| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | BI-3406 perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the BI-3406_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.268114 |
| IGF2 | insulin-like growth factor 2 | 0.260941 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.066308 |
| SVIL | supervillin | 0.0611396 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0593215 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0552308 |
| ASPH | aspartate beta-hydroxylase | 0.0528878 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0522624 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.052142 |
| RPL3 | ribosomal protein L3 | 0.0441131 |
| FAM107B | family with sequence similarity 107, member B | 0.0374824 |
| HMGA1 | high mobility group AT-hook 1 | 0.0351535 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0330191 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0323573 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0323109 |
| MCL1 | myeloid cell leukemia 1 | 0.0305443 |
| CCL20 | chemokine (C-C motif) ligand 20 | 0.0293927 |
| FAT1 | FAT atypical cadherin 1 | 0.0290034 |
| RPL23 | ribosomal protein L23 | 0.0276683 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0264326 |
| RACK1 | receptor for activated C kinase 1 | 0.0245464 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.024401 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0231357 |
| FRMD5 | FERM domain containing 5 | 0.0225131 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0224005 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0222891 |
| PLIN2 | perilipin 2 | 0.021968 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0214175 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0206731 |
| PLEC | plectin | 0.0197335 |
| TPM3 | tropomyosin 3 | 0.0195054 |
| KYNU | kynureninase | 0.0193066 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0191982 |
| ITGA6 | integrin, alpha 6 | 0.0185904 |
| INTS6 | integrator complex subunit 6 | 0.018117 |
| FLNA | filamin A, alpha | 0.0181048 |
| DSPP | dentin sialophosphoprotein | 0.0178669 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0177339 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.017662 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0176358 |
| RPL7 | ribosomal protein L7 | 0.0175649 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0173718 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0171851 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0170412 |
| ENO1 | enolase 1, (alpha) | 0.0170202 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0169172 |
| RPS12 | ribosomal protein S12 | 0.0168165 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0166795 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0158661 |
| STC2 | stanniocalcin 2 | 0.0156882 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0155332 |
| TARS1 | threonyl-tRNA synthetase 1 | 0.015468 |
| HSPA8 | heat shock 70kDa protein 8 | 0.015368 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0152334 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0148818 |
| RPL21 | ribosomal protein L21 | 0.0148213 |
| BCL2L1 | BCL2-like 1 | 0.0147163 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0146477 |
| PMM2 | phosphomannomutase 2 | 0.0143547 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.0141919 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0139659 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.013428 |
| HM13 | histocompatibility (minor) 13 | 0.0133352 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0132989 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0132717 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0130338 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0130205 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0129764 |
| HPCAL1 | hippocalcin-like 1 | 0.0129018 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0128606 |
| RASA2 | RAS p21 protein activator 2 | 0.0128247 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0128059 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 0.0127474 |
| ATXN1 | ataxin 1 | 0.0127223 |
| JAG1 | jagged 1 | 0.0125782 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0125453 |
| NDRG1 | N-myc downstream regulated 1 | 0.0124568 |
| RPS7 | ribosomal protein S7 | 0.0123674 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0122854 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0121374 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.012129 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0121019 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0121016 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0120611 |
| EGFR | epidermal growth factor receptor | 0.0120351 |
| MAPK6 | mitogen-activated protein kinase 6 | 0.0118557 |
| TARDBP | TAR DNA binding protein | 0.0117324 |
| EZR | ezrin | 0.0115991 |
| HYOU1 | hypoxia up-regulated 1 | 0.0114211 |
| PKM | pyruvate kinase, muscle | 0.0113813 |
| RPL4 | ribosomal protein L4 | 0.0112691 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0112625 |
| MAP1B | microtubule-associated protein 1B | 0.0112203 |
| TMSB10 | thymosin beta 10 | 0.0112181 |
| SHB | Src homology 2 domain containing adaptor protein B | 0.0112123 |
| DIAPH1 | diaphanous-related formin 1 | 0.0112011 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0110467 |
| TPI1 | triosephosphate isomerase 1 | 0.0109923 |
| DDX3X | DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked | 0.0108236 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0107792 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.227704 |
