0.0187845
ADM adrenomedullin -0.018747
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0186668
COPA coatomer protein complex, subunit alpha -0.0185873
LCORL ligand dependent nuclear receptor corepressor-like -0.0185241
BIRC6 baculoviral IAP repeat containing 6 -0.0184703
PRRC1 proline-rich coiled-coil 1 -0.0184307
BRWD3 bromodomain and WD repeat domain containing 3 -0.0183594
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.018348
METTL15 methyltransferase like 15 -0.0183061
PDK3 pyruvate dehydrogenase kinase, isozyme 3 -0.0182455
DLG1 discs, large homolog 1 (Drosophila) -0.0181287
TXNIP thioredoxin interacting protein -0.0181173
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0180641
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.0179897
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0178433
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0177601
GRK3 G protein-coupled receptor kinase 3 -0.0176135
HBP1 HMG-box transcription factor 1 -0.0174784
SREBF2 sterol regulatory element binding transcription factor 2 -0.0174042
TRA2A transformer 2 alpha homolog (Drosophila) -0.0172981
BHLHE40 basic helix-loop-helix family, member e40 -0.0172685
ZDHHC20 zinc finger, DHHC-type containing 20 -0.0170731
PRELID2 PRELI domain containing 2 -0.0169885
RNMT RNA (guanine-7-) methyltransferase -0.0169
PDXDC1 pyridoxal-dependent decarboxylase domain containing 1 -0.0166492
HDLBP high density lipoprotein binding protein -0.016616
ARF1 ADP-ribosylation factor 1 -0.0165682
CEP350 centrosomal protein 350kDa -0.0163575
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0161602
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0160874
SFXN1 sideroflexin 1 -0.0159015
CLTC clathrin, heavy chain (Hc) -0.0158318
EPB41 erythrocyte membrane protein band 4.1 -0.0158165
ATOSA atos homolog A -0.0157957
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0157178
MT1X metallothionein 1X -0.0156795
TMEM39A transmembrane protein 39A -0.0154128