| APOB | apolipoprotein B | -0.155452 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.118373 |
| GPC3 | glypican 3 | -0.109029 |
| FN1 | fibronectin 1 | -0.100676 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0780599 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0775915 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.076299 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.072294 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0699972 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.069653 |
| C3 | complement component 3 | -0.0664693 |
| APOA2 | apolipoprotein A-II | -0.0600893 |
| TRIM26 | tripartite motif containing 26 | -0.0593235 |
| A2M | alpha-2-macroglobulin | -0.0584427 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.05587 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0527392 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0503421 |
| JMJD1C | jumonji domain containing 1C | -0.047368 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0462816 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0452625 |
| RBM39 | RNA binding motif protein 39 | -0.0445442 |
| GPC6 | glypican 6 | -0.0444089 |
| TMEM123 | transmembrane protein 123 | -0.0412047 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0405545 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0397592 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0386446 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0383189 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0363307 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0360923 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0356151 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0352865 |
| RPS24 | ribosomal protein S24 | -0.0346983 |
| SDC4 | syndecan 4 | -0.0346485 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0342049 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0337382 |
| CP | ceruloplasmin (ferroxidase) | -0.0327015 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0317746 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0313419 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0313398 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0309127 |
| GNAS | GNAS complex locus | -0.0302717 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0300842 |
| MBNL3 | muscleblind-like splicing regulator 3 | -0.030001 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0287428 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | -0.0285995 |
| GLG1 | golgi glycoprotein 1 | -0.0284423 |
| CFB | complement factor B | -0.0280643 |
| RPL35A | ribosomal protein L35a | -0.027726 |
| PEG3 | paternally expressed 3 | -0.0271659 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0271312 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0269612 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.0269315 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0267525 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0266781 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0265772 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0260765 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0260393 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0257852 |
| QKI | QKI, KH domain containing, RNA binding | -0.0256915 |
| AUH | AU RNA binding protein/enoyl-CoA hydratase | -0.0247744 |
| RPS6 | ribosomal protein S6 | -0.0246868 |
| ZNF292 | zinc finger protein 292 | -0.0244559 |
| TF | transferrin | -0.0240449 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0240025 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0239308 |
| KIAA1958 | KIAA1958 | -0.0233532 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0232511 |
| FOXN3 | forkhead box N3 | -0.0228958 |
| SBF2 | SET binding factor 2 | -0.0227718 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0226985 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0225387 |
| DDIT4 | DNA-damage-inducible transcript 4 | -0.0220161 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0219263 |
| APOE | apolipoprotein E | -0.0219191 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0217465 |
| RPLP1 | ribosomal protein, large, P1 | -0.0217405 |
| PHF3 | PHD finger protein 3 | -0.0213863 |
| RPS21 | ribosomal protein S21 | -0.0213617 |
| FTL | ferritin, light polypeptide | -0.0212769 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0212557 |
| RPLP0 | ribosomal protein, large, P0 | -0.0211977 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0210622 |
| SESTD1 | SEC14 and spectrin domains 1 | -0.0209787 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | -0.0208561 |
| RPL34 | ribosomal protein L34 | -0.0207 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0203886 |
| APOA1 | apolipoprotein A-I | -0.0203665 |
| MALT1 | MALT1 paracaspase | -0.0203416 |
| GRK3 | G protein-coupled receptor kinase 3 | -0.0201612 |
| ITGA1 | integrin, alpha 1 | -0.0200026 |
| TLK1 | tousled-like kinase 1 | -0.0196523 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0196324 |
| PTCHD4 | patched domain containing 4 | -0.0195233 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.019511 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0193702 |
| PDGFB | platelet-derived growth factor beta polypeptide | -0.0192875 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0191239 |
| RLF | rearranged L-myc fusion | -0.0189623 |
| USP3 | ubiquitin specific peptidase 3 | -0.0189217 |